FI65630C - Foerfarande foer framstaellning av glykopeptid-antibiotikumet a/16686 - Google Patents
Foerfarande foer framstaellning av glykopeptid-antibiotikumet a/16686 Download PDFInfo
- Publication number
- FI65630C FI65630C FI800881A FI800881A FI65630C FI 65630 C FI65630 C FI 65630C FI 800881 A FI800881 A FI 800881A FI 800881 A FI800881 A FI 800881A FI 65630 C FI65630 C FI 65630C
- Authority
- FI
- Finland
- Prior art keywords
- butanol
- water
- methanol
- antibiotic
- positive
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10G—CRACKING HYDROCARBON OILS; PRODUCTION OF LIQUID HYDROCARBON MIXTURES, e.g. BY DESTRUCTIVE HYDROGENATION, OLIGOMERISATION, POLYMERISATION; RECOVERY OF HYDROCARBON OILS FROM OIL-SHALE, OIL-SAND, OR GASES; REFINING MIXTURES MAINLY CONSISTING OF HYDROCARBONS; REFORMING OF NAPHTHA; MINERAL WAXES
- C10G49/00—Treatment of hydrocarbon oils, in the presence of hydrogen or hydrogen-generating compounds, not provided for in a single one of groups C10G45/02, C10G45/32, C10G45/44, C10G45/58 or C10G47/00
- C10G49/02—Treatment of hydrocarbon oils, in the presence of hydrogen or hydrogen-generating compounds, not provided for in a single one of groups C10G45/02, C10G45/32, C10G45/44, C10G45/58 or C10G47/00 characterised by the catalyst used
- C10G49/08—Treatment of hydrocarbon oils, in the presence of hydrogen or hydrogen-generating compounds, not provided for in a single one of groups C10G45/02, C10G45/32, C10G45/44, C10G45/58 or C10G47/00 characterised by the catalyst used containing crystalline alumino-silicates, e.g. molecular sieves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J29/00—Catalysts comprising molecular sieves
- B01J29/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B33/00—Silicon; Compounds thereof
- C01B33/20—Silicates
- C01B33/26—Aluminium-containing silicates, i.e. silico-aluminates
- C01B33/28—Base exchange silicates, e.g. zeolites
- C01B33/2807—Zeolitic silicoaluminates with a tridimensional crystalline structure possessing molecular sieve properties; Isomorphous compounds wherein a part of the aluminium ore of the silicon present may be replaced by other elements such as gallium, germanium, phosphorus; Preparation of zeolitic molecular sieves from molecular sieves of another type or from preformed reacting mixtures
- C01B33/2884—Zeolitic silicoaluminates with a tridimensional crystalline structure possessing molecular sieve properties; Isomorphous compounds wherein a part of the aluminium ore of the silicon present may be replaced by other elements such as gallium, germanium, phosphorus; Preparation of zeolitic molecular sieves from molecular sieves of another type or from preformed reacting mixtures the aluminium or the silicon in the network being partly replaced
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/02—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon
- C07C1/04—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon from carbon monoxide with hydrogen
- C07C1/0425—Catalysts; their physical properties
- C07C1/043—Catalysts; their physical properties characterised by the composition
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/02—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon
- C07C1/04—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon from carbon monoxide with hydrogen
- C07C1/0425—Catalysts; their physical properties
- C07C1/043—Catalysts; their physical properties characterised by the composition
- C07C1/0435—Catalysts; their physical properties characterised by the composition containing a metal of group 8 or a compound thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
- C07C1/02—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon
- C07C1/04—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon from oxides of a carbon from carbon monoxide with hydrogen
- C07C1/0425—Catalysts; their physical properties
- C07C1/043—Catalysts; their physical properties characterised by the composition
- C07C1/0435—Catalysts; their physical properties characterised by the composition containing a metal of group 8 or a compound thereof
- C07C1/044—Catalysts; their physical properties characterised by the composition containing a metal of group 8 or a compound thereof containing iron
-
- C—CHEMISTRY; METALLURGY
- C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
- C10G—CRACKING HYDROCARBON OILS; PRODUCTION OF LIQUID HYDROCARBON MIXTURES, e.g. BY DESTRUCTIVE HYDROGENATION, OLIGOMERISATION, POLYMERISATION; RECOVERY OF HYDROCARBON OILS FROM OIL-SHALE, OIL-SAND, OR GASES; REFINING MIXTURES MAINLY CONSISTING OF HYDROCARBONS; REFORMING OF NAPHTHA; MINERAL WAXES
- C10G35/00—Reforming naphtha
- C10G35/04—Catalytic reforming
- C10G35/06—Catalytic reforming characterised by the catalyst used
- C10G35/065—Catalytic reforming characterised by the catalyst used containing crystalline zeolitic molecular sieves, other than aluminosilicates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2529/00—Catalysts comprising molecular sieves
- C07C2529/04—Catalysts comprising molecular sieves having base-exchange properties, e.g. crystalline zeolites, pillared clays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/045—Actinoplanes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/827—Actinoplanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (3)
1. Förfarande för framställning av ett glykopeptid-antibiotikum, vilket är antibiotikumet A/16686 som en fri bas eller ett farmaceutisk acceptabelt syra-additionssalt därav och vilket i form av dess hydro-klorid uppvisar följande kännetecken: A) ett vitt kristalliniskt ämne, vilket smälter i 224-226°C; B) väl löslig i vatten och dimetylformamid; löslig i metanol, etano] propanol och butanol; men olöslig i etyleter, petroleter och bensen; C) ungefärlig elementarkomposition: 51,73 % koi; 6,3»+ % väte, 9,96 % kväve, 5,84 % klor (totalhalt), 4,74 % klor-joner och 1 % rest; D) infrarött-absorptionsspektrum i nujol med följande observerbara absorptionsmaximivärden; (se fig. 1): 3290-3070, 2930 och 2860 (nujol), 1765, 1630, 1510, 1455, 1375 (nujol), 1230, 1175, 1130, 1065, 1030, 1015, 980, 840 och 820 cm"1; E) ultraviolett absorptionsspektrum med följande absorptionsmaximivärden (se fig. 2): a) i metanol: 232 nm (E1^ = 178) 265 nm (E1' = 107) b) i metanol, vilken innehäller 0,1 N HC1: 231 nm (E1^ = 167) 270 nm (E^' s 96) c) i metanol, vilken innehäller 0,1 N NaOH: 250 nm (E1^ = 232) 295 nm (skuldra) d) i metanol, vilken innehäller buffert pH 7,38: 231 nm (E1% = 167) icm 270 nm (E1^ = 96) F) specifik vridning jV] s + 49,7° (c s 0,43 % i IMF) G) följande karakteristiska reaktioner: ninhydrin (3 % etanolisk lösning) negativ ninhydrin (3 % etanolisk lösning + natriumacetat) positiv
1. FeClg - 1 % K3Fe(CN)g positiv (grön) Molish positiv Fehling negativ 22 65630 Biuret positiv Antron positiv Millon negativ l^SO^ kone. negativ KMnO^ positiv H) följande R^-värden vid papperskromatografi pä Whatman no. 1 papper, användning S. aureus ATCC 6538 som deteckteringorganism: elueringssystem Rf-värden I) med Sörensen buffert, pH 6,0, mättad n-butanol 0,00 2. med vatten, vilket innehäller 2 % p-toluen- sulfonsyra, mättad n-butanol 0,00 3. med vatten, vilket innehaller 2 % ammonium- hydroxid, mättad n-butanol 0,00 4. med n-butanol mättad Sörensen buffert, pH 6,0 0,05 5. n-butanol:metanol:vatten 4:1:2 0,43 6. med vatten mättad etylacetat 0,00 7. n-butanol:ättikssyra:vatten 2:1:1 0,52 8. n-butanol:pyridin:vatten 4:3:7 0,87 I) följande R^-värden vid olika tunnskiktskromatografisystem är uppvisar nedanför: elueringssystem (vol./voi./vol.) R^-värden 1. n-propanol:n-butanol:N ammoniumhydroxid 2:3:4 (Övre fasen) 0,15 2. n-butanol:ättikssyra:vatten 4:2:5 0,61 3. n-butanol:etanol:0,1 N klorvätesyra 0,61 4. kloroform:etanol:10 % ättikssyra 4:7:2 0,00 5. n-butanol:ättikssyra:vatten 4:1:5 0,17 6. metanol:10 % vattenhaltig ammoniumacetat: 10. ammoniumhydroxid 10:9:1 0,52 7. n-butanol:pyridin:vatten:ättikssyra 6:4:3:1 0,45 8. metanol:10% vattenhaltig ammoniumacetat: 10. ammoniumhydroxid 10:9:1 0,11 9) 0,25 M vattenhaltig Na^PO^: acetonitril 1:1 0,68 10. metanol:10 % vattenhaltig ammoniumacetat 1:1 0,65 11. n-butanol:ättikssyra:vatten 4:2:5 0,77 plattorna 1-7 Sr silikagel 60 F25 ^-plattor·, 8, 9 är silanerade silikagel 60 F2&l+-plattor och 10, 11 är cellulosa F-plattor; J) aminsyra-analys, efter en sur hydrolys i 6 N klorvätesyra i 110°C 6 timmar, uppvisar närvaro av ätminstone följande identifierbara aminsyror: ornitin, asparaginsyra, treonin, glyein, alanin, leuoin, fenylalanin , p-hydroxi-fenylglycin och hydroxi-, k lor-substituerad fenyl-glycin;
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7912298 | 1979-04-07 | ||
| GB7912298 | 1979-04-07 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI800881A FI800881A (fi) | 1980-10-08 |
| FI65630B FI65630B (fi) | 1984-02-29 |
| FI65630C true FI65630C (fi) | 1984-06-11 |
Family
ID=10504421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI800881A FI65630C (fi) | 1979-04-07 | 1980-03-21 | Foerfarande foer framstaellning av glykopeptid-antibiotikumet a/16686 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US4303646A (sv) |
| JP (2) | JPS5697237A (sv) |
| AR (1) | AR222217A1 (sv) |
| AT (1) | AT370130B (sv) |
| AU (2) | AU533951B2 (sv) |
| BE (1) | BE882632A (sv) |
| CA (1) | CA1142866A (sv) |
| CH (1) | CH655515B (sv) |
| DE (1) | DE3013246A1 (sv) |
| DK (1) | DK149336C (sv) |
| ES (1) | ES8103170A1 (sv) |
| FI (1) | FI65630C (sv) |
| FR (1) | FR2452931A1 (sv) |
| GR (1) | GR67279B (sv) |
| HK (1) | HK23584A (sv) |
| HU (1) | HU181534B (sv) |
| IE (1) | IE49327B1 (sv) |
| IL (1) | IL59704A (sv) |
| IT (1) | IT1212411B (sv) |
| LU (1) | LU82327A1 (sv) |
| MX (1) | MX5958E (sv) |
| NL (1) | NL192989C (sv) |
| NO (1) | NO155496C (sv) |
| NZ (1) | NZ193357A (sv) |
| PH (1) | PH17230A (sv) |
| PT (1) | PT71064A (sv) |
| SE (1) | SE441188B (sv) |
| SG (1) | SG22687G (sv) |
| YU (1) | YU41917B (sv) |
| ZA (1) | ZA801629B (sv) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3163075D1 (en) | 1980-08-16 | 1984-05-17 | Lepetit Spa | Antibiotic a/16686 factor a2, the process for the preparation thereof, and the co-produced antibiotic a/16686 factors a1 and a3 |
| US4375513A (en) * | 1980-12-18 | 1983-03-01 | Eli Lilly And Company | Biologically pure culture of Actinoplanes missouriensis |
| US4613503A (en) * | 1984-10-11 | 1986-09-23 | The Dow Chemical Company | Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes |
| US4859599A (en) * | 1984-10-11 | 1989-08-22 | The Dow Chemical Company | Antibiotic A26201-1 and antibiotic A26201-2 produced by a novel strain of actinoplanes |
| GB8624806D0 (en) * | 1986-10-16 | 1986-11-19 | Pfizer Ltd | Glycopeptide antibiotic |
| GB8720980D0 (en) * | 1987-09-07 | 1987-10-14 | Lepetit Spa | Derivatives |
| GB8729989D0 (en) * | 1987-12-23 | 1988-02-03 | Lepetit Spa | Novel hydrogenated derivatives of antibiotic a/16686 |
| GB8808658D0 (en) * | 1988-04-13 | 1988-05-18 | Lepetit Spa | Aglycons of a/16686 antibiotics |
| WO2001053533A2 (en) * | 2000-01-21 | 2001-07-26 | Kosan Biosciences, Inc. | Method for cloning polyketide synthase genes |
| JP2004510449A (ja) * | 2000-10-13 | 2004-04-08 | エコピア バイオサイエンス インク | ラモプラニン生合成用遺伝子クラスター |
| US7257562B2 (en) * | 2000-10-13 | 2007-08-14 | Thallion Pharmaceuticals Inc. | High throughput method for discovery of gene clusters |
| US20030211567A1 (en) * | 2001-07-24 | 2003-11-13 | Ecopia Biosciences, Inc. | Compositions, methods and systems for discovery of lipopeptides |
| JP2005529852A (ja) | 2002-03-08 | 2005-10-06 | ビクロン・フアーマシユーチカルズ・インコーポレーテツド | ラモプラニン−様アミド誘導体の製造法 |
| WO2003089641A2 (en) * | 2002-04-17 | 2003-10-30 | Ecopia Biosciences Inc. | Dual condensation/epimerization domain in non-ribosomal peptide synthetase systems |
| CA2488803C (en) * | 2002-06-06 | 2013-08-13 | Vicuron Pharmaceuticals Inc. | Use of ramoplanin to treat diseases associated with the use of antibiotics |
| WO2004017925A2 (en) * | 2002-08-23 | 2004-03-04 | Genome Therapeutics Corporation | Methods and reagents for preventing bacteremias |
| US20040127403A1 (en) * | 2002-09-06 | 2004-07-01 | Francesco Parenti | Methods for treating and preventing Gram-positive bacteremias |
| CA2523573A1 (en) * | 2003-04-25 | 2004-11-11 | Oscient Pharmaceuticals Corporation | Methods for reducing or preventing transmission of nosocomial pathogens in a health care facility |
| CA2945768A1 (en) | 2014-04-16 | 2015-10-22 | Nanotherapeutics, Inc. | Methods of treatment of c. difficile spores with ramoplanin |
| US20180002741A1 (en) | 2016-07-01 | 2018-01-04 | The United States Of America As Represented By The Department Of Veterans Affairs | Method of diagnosis and treating gastrointestinal and neurological diseases associated with species of genus clostridium |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE790627A (fr) * | 1971-10-27 | 1973-04-27 | Lilly Co Eli | L'antibiotique a477 et son procede de preparation |
| GB1458512A (en) * | 1973-11-22 | 1976-12-15 | Lepetit Spa | Antibiotic substance |
| US4038383A (en) * | 1975-01-17 | 1977-07-26 | Pfizer Inc. | Mixture of antibiotics produced by a species of actinoplanes |
| US4001397A (en) * | 1975-08-11 | 1977-01-04 | Pfizer Inc. | Antibiotic compound 41,012 |
| US4115552A (en) * | 1976-04-19 | 1978-09-19 | Eli Lilly And Company | Factor A and B of antibiotic A-4696 |
| US4169887A (en) * | 1978-02-21 | 1979-10-02 | Pfizer Inc. | Antibiotics produced by species of actinoplanes |
| JPS54135703A (en) * | 1978-04-11 | 1979-10-22 | Dainippon Pharmaceut Co Ltd | Antibiotic ab-102 and preparation thereof |
-
1980
- 1980-03-20 ZA ZA00801629A patent/ZA801629B/xx unknown
- 1980-03-21 FI FI800881A patent/FI65630C/fi not_active IP Right Cessation
- 1980-03-22 GR GR61511A patent/GR67279B/el unknown
- 1980-03-25 NO NO800869A patent/NO155496C/no unknown
- 1980-03-25 IL IL59704A patent/IL59704A/xx unknown
- 1980-03-31 US US06/135,560 patent/US4303646A/en not_active Expired - Lifetime
- 1980-03-31 PH PH23840A patent/PH17230A/en unknown
- 1980-04-01 CH CH256780A patent/CH655515B/it unknown
- 1980-04-01 AU AU57036/80A patent/AU533951B2/en not_active Expired
- 1980-04-01 DK DK140080A patent/DK149336C/da not_active IP Right Cessation
- 1980-04-02 ES ES490236A patent/ES8103170A1/es not_active Expired
- 1980-04-03 NL NL8001982A patent/NL192989C/nl not_active IP Right Cessation
- 1980-04-03 PT PT71064A patent/PT71064A/pt unknown
- 1980-04-03 SE SE8002601A patent/SE441188B/sv not_active IP Right Cessation
- 1980-04-03 DE DE19803013246 patent/DE3013246A1/de active Granted
- 1980-04-03 NZ NZ193357A patent/NZ193357A/xx unknown
- 1980-04-03 LU LU82327A patent/LU82327A1/fr unknown
- 1980-04-03 IE IE697/80A patent/IE49327B1/en not_active IP Right Cessation
- 1980-04-03 FR FR8007547A patent/FR2452931A1/fr active Granted
- 1980-04-03 BE BE0/200117A patent/BE882632A/fr not_active IP Right Cessation
- 1980-04-03 HU HU80822A patent/HU181534B/hu unknown
- 1980-04-03 IT IT8021162A patent/IT1212411B/it active
- 1980-04-04 YU YU935/80A patent/YU41917B/xx unknown
- 1980-04-04 AT AT0187480A patent/AT370130B/de not_active IP Right Cessation
- 1980-04-07 MX MX808745U patent/MX5958E/es unknown
- 1980-04-07 JP JP4476480A patent/JPS5697237A/ja active Granted
- 1980-04-07 AR AR280577A patent/AR222217A1/es active
- 1980-04-08 CA CA000349360A patent/CA1142866A/en not_active Expired
- 1980-06-04 AU AU59036/80A patent/AU535727B2/en not_active Ceased
- 1980-12-11 US US06/215,310 patent/US4328316A/en not_active Expired - Lifetime
-
1984
- 1984-03-15 HK HK235/84A patent/HK23584A/xx not_active IP Right Cessation
-
1987
- 1987-03-06 SG SG226/87A patent/SG22687G/en unknown
- 1987-04-13 JP JP62088966A patent/JPS62282579A/ja active Granted
Also Published As
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