FI65248C - Foerfarande foer framstaellning av terapeutiskt anvaendbara trns-dl-5-alkyl-4,4a,5,6,7,8,8a,9-oktahydro-2h-pyrrolo(3,4- g)inoliner - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara trns-dl-5-alkyl-4,4a,5,6,7,8,8a,9-oktahydro-2h-pyrrolo(3,4- g)inoliner Download PDF

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Publication number
FI65248C
FI65248C FI792047A FI792047A FI65248C FI 65248 C FI65248 C FI 65248C FI 792047 A FI792047 A FI 792047A FI 792047 A FI792047 A FI 792047A FI 65248 C FI65248 C FI 65248C
Authority
FI
Finland
Prior art keywords
trans
mixture
octahydro
pyrrolo
solution
Prior art date
Application number
FI792047A
Other languages
English (en)
Finnish (fi)
Other versions
FI792047A (fi
FI65248B (fi
Inventor
Nicholas James Bach
Edmund Carl Kornfeld
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/031,642 external-priority patent/US4235909A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI792047A publication Critical patent/FI792047A/fi
Application granted granted Critical
Publication of FI65248B publication Critical patent/FI65248B/fi
Publication of FI65248C publication Critical patent/FI65248C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI792047A 1979-01-22 1979-06-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara trns-dl-5-alkyl-4,4a,5,6,7,8,8a,9-oktahydro-2h-pyrrolo(3,4- g)inoliner FI65248C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US506279A 1979-01-22 1979-01-22
US506279 1979-01-22
US06/031,642 US4235909A (en) 1979-04-19 1979-04-19 Octahydro-2H-pyrrolo[3,4-g]quinolines
US3164279 1979-04-19

Publications (3)

Publication Number Publication Date
FI792047A FI792047A (fi) 1980-07-23
FI65248B FI65248B (fi) 1983-12-30
FI65248C true FI65248C (fi) 1984-04-10

Family

ID=26673871

Family Applications (1)

Application Number Title Priority Date Filing Date
FI792047A FI65248C (fi) 1979-01-22 1979-06-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara trns-dl-5-alkyl-4,4a,5,6,7,8,8a,9-oktahydro-2h-pyrrolo(3,4- g)inoliner

Country Status (25)

Country Link
EP (1) EP0013788B1 (fr)
JP (1) JPS55100385A (fr)
AR (1) AR225012A1 (fr)
AT (1) AT365189B (fr)
AU (1) AU528035B2 (fr)
BE (1) BE877328A (fr)
CA (1) CA1131227A (fr)
CH (2) CH641801A5 (fr)
DD (1) DD144668A5 (fr)
DE (1) DE2965277D1 (fr)
DK (1) DK268979A (fr)
ES (1) ES482084A1 (fr)
FI (1) FI65248C (fr)
FR (2) FR2446833A1 (fr)
GB (1) GB2040917B (fr)
IE (1) IE48295B1 (fr)
IL (1) IL57665A (fr)
LU (1) LU81440A1 (fr)
NZ (1) NZ190834A (fr)
PH (2) PH15118A (fr)
PL (1) PL125785B1 (fr)
PT (1) PT69828A (fr)
RO (1) RO77442A (fr)
SU (1) SU1113006A3 (fr)
ZA (1) ZA793244B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65269A0 (en) * 1981-03-24 1982-05-31 Lilly Co Eli 6-substituted hexahydroindazolo or hexahydroisoindolo isoquinolines
EP0127708B1 (fr) * 1983-06-03 1987-09-09 Eli Lilly And Company Trans-dl-1-alkyl-6-alcoxyoctahydroquinoléines
IL73001A0 (en) * 1983-09-26 1984-12-31 Lilly Co Eli Improvements in and relating to 6-oxodecahydroquinolines
US4595754A (en) * 1985-03-04 1986-06-17 Eli Lilly And Company Process for preparing cis N-alkylperhydroquinolines
AR067027A1 (es) * 2007-06-19 2009-09-30 Astrazeneca Ab Derivados de 2, 3-dihidro-1h-pirrol[3, 4b]quinolin-1-ona, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion de la actividad del receptor gaba a.
TWI537274B (zh) 2011-03-14 2016-06-11 橘生藥品工業股份有限公司 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途

Also Published As

Publication number Publication date
IL57665A (en) 1982-11-30
SU1113006A3 (ru) 1984-09-07
PT69828A (en) 1979-07-01
ZA793244B (en) 1981-02-25
CA1131227A (fr) 1982-09-07
AT365189B (de) 1981-12-28
JPS6233233B2 (fr) 1987-07-20
IL57665A0 (en) 1979-10-31
DK268979A (da) 1980-07-23
PL125785B1 (en) 1983-06-30
PL216721A1 (fr) 1980-06-16
AU528035B2 (en) 1983-04-14
DE2965277D1 (en) 1983-06-01
AU4844479A (en) 1980-07-31
NZ190834A (en) 1984-07-06
JPS55100385A (en) 1980-07-31
CH643258A5 (fr) 1984-05-30
GB2040917B (en) 1983-01-06
IE48295B1 (en) 1984-11-28
GB2040917A (en) 1980-09-03
AR225012A1 (es) 1982-02-15
PH16181A (en) 1983-07-25
FI792047A (fi) 1980-07-23
FR2446835B1 (fr) 1982-04-23
IE791210L (en) 1980-10-19
DD144668A5 (de) 1980-10-29
FR2446833B1 (fr) 1982-03-05
BE877328A (fr) 1979-12-28
ES482084A1 (es) 1980-08-01
EP0013788A1 (fr) 1980-08-06
RO77442A (fr) 1982-10-26
FI65248B (fi) 1983-12-30
FR2446835A1 (fr) 1980-08-14
LU81440A1 (fr) 1979-09-12
PH15118A (en) 1982-08-10
FR2446833A1 (fr) 1980-08-14
EP0013788B1 (fr) 1983-04-27
ATA452579A (de) 1981-05-15
CH641801A5 (fr) 1984-03-15

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Owner name: ELI LILLY AND COMPANY