FI64585C - Foerfarande foer framstaellning av ett terapeutiskt aktivt arylpyridazinylhydrazinsalt - Google Patents
Foerfarande foer framstaellning av ett terapeutiskt aktivt arylpyridazinylhydrazinsalt Download PDFInfo
- Publication number
- FI64585C FI64585C FI782705A FI782705A FI64585C FI 64585 C FI64585 C FI 64585C FI 782705 A FI782705 A FI 782705A FI 782705 A FI782705 A FI 782705A FI 64585 C FI64585 C FI 64585C
- Authority
- FI
- Finland
- Prior art keywords
- monohydrate
- water
- solution
- dihydrochloride monohydrate
- dihydrochloride
- Prior art date
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 45
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 40
- QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 34
- 239000000243 solution Substances 0.000 description 31
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- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 28
- 239000007787 solid Substances 0.000 description 25
- 150000003839 salts Chemical class 0.000 description 19
- -1 3-t-butylamino-2-hydroxypropoxy Chemical group 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 16
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 13
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- 239000003826 tablet Substances 0.000 description 8
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- 239000002253 acid Substances 0.000 description 5
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- 239000007789 gas Substances 0.000 description 4
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- 238000001556 precipitation Methods 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 3
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- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 description 2
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- ITZYTHBKTGVTFU-UHFFFAOYSA-N 3-[2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1h-pyridazine-6-thione Chemical compound CC(C)(C)NCC(O)COC1=CC=CC=C1C1=NNC(=S)C=C1 ITZYTHBKTGVTFU-UHFFFAOYSA-N 0.000 description 1
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- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
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- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000001175 calcium sulphate Substances 0.000 description 1
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
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- 229910001385 heavy metal Inorganic materials 0.000 description 1
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- GSEPHVGFSQHACX-UHFFFAOYSA-N hydrazine;pyridine Chemical compound NN.C1=CC=NC=C1 GSEPHVGFSQHACX-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
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- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7832312 | 1978-08-04 | ||
| GB7832312 | 1978-08-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI782705A7 FI782705A7 (fi) | 1980-02-05 |
| FI64585B FI64585B (fi) | 1983-08-31 |
| FI64585C true FI64585C (fi) | 1983-12-12 |
Family
ID=10498866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI782705A FI64585C (fi) | 1978-08-04 | 1978-09-04 | Foerfarande foer framstaellning av ett terapeutiskt aktivt arylpyridazinylhydrazinsalt |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0007930B1 (en, 2012) |
| JP (1) | JPS6040424B2 (en, 2012) |
| AR (1) | AR223327A1 (en, 2012) |
| AT (1) | AT361001B (en, 2012) |
| BG (1) | BG34335A3 (en, 2012) |
| CA (1) | CA1098522A (en, 2012) |
| CS (1) | CS204035B2 (en, 2012) |
| DD (1) | DD138656A5 (en, 2012) |
| DE (1) | DE2862214D1 (en, 2012) |
| DK (1) | DK147761C (en, 2012) |
| EG (1) | EG13469A (en, 2012) |
| ES (1) | ES473056A1 (en, 2012) |
| FI (1) | FI64585C (en, 2012) |
| GR (1) | GR64897B (en, 2012) |
| HU (1) | HU181959B (en, 2012) |
| IE (1) | IE47555B1 (en, 2012) |
| IL (1) | IL55455A (en, 2012) |
| IN (1) | IN148775B (en, 2012) |
| IT (1) | IT1110169B (en, 2012) |
| MT (1) | MTP851B (en, 2012) |
| MX (1) | MX5425E (en, 2012) |
| NO (1) | NO783005L (en, 2012) |
| NZ (1) | NZ188281A (en, 2012) |
| OA (1) | OA06046A (en, 2012) |
| PL (1) | PL119444B1 (en, 2012) |
| SU (1) | SU897110A3 (en, 2012) |
| YU (1) | YU209078A (en, 2012) |
| ZA (1) | ZA785008B (en, 2012) |
| ZM (1) | ZM8078A1 (en, 2012) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE42214B1 (en) * | 1974-06-18 | 1980-07-02 | Smith Kline French Lab | Hydrazinopyredazines |
-
1978
- 1978-08-21 IN IN619/DEL/78A patent/IN148775B/en unknown
- 1978-08-22 IE IE1702/78A patent/IE47555B1/en unknown
- 1978-08-28 NZ NZ188281A patent/NZ188281A/xx unknown
- 1978-08-28 GR GR57100A patent/GR64897B/el unknown
- 1978-08-29 JP JP53106180A patent/JPS6040424B2/ja not_active Expired
- 1978-08-29 IL IL55455A patent/IL55455A/xx unknown
- 1978-08-30 EG EG541/78A patent/EG13469A/xx active
- 1978-08-31 IT IT27234/78A patent/IT1110169B/it active
- 1978-09-01 HU HU78SI1646A patent/HU181959B/hu unknown
- 1978-09-01 CA CA310,530A patent/CA1098522A/en not_active Expired
- 1978-09-01 ZA ZA00785008A patent/ZA785008B/xx unknown
- 1978-09-04 BG BG040811A patent/BG34335A3/xx unknown
- 1978-09-04 AT AT638378A patent/AT361001B/de not_active IP Right Cessation
- 1978-09-04 ES ES473056A patent/ES473056A1/es not_active Expired
- 1978-09-04 DD DD78207634A patent/DD138656A5/xx unknown
- 1978-09-04 FI FI782705A patent/FI64585C/fi not_active IP Right Cessation
- 1978-09-04 SU SU782660649A patent/SU897110A3/ru active
- 1978-09-04 EP EP78300341A patent/EP0007930B1/en not_active Expired
- 1978-09-04 PL PL1978209407A patent/PL119444B1/pl unknown
- 1978-09-04 NO NO783005A patent/NO783005L/no unknown
- 1978-09-04 MX MX787372U patent/MX5425E/es unknown
- 1978-09-04 DE DE7878300341T patent/DE2862214D1/de not_active Expired
- 1978-09-04 CS CS785723A patent/CS204035B2/cs unknown
- 1978-09-04 DK DK389378A patent/DK147761C/da not_active IP Right Cessation
- 1978-09-04 OA OA56598A patent/OA06046A/xx unknown
- 1978-09-04 YU YU02090/78A patent/YU209078A/xx unknown
- 1978-09-05 AR AR273573A patent/AR223327A1/es active
- 1978-09-15 ZM ZM80/78A patent/ZM8078A1/xx unknown
-
1979
- 1979-07-23 MT MT851A patent/MTP851B/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SMITH KLINE & FRENCH LABORATORIES LTD |