ES473056A1 - Procedimiento para la preparacion de monohidrato de dihidro-cloruro de 3-(2-(3-t-butilamino-2-hidroxipropoxi)fenil-6-hi-drazinopiridazina racemica. - Google Patents

Procedimiento para la preparacion de monohidrato de dihidro-cloruro de 3-(2-(3-t-butilamino-2-hidroxipropoxi)fenil-6-hi-drazinopiridazina racemica.

Info

Publication number
ES473056A1
ES473056A1 ES473056A ES473056A ES473056A1 ES 473056 A1 ES473056 A1 ES 473056A1 ES 473056 A ES473056 A ES 473056A ES 473056 A ES473056 A ES 473056A ES 473056 A1 ES473056 A1 ES 473056A1
Authority
ES
Spain
Prior art keywords
preparing
arylpyridazinylhydrazine
salt
processes
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473056A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES473056A1 publication Critical patent/ES473056A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Procedimiento para la preparación de monohidrato de dihidrocloruro de 3-[2-(3-t-butilamino-2-hidroxipripoxi)fenil]-6-hidrazinopiridazina racemica, caracterizado porque comprende hacer reaccionar 3-[2-(3-t-butilamino-2-hidroxipropoxi)fenil]-6-hidrazinopiridazina racémica, u otra sal de edición de ácido de este compuesto, con cloruro de hidrógeno y agua en cantidades requeridas para producir el monohidrato de dihidrocloruro, y el monohidrato de dihidrocloruro se aísla como la sal particulada sólida.
ES473056A 1978-08-04 1978-09-04 Procedimiento para la preparacion de monohidrato de dihidro-cloruro de 3-(2-(3-t-butilamino-2-hidroxipropoxi)fenil-6-hi-drazinopiridazina racemica. Expired ES473056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7832312 1978-08-04

Publications (1)

Publication Number Publication Date
ES473056A1 true ES473056A1 (es) 1979-05-01

Family

ID=10498866

Family Applications (1)

Application Number Title Priority Date Filing Date
ES473056A Expired ES473056A1 (es) 1978-08-04 1978-09-04 Procedimiento para la preparacion de monohidrato de dihidro-cloruro de 3-(2-(3-t-butilamino-2-hidroxipropoxi)fenil-6-hi-drazinopiridazina racemica.

Country Status (29)

Country Link
EP (1) EP0007930B1 (es)
JP (1) JPS6040424B2 (es)
AR (1) AR223327A1 (es)
AT (1) AT361001B (es)
BG (1) BG34335A3 (es)
CA (1) CA1098522A (es)
CS (1) CS204035B2 (es)
DD (1) DD138656A5 (es)
DE (1) DE2862214D1 (es)
DK (1) DK147761C (es)
EG (1) EG13469A (es)
ES (1) ES473056A1 (es)
FI (1) FI64585C (es)
GR (1) GR64897B (es)
HU (1) HU181959B (es)
IE (1) IE47555B1 (es)
IL (1) IL55455A (es)
IN (1) IN148775B (es)
IT (1) IT1110169B (es)
MT (1) MTP851B (es)
MX (1) MX5425E (es)
NO (1) NO783005L (es)
NZ (1) NZ188281A (es)
OA (1) OA06046A (es)
PL (1) PL119444B1 (es)
SU (1) SU897110A3 (es)
YU (1) YU209078A (es)
ZA (1) ZA785008B (es)
ZM (1) ZM8078A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE42214B1 (en) * 1974-06-18 1980-07-02 Smith Kline French Lab Hydrazinopyredazines

Also Published As

Publication number Publication date
GR64897B (en) 1980-06-07
EP0007930B1 (en) 1983-03-30
JPS6040424B2 (ja) 1985-09-11
FI782705A (fi) 1980-02-05
IT1110169B (it) 1985-12-23
ZM8078A1 (en) 1979-07-19
IE781702L (en) 1980-02-04
EG13469A (en) 1982-06-30
CA1098522A (en) 1981-03-31
AT361001B (de) 1981-02-10
IL55455A (en) 1981-11-30
DD138656A5 (de) 1979-11-14
IE47555B1 (en) 1984-04-18
YU209078A (en) 1982-10-31
JPS5522651A (en) 1980-02-18
EP0007930A1 (en) 1980-02-20
OA06046A (fr) 1981-06-30
AR223327A1 (es) 1981-08-14
PL209407A1 (es) 1980-05-19
DK147761C (da) 1985-05-20
BG34335A3 (en) 1983-08-15
PL119444B1 (en) 1981-12-31
DK147761B (da) 1984-12-03
NO783005L (no) 1980-02-05
ATA638378A (de) 1980-07-15
NZ188281A (en) 1980-11-14
FI64585B (fi) 1983-08-31
DE2862214D1 (en) 1983-05-05
CS204035B2 (en) 1981-03-31
IN148775B (es) 1981-06-13
MTP851B (en) 1980-06-30
SU897110A3 (ru) 1982-01-07
FI64585C (fi) 1983-12-12
ZA785008B (en) 1979-08-29
MX5425E (es) 1983-08-03
HU181959B (en) 1983-11-28
DK389378A (da) 1980-02-05
IT7827234A0 (it) 1978-08-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990503