ES8301460A1 - Un procedimiento para la preparacion de l-amino acidos n-sustituidos. - Google Patents

Un procedimiento para la preparacion de l-amino acidos n-sustituidos.

Info

Publication number
ES8301460A1
ES8301460A1 ES497907A ES497907A ES8301460A1 ES 8301460 A1 ES8301460 A1 ES 8301460A1 ES 497907 A ES497907 A ES 497907A ES 497907 A ES497907 A ES 497907A ES 8301460 A1 ES8301460 A1 ES 8301460A1
Authority
ES
Spain
Prior art keywords
processes
making
amino acids
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES497907A
Other languages
English (en)
Other versions
ES497907A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES497907A0 publication Critical patent/ES497907A0/es
Publication of ES8301460A1 publication Critical patent/ES8301460A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE <007>-AMINOACIDOS N-SUSTITUIDO, ASI COMO DE SUS SALES, ESTERES O BIOPRECURSORES CORRESPONDIENTES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R ES UN FENILO, OPCIONALMENTE SUSTITUIDO, Y R PUEDE SER VARIOS TIPOS DE RADICALES AROMATICOS. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II) CON UN ALDEHIDO DE FORMULA R CHO, EN LAS QUE R ES HIDROGENO O UN GRUPO PROTECTOR DE CARBOXILO; Y R Y R SON LOS MISMOS QUE EN LA FORMULA (I) SEGUIDA DE LA REDUCCION DE LA BASE DE SCHIFF FORMADA CON UN HIDRURO O HIDROGENO EN PRESENCIA DE UN CATALIZADOR TAL COMO OXIDO DE PLATINO O NIQUEL RANEY. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, A UN TEMPERATURA SUPERIOR A LA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS EN EL TRATAMIENTO DE LA ARTERIOESCLEROSIS.
ES497907A 1979-12-19 1980-12-18 Un procedimiento para la preparacion de l-amino acidos n-sustituidos. Expired ES8301460A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7943794 1979-12-19

Publications (2)

Publication Number Publication Date
ES497907A0 ES497907A0 (es) 1982-05-01
ES8301460A1 true ES8301460A1 (es) 1982-05-01

Family

ID=10509949

Family Applications (4)

Application Number Title Priority Date Filing Date
ES497907A Expired ES8301460A1 (es) 1979-12-19 1980-12-18 Un procedimiento para la preparacion de l-amino acidos n-sustituidos.
ES507916A Expired ES8308302A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507917A Expired ES8307205A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507915A Expired ES8306096A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustttuidos.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES507916A Expired ES8308302A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507917A Expired ES8307205A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507915A Expired ES8306096A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustttuidos.

Country Status (9)

Country Link
EP (1) EP0031653A1 (es)
JP (1) JPS5692843A (es)
AU (1) AU6546780A (es)
DK (1) DK541580A (es)
ES (4) ES8301460A1 (es)
GR (1) GR72257B (es)
IL (1) IL61675A0 (es)
NO (1) NO803835L (es)
ZA (1) ZA807795B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067641A3 (en) * 1981-06-17 1983-03-09 Beecham Group Plc Amino acids
EP0375133A1 (en) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5245046A (en) * 1988-11-14 1993-09-14 The Upjohn Company α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
AU4649189A (en) * 1988-11-14 1990-06-12 Upjohn Company, The Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5163131A (en) * 1989-09-08 1992-11-10 Auspex Systems, Inc. Parallel i/o network file server architecture
KR101317947B1 (ko) * 2013-07-04 2013-10-16 이영우 실린더 검사장치

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950542A (en) * 1967-02-21 1976-04-13 L'oreal Cysteamine derivatives for oral treatment of seborrhea

Also Published As

Publication number Publication date
ES507915A0 (es) 1982-10-01
JPS5692843A (en) 1981-07-27
ES507916A0 (es) 1983-01-01
ZA807795B (en) 1982-01-27
AU6546780A (en) 1981-06-25
EP0031653A1 (en) 1981-07-08
ES497907A0 (es) 1982-05-01
GR72257B (es) 1983-10-06
IL61675A0 (en) 1981-01-30
NO803835L (no) 1981-06-22
ES8308302A1 (es) 1983-01-01
DK541580A (da) 1981-06-20
ES507917A0 (es) 1982-11-01
ES8306096A1 (es) 1982-10-01
ES8307205A1 (es) 1982-11-01

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