ES8307205A1 - Un procedimiento para la preparacion de-amino acidos n-sustituidos. - Google Patents

Un procedimiento para la preparacion de-amino acidos n-sustituidos.

Info

Publication number
ES8307205A1
ES8307205A1 ES507917A ES507917A ES8307205A1 ES 8307205 A1 ES8307205 A1 ES 8307205A1 ES 507917 A ES507917 A ES 507917A ES 507917 A ES507917 A ES 507917A ES 8307205 A1 ES8307205 A1 ES 8307205A1
Authority
ES
Spain
Prior art keywords
processes
making
amino acids
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507917A
Other languages
English (en)
Other versions
ES507917A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES507917A0 publication Critical patent/ES507917A0/es
Publication of ES8307205A1 publication Critical patent/ES8307205A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE ~C-AMINO ACIDOS N-SUSTITUIDOS. CONSISTE EN REDUCIR HIDRURO DE UN N-ACIL DERIVADO DE FORMULA GENERAL (I), PARA A CONTINUACION Y OPCIONALMENTE EFECTUAR UNA O MAS DE LAS SIGUIENTES ETAPAS: A) ELIMINACION DE CUALQUIER GRUPO R>X BLOQUEANTE DE CARBOXILO; B) ELIMINACION DE CUALQUIERA DE LOS GRUPOS PROTECTORES DE R O R ; C) CONVERSION DEL PRODUCTO EN UNA SAL FARMACEUTICAMENTE ACEPTABLE, ESTER O BIOPRECURSOR FARMACEUTICAMENTE ACEPTABLE. SE OBTIENE EL COMPUESTO (II) EN QUE R ES ARILO, ARALQUILO, HETEROCICLICO O HETEROCICLO AROMATICO ALQUILO; R ES UN GRUPO FENILO OPCIONALMENTE SUSTITUIDO CON UN GRUPO ALQUILO C <- , HALOGENO, HIDROXILO, TRIFLUOROMETILO O METILENDIOXI.
ES507917A 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos. Expired ES8307205A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7943794 1979-12-19

Publications (2)

Publication Number Publication Date
ES507917A0 ES507917A0 (es) 1982-11-01
ES8307205A1 true ES8307205A1 (es) 1982-11-01

Family

ID=10509949

Family Applications (4)

Application Number Title Priority Date Filing Date
ES497907A Granted ES497907A0 (es) 1979-12-19 1980-12-18 Un procedimiento para la preparacion de l-amino acidos n-sustituidos.
ES507916A Granted ES507916A0 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507917A Expired ES8307205A1 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.
ES507915A Granted ES507915A0 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustttuidos.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES497907A Granted ES497907A0 (es) 1979-12-19 1980-12-18 Un procedimiento para la preparacion de l-amino acidos n-sustituidos.
ES507916A Granted ES507916A0 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustituidos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES507915A Granted ES507915A0 (es) 1979-12-19 1981-12-11 Un procedimiento para la preparacion de-amino acidos n-sustttuidos.

Country Status (9)

Country Link
EP (1) EP0031653A1 (es)
JP (1) JPS5692843A (es)
AU (1) AU6546780A (es)
DK (1) DK541580A (es)
ES (4) ES497907A0 (es)
GR (1) GR72257B (es)
IL (1) IL61675A0 (es)
NO (1) NO803835L (es)
ZA (1) ZA807795B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0067641A3 (en) * 1981-06-17 1983-03-09 Beecham Group Plc Amino acids
JPH04501722A (ja) * 1988-11-14 1992-03-26 ジ・アップジョン・カンパニー 抗―糖尿病、抗―肥満症および抗―アテローム性動脈硬化症薬として有用なα―アミノ―インドール―３―酢酸
US5245046A (en) * 1988-11-14 1993-09-14 The Upjohn Company α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
EP0375133A1 (en) * 1988-11-14 1990-06-27 The Upjohn Company Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
US5163131A (en) * 1989-09-08 1992-11-10 Auspex Systems, Inc. Parallel i/o network file server architecture
KR101317947B1 (ko) * 2013-07-04 2013-10-16 이영우 실린더 검사장치

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950542A (en) * 1967-02-21 1976-04-13 L'oreal Cysteamine derivatives for oral treatment of seborrhea

Also Published As

Publication number Publication date
GR72257B (es) 1983-10-06
NO803835L (no) 1981-06-22
ES507917A0 (es) 1982-11-01
ES8301460A1 (es) 1982-05-01
ES8308302A1 (es) 1983-01-01
JPS5692843A (en) 1981-07-27
ES8306096A1 (es) 1982-10-01
DK541580A (da) 1981-06-20
ES497907A0 (es) 1982-05-01
AU6546780A (en) 1981-06-25
ES507915A0 (es) 1982-10-01
EP0031653A1 (en) 1981-07-08
ES507916A0 (es) 1983-01-01
IL61675A0 (en) 1981-01-30
ZA807795B (en) 1982-01-27

Similar Documents

Publication Publication Date Title
AU550774B2 (en) 1-aryl-2-aminomethyl cyclopropane carboxylates
NO890813L (no) 5-lipoxygenase-inhiberende 4-(4-fenyl-1-piperazinyl)fenoler.
ES8300112A1 (es) Un procedimiento para preparar compuestos de cefem .
LU90159I2 (fr) Difloxacin optionnellement sous forme d&#39;un sel ou ester pharmaceutique
ES483767A1 (es) Procedimiento para producir n-arilsulfonil-l-argininamidas
ES8609204A1 (es) Procedimiento de preparar derivados aminicos
ES463803A1 (es) Procedimiento para la produccion de hidroxilaminas o-alqui- ladas.
PT87578A (pt) Process for the preparation of new alkanesulfonanilide derivatives and of pharmaceutical composition comprising the same
ES8301460A1 (es) Un procedimiento para la preparacion de l-amino acidos n-sustituidos.
DK240184D0 (da) Beta-carboline-3-carboxylic acid derivatives and method of preparing the same
ES446993A1 (es) Un procedimiento para la preparacion de nuevos derivados de benzofenona.
ES8604533A1 (es) Procedimiento para la produccion de acilamino-s-triacinas sustituidas
GB1452448A (en) Derivatives of 2-amino-1,3-thiazine
DE3267188D1 (en) Hydroxybenzylamino-aryl compounds, process for preparing and pharmaceutical compositions containing the same
ES8300097A1 (es) &#34;un procedimiento para preparar derivados de halofenil-piridil-alilamina&#34;.
ES8307766A1 (es) Procedimiento para la preparacion de derivados de azolil-penteno.
ES8106703A1 (es) Un procedimiento de preparacion de una 7-acilindolin-2-ona
IL64490A0 (en) 2,2,4-trisubstituted dioxolane derivatives,their production and their use as pesticides
GB1469410A (en) Benzodioxole derivatives
DE3370326D1 (en) Substituted 1-((3-(amino)-propoxy)-phenyl)-1-(phenyl)-propan-1-ols, their acid addition salts and quaternary salts, process for their preparation and medicines containing these compounds
ATE19629T1 (de) N-substituierte derivate des tetrahydroisophthalimids.
ES8304556A1 (es) Procedimiento para preparar 5-(opcionalmente fenil sustitui-das)-6h-1,3,4-tiadiacin-2-aminas
SE7906433L (sv) Pyrazolylaminoimidazoliner
CH653840GA3 (en) Process for protecting keratin-containing materials from attack by keratin-eating insects and 5-phenylcarbamoylbarbituric acid compounds