FI63037C - Foerfarande foer framstaellning av terapeutiskt anvaendbara stbila sulfonater av s-adenosyl-l-metionin - Google Patents

Foerfarande foer framstaellning av terapeutiskt anvaendbara stbila sulfonater av s-adenosyl-l-metionin Download PDF

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Publication number
FI63037C
FI63037C FI751946A FI751946A FI63037C FI 63037 C FI63037 C FI 63037C FI 751946 A FI751946 A FI 751946A FI 751946 A FI751946 A FI 751946A FI 63037 C FI63037 C FI 63037C
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FI
Finland
Prior art keywords
acid
sam
solution
added
methionine
Prior art date
Application number
FI751946A
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English (en)
Finnish (fi)
Other versions
FI63037B (fi
FI751946A (fr
Inventor
Alberto Fiecchi
Original Assignee
Bioresearch Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioresearch Bv filed Critical Bioresearch Bv
Publication of FI751946A publication Critical patent/FI751946A/fi
Publication of FI63037B publication Critical patent/FI63037B/fi
Application granted granted Critical
Publication of FI63037C publication Critical patent/FI63037C/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI751946A 1974-07-12 1975-07-03 Foerfarande foer framstaellning av terapeutiskt anvaendbara stbila sulfonater av s-adenosyl-l-metionin FI63037C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2512874 1974-07-12
IT2512874 1974-07-12

Publications (3)

Publication Number Publication Date
FI751946A FI751946A (fr) 1976-01-13
FI63037B FI63037B (fi) 1982-12-31
FI63037C true FI63037C (fi) 1983-04-11

Family

ID=11215784

Family Applications (1)

Application Number Title Priority Date Filing Date
FI751946A FI63037C (fi) 1974-07-12 1975-07-03 Foerfarande foer framstaellning av terapeutiskt anvaendbara stbila sulfonater av s-adenosyl-l-metionin

Country Status (27)

Country Link
US (1) US4057686A (fr)
JP (1) JPS51125717A (fr)
AR (1) AR221676A1 (fr)
AT (1) AT366064B (fr)
AU (1) AU498365B2 (fr)
BE (1) BE831310A (fr)
CA (1) CA1057681A (fr)
CH (1) CH606085A5 (fr)
DD (1) DD118643A5 (fr)
DE (1) DE2530898A1 (fr)
DK (1) DK144946C (fr)
ES (1) ES439316A1 (fr)
FI (1) FI63037C (fr)
FR (1) FR2277590A1 (fr)
GB (1) GB1506640A (fr)
HU (1) HU170264B (fr)
IE (1) IE41421B1 (fr)
IL (1) IL47656A (fr)
NL (1) NL171987C (fr)
NO (1) NO142175C (fr)
NZ (1) NZ178014A (fr)
PL (1) PL94268B1 (fr)
RO (1) RO77525A (fr)
SE (1) SE420204B (fr)
SU (1) SU676169A3 (fr)
YU (1) YU39271B (fr)
ZA (1) ZA754167B (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5428808A (en) * 1977-08-03 1979-03-03 Yamasa Shoyu Co Ltd Composition containing s-adenoyl-l-methionine and its preparation
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
JPS5596099A (en) * 1979-01-12 1980-07-21 Tanabe Seiyaku Co Ltd Production of s-adenosyl-l-methionine using enzyme
GB2064523B (en) * 1979-12-04 1983-06-29 Kanegafuchi Chemical Ind Stable composition of s-adenosyl-l-methionine
IT1137640B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1137892B (it) * 1981-08-24 1986-09-10 Bioresearch Srl Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
IT1139974B (it) * 1981-09-11 1986-09-24 Bioresearch Srl Derivati della s-adenosilmetionina,processo per la preparazione e composizioni terapeutiche che li contengono come principio attivo
US4419358A (en) * 1981-11-12 1983-12-06 Mead Johnson & Company Isethionic acid salt of 9-cyclohexyl-2-propoxy-9H-purine-6-amine and compositions containing an effective bronchodilating concentration of it
IT1169773B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1169772B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche per uso orale contenenti sali stabili della s-adenosil-l-metionina
IT1169774B (it) * 1983-08-24 1987-06-03 Bioresearch Spa Composizioni terapeutiche iniettabili contenenti sali stabili della s-adenosil-l-metionina
IT1173990B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente adatti per uso parenterale
IT1173992B (it) * 1984-05-16 1987-06-24 Bioresearch Spa Sali stabili della solfo-adenosil-l-metionina (same) particolarmente idonei per uso farmaceutico orale
IT1177373B (it) * 1984-12-06 1987-08-26 Bioresearch Spa Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
IT1200589B (it) * 1985-02-14 1989-01-27 Gibipharma Spa Derivati naturali attivita farmagologica
US4962451A (en) * 1985-11-07 1990-10-09 International Business Machines Corporation Cache-effective sort string generation method
JPH0532181Y2 (fr) * 1987-09-16 1993-08-18
DE3874352T2 (de) * 1987-10-09 1992-12-17 Mario De Rosa Lipophile salze von s-adenosyl-l-methionin (sam) mit acyltaurinderivaten.
FR2623396B1 (fr) * 1987-11-25 1990-03-30 Sanofi Sa Utilisation de l'ademetionine contre le vieillissement de la peau
IT1229477B (it) * 1989-03-13 1991-09-03 Bioresearch Spa Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
JPH02290896A (ja) * 1989-04-28 1990-11-30 Fuji Kagaku Kogyo Kk 新規なｓ―アデノシルメチオニン誘導体
JPH03123514U (fr) * 1990-03-27 1991-12-16
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
US6635615B1 (en) * 1999-11-17 2003-10-21 Rolland F. Hebert Stable salts of S-adenosyl-l-methionine
DE10022856A1 (de) * 2000-05-10 2001-11-15 Basf Ag Therapeutische Kombination von Liponsäure und C1-Donoren zur Behandlung von Störungen des Zentralen Nervensystems
US6759395B2 (en) 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
FR2823211A1 (fr) * 2001-04-10 2002-10-11 Virbac Sa Composition a base d'un polyphosphate de s-adenosyl-l-methionine et utilisations d'un tel polyphosphate
US6649753B2 (en) 2001-06-07 2003-11-18 Orchid Chemicals & Pharmaceuticals Ltd. Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
US6881837B2 (en) 2001-06-07 2005-04-19 Orchid Chemicals & Pharmaceuticals Ltd. Chemical synthesis of S-adenosyl-L-methionine with enrichment of (S,S)-isomer
WO2002102823A1 (fr) * 2001-06-14 2002-12-27 Orchid Chemicals & Pharmaceuticals Limited Sels stables de s-adenosyl-l-methionine (same) et procede de preparation
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
EP1812454A2 (fr) 2004-06-23 2007-08-01 Orchid Chemicals and Pharmaceuticals Ltd Synthese chimique de <i>s-adenosyl-l-methionine </i>avec augmentation de la teneur en <i>(s,s)-isomere</i>
WO2006079212A1 (fr) 2005-01-26 2006-08-03 Diamedica Inc. Utilisation du compose s-adenosylmethionine, de la vitamine e, et de la vitamine c pour traiter les lesions hepatiques et la resistance a l'insuline causees par le stress oxydatif
FR2884421B1 (fr) 2005-04-15 2007-08-10 Virbac Sa Nouveaux moyens de regulation des troubles du comportement chez les animaux de compagnie
US7902423B2 (en) * 2005-04-20 2011-03-08 Basf Plant Science Gmbh Expression cassettes for seed-preferential expression that utilize the promoter from a flax tonoplast intrinsic protein gene
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
ITMI20060629A1 (it) * 2006-03-31 2007-10-01 Daniele Giovannone Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
US8202515B2 (en) * 2006-05-10 2012-06-19 Mitsubishi Gas Chemical Company, Inc. Method of producing dry yeast containing S-adenosyl-L-methionine and composition for oral intake
US20090088404A1 (en) * 2007-01-31 2009-04-02 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
CA2677053C (fr) * 2007-01-31 2016-03-15 Methylation Sciences International Srl Formulations pharmaceutiques a liberation prolongee de s-adenosylmethionine
US20090197824A1 (en) * 2008-01-31 2009-08-06 Methylation Sciences International Srl Extended Release Pharmaceutical Formulations of S-Adenosylmethionine
ITMI20071374A1 (it) * 2007-07-10 2009-01-11 Gnosis Spa Sali stabili di s-adenosilmetionina e processo per il loro ottenimento.
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
EP2193787A1 (fr) * 2008-12-02 2010-06-09 Giorgio Stramentinoli Formulations pour l'administration orale systémique comprenant de la s-adénosylméthionine, leur préparation et utilisation
US20110027342A1 (en) 2009-07-28 2011-02-03 Msi Methylation Sciences, Inc. S-adenosylmethionine formulations with enhanced bioavailability
US8329208B2 (en) * 2009-07-28 2012-12-11 Methylation Sciences International Srl Pharmacokinetics of S-adenosylmethionine formulations
CA2833043A1 (fr) 2011-04-15 2012-10-18 Scimar Ltd. Utilisation de s-adenosylmethionine, de vitamine e et de vitamine c dans la prevention et le traitement d'un dysfonctionnement cardiovasculaire
CN102321136B (zh) * 2011-09-19 2014-10-22 北京化工大学 S-腺苷-l-甲硫氨酸对甲苯磺酸硫酸双盐的制备方法
KR102186066B1 (ko) 2013-01-16 2020-12-04 허버트 샘-이 엘엘씨 S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
RU2537556C1 (ru) * 2013-07-30 2015-01-10 Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Способ получения соли адеметионина с хондроитинсульфокислотой

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1803978C2 (de) * 1968-10-18 1985-05-02 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin
IE37913B1 (en) * 1972-08-02 1977-11-09 Bioresearch Sas Salt of s-adenosyl-l-methionine
IE39517B1 (en) * 1973-06-27 1978-10-25 Bioresearch Sas Double salts of s-adenosyl-l-methhionine

Also Published As

Publication number Publication date
JPS51125717A (en) 1976-11-02
JPS5610920B2 (fr) 1981-03-11
IE41421B1 (en) 1980-01-02
DK144946B (da) 1982-07-12
FI63037B (fi) 1982-12-31
NO142175C (no) 1980-07-09
DK144946C (da) 1982-12-06
BE831310A (fr) 1975-11-03
DK315375A (da) 1976-01-13
IL47656A0 (en) 1975-10-15
US4057686A (en) 1977-11-08
AT366064B (de) 1982-03-10
AU498365B2 (en) 1979-03-08
SE420204B (sv) 1981-09-21
NL171987B (nl) 1983-01-17
SU676169A3 (ru) 1979-07-25
CH606085A5 (fr) 1978-10-13
DE2530898C2 (fr) 1988-08-11
RO77525A (fr) 1982-09-09
AU8295975A (en) 1977-01-13
FI751946A (fr) 1976-01-13
DE2530898A1 (de) 1976-01-29
DD118643A5 (fr) 1976-03-12
HU170264B (fr) 1977-05-28
YU39271B (en) 1984-10-31
IL47656A (en) 1978-04-30
NO752499L (fr) 1976-01-13
CA1057681A (fr) 1979-07-03
SE7507966L (sv) 1976-01-13
PL94268B1 (fr) 1977-07-30
FR2277590B1 (fr) 1978-07-28
ATA521275A (de) 1981-07-15
NL7508316A (nl) 1976-01-14
GB1506640A (en) 1978-04-05
ZA754167B (en) 1976-05-26
FR2277590A1 (fr) 1976-02-06
NO142175B (no) 1980-03-31
ES439316A1 (es) 1977-02-16
AR221676A1 (es) 1981-03-13
IE41421L (en) 1976-01-12
NZ178014A (en) 1978-03-06
NL171987C (nl) 1983-06-16
YU174475A (en) 1982-08-31

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