FI62297C - Foerfarande foer framstaellning av 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensotiazin-3-karboxylsyra-1,1-dioxid vilken foereningkan anvaendas saosom mellanprodukt vid framstaellning av taninflammatoriska 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensoti iaz-3-karboxamid-1,1-dioxider - Google Patents
Foerfarande foer framstaellning av 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensotiazin-3-karboxylsyra-1,1-dioxid vilken foereningkan anvaendas saosom mellanprodukt vid framstaellning av taninflammatoriska 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensoti iaz-3-karboxamid-1,1-dioxider Download PDFInfo
- Publication number
- FI62297C FI62297C FI771799A FI771799A FI62297C FI 62297 C FI62297 C FI 62297C FI 771799 A FI771799 A FI 771799A FI 771799 A FI771799 A FI 771799A FI 62297 C FI62297 C FI 62297C
- Authority
- FI
- Finland
- Prior art keywords
- oxo
- methyl
- dihydro
- dioxide
- crown
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (10)
1. Förfarande för framställning av 3,4-dihydro-2-metyl-4-oxo-2H-1,2-bensotiazin-3-karbonsyra-1,1-dioxid, känne- t e c k n a t därav, att man i närvaro av en källa för hydroxid-joner hydrolyserar en förening med formeln 0 (Oi * 111 I ^ L N CH °2 väri R,j är en alkyl med 1-12 kolatomer eller en fenylalkyl med 1 - 3 kolatomer i alkyldelen, varefter den resulterande produkten görs sur tili ett pH pä ca. 0 - 5,5.
2. Förfarande enligt patentkravet 1,känneteck- n a t därav, att hydrolysen utföres i ett vattenhaltigt lösnings-medelsystem.
3. Förfarande enligt patentkravet 2, känneteck-n a d därav, att hydrolysen utföres vid en temperatur pä ca. 20°C - äterflödestemperaturen för lösningsmedlet.
4. Förfarande enligt patentkravet 3, känneteck-n a t därav, att är alkyl, företrädesvis metyl.
5. Förfarande enligt patentkravet 1, känneteck-n a t därav, att hydrolysen utföres i ett vattenfritt lösnings-medelsystera i närvaro av en kroneter.
6. Förfarande enligt nägot av föregäende patentkravet, kännetecknat därav, att källan för hydroxidjoner är en alkalimetallhydroxid.
7. Förfarande enligt patentkravet 6, kännetecknat därav, att alkalimetallhydroxiden är natriumhydroxid.
8. Förfarande enligt patentkraven 1-5, känne^ t e c k n a t därav, att alkalimetallhydroxiden är kaliumhydr-oxid, det vattenfria lösningsmedlet är bensen eller toluen och kronetern ät 18-kron-6, dicyklohexyl-18-kron-6, dibenso-18-
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/694,572 US4100347A (en) | 1976-06-10 | 1976-06-10 | 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide |
| US69457276 | 1976-06-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI771799A FI771799A (sv) | 1977-12-11 |
| FI62297B FI62297B (fi) | 1982-08-31 |
| FI62297C true FI62297C (fi) | 1982-12-10 |
Family
ID=24789395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI771799A FI62297C (fi) | 1976-06-10 | 1977-06-07 | Foerfarande foer framstaellning av 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensotiazin-3-karboxylsyra-1,1-dioxid vilken foereningkan anvaendas saosom mellanprodukt vid framstaellning av taninflammatoriska 3,4-dihydro-2-metyl-4-oxo-2h-1,2-bensoti iaz-3-karboxamid-1,1-dioxider |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US4100347A (sv) |
| JP (1) | JPS5912673B2 (sv) |
| AR (1) | AR215006A1 (sv) |
| AT (1) | AT356126B (sv) |
| AU (1) | AU511643B2 (sv) |
| BE (1) | BE855532A (sv) |
| BG (1) | BG41307A3 (sv) |
| CA (1) | CA1077934A (sv) |
| CH (1) | CH634312A5 (sv) |
| CS (2) | CS191347B2 (sv) |
| CY (1) | CY1128A (sv) |
| DD (2) | DD132014A5 (sv) |
| DE (1) | DE2726175A1 (sv) |
| DK (1) | DK147337C (sv) |
| EG (1) | EG12644A (sv) |
| ES (2) | ES459601A1 (sv) |
| FI (1) | FI62297C (sv) |
| FR (1) | FR2354325A1 (sv) |
| GB (2) | GB1544359A (sv) |
| GR (1) | GR66969B (sv) |
| HK (2) | HK31381A (sv) |
| HU (1) | HU184665B (sv) |
| IE (1) | IE44997B1 (sv) |
| IL (1) | IL52203A (sv) |
| LU (1) | LU77516A1 (sv) |
| MY (2) | MY8100269A (sv) |
| NL (1) | NL7706338A (sv) |
| NO (1) | NO150761C (sv) |
| NZ (1) | NZ184249A (sv) |
| PH (1) | PH14751A (sv) |
| PL (2) | PL108606B1 (sv) |
| PT (1) | PT66639B (sv) |
| RO (2) | RO77179A (sv) |
| SE (1) | SE442200B (sv) |
| SU (2) | SU657747A3 (sv) |
| YU (1) | YU39493B (sv) |
| ZA (1) | ZA773248B (sv) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2756113A1 (de) * | 1977-12-16 | 1979-06-21 | Thomae Gmbh Dr K | Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4434164A (en) | 1981-06-01 | 1984-02-28 | Pfizer Inc. | Crystalline benzothiazine dioxide salts |
| US4474955A (en) * | 1981-06-17 | 1984-10-02 | Vincenzo Iannella | Process for preparing 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-[N-(2-pyridinyl)carboxamide]-1,1-dioxide, and its phosphoric ester |
| IN159273B (sv) * | 1981-10-05 | 1987-04-25 | Pfizer | |
| ATE31309T1 (de) * | 1982-07-07 | 1987-12-15 | Siegfried Ag | Verfahren zur herstellung von 4-hydroxy-2-methyln-2-pyridyl-2h-1,2-benzothiazin-3-carboxamid 1,1- dioxid. |
| DE3311165A1 (de) * | 1983-03-26 | 1984-09-27 | Gödecke AG, 1000 Berlin | Feinkristallines isoxicam |
| IT1194522B (it) * | 1983-12-16 | 1988-09-22 | Prodotti Antibiotici Spa | Metodo di sintesi di derivanti benzotiazinici |
| US4530272A (en) * | 1984-01-13 | 1985-07-23 | International Business Machines Corporation | Method for controlling contamination in a clean room |
| US5741798A (en) * | 1996-06-03 | 1998-04-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | 2-benzyl-4-sulfonyl-4H-isoquinolin-1,3-diones and their use as antiinflammatory agents |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3501466A (en) * | 1967-11-30 | 1970-03-17 | Mcneilab Inc | 3-carbamoyl and 3-alkoxycarbonyl benzothiazine-1,1-dioxides |
| US3492298A (en) * | 1968-02-21 | 1970-01-27 | Mcneilab Inc | Oxazino-benzothiazine-6,6-dioxides |
| US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
| US3808205A (en) * | 1971-09-10 | 1974-04-30 | Warner Lambert Co | Process for the preparation of 4-hydroxy-3-carbamyl-2h-1,2-benzothiazine 1,1-dioxides and 4-hydroxy-3(2h)-1,2-benzothiazine carboxylate-1,1-dioxides |
| US3853862A (en) * | 1973-04-23 | 1974-12-10 | Pfizer | Production of 4-hydroxy-1,2-benzothiazine-3-carboxamides |
| US3892740A (en) * | 1974-10-15 | 1975-07-01 | Pfizer | Process for the production of carboxamides of oxo-1,2-benzothiazine-1,1-dioxides |
| US3991584A (en) | 1975-01-31 | 1976-11-16 | Western Gear Corporation | Shock absorbing and retracting system for pipe laying vessel |
| US3960856A (en) * | 1975-06-20 | 1976-06-01 | Warner-Lambert Company | Process for the preparation of 4-hydroxy-3-(5-methyl-3-isoxazolylcarbamoyl)-2-methyl-2H-1,2-benzothiazine 1,1-dioxide |
-
1976
- 1976-06-10 US US05/694,572 patent/US4100347A/en not_active Expired - Lifetime
-
1977
- 1977-05-24 SE SE7706078A patent/SE442200B/sv not_active IP Right Cessation
- 1977-05-25 CA CA279,137A patent/CA1077934A/en not_active Expired
- 1977-05-26 GR GR53565A patent/GR66969B/el unknown
- 1977-05-27 NO NO771870A patent/NO150761C/no unknown
- 1977-05-30 ZA ZA00773248A patent/ZA773248B/xx unknown
- 1977-05-31 IL IL52203A patent/IL52203A/xx unknown
- 1977-05-31 AU AU25666/77A patent/AU511643B2/en not_active Expired
- 1977-05-31 NZ NZ184249A patent/NZ184249A/xx unknown
- 1977-05-31 PH PH19832A patent/PH14751A/en unknown
- 1977-05-31 YU YU1348/77A patent/YU39493B/xx unknown
- 1977-06-05 EG EG348/77A patent/EG12644A/xx active
- 1977-06-06 PT PT66639A patent/PT66639B/pt unknown
- 1977-06-06 BG BG036517A patent/BG41307A3/xx unknown
- 1977-06-07 CS CS78574A patent/CS191347B2/cs unknown
- 1977-06-07 CS CS773743A patent/CS191341B2/cs unknown
- 1977-06-07 FI FI771799A patent/FI62297C/fi not_active IP Right Cessation
- 1977-06-08 JP JP52067768A patent/JPS5912673B2/ja not_active Expired
- 1977-06-08 DE DE19772726175 patent/DE2726175A1/de not_active Ceased
- 1977-06-08 ES ES459601A patent/ES459601A1/es not_active Expired
- 1977-06-09 DK DK255577A patent/DK147337C/da not_active IP Right Cessation
- 1977-06-09 DD DD7700199392A patent/DD132014A5/xx unknown
- 1977-06-09 CY CY1128A patent/CY1128A/xx unknown
- 1977-06-09 GB GB32370/78A patent/GB1544359A/en not_active Expired
- 1977-06-09 HU HU77PI577A patent/HU184665B/hu not_active IP Right Cessation
- 1977-06-09 NL NL7706338A patent/NL7706338A/xx unknown
- 1977-06-09 LU LU77516A patent/LU77516A1/xx unknown
- 1977-06-09 GB GB24161/77A patent/GB1544358A/en not_active Expired
- 1977-06-09 SU SU772494203A patent/SU657747A3/ru active
- 1977-06-09 FR FR7717722A patent/FR2354325A1/fr active Granted
- 1977-06-09 BE BE178318A patent/BE855532A/xx not_active IP Right Cessation
- 1977-06-09 DD DD77206002A patent/DD137104A5/xx unknown
- 1977-06-09 IE IE1181/77A patent/IE44997B1/en not_active IP Right Cessation
- 1977-06-10 PL PL1977210107A patent/PL108606B1/pl unknown
- 1977-06-10 RO RO7796790A patent/RO77179A/ro unknown
- 1977-06-10 PL PL1977198768A patent/PL104307B1/pl unknown
- 1977-06-10 CH CH721077A patent/CH634312A5/de not_active IP Right Cessation
- 1977-06-10 AR AR268003A patent/AR215006A1/es active
- 1977-06-10 AT AT412177A patent/AT356126B/de not_active IP Right Cessation
- 1977-06-10 RO RO7790640A patent/RO70629A/ro unknown
- 1977-10-06 ES ES462973A patent/ES462973A1/es not_active Expired
-
1978
- 1978-04-27 SU SU782607699A patent/SU833159A3/ru active
-
1981
- 1981-07-02 HK HK313/81A patent/HK31381A/xx unknown
- 1981-07-02 HK HK312/81A patent/HK31281A/xx unknown
- 1981-12-30 MY MY269/81A patent/MY8100269A/xx unknown
- 1981-12-30 MY MY274/81A patent/MY8100274A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed | ||
| MM | Patent lapsed |
Owner name: PFIZER INC. |