FI62079C - Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter - Google Patents

Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter Download PDF

Info

Publication number
FI62079C
FI62079C FI3141/74A FI314174A FI62079C FI 62079 C FI62079 C FI 62079C FI 3141/74 A FI3141/74 A FI 3141/74A FI 314174 A FI314174 A FI 314174A FI 62079 C FI62079 C FI 62079C
Authority
FI
Finland
Prior art keywords
group
methyl
formula
compounds
hydrogen atom
Prior art date
Application number
FI3141/74A
Other languages
English (en)
Finnish (fi)
Other versions
FI314174A (ja
FI62079B (fi
Inventor
Herbert Merz
Adolf Langbein
Gerhard Walther
Klaus Stockhaus
Original Assignee
Boehringer Sohn Ingelheim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Sohn Ingelheim filed Critical Boehringer Sohn Ingelheim
Publication of FI314174A publication Critical patent/FI314174A/fi
Application granted granted Critical
Publication of FI62079B publication Critical patent/FI62079B/fi
Publication of FI62079C publication Critical patent/FI62079C/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FI3141/74A 1973-10-27 1974-10-25 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter FI62079C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2354002 1973-10-27
DE19732354002 DE2354002A1 (de) 1973-10-27 1973-10-27 Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (3)

Publication Number Publication Date
FI314174A FI314174A (ja) 1975-04-28
FI62079B FI62079B (fi) 1982-07-30
FI62079C true FI62079C (fi) 1982-11-10

Family

ID=5896658

Family Applications (1)

Application Number Title Priority Date Filing Date
FI3141/74A FI62079C (fi) 1973-10-27 1974-10-25 Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter

Country Status (27)

Country Link
US (1) US3981874A (ja)
JP (1) JPS5738590B2 (ja)
AT (6) AT336202B (ja)
BE (1) BE821505A (ja)
BG (3) BG27902A3 (ja)
CA (1) CA1056377A (ja)
CH (6) CH609048A5 (ja)
CS (3) CS171195B2 (ja)
DD (1) DD115909A5 (ja)
DE (1) DE2354002A1 (ja)
DK (1) DK138325C (ja)
ES (6) ES431056A1 (ja)
FI (1) FI62079C (ja)
FR (1) FR2248838B1 (ja)
GB (1) GB1482552A (ja)
HU (1) HU176479B (ja)
IE (1) IE41528B1 (ja)
IL (1) IL45938A (ja)
NL (1) NL7413980A (ja)
NO (1) NO140859C (ja)
PH (1) PH11894A (ja)
PL (3) PL92053B1 (ja)
RO (5) RO65656A (ja)
SE (1) SE422791B (ja)
SU (6) SU510999A3 (ja)
YU (5) YU36952B (ja)
ZA (1) ZA746790B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
AR067673A1 (es) 2007-07-26 2009-10-21 Vitae Pharmaceuticals Inc Derivados de 1,3 oxazinan - 2 - ona como inhibidores ciclicos de la 11 beta -hidroxiesteroide deshidrogenasa 1. composiciones farmaceuticas.
AR069545A1 (es) * 2007-11-16 2010-02-03 Boehringer Ingelheim Pharma Derivados de aril y heteroarilcarbonilo de benzomorfanos y estructuras relacionadas, composiciones farmaceuticas que contienen dichos compuestos, obtencion de las mismas, su uso en el tratamiento de enfermedades mediadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa (hsd) 1 y
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US20110028445A1 (en) * 2008-02-12 2011-02-03 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
JP5730021B2 (ja) 2008-02-15 2015-06-03 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤としてのシクロアルキルラクタム誘導体
ES2421537T3 (es) 2008-05-01 2013-09-03 Vitae Pharmaceuticals Inc Inhibidores cíclicos de la 11beta-hidroxiesteroide deshidrogenasa 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
CA2723034A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
PL2324018T3 (pl) 2008-07-25 2014-02-28 Boehringer Ingelheim Int Cykliczne inhibitory dehydrogenazy 11 beta-hydroksysteroidowej typu 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
UY33001A (es) * 2009-11-06 2011-05-31 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
EP2744783A1 (en) 2011-08-17 2014-06-25 Boehringer Ingelheim International GmbH Indenopyridine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632591A (en) * 1968-07-19 1972-01-04 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
CS166804B2 (ja) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim

Also Published As

Publication number Publication date
FR2248838A1 (ja) 1975-05-23
BG27901A3 (en) 1980-01-15
ATA828774A (de) 1976-07-15
AT335631B (de) 1977-03-25
PH11894A (en) 1978-08-29
IE41528L (en) 1975-04-27
YU36952B (en) 1984-08-31
CH609047A5 (ja) 1979-02-15
SU578870A3 (ru) 1977-10-30
RO65659A (ro) 1980-06-15
ES431059A1 (es) 1976-10-16
FI314174A (ja) 1975-04-28
CA1056377A (en) 1979-06-12
YU285174A (en) 1982-06-18
CH609686A5 (ja) 1979-03-15
DD115909A5 (ja) 1975-10-20
YU285474A (en) 1982-06-18
SU508193A3 (ru) 1976-03-25
IE41528B1 (en) 1980-01-30
AT335634B (de) 1977-03-25
RO65658A (fr) 1979-07-15
ATA828874A (de) 1976-06-15
YU36949B (en) 1984-08-31
GB1482552A (en) 1977-08-10
RO65657A (ro) 1980-06-15
SU508192A3 (ru) 1976-03-25
RO65655A (ro) 1980-06-15
ATA828574A (de) 1976-07-15
JPS5738590B2 (ja) 1982-08-16
NO140859C (no) 1979-11-28
ES431054A1 (es) 1976-10-16
RO65656A (ro) 1980-06-15
ES431056A1 (es) 1976-10-16
AT335633B (de) 1977-03-25
HU176479B (en) 1981-03-28
BE821505A (fr) 1975-04-25
ATA829074A (de) 1976-07-15
BG27903A3 (en) 1980-01-15
IL45938A (en) 1977-12-30
YU36519B (en) 1984-02-29
SU511005A3 (ru) 1976-04-15
CS171196B2 (ja) 1976-10-29
FI62079B (fi) 1982-07-30
NO743845L (ja) 1975-05-26
CH609340A5 (ja) 1979-02-28
SU510999A3 (ru) 1976-04-15
JPS5071679A (ja) 1975-06-13
NO140859B (no) 1979-08-20
AT335076B (de) 1977-02-25
ES431058A1 (es) 1976-10-16
SE7413485L (ja) 1975-04-28
DE2354002A1 (de) 1975-05-07
SE422791B (sv) 1982-03-29
FR2248838B1 (ja) 1977-11-04
PL92053B1 (ja) 1977-03-31
CS171195B2 (ja) 1976-10-29
YU285374A (en) 1982-06-18
CH609048A5 (ja) 1979-02-15
ES431055A1 (es) 1976-10-16
BG27902A3 (en) 1980-01-15
PL92086B1 (ja) 1977-03-31
DK138325B (da) 1978-08-14
DK559874A (ja) 1975-06-23
ATA828674A (de) 1976-07-15
YU36950B (en) 1984-08-31
YU36951B (en) 1984-08-31
CH609685A5 (ja) 1979-03-15
IL45938A0 (en) 1974-12-31
SU512707A3 (ru) 1976-04-30
US3981874A (en) 1976-09-21
CH609046A5 (ja) 1979-02-15
YU285674A (en) 1982-06-18
PL92052B1 (ja) 1977-03-31
AT335632B (de) 1977-03-25
ES431057A1 (es) 1976-10-16
NL7413980A (nl) 1975-04-29
DK138325C (da) 1979-01-22
AT336202B (de) 1977-04-25
ATA828974A (de) 1976-08-15
CS171194B2 (ja) 1976-10-29
ZA746790B (en) 1976-06-30
YU285274A (en) 1982-02-25

Similar Documents

Publication Publication Date Title
FI62079C (fi) Foerfarande foer framstaellning av pao centralnervsystemet verkande n-(metoximetylfurylmetyl)-6,7-benzomorfaner och deras syraadditionssalter
FI63229B (fi) Foerfarande foer framstaellning av analgetiskt verkande racemiskt eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-5,9beta-dimetyl-6,7-bensomorfaner och deras syraadditionssalter
FI63571B (fi) Foerfarande foer framstaellning av analgetiskt verkande racemiska eller diastereomera och optiskt aktiva 2-tetrahydrofurfuryl-(1r/s 5r/s 9r/s)-2'-hydroxi-5,9-dimetyl-6,7-bensomorfaner och deras syraadditionssalter
FI65064B (fi) Foerfarande foer framstaellning av terapeutiskt verkande 2-(2-substituerad metyl)-2'-hydroxi-5,9-dimetyl-6,7-benzomorfaneroch deras syraadditionssalter
MAY et al. Structures related to morphine. III. Synthesis of an analog of N-methylmorphinan
US4087532A (en) Analgesically useful 2-tetrahydrofurfuryl-5-lower alkyl-2-oxy-6,7-benzomorphans and salts thereof
INUBUSHI et al. Total synthesis of dl-cepharamine
SE410606B (sv) Analogiforfarande for framstellning av normorfinonderivat
Fujii et al. Aerobic oxidation of indolomorphinan without the 4, 5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative
Ferrarini et al. Synthesis and β-blocking activity of (E)-and (Z)-iminoethers of 1, 8-naphthyridine. Potential antihypertensive agents. 4
ZA200210201B (en) Benzofuran Derivatives.
CA1132553A (en) Isoquinoline derivatives
Kametani et al. Studies on the syntheses of heterocyclic compounds. Part DCL. Total synthesis of corytenchirine
JPH01131159A (ja) アクリジニルアミノメタンスルホンアニリド誘導体の製造に有用な中間体の製造法
KAMETANI et al. Synthesis of Melanthioidine Derivative by Double Ullmann Reaction (Studies on the Syntheses of Heterocyclic Compounds. CCXXVI)
Parker et al. Convergent approaches to indoloquinones: additions to quinone monoimides
CN117362273B (zh) 一种吲哚吗啡烷衍生物的制备方法
Gößnitzer et al. Novel high energy intermediate analogues with triazasterol-related structures as inhibitors of ergosterol biosynthesis: III. Synthesis and antifungal activity of N4-alkyl-1, 6, 7, 11b-tetrahydro-2H-pyrimido [4, 3-a] isoquinolin-4-amine salts
Waters Pyrrole esters of Tropanols and related structures as analgesics
KANO et al. Syntheses of 13a-Substituted Dibenzo [a, f] quinolizines
US3966740A (en) 2-Methyl-3-phenyl-1,2,3,7,8,8a-hexahydro-1H-cyclopent[i,j]-isoquinoline hydrobromide
Baarschers et al. The syntheses of 1, 2, 9-trimethoxy-10-hydroxyaporphine and 2-methoxy-N-acetylnoraporphine
Gan et al. An improved synthesis of substituted indan-1-carboxylic acid
Kuo et al. Studies on Heterocyclic Compounds, V. Synthetic Investigation of Glycarpine
Gan The Design of Novel DCB-3503 Analogues: Ligand-Based and Structure-Based Approaches