FI60564C - Foerfarande foer framstaellning av farmakologiskt anvaendbar n-substituerad-9-alkoxi-5-alkyl-6,7-bensomorfan - Google Patents

Foerfarande foer framstaellning av farmakologiskt anvaendbar n-substituerad-9-alkoxi-5-alkyl-6,7-bensomorfan Download PDF

Info

Publication number
FI60564C
FI60564C FI751106A FI751106A FI60564C FI 60564 C FI60564 C FI 60564C FI 751106 A FI751106 A FI 751106A FI 751106 A FI751106 A FI 751106A FI 60564 C FI60564 C FI 60564C
Authority
FI
Finland
Prior art keywords
compound
group
methyl
alkyl
hydroxy
Prior art date
Application number
FI751106A
Other languages
English (en)
Finnish (fi)
Other versions
FI751106A (nl
FI60564B (fi
Inventor
Thomas Alfred Montzka
John Daniel Matiskella
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FI751106A publication Critical patent/FI751106A/fi
Publication of FI60564B publication Critical patent/FI60564B/fi
Application granted granted Critical
Publication of FI60564C publication Critical patent/FI60564C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/26Benzomorphans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI751106A 1974-04-18 1975-04-15 Foerfarande foer framstaellning av farmakologiskt anvaendbar n-substituerad-9-alkoxi-5-alkyl-6,7-bensomorfan FI60564C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46200774A 1974-04-18 1974-04-18
US46200774 1974-04-18

Publications (3)

Publication Number Publication Date
FI751106A FI751106A (nl) 1975-10-19
FI60564B FI60564B (fi) 1981-10-30
FI60564C true FI60564C (fi) 1982-02-10

Family

ID=23834846

Family Applications (1)

Application Number Title Priority Date Filing Date
FI751106A FI60564C (fi) 1974-04-18 1975-04-15 Foerfarande foer framstaellning av farmakologiskt anvaendbar n-substituerad-9-alkoxi-5-alkyl-6,7-bensomorfan

Country Status (23)

Country Link
JP (3) JPS6218552B2 (nl)
BE (1) BE828054A (nl)
CA (1) CA1040630A (nl)
CH (1) CH623812A5 (nl)
CS (1) CS199586B2 (nl)
DD (1) DD119787A5 (nl)
DE (1) DE2517220A1 (nl)
DK (2) DK155999C (nl)
FI (1) FI60564C (nl)
FR (1) FR2267774B1 (nl)
GB (1) GB1493420A (nl)
HU (1) HU173039B (nl)
IE (1) IE41003B1 (nl)
IL (1) IL47114A (nl)
LU (1) LU72315A1 (nl)
NL (1) NL159971C (nl)
NO (1) NO143155C (nl)
OA (1) OA04983A (nl)
PH (1) PH12067A (nl)
SE (1) SE427181B (nl)
SU (1) SU721002A3 (nl)
YU (1) YU93275A (nl)
ZA (1) ZA752471B (nl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01179624A (ja) * 1988-01-12 1989-07-17 Matsushita Refrig Co Ltd 生鮮物貯蔵装置
GB2442535B (en) 2006-10-05 2011-07-13 Ngf Europ Ltd Method and articles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation

Also Published As

Publication number Publication date
FI751106A (nl) 1975-10-19
PH12067A (en) 1978-10-30
SU721002A3 (ru) 1980-03-05
DK194088A (da) 1988-04-08
NO143155C (no) 1980-12-29
IE41003B1 (en) 1979-09-26
JPS6127390B2 (nl) 1986-06-25
CH623812A5 (en) 1981-06-30
JPS6218552B2 (nl) 1987-04-23
NL159971C (nl) 1979-09-17
SE427181B (sv) 1983-03-14
FI60564B (fi) 1981-10-30
NO751371L (nl) 1975-10-21
OA04983A (fr) 1980-11-30
DE2517220C2 (nl) 1990-04-19
CA1040630A (en) 1978-10-17
JPH0119387B2 (nl) 1989-04-11
DE2517220A1 (de) 1975-11-06
DK155999B (da) 1989-06-12
IL47114A0 (en) 1975-06-25
DK155999C (da) 1989-11-06
BE828054A (fr) 1975-10-17
ZA752471B (en) 1976-03-31
JPS60142964A (ja) 1985-07-29
LU72315A1 (nl) 1976-03-17
FR2267774B1 (nl) 1978-08-04
JPS60120868A (ja) 1985-06-28
SE7504469L (sv) 1975-10-20
DK194088D0 (da) 1988-04-08
FR2267774A1 (nl) 1975-11-14
GB1493420A (en) 1977-11-30
DD119787A5 (nl) 1976-05-12
IE41003L (en) 1975-10-18
AU8025875A (en) 1976-10-21
NO143155B (no) 1980-09-15
IL47114A (en) 1979-01-31
HU173039B (hu) 1979-02-28
NL7504648A (nl) 1975-10-21
CS199586B2 (en) 1980-07-31
JPS50142568A (nl) 1975-11-17
YU93275A (en) 1982-02-28
DK166375A (da) 1975-10-19

Similar Documents

Publication Publication Date Title
US4613668A (en) Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
EP0023576B1 (en) 7- and 7,8-substituted 4,5-alpha-epoxymorphinan-6-ones and therapeutically active compositions containing them
SK139696A3 (en) New agonist compounds
Schmidhammer et al. Synthesis and biological evaluation of 14-alkoxymorphinans. 1. Highly potent opioid agonists in the series of (-)-14-methoxy-N-methylmorphinan-6-ones
US4277605A (en) Chemical compounds
JPS5823691A (ja) アザビシクロオクテン化合物の製法
US3853889A (en) 3,14-substituted-8-oxamorphinans
US4272540A (en) 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
US4230712A (en) 7-Methyl-8β-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them
Jolad et al. Constituents of Trichilia hispida (Meliaceae). 2. A new triterpenoid, hispidone, and bourjotinolone A
FI60564C (fi) Foerfarande foer framstaellning av farmakologiskt anvaendbar n-substituerad-9-alkoxi-5-alkyl-6,7-bensomorfan
US4425353A (en) Analgesic 5-oxygenated-6,7-benzomorphan derivatives
US3513169A (en) 5,9-diethyl benzomorphan derivatives
US4390699A (en) 6-Keto-morphinans belonging to the 14-hydroxy-series
GB1559979A (en) N-substituted - 6,8 - dioxamorphinans and process for their preparation
US4370333A (en) 17-Cyclopropylmethyl-3-hydroxy-14-methoxy 7α-methyl-morphinan-6-one and therapeutic method of treating pain with it
Manmade et al. (-)-4-Hydroxymorphinanones: their synthesis and analgesic activity
US4154932A (en) 6-Oxamorphinans
AU2005229344B2 (en) A process for the semisynthesis of deserpidine
EP0068382B1 (en) N-cyclopropylmethyl-14-ethoxymorphinan-6-one compounds exhibiting mixed analgesic/narcotic antagonist activity and precursors therefore
US4242514A (en) Method for the introduction of a methyl group into the 7 position of the morphinan nucleus
US3956336A (en) 9-Alkoxy-5-methyl-6,7-benzomorphans
EP0019254B1 (en) 7-methyl and 7-methyl-8-lower alkyl b/c cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them
US4552962A (en) Antitussive 6-keto morphinans of the (+)-series
JPS6212221B2 (nl)

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: BRISTOL-MYERS CO