FI60216C - Biologiskt aktivt vid affinitetsreaktioner anvaendbart adsorptionsmedel - Google Patents

Biologiskt aktivt vid affinitetsreaktioner anvaendbart adsorptionsmedel Download PDF

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Publication number
FI60216C
FI60216C FI751299A FI751299A FI60216C FI 60216 C FI60216 C FI 60216C FI 751299 A FI751299 A FI 751299A FI 751299 A FI751299 A FI 751299A FI 60216 C FI60216 C FI 60216C
Authority
FI
Finland
Prior art keywords
polyhydroxymethylene
biologically active
washed
solution
water
Prior art date
Application number
FI751299A
Other languages
English (en)
Finnish (fi)
Other versions
FI751299A (es
FI60216B (fi
Inventor
Rudolf Schmidtberger
Heinrich Huemer
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742421789 external-priority patent/DE2421789C3/de
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of FI751299A publication Critical patent/FI751299A/fi
Priority to FI783694A priority Critical patent/FI61811C/fi
Application granted granted Critical
Publication of FI60216B publication Critical patent/FI60216B/fi
Publication of FI60216C publication Critical patent/FI60216C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
FI751299A 1974-05-06 1975-04-30 Biologiskt aktivt vid affinitetsreaktioner anvaendbart adsorptionsmedel FI60216C (fi)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FI783694A FI61811C (fi) 1974-05-06 1978-12-01 Anvaendning av en biologiskt aktiv produkt bestaoende av en i atten oloeslig baerare och ett biologiskt aktivt aemne sa osm adsorptionsmedel foer affinitetskromatografi

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2421789 1974-05-06
DE19742421789 DE2421789C3 (de) 1974-05-06 Biologisch aktive Produkte und Verfahren zu ihrer Herstellung

Publications (3)

Publication Number Publication Date
FI751299A FI751299A (es) 1975-11-07
FI60216B FI60216B (fi) 1981-08-31
FI60216C true FI60216C (fi) 1981-12-10

Family

ID=5914739

Family Applications (1)

Application Number Title Priority Date Filing Date
FI751299A FI60216C (fi) 1974-05-06 1975-04-30 Biologiskt aktivt vid affinitetsreaktioner anvaendbart adsorptionsmedel

Country Status (16)

Country Link
JP (1) JPS599153B2 (es)
AT (1) AT338417B (es)
BE (1) BE828776A (es)
CA (1) CA1063049A (es)
CH (1) CH630410A5 (es)
DK (1) DK196175A (es)
ES (1) ES437153A1 (es)
FI (1) FI60216C (es)
FR (1) FR2270266B1 (es)
GB (1) GB1512651A (es)
IE (1) IE41040B1 (es)
IT (1) IT1054620B (es)
LU (1) LU72407A1 (es)
NL (1) NL181782C (es)
NO (1) NO144672C (es)
SE (2) SE427086B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552510C3 (de) * 1975-11-22 1981-02-19 Behringwerke Ag, 3550 Marburg Biologisch aktive Verbindungen und Verfahren zu ihrer Herstellung
EP1585817B1 (en) * 2002-02-20 2009-09-02 The General Hospital Corporation Conjugates comprising a biodegradable polymer and uses therefor
JP6476934B2 (ja) * 2015-02-02 2019-03-06 東ソー株式会社 新規重合体、およびそれを有する細胞培養基材

Also Published As

Publication number Publication date
FR2270266A1 (es) 1975-12-05
LU72407A1 (es) 1977-02-09
CA1063049A (en) 1979-09-25
IE41040B1 (en) 1979-10-10
BE828776A (fr) 1975-11-06
FI751299A (es) 1975-11-07
NO144672C (no) 1981-10-14
NO144672B (no) 1981-07-06
FI60216B (fi) 1981-08-31
JPS599153B2 (ja) 1984-02-29
FR2270266B1 (es) 1979-03-16
SE444947B (sv) 1986-05-20
NL181782C (nl) 1987-11-02
SE7505275L (sv) 1975-11-07
NL181782B (nl) 1987-06-01
ATA342275A (de) 1976-12-15
IT1054620B (it) 1981-11-30
AU8081875A (en) 1976-11-11
GB1512651A (en) 1978-06-01
CH630410A5 (en) 1982-06-15
DE2421789B2 (de) 1976-10-07
DE2421789A1 (de) 1975-11-13
AT338417B (de) 1977-08-25
NL7505152A (nl) 1975-11-10
JPS50155679A (es) 1975-12-16
NO751599L (es) 1975-11-07
ES437153A1 (es) 1977-04-16
DK196175A (da) 1975-11-07
SE427086B (sv) 1983-03-07
IE41040L (en) 1975-11-06

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Owner name: BEHRINGWERKE AG