SE427086B - Anvendning av biologiskt aktiva foreningar bestaende av en biologiskt aktivsubstans bunden till en hydrofil berarpolymer, som utgores av polyhydroximetylen, for affinitetskromatografering, utvinning av antikroppar eller - Google Patents

Anvendning av biologiskt aktiva foreningar bestaende av en biologiskt aktivsubstans bunden till en hydrofil berarpolymer, som utgores av polyhydroximetylen, for affinitetskromatografering, utvinning av antikroppar eller

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Publication number
SE427086B
SE427086B SE7505275A SE7505275A SE427086B SE 427086 B SE427086 B SE 427086B SE 7505275 A SE7505275 A SE 7505275A SE 7505275 A SE7505275 A SE 7505275A SE 427086 B SE427086 B SE 427086B
Authority
SE
Sweden
Prior art keywords
polyhydroximymyle
antics
polyme
hydrophilic
extraction
Prior art date
Application number
SE7505275A
Other languages
English (en)
Other versions
SE7505275L (sv
Inventor
R Schmidtberger
H Huemer
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742421789 external-priority patent/DE2421789C3/de
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of SE7505275L publication Critical patent/SE7505275L/sv
Publication of SE427086B publication Critical patent/SE427086B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
SE7505275A 1974-05-06 1975-05-06 Anvendning av biologiskt aktiva foreningar bestaende av en biologiskt aktivsubstans bunden till en hydrofil berarpolymer, som utgores av polyhydroximetylen, for affinitetskromatografering, utvinning av antikroppar eller SE427086B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742421789 DE2421789C3 (de) 1974-05-06 Biologisch aktive Produkte und Verfahren zu ihrer Herstellung

Publications (2)

Publication Number Publication Date
SE7505275L SE7505275L (sv) 1975-11-07
SE427086B true SE427086B (sv) 1983-03-07

Family

ID=5914739

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7505275A SE427086B (sv) 1974-05-06 1975-05-06 Anvendning av biologiskt aktiva foreningar bestaende av en biologiskt aktivsubstans bunden till en hydrofil berarpolymer, som utgores av polyhydroximetylen, for affinitetskromatografering, utvinning av antikroppar eller
SE7805544A SE444947B (sv) 1974-05-06 1978-05-16 Biologiskt aktiva foreningar bestaende av en vattenoloslig hydrofil berarpolymer och en biologiskt aktiv substans, vilka er bundna till varandra

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7805544A SE444947B (sv) 1974-05-06 1978-05-16 Biologiskt aktiva foreningar bestaende av en vattenoloslig hydrofil berarpolymer och en biologiskt aktiv substans, vilka er bundna till varandra

Country Status (16)

Country Link
JP (1) JPS599153B2 (sv)
AT (1) AT338417B (sv)
BE (1) BE828776A (sv)
CA (1) CA1063049A (sv)
CH (1) CH630410A5 (sv)
DK (1) DK196175A (sv)
ES (1) ES437153A1 (sv)
FI (1) FI60216C (sv)
FR (1) FR2270266B1 (sv)
GB (1) GB1512651A (sv)
IE (1) IE41040B1 (sv)
IT (1) IT1054620B (sv)
LU (1) LU72407A1 (sv)
NL (1) NL181782C (sv)
NO (1) NO144672C (sv)
SE (2) SE427086B (sv)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552510C3 (de) * 1975-11-22 1981-02-19 Behringwerke Ag, 3550 Marburg Biologisch aktive Verbindungen und Verfahren zu ihrer Herstellung
EP1585817B1 (en) * 2002-02-20 2009-09-02 The General Hospital Corporation Conjugates comprising a biodegradable polymer and uses therefor
JP6476934B2 (ja) * 2015-02-02 2019-03-06 東ソー株式会社 新規重合体、およびそれを有する細胞培養基材

Also Published As

Publication number Publication date
FR2270266A1 (sv) 1975-12-05
LU72407A1 (sv) 1977-02-09
CA1063049A (en) 1979-09-25
IE41040B1 (en) 1979-10-10
FI60216C (fi) 1981-12-10
BE828776A (fr) 1975-11-06
FI751299A (sv) 1975-11-07
NO144672C (no) 1981-10-14
NO144672B (no) 1981-07-06
FI60216B (fi) 1981-08-31
JPS599153B2 (ja) 1984-02-29
FR2270266B1 (sv) 1979-03-16
SE444947B (sv) 1986-05-20
NL181782C (nl) 1987-11-02
SE7505275L (sv) 1975-11-07
NL181782B (nl) 1987-06-01
ATA342275A (de) 1976-12-15
IT1054620B (it) 1981-11-30
AU8081875A (en) 1976-11-11
GB1512651A (en) 1978-06-01
CH630410A5 (en) 1982-06-15
DE2421789B2 (de) 1976-10-07
DE2421789A1 (de) 1975-11-13
AT338417B (de) 1977-08-25
NL7505152A (nl) 1975-11-10
JPS50155679A (sv) 1975-12-16
NO751599L (sv) 1975-11-07
ES437153A1 (es) 1977-04-16
DK196175A (da) 1975-11-07
IE41040L (en) 1975-11-06

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