GB1512651A - Biologically active compounds and process for their manufacture - Google Patents

Biologically active compounds and process for their manufacture

Info

Publication number
GB1512651A
GB1512651A GB18761/75A GB1876175A GB1512651A GB 1512651 A GB1512651 A GB 1512651A GB 18761/75 A GB18761/75 A GB 18761/75A GB 1876175 A GB1876175 A GB 1876175A GB 1512651 A GB1512651 A GB 1512651A
Authority
GB
United Kingdom
Prior art keywords
biologically active
poly
manufacture
active compounds
vinylenecarbonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB18761/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19742421789 external-priority patent/DE2421789C3/en
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of GB1512651A publication Critical patent/GB1512651A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/089—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The biologically active substance is bound covalently to poly(hydroxymethylene) or poly(vinylenecarbonate) either directly or after reaction with a coupling component. The coupling component, which is optionally employed, is bound to the poly(hydroxymethylene) and the biologically active compound by a covalent bond in each case. When poly(vinylenecarbonate) is used, the remaining carbonate groups are hydrolysed. The biologically active substances which are obtained are suitable for use in affinity chromatography.
GB18761/75A 1974-05-06 1975-05-05 Biologically active compounds and process for their manufacture Expired GB1512651A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742421789 DE2421789C3 (en) 1974-05-06 Biologically active products and processes for their manufacture

Publications (1)

Publication Number Publication Date
GB1512651A true GB1512651A (en) 1978-06-01

Family

ID=5914739

Family Applications (1)

Application Number Title Priority Date Filing Date
GB18761/75A Expired GB1512651A (en) 1974-05-06 1975-05-05 Biologically active compounds and process for their manufacture

Country Status (16)

Country Link
JP (1) JPS599153B2 (en)
AT (1) AT338417B (en)
BE (1) BE828776A (en)
CA (1) CA1063049A (en)
CH (1) CH630410A5 (en)
DK (1) DK196175A (en)
ES (1) ES437153A1 (en)
FI (1) FI60216C (en)
FR (1) FR2270266B1 (en)
GB (1) GB1512651A (en)
IE (1) IE41040B1 (en)
IT (1) IT1054620B (en)
LU (1) LU72407A1 (en)
NL (1) NL181782C (en)
NO (1) NO144672C (en)
SE (2) SE427086B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138575A1 (en) * 2002-02-20 2009-12-30 The General Hospital Corporation Conjugates comprising a biodegradable polymer and uses therefor

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2552510C3 (en) * 1975-11-22 1981-02-19 Behringwerke Ag, 3550 Marburg Biologically active compounds and processes for their preparation
JP6476934B2 (en) * 2015-02-02 2019-03-06 東ソー株式会社 Novel polymer and cell culture substrate having the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2138575A1 (en) * 2002-02-20 2009-12-30 The General Hospital Corporation Conjugates comprising a biodegradable polymer and uses therefor
US7785618B2 (en) 2002-02-20 2010-08-31 Elmaleh David R Conjugates comprising a biodegradable polymer and uses therefor

Also Published As

Publication number Publication date
ES437153A1 (en) 1977-04-16
NL181782B (en) 1987-06-01
FI60216B (en) 1981-08-31
NL181782C (en) 1987-11-02
SE7505275L (en) 1975-11-07
ATA342275A (en) 1976-12-15
FI751299A (en) 1975-11-07
IE41040B1 (en) 1979-10-10
NO751599L (en) 1975-11-07
DK196175A (en) 1975-11-07
NO144672C (en) 1981-10-14
NO144672B (en) 1981-07-06
DE2421789A1 (en) 1975-11-13
CA1063049A (en) 1979-09-25
AU8081875A (en) 1976-11-11
SE427086B (en) 1983-03-07
FR2270266B1 (en) 1979-03-16
SE444947B (en) 1986-05-20
BE828776A (en) 1975-11-06
LU72407A1 (en) 1977-02-09
FR2270266A1 (en) 1975-12-05
IT1054620B (en) 1981-11-30
DE2421789B2 (en) 1976-10-07
JPS50155679A (en) 1975-12-16
JPS599153B2 (en) 1984-02-29
FI60216C (en) 1981-12-10
CH630410A5 (en) 1982-06-15
NL7505152A (en) 1975-11-10
AT338417B (en) 1977-08-25
IE41040L (en) 1975-11-06

Similar Documents

Publication Publication Date Title
SE8304027L (en) VERMICULITE AS A CARRIER FOR BIOLOGICAL MATERIALS
AU8538275A (en) Biological substances covalently bound to plastic materials
JPS52104591A (en) Carrier for organic compounds* process for preparing the same* biological reagent and catalyst containing the same
SE7407173L (en) TIOL POLYMERS AND DERIVATIVES AND THEIR PREPARATION AND USE
AU8223475A (en) Immobilized biologically active substances
NL158814B (en) PROCESS FOR PREPARING AN ANAEROBIC CURING MIXTURE AND PROCESS FOR BONDING SURFACES TOGETHER.
NL7415117A (en) PROCESS FOR THE PREPARATION OF AN INORGANIC CARRIER, AS WELL AS FOR THE PREPARATION OF A PERFUMED PLASTER OBJECT AND THE ARTICLES SO MANUFACTURED.
FR2433544B1 (en)
DE2960357D1 (en) Substituted cyanamides, process for their preparation and their use as fungicides
GB1512651A (en) Biologically active compounds and process for their manufacture
JPS55160786A (en) Hydroalkenyloxysilane
NL162418B (en) PROCESS FOR THE PREPARATION OF A THERMO-HARDING POWDER COATING COMPOSITION, AS WELL AS COATED MATERIAL OBTAINED USING SUCH POWDER COATING COMPOSITION.
NL7500661A (en) PROCESS FOR THE PREPARATION OF A POLYPHOSPHANE POLYMER CONTAINING MIXTURE.
NL184000C (en) Process for the preparation of a beta-naphthalene amidine derivative-containing medicament, as well as compounds suitable therefor.
CA1029737A (en) Phosphorus compounds, process for their manufacture and process for flameproofing organic fibre materials by the transfer process
NL971002I1 (en) Process for the preparation of 4-amino-5-chloro-1-phenylpyridazone- (6).
CA1030309A (en) Process for flameproofing organic fiber material by the transfer process
SU540208A1 (en) Filler for nozzles
NL7601233A (en) PROCESS FOR THE PREPARATION OF A MATERIAL CONTAINING A MATRIX AND CALCIUM SULPHATE WHISKERS AND ARTICLES MADE BY USING THE MATERIAL SO PREPARED.
CA962284A (en) Halodimethanonaphthalenes, method of making same, and use thereof for flameproofing polymeric materials
NL7504088A (en) PROCESS FOR PREPARING A HARDABLE COVER-LAYER COMPOSITION.
ZA744010B (en) Phosphorus compounds, process for their manufacture and process for flameproofing organic fibre materials by the transfer process
JPS53149874A (en) Production of compound semipermeable membrane
JPS52138482A (en) Production of hydrophiric compound gel
CH542651A (en) Mixing device, in particular for the production of carbon electrode compounds

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee