FI60205C - Analogifoerfarande foer framstaellning av terapeutiskt aktiva 1-(aminoalkyl)-2-arylsyklohexanalkoholer och -estrar - Google Patents

Analogifoerfarande foer framstaellning av terapeutiskt aktiva 1-(aminoalkyl)-2-arylsyklohexanalkoholer och -estrar Download PDF

Info

Publication number
FI60205C
FI60205C FI750601A FI750601A FI60205C FI 60205 C FI60205 C FI 60205C FI 750601 A FI750601 A FI 750601A FI 750601 A FI750601 A FI 750601A FI 60205 C FI60205 C FI 60205C
Authority
FI
Finland
Prior art keywords
formula
compound
solution
give
methyl
Prior art date
Application number
FI750601A
Other languages
English (en)
Finnish (fi)
Other versions
FI750601A (nl
FI60205B (fi
Inventor
Bola Vithal Shetty
Telfer Lawson Thomas
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of FI750601A publication Critical patent/FI750601A/fi
Application granted granted Critical
Publication of FI60205B publication Critical patent/FI60205B/fi
Publication of FI60205C publication Critical patent/FI60205C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FI750601A 1974-03-04 1975-02-28 Analogifoerfarande foer framstaellning av terapeutiskt aktiva 1-(aminoalkyl)-2-arylsyklohexanalkoholer och -estrar FI60205C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US44780474A 1974-03-04 1974-03-04
US44780474 1974-03-04
US05/545,074 US3974157A (en) 1974-03-04 1975-01-29 1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters
US54507475 1975-01-29

Publications (3)

Publication Number Publication Date
FI750601A FI750601A (nl) 1975-09-05
FI60205B FI60205B (fi) 1981-08-31
FI60205C true FI60205C (fi) 1981-12-10

Family

ID=27035098

Family Applications (1)

Application Number Title Priority Date Filing Date
FI750601A FI60205C (fi) 1974-03-04 1975-02-28 Analogifoerfarande foer framstaellning av terapeutiskt aktiva 1-(aminoalkyl)-2-arylsyklohexanalkoholer och -estrar

Country Status (13)

Country Link
US (1) US3974157A (nl)
JP (1) JPS50157342A (nl)
BE (1) BE826260A (nl)
CH (4) CH621329A5 (nl)
DK (2) DK143698C (nl)
FI (1) FI60205C (nl)
FR (1) FR2262974B1 (nl)
GB (1) GB1474004A (nl)
IE (1) IE40733B1 (nl)
LU (1) LU71964A1 (nl)
NL (1) NL7502450A (nl)
NO (1) NO140100C (nl)
SE (2) SE7502407L (nl)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115589A (en) * 1977-05-17 1978-09-19 The Upjohn Company Compounds, compositions and method of use
US4306097A (en) * 1977-09-13 1981-12-15 Pfizer Inc. 3-[2-Hydroxy-4-(substituted)phenyl]-cycloalkanol analgesic agents
US4366172A (en) * 1977-09-29 1982-12-28 The Upjohn Company 4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use
FR2472559A1 (fr) * 1979-12-31 1981-07-03 Cerm Cent Europ Rech Mauvernay Derives du 1-aminomethyl 2-phenoxy cyclohexanol, procede d'obtention, application en therapeutique et compositions les contenant
US4391827A (en) * 1980-09-08 1983-07-05 Pfizer Inc. 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor
US4285867A (en) * 1980-09-19 1981-08-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4831059A (en) * 1980-09-19 1989-05-16 Pfizer Inc. Producing analgesia with pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes derivatives
US4739079A (en) * 1980-09-19 1988-04-19 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4331602A (en) * 1980-09-19 1982-05-25 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted]phenyl)naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4371720A (en) * 1980-09-19 1983-02-01 Pfizer Inc. 2-Hydroxy-4-(substituted) phenyl cycloalkanes and derivatives
US4593131A (en) * 1980-09-19 1986-06-03 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4921994A (en) * 1980-09-19 1990-05-01 Pfizer Inc. Pharmacologically active 2-hydroxy-4-(substituted) phenyl cycloalkanes and derivatives thereof
US4486609A (en) * 1981-03-16 1984-12-04 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4835192A (en) * 1980-09-19 1989-05-30 Pfizer Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
US4933475A (en) * 1980-09-19 1990-06-12 Pfizer, Inc. Pharmacologically active 4-[2-hydroxy-4-(substituted)phenyl]naphthalen-2(1H)-ones and 2-ols, derivatives thereof and intermediates therefor
JPS57122041A (en) * 1981-01-21 1982-07-29 Suntory Ltd Phenylclohexane derivative
US4847414A (en) * 1981-10-19 1989-07-11 Hoechst-Roussel Pharmaceuticals, Inc. 2'-substituted-spiro[benzofuran-2(3H),1'-cyclohexanes] and intermediates thereof
US4535186A (en) * 1983-04-19 1985-08-13 American Home Products Corporation 2-Phenyl-2-(1-hydroxycycloalkyl or 1-hydroxycycloalk-2-enyl)ethylamine derivatives
DE3467341D1 (en) * 1983-08-19 1987-12-17 Pennwalt Corp Cyclohexane carboxylic acids and derivatives thereof as antidysrhythmic agents
GB8405112D0 (en) * 1984-02-28 1984-04-04 Akzo Nv Anti-arrhythmic amino-alcohols
US4760146A (en) * 1986-02-18 1988-07-26 Pennwalt Corporation Cyclohexene carboxylic esters and amides as antidysrhythmic agents
US5248830A (en) * 1989-08-24 1993-09-28 Rhone-Poulenc Rorer Pharmaceuticals Inc. Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydro-pyran-2-ones
WO1992014692A1 (en) * 1991-02-11 1992-09-03 Rhone-Poulenc Rorer International (Holdings) Inc. Enantioselective preparation of acetylenic or olefinic substituted cycloalkenyl dihydroxybutyrates and 4-hydroxy-tetrahydropyran-2-ones
NZ260408A (en) 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
US5891471A (en) * 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
KR100354702B1 (ko) * 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5843480A (en) * 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) * 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
DE10000311A1 (de) * 2000-01-05 2001-07-12 Gruenenthal Gmbh Aminomethyl-Phonyl-Cyclohexanonderivate
DE10048714A1 (de) * 2000-09-30 2002-04-11 Gruenenthal Gmbh 5-Amino-1-penlen-3-ol-Derivate
BRPI0811639A2 (pt) * 2007-05-31 2014-09-30 Sepracor Inc Cicloaquilaminas fenil substituídas como inibidores da recaptação de monoamina
US10968209B2 (en) 2016-05-19 2021-04-06 Glaxosmithkline Intellectual Property (No.2) Limited TRPV4 antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2586512A (en) * 1948-09-15 1952-02-19 Searle & Co Cyclohexyl-amino-alcohols
US2680115A (en) * 1949-01-28 1954-06-01 Maurice L Tainter Substituted tertiary-aminoalkyl carbinols
US2656386A (en) * 1951-02-24 1953-10-20 Upjohn Co Aminoethylhydrocarbonoxycyclohexenes
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols

Also Published As

Publication number Publication date
US3974157A (en) 1976-08-10
CH615413A5 (en) 1980-01-31
DK143698C (da) 1982-03-08
FR2262974B1 (nl) 1980-01-25
CH617921A5 (en) 1980-06-30
IE40733B1 (en) 1979-08-01
NO750706L (nl) 1975-09-05
AU7877375A (en) 1976-09-09
FI750601A (nl) 1975-09-05
DK328479A (da) 1979-08-03
IE40733L (en) 1975-09-04
LU71964A1 (nl) 1975-08-20
CH619207A5 (en) 1980-09-15
NO140100B (no) 1979-03-26
SE8203051L (sv) 1982-05-14
CH621329A5 (nl) 1981-01-30
FR2262974A1 (nl) 1975-10-03
NL7502450A (nl) 1975-09-08
FI60205B (fi) 1981-08-31
GB1474004A (en) 1977-05-18
DK143698B (da) 1981-09-28
SE7502407L (nl) 1975-09-05
DK83575A (nl) 1975-09-05
NO140100C (no) 1979-07-04
BE826260A (nl) 1975-06-30
JPS50157342A (nl) 1975-12-19

Similar Documents

Publication Publication Date Title
FI60205C (fi) Analogifoerfarande foer framstaellning av terapeutiskt aktiva 1-(aminoalkyl)-2-arylsyklohexanalkoholer och -estrar
AU664188B2 (en) Aromatic compounds, pharmaceutical compositions containing them and their use in therapy
DK172103B1 (da) Hidtil ukendte 3,3-difenylpropylaminer, farmaceutiske præparater indeholdende disse, deres anvendelse til fremstilling af et anticholinergt lægemiddel samt fremgangsmåde til deres fremstilling
AU626949B2 (en) 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US6469010B1 (en) Medicament for the alleviation or treatment of symptom derived from the ischemic disease and compound useful thereof
UA81749C2 (uk) Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
RU2114108C1 (ru) ПРОИЗВОДНЫЕ 7-(2-АМИНОЭТИЛ)БЕНЗОТИАЗОЛОНА ИЛИ ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ, ПРОИЗВОДНЫЕ N-[2-(4-ГИДРОКСИ-2-ОКСО-3H-1,3-БЕНЗОТИАЗОЛ-7-ИЛ)ЭТИЛАМИДА]ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОЯВЛЯЮЩАЯ АГОНИСТИЧЕСКУЮ АКТИВНОСТЬ В ОТНОШЕНИИ β2-АДРЕНОРЕЦЕПТОРОВ
JPH07267908A (ja) 興奮性アミノ酸受容体拮抗剤
JPH0819065B2 (ja) ベンゾ融合シクロアルカンおよびオキサ‐およびチア‐シクロアルカントランス‐１，２‐ジアミン誘導体
EP0164865B1 (en) N-(aminoalkylphenyl)sulfonamides their preparation and therapeutic use
HU184669B (en) New process for producing n-alkyl-imidazol derivatives
NZ202728A (en) 2-(phenylmethylene)-cycloalkylamine and-azetidine derivatives
JP2543690B2 (ja) 医薬組成物
AU725042B2 (en) 3,4-disubstituted phenylethanolaminotetralincarboxamide derivatives
FI87068B (fi) Foerfarande foer framstaellning av terapeutiskt aktiva aminoalkoholer.
CZ181891A3 (en) Hexahydroazepine derivatives
PT87503B (pt) Processo para a preparacao de novos derivados de catecolamina
US20040034104A1 (en) 2,2-Diphenylbutanamide derivatives and medicines containing the same
US6498196B1 (en) Compounds useful in pain management
NZ196086A (en) 1-phenyl-2-cyclohexene-1-alkylamine derivatives and pharmaceutical compositions
US6844368B1 (en) Compounds useful in pain management
US6417183B1 (en) 1,4-diazacycloheptane derivatives
US4404215A (en) Piperidyl phenyl trifluoroethanols
EP0467435A2 (en) Benzhydryl derivatives having calmodulin inhibitor properties
GB2235198A (en) Novel aminopropanol derivatives

Legal Events

Date Code Title Description
MM Patent lapsed

Owner name: PENNWALT CORPORATION