FI58943C - Foerfarande foer samtidig eller enskild bestaemning av laktatdehydrogenasernas isoenzymer - Google Patents
Foerfarande foer samtidig eller enskild bestaemning av laktatdehydrogenasernas isoenzymer Download PDFInfo
- Publication number
- FI58943C FI58943C FI752550A FI752550A FI58943C FI 58943 C FI58943 C FI 58943C FI 752550 A FI752550 A FI 752550A FI 752550 A FI752550 A FI 752550A FI 58943 C FI58943 C FI 58943C
- Authority
- FI
- Finland
- Prior art keywords
- lactate
- buffer
- ldh
- tampon
- nad
- Prior art date
Links
- 108010044467 Isoenzymes Proteins 0.000 claims description 27
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims description 24
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims description 24
- 238000006243 chemical reaction Methods 0.000 claims description 20
- 239000000872 buffer Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 13
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 13
- RXGJTUSBYWCRBK-UHFFFAOYSA-M 5-methylphenazinium methyl sulfate Chemical compound COS([O-])(=O)=O.C1=CC=C2[N+](C)=C(C=CC=C3)C3=NC2=C1 RXGJTUSBYWCRBK-UHFFFAOYSA-M 0.000 claims description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 229950006238 nadide Drugs 0.000 claims description 11
- 238000003556 assay Methods 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 238000010186 staining Methods 0.000 claims description 9
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 claims description 8
- 108010088350 Lactate Dehydrogenase 5 Proteins 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 108010088351 lactate dehydrogenase 4 Proteins 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims description 3
- 230000002255 enzymatic effect Effects 0.000 claims description 2
- 230000028327 secretion Effects 0.000 claims description 2
- 159000000000 sodium salts Chemical class 0.000 claims description 2
- FSVCQIDHPKZJSO-UHFFFAOYSA-L nitro blue tetrazolium dichloride Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC(=CC=2)[N+]([O-])=O)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=C([N+]([O-])=O)C=C1 FSVCQIDHPKZJSO-UHFFFAOYSA-L 0.000 claims 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 229940101270 nicotinamide adenine dinucleotide (nad) Drugs 0.000 claims 2
- 108010020056 Hydrogenase Proteins 0.000 claims 1
- 239000007853 buffer solution Substances 0.000 claims 1
- 210000003756 cervix mucus Anatomy 0.000 claims 1
- 108010088074 lactate dehydrogenase 3 Proteins 0.000 claims 1
- 229960000448 lactic acid Drugs 0.000 claims 1
- 238000012360 testing method Methods 0.000 description 33
- 239000012530 fluid Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 8
- 239000011888 foil Substances 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
- 210000001124 body fluid Anatomy 0.000 description 7
- 239000010839 body fluid Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 6
- 210000001215 vagina Anatomy 0.000 description 6
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- BAWFJGJZGIEFAR-NNYOXOHSSA-O NAD(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-O 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 229960000583 acetic acid Drugs 0.000 description 3
- 239000005515 coenzyme Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 201000009030 Carcinoma Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229920002301 cellulose acetate Polymers 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000004392 genitalia Anatomy 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
- 239000012464 large buffer Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- CYTCTRAEJYIZRX-UHFFFAOYSA-N (9a-hydroxy-3,5a-dimethyl-9-methylidene-2-oxo-3,3a,4,5,6,7,8,9b-octahydrobenzo[g][1]benzofuran-6-yl) acetate Chemical compound C1CC2(C)C(OC(C)=O)CCC(=C)C2(O)C2C1C(C)C(=O)O2 CYTCTRAEJYIZRX-UHFFFAOYSA-N 0.000 description 1
- QLAJNZSPVITUCQ-UHFFFAOYSA-N 1,3,2-dioxathietane 2,2-dioxide Chemical compound O=S1(=O)OCO1 QLAJNZSPVITUCQ-UHFFFAOYSA-N 0.000 description 1
- PKDBCJSWQUOKDO-UHFFFAOYSA-M 2,3,5-triphenyltetrazolium chloride Chemical compound [Cl-].C1=CC=CC=C1C(N=[N+]1C=2C=CC=CC=2)=NN1C1=CC=CC=C1 PKDBCJSWQUOKDO-UHFFFAOYSA-M 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 231100000416 LDH assay Toxicity 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000011340 continuous therapy Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 201000004933 in situ carcinoma Diseases 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 108010087599 lactate dehydrogenase 1 Proteins 0.000 description 1
- 238000002843 lactate dehydrogenase assay Methods 0.000 description 1
- 150000003893 lactate salts Chemical class 0.000 description 1
- 101150095787 ldh2 gene Proteins 0.000 description 1
- 101150100271 ldhb gene Proteins 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 238000010979 pH adjustment Methods 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/805—Test papers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/904—Tampons
Claims (6)
1. Sätt att bestämma laktatdehydrogenasaktiviteten i vaginal-sekret medelst en pd bärare, företrädesvis en tampong, anbragt komposition innefattande laktat NAD (nikotinamid-adenin-dinukleo-tid), PMS (fenazinmetosulfat), tetrazoliumsalt och en buffert, kännetecknat av att bufferten användes i sddan mängd att den förmdr bringa den av bäraren absorberade mängden sekret till ett pH-värde av 6-6,5, företrädesvis 6,3-6,4, varigenom akti-viteten för isoenzymerna, isynnerhet LDH-4 och LDH-5 och i ndgon man LDH-3 registreras i form av en bldfärgning av bäraren.
2. Sätt enligt patentkravet 1, kännetecknat av att bestämningen sker i ett trietanolamin-NaOH-buffert-system vid pH 6-6,5, speciellt pH 6,3-6,4.
3. Reagens anbragt pd bärare, företrädesvis tampong, för gemen-sam bestämning av alla eller flera isoenzym av laktatdehydrogenas enligt patentkravet 1, kännetecknat av att det bestdr av laktat, nikotinamid-adenin-dinukleotid, PMS och ett tetrazoliumsalt sora gör den enzymatiska NAD-reduktionen synlig, samt en buffert som säkerställer att reaktionen med laktathydrogenas sker vid ett pH-värde av 6-6,5 och isynnerhet 6,3-6,4.
4. Reagens enligt patentkravet 3, kännetecknat av att det som buffert innehdller trietanolamin-NaOH.
5. Reagens enligt patentkravet 4, kännetecknat av att det bestdr av 1,0-150 mM trietanolaminbuffert, pH 7,0 20-350 mM Na-laktat (natriumsalt av DL-mjölksyra) 0,01-1,0 mM fenazinmetosulfat (PMS) 0,1-10 mM nikotinamid-adenin-dinukleotid (NAD+) och 0,01-1,5 mM nitrobld tetrazoliumklorid (NBT).
6. Reagens enligt patentkravet 5, kännetecknat av
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19742443741 DE2443741C3 (de) | 1974-09-12 | Verfahren zur gemeinsamen Bestimmung der Isoenzyme 4 und 5 der LDH | |
| DE2443741 | 1974-09-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI752550A FI752550A (sv) | 1976-03-13 |
| FI58943B FI58943B (fi) | 1981-01-30 |
| FI58943C true FI58943C (fi) | 1981-05-11 |
Family
ID=5925603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI752550A FI58943C (fi) | 1974-09-12 | 1975-09-11 | Foerfarande foer samtidig eller enskild bestaemning av laktatdehydrogenasernas isoenzymer |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US4003795A (sv) |
| JP (2) | JPS5512239B2 (sv) |
| AR (1) | AR211523A1 (sv) |
| AT (1) | AT351173B (sv) |
| AU (1) | AU503460B2 (sv) |
| BE (1) | BE833348A (sv) |
| BR (1) | BR7505850A (sv) |
| CA (1) | CA1076010A (sv) |
| CH (1) | CH631209A5 (sv) |
| CS (1) | CS251752B2 (sv) |
| DD (1) | DD120296A1 (sv) |
| DK (1) | DK144659C (sv) |
| ES (1) | ES440870A1 (sv) |
| FI (1) | FI58943C (sv) |
| FR (1) | FR2284882A1 (sv) |
| GB (1) | GB1527243A (sv) |
| HK (1) | HK79879A (sv) |
| HU (1) | HU171962B (sv) |
| IE (1) | IE41901B1 (sv) |
| IL (1) | IL48071A (sv) |
| IN (1) | IN142896B (sv) |
| IT (1) | IT1155451B (sv) |
| NL (1) | NL178086C (sv) |
| NO (1) | NO144929C (sv) |
| PL (1) | PL98619B1 (sv) |
| RO (1) | RO68447A (sv) |
| SE (1) | SE417109B (sv) |
| SU (2) | SU663329A3 (sv) |
| TR (1) | TR19139A (sv) |
| YU (1) | YU218175A (sv) |
| ZA (1) | ZA755704B (sv) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311791A (en) * | 1978-06-05 | 1982-01-19 | Bernstein Larry H | Automated kinetic determination of lactate dehydrogenase isoenzymes in serum |
| US4309184A (en) * | 1980-05-08 | 1982-01-05 | Majid Ali | Method of determining food or chemical allergy and intolerance |
| US4543327A (en) * | 1980-06-10 | 1985-09-24 | Bernstein Larry H | Malate dehydrogenase method |
| DE3231287C2 (de) * | 1982-08-23 | 1984-09-06 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Verfahren zum Herstellen einer diagnostischen Vorrichtung |
| DE3231288C2 (de) * | 1982-08-23 | 1984-06-28 | MEDI-PHARMA Vertriebsgesellschaft mbH, 5000 Köln | Diagnostische Vorrichtung und ihre Verwendung |
| GB2147415B (en) * | 1983-08-05 | 1987-02-11 | Powell & Scholefield Limited | Device and method for antibiotic sensitivity testing |
| DK427784A (da) * | 1984-09-06 | 1986-03-07 | Forenede Bryggerier As | Fremgangsmaade og apparat til bestemmelse af vitalitet i froe |
| US4849347A (en) * | 1984-11-29 | 1989-07-18 | Hoffmann-La Roche Inc. | Colorimetric biological assay |
| US5141853A (en) * | 1988-07-22 | 1992-08-25 | Abbott Laboratories | Determination of ammonia levels in a sample |
| ATE117727T1 (de) * | 1989-06-09 | 1995-02-15 | Abbott Lab | Verfahren zur bestimmung von isoenzymen. |
| US5468236A (en) * | 1993-06-09 | 1995-11-21 | Kimberly-Clark Corporation | Disposable absorbent product incorporating chemically reactive substance |
| US20070134740A1 (en) * | 2005-12-12 | 2007-06-14 | David Brusilovsky | Compositions and articles for detection of analytes exceeding a pre-set threshold |
| US7947467B2 (en) * | 2001-07-19 | 2011-05-24 | Common Sense Ltd. | Methods for monitoring pathological conditions in a female subject |
| US7083569B2 (en) * | 2001-08-03 | 2006-08-01 | Zassi Medical Evolutions, Inc. | Ostomy cartridge |
| US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
| US8053625B2 (en) * | 2006-12-14 | 2011-11-08 | Kimberly-Clark Worldwide, Inc. | Absorbent articles including a body fluid signaling device |
| CN109613177B (zh) | 2014-07-01 | 2021-08-20 | 科蒙森斯公司 | 用于鉴定羊水的诊断组合物 |
| CN113329697A (zh) * | 2019-01-23 | 2021-08-31 | 吉娜-生命诊断有限公司 | 癌症诊断和监测设备、其系统和方法 |
| JPWO2020170977A1 (sv) | 2019-02-19 | 2020-08-27 | ||
| US20230054322A1 (en) * | 2021-08-23 | 2023-02-23 | Leslie P. Taylor | Urine indication pad with inbuilt diagnostics for training and indication of potential disease |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2905169A (en) * | 1955-03-10 | 1959-09-22 | Herbert E Nieburgs | Device for cancer detection |
| US2999052A (en) | 1959-03-16 | 1961-09-05 | Miles Lab | Composition for colorimetric test for serum enzymes |
| US3326777A (en) * | 1964-12-10 | 1967-06-20 | Warner Lambert Pharmaceutical | Process for differentiating the isoenzymes of lactic dehydrogenase |
| US3388044A (en) * | 1965-12-07 | 1968-06-11 | Warner Lambert Pharmaceutical | Process for differentiating the isoenzymes of lactic dehydrogenase |
| DE1959410C3 (de) * | 1969-11-26 | 1974-02-28 | Boehringer Mannheim Gmbh, 6800 Mannheim | Indikator zur Bestimmung der reduzierten Pyridincöenzyme |
| US3663374A (en) * | 1970-08-14 | 1972-05-16 | Geomet | Method and apparatus for quantitating enzyme activity |
| DE2061984C3 (de) | 1970-12-16 | 1974-04-11 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur Bestimmung der Lactat-Dehydrogenase im Farbtest |
| US3862010A (en) * | 1972-06-09 | 1975-01-21 | Technicon Instr | Method of heat fractionating ldh into isoenzyme components |
| US3867258A (en) * | 1973-11-08 | 1975-02-18 | American Cyanamid Co | Lactate dehydrogenase test material |
| US4046634A (en) * | 1974-05-28 | 1977-09-06 | Mercer Donald W | Assay of isoenzymes by ion exchange chromatography |
| US4080263A (en) * | 1976-08-11 | 1978-03-21 | Boehringer Mannheim Gmbh | Process and reagent for the rapid quantitative determination of lactate or alanine |
-
1975
- 1975-08-27 YU YU02181/75A patent/YU218175A/xx unknown
- 1975-08-29 AT AT667075A patent/AT351173B/de not_active IP Right Cessation
- 1975-09-01 NL NLAANVRAGE7510277,A patent/NL178086C/xx not_active IP Right Cessation
- 1975-09-03 GB GB36351/75A patent/GB1527243A/en not_active Expired
- 1975-09-05 ZA ZA00755704A patent/ZA755704B/xx unknown
- 1975-09-09 IT IT69244/75A patent/IT1155451B/it active
- 1975-09-10 RO RO7583353A patent/RO68447A/ro unknown
- 1975-09-10 DD DD188274A patent/DD120296A1/xx unknown
- 1975-09-10 IL IL48071A patent/IL48071A/xx unknown
- 1975-09-11 CH CH1178775A patent/CH631209A5/de not_active IP Right Cessation
- 1975-09-11 ES ES440870A patent/ES440870A1/es not_active Expired
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- 1975-09-12 SU SU752171403A patent/SU663329A3/ru active
- 1975-09-12 NO NO753119A patent/NO144929C/no unknown
- 1975-09-12 HU HU75SCHA170A patent/HU171962B/hu unknown
- 1975-09-12 JP JP11079975A patent/JPS5512239B2/ja not_active Expired
- 1975-09-12 US US05/612,633 patent/US4003795A/en not_active Expired - Lifetime
- 1975-09-12 BE BE159982A patent/BE833348A/xx not_active IP Right Cessation
- 1975-09-12 TR TR19139A patent/TR19139A/xx unknown
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- 1975-09-12 PL PL1975183289A patent/PL98619B1/pl unknown
- 1975-09-12 IE IE2000/75A patent/IE41901B1/en unknown
- 1975-09-12 FR FR7528099A patent/FR2284882A1/fr active Granted
- 1975-09-12 CS CS756214A patent/CS251752B2/cs unknown
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1976
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1978
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1979
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Owner name: ESAI CO. LTD. |