FI56843C - Foerfarande foer framstaellning av antibakteriella 7-(alfa-amino-p-hydroxifenylacetamido)-3-heterocykliska tiometylcefalosporiner - Google Patents

Foerfarande foer framstaellning av antibakteriella 7-(alfa-amino-p-hydroxifenylacetamido)-3-heterocykliska tiometylcefalosporiner Download PDF

Info

Publication number
FI56843C
FI56843C FI1610/73A FI161073A FI56843C FI 56843 C FI56843 C FI 56843C FI 1610/73 A FI1610/73 A FI 1610/73A FI 161073 A FI161073 A FI 161073A FI 56843 C FI56843 C FI 56843C
Authority
FI
Finland
Prior art keywords
amino
triazol
hydroxyphenylacetamido
formula
heterocyclic
Prior art date
Application number
FI1610/73A
Other languages
English (en)
Finnish (fi)
Other versions
FI56843B (fi
Inventor
George Lawrence Dunn
John Russel Eugene Hoover
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US262903A external-priority patent/US3867380A/en
Priority claimed from US00289499A external-priority patent/US3855213A/en
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of FI56843B publication Critical patent/FI56843B/fi
Application granted granted Critical
Publication of FI56843C publication Critical patent/FI56843C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI1610/73A 1972-06-14 1973-05-17 Foerfarande foer framstaellning av antibakteriella 7-(alfa-amino-p-hydroxifenylacetamido)-3-heterocykliska tiometylcefalosporiner FI56843C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26290372 1972-06-14
US262903A US3867380A (en) 1971-02-18 1972-06-14 3-Heterocyclic thiomethylcephalosporins
US28949972 1972-09-15
US00289499A US3855213A (en) 1971-02-18 1972-09-15 3-heterocyclic thiomethyl-cephalosporins

Publications (2)

Publication Number Publication Date
FI56843B FI56843B (fi) 1979-12-31
FI56843C true FI56843C (fi) 1980-04-10

Family

ID=26949532

Family Applications (1)

Application Number Title Priority Date Filing Date
FI1610/73A FI56843C (fi) 1972-06-14 1973-05-17 Foerfarande foer framstaellning av antibakteriella 7-(alfa-amino-p-hydroxifenylacetamido)-3-heterocykliska tiometylcefalosporiner

Country Status (20)

Country Link
JP (2) JPS5518716B2 (xx)
AR (1) AR197237A1 (xx)
AT (1) AT324560B (xx)
AU (1) AU464107B2 (xx)
CA (2) CA1076560A (xx)
CH (2) CH589093A5 (xx)
DD (1) DD105238A5 (xx)
DE (1) DE2316867C2 (xx)
DK (1) DK142913B (xx)
ES (2) ES412207A1 (xx)
FI (1) FI56843C (xx)
FR (2) FR2187298B1 (xx)
GB (2) GB1363833A (xx)
HU (1) HU168689B (xx)
IE (2) IE37409B1 (xx)
IL (1) IL42126A (xx)
NL (2) NL7302817A (xx)
PH (1) PH9941A (xx)
PL (1) PL91074B1 (xx)
SE (2) SE416472B (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR780000197B1 (en) * 1972-12-26 1978-05-26 Bristol Myers Co Method for preparing antibacterial agent
FR2215942B1 (xx) * 1973-01-31 1978-12-22 Bristol Myers Co
GB1476981A (en) * 1974-06-05 1977-06-16 Bristol Myers Co Substituted penicillanic acids
CA1074784A (en) * 1974-09-06 1980-04-01 Sumitomo Chemical Company N-ACYLAMINO-.alpha.-ARYLACETAMIDO CEPHALOSPORINS
JPS5346995A (en) * 1976-10-12 1978-04-27 Sangyo Kagaku Kenkyu Kyokai Antibacterial agents
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
JPS6010226U (ja) * 1983-06-30 1985-01-24 松下電工株式会社 昇降装置
JPS6182606A (ja) * 1984-09-29 1986-04-26 東芝ライテック株式会社 昇降装置

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA698494B (en) * 1969-02-26 1971-07-28 Lilly Co Eli Sulfur-containing cephalosporing antibiotics
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds

Also Published As

Publication number Publication date
AT324560B (de) 1975-09-10
AR197237A1 (es) 1974-03-22
DK142913C (xx) 1981-09-28
CH586709A5 (xx) 1977-04-15
NL7305206A (xx) 1973-12-18
FR2187299A1 (xx) 1974-01-18
AU5234573A (en) 1974-08-22
GB1363833A (en) 1974-08-21
PL91074B1 (en) 1977-02-28
SE404190B (sv) 1978-09-25
GB1358027A (en) 1974-06-26
ES413501A1 (es) 1976-07-16
JPS4954393A (xx) 1974-05-27
DK142913B (da) 1981-02-23
PH9941A (en) 1976-06-14
FI56843B (fi) 1979-12-31
CA999293A (en) 1976-11-02
DD105238A5 (xx) 1974-04-12
DE2316867C2 (de) 1982-05-19
AU464107B2 (en) 1975-08-14
SE416472B (sv) 1981-01-05
JPS4931689A (xx) 1974-03-22
HU168689B (xx) 1976-06-28
IL42126A0 (en) 1973-06-29
NL7302817A (xx) 1973-12-18
IE37499B1 (en) 1977-08-03
FR2187299B1 (xx) 1976-12-03
JPS5518716B2 (xx) 1980-05-21
ES412207A1 (es) 1976-01-01
DE2316866A1 (de) 1974-01-03
IL42126A (en) 1975-12-31
IE37499L (en) 1973-12-14
JPS5953274B2 (ja) 1984-12-24
FR2187298B1 (xx) 1976-12-03
CH589093A5 (xx) 1977-06-30
DE2316867A1 (de) 1974-01-03
FR2187298A1 (xx) 1974-01-18
IE37409B1 (en) 1977-07-20
DE2316866B2 (de) 1976-10-07
IE37409L (en) 1973-12-14
CA1076560A (en) 1980-04-29

Similar Documents

Publication Publication Date Title
FI66618C (fi) Foerfarande foer framstaellning av terapeutiskt verkande 7-(2-(2-aminotiazol-4-yl)-2-(syn)-metoxi-iminoacetamido-cefalosporinderivat
US4264595A (en) 7-[2-(2-Imino-4-thiazolin-4-yl)-2-(syn)-hydroxy-iminoacetamido]-cephalosporins
US4839350A (en) Cephalosporin compounds and the production thereof
NO155347B (no) Analogifremgangsmaate ved fremstilling av et terapeutisk aktivt (6r,7r)-7-((z)-2-(2-amino-tiazol-4-yl)-2-(2-karboksy-prop-2-oksyimino)-acetamido)-3-(1-pyridiniummetyl)cef-3-em-4-karboksylat.
JPH0365350B2 (xx)
US3989694A (en) 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins
US3766175A (en) Certain 7 - (o-aminomethylphenylacetamido) - 3-((heterocyclylthio)methyl)ceph-3-em-4-carboxylic acids
FI56843C (fi) Foerfarande foer framstaellning av antibakteriella 7-(alfa-amino-p-hydroxifenylacetamido)-3-heterocykliska tiometylcefalosporiner
FI76349B (fi) Foerfarande i ett steg foer framstaellning av cefalosporiner med en acylamidogrupp i 7-sidokedjan i 7-staellningen och en heterocyklisk tiometylgrupp i 3-staellningen.
US3813388A (en) 7-(d-(alpha-amino-alpha-phenyl-,2-thienyl-and 3-thienyl-acetamido))-3-(s-(2-methyl-1,2,3-triazole-4-yl)thiomethyl)-3-cephem-4-carboxylic acids
KR930007416B1 (ko) 3-(치환된)프로페닐아미노 티아졸릴 세팔로스포란산 및 그 에스텔의 제조방법
US3814755A (en) 7-(omikron-aminomethylphenylacetamido)-3-(tetrazolo(4,5-b)pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acid
HU184805B (en) Process for preparing new substituted alkyl-oximes derived from 7-/2-amino-4-thazolyl/-acetamido-cephalosporanic acid
US4018921A (en) Substituted phenylglycylcephalosporins
US3953439A (en) Substituted phenylglycylcephalosporins
PT88276B (pt) Processo para a preparacao de acidos 3-propenil substituido-7-(amino-tiazolilacetamido)-3-cefem-4-carboxilicos e dos seus esteres
US4179502A (en) 7[2-Hydroxyiminoacetamido]cephalosporins
US3743644A (en) 7-(d-(alpha-amino-alpha-phenyl-,2-thienyl-and 3-thienyl-acetamido))-3-(s-(isothiazol-3-,4-and 5-yl)carbonyl(thiomethyl-3-cephem-4-carboxylic acids
US4107440A (en) Intermediates for preparing substituted phenylglycylcephalosporins
JP2000514832A (ja) 抗菌性の置換７−アシルアミノ−３−（メチルヒドラゾノ）メチルセファロスポリンおよび中間体
US4044047A (en) Intermediates for preparing substituted phenylglycylcephalosporins
IE53116B1 (en) Cephem derivatives and a process for their preparation
US4022895A (en) Substituted phenylglycylcephalosporins
CA1072543A (en) Cephalosporin compounds
US3687948A (en) 7-{8 D-(a-AMINO-a-PHENYLACETAMIDO){9 -3-(4-METHYL-1,3-OXAZOL-2-YLTHIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID AND SALTS THEREOF