FI3812453T3 - Metabolisesti optimoitu soluviljelmä - Google Patents
Metabolisesti optimoitu soluviljelmäInfo
- Publication number
- FI3812453T3 FI3812453T3 FIEP20193898.2T FI20193898T FI3812453T3 FI 3812453 T3 FI3812453 T3 FI 3812453T3 FI 20193898 T FI20193898 T FI 20193898T FI 3812453 T3 FI3812453 T3 FI 3812453T3
- Authority
- FI
- Finland
- Prior art keywords
- cell culture
- cells
- cell
- culture
- lactate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
- C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361889815P | 2013-10-11 | 2013-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3812453T3 true FI3812453T3 (fi) | 2026-05-08 |
Family
ID=52813657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP20193898.2T FI3812453T3 (fi) | 2013-10-11 | 2014-10-10 | Metabolisesti optimoitu soluviljelmä |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20160244725A1 (enExample) |
| EP (4) | EP3055409B1 (enExample) |
| JP (3) | JP6663854B2 (enExample) |
| KR (4) | KR102243980B1 (enExample) |
| CN (2) | CN105637085A (enExample) |
| AU (2) | AU2014331776B2 (enExample) |
| CA (1) | CA2926049C (enExample) |
| DK (3) | DK3351620T3 (enExample) |
| EA (2) | EA201991976A1 (enExample) |
| ES (3) | ES3071435T3 (enExample) |
| FI (1) | FI3812453T3 (enExample) |
| HU (2) | HUE039551T2 (enExample) |
| IL (2) | IL244511A0 (enExample) |
| MX (2) | MX376623B (enExample) |
| PL (3) | PL3812453T3 (enExample) |
| SG (2) | SG11201601681QA (enExample) |
| WO (1) | WO2015054554A1 (enExample) |
| ZA (1) | ZA201601550B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160244726A1 (en) * | 2013-10-11 | 2016-08-25 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| PL3812453T3 (pl) | 2013-10-11 | 2026-07-13 | Regeneron Pharmaceuticals, Inc. | Hodowla komórkowa zoptymalizowana metabolicznie |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| JP7260018B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260020B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260011B2 (ja) * | 2017-03-31 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7310947B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7260021B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260009B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7310952B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7272480B2 (ja) * | 2017-04-27 | 2023-05-12 | 株式会社三洋物産 | 遊技機 |
| JP7310945B2 (ja) * | 2017-04-27 | 2023-07-19 | 株式会社三洋物産 | 遊技機 |
| JP7260012B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| JP7260013B2 (ja) * | 2017-04-27 | 2023-04-18 | 株式会社三洋物産 | 遊技機 |
| WO2019071076A1 (en) | 2017-10-06 | 2019-04-11 | Lonza Ltd. | AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN |
| HUE058924T2 (hu) | 2017-10-16 | 2022-09-28 | Regeneron Pharma | Perfúziós eljárások |
| CN111406112A (zh) * | 2017-11-30 | 2020-07-10 | 豪夫迈·罗氏有限公司 | 用于培养哺乳动物细胞的工艺 |
| JP2021519073A (ja) * | 2018-03-29 | 2021-08-10 | ジェネンテック， インコーポレイテッド | 哺乳動物細胞におけるラクトジェニック活性の制御 |
| GB201810772D0 (en) | 2018-06-29 | 2018-08-15 | Ge Healthcare Bio Sciences Ab | Method in bioprocess purification system |
| JP7231355B2 (ja) * | 2018-08-22 | 2023-03-01 | 日機装株式会社 | 細胞培養方法および細胞培養装置 |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| KR102559149B1 (ko) | 2018-10-26 | 2023-07-24 | 에프. 호프만-라 로슈 아게 | 재조합효소 매개 카세트 교환을 이용한 다중특이적 항체 스크리닝 방법 |
| JP2020151559A (ja) * | 2020-06-24 | 2020-09-24 | 株式会社三洋物産 | 遊技機 |
| JP2020151560A (ja) * | 2020-06-24 | 2020-09-24 | 株式会社三洋物産 | 遊技機 |
| EP3985097A1 (en) * | 2020-10-14 | 2022-04-20 | Sartorius Stedim Biotech GmbH | A method and system for configuring and/or setup of a downstream process for processing a biomass |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| KR970029803A (ko) | 1995-11-03 | 1997-06-26 | 김광호 | 반도체 메모리장치의 프리차지 회로 |
| US6165741A (en) | 1997-05-30 | 2000-12-26 | The Trustees Of The University Of Pennsylvania | Method for rapid detection of bacterial growth in cultures |
| US5972650A (en) | 1997-06-26 | 1999-10-26 | Brigham And Women's Hospital | Tetracycline repressor regulated mammalian cell transcription and viral replication switch |
| ATE325865T1 (de) | 2001-01-16 | 2006-06-15 | Regeneron Pharma | Isolierung von sezernierte proteine exprimierenden zellen |
| US6953692B2 (en) * | 2001-12-18 | 2005-10-11 | Bayer Pharmaceuticals Corporation | Device and method for seed-train expansion of mammalian cells |
| US7039770B1 (en) | 2002-03-05 | 2006-05-02 | Juniper Networks, Inc. | Low latency request dispatcher |
| CA2417689C (en) | 2002-03-05 | 2006-05-09 | F. Hoffmann-La Roche Ag | Improved methods for growing mammalian cells in vitro |
| US8673589B2 (en) | 2002-05-29 | 2014-03-18 | Regeneron Pharmaceuticals, Inc. | Inducible eukaryotic expression system |
| DE602004027905D1 (de) | 2003-05-15 | 2010-08-12 | Wyeth Llc | Kontrollierte glukosezufuhr für tierzellkultur |
| US7531327B2 (en) * | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7300773B2 (en) * | 2004-08-27 | 2007-11-27 | Wyeth Research Ireland Limited | Production of TNFR-Ig |
| US7335491B2 (en) | 2004-08-27 | 2008-02-26 | Wyeth Research Ireland Limited | Production of anti-abeta |
| CA2628340A1 (en) * | 2005-11-02 | 2007-05-18 | Wyeth | Methods for adapting mammalian cells |
| KR101866623B1 (ko) | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 １가 항체 및 그의 제조 방법 |
| US7575890B2 (en) | 2006-01-18 | 2009-08-18 | Oxygen Enterprises, Ltd. | Method for rapid detection and evaluation of cultured cell growth |
| MX2009004519A (es) | 2006-11-03 | 2009-05-12 | Wyeth Corp | Sustancias que inhiben la glucolisis en un cultivo de celulas. |
| DK2150617T3 (en) | 2007-06-04 | 2015-01-12 | Regeneron Pharma | Regions with increased expression and stability |
| WO2009023562A2 (en) | 2007-08-09 | 2009-02-19 | Wyeth | Use of perfusion to enhance production of fed-batch cell culture in bioreactors |
| WO2009152413A1 (en) * | 2008-06-13 | 2009-12-17 | Centocor Ortho Biotech Inc. | Methods for obtaining high viable cell density in mammalian cell culture |
| US8470552B2 (en) * | 2009-10-12 | 2013-06-25 | Keck Graduate Institute | Strategy to reduce lactic acid production and control PH in animal cell culture |
| AU2011246503B2 (en) * | 2010-04-26 | 2013-09-26 | Novartis Ag | Improved cell culture medium |
| JP6050226B2 (ja) * | 2010-05-28 | 2016-12-21 | ジェネンテック， インコーポレイテッド | Ｌｄｈ及びｐｄｈｋ発現を下方制御することによる乳酸レベルの低下及びポリペプチド生産の増加 |
| TWI637057B (zh) | 2012-11-09 | 2018-10-01 | 拜爾沙納有限公司 | 具交替生物反應器用途之不連續進料批次製程 |
| US20150353542A1 (en) * | 2013-01-14 | 2015-12-10 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
| PL3812453T3 (pl) | 2013-10-11 | 2026-07-13 | Regeneron Pharmaceuticals, Inc. | Hodowla komórkowa zoptymalizowana metabolicznie |
-
2014
- 2014-10-10 PL PL20193898.2T patent/PL3812453T3/pl unknown
- 2014-10-10 ES ES20193898T patent/ES3071435T3/es active Active
- 2014-10-10 KR KR1020167009163A patent/KR102243980B1/ko active Active
- 2014-10-10 WO PCT/US2014/059993 patent/WO2015054554A1/en not_active Ceased
- 2014-10-10 PL PL18161278T patent/PL3351620T3/pl unknown
- 2014-10-10 ES ES18161278T patent/ES2833471T3/es active Active
- 2014-10-10 EP EP14851841.8A patent/EP3055409B1/en not_active Revoked
- 2014-10-10 FI FIEP20193898.2T patent/FI3812453T3/fi active
- 2014-10-10 JP JP2016547976A patent/JP6663854B2/ja active Active
- 2014-10-10 KR KR1020217011547A patent/KR102358807B1/ko active Active
- 2014-10-10 MX MX2016004564A patent/MX376623B/es active IP Right Grant
- 2014-10-10 DK DK18161278.9T patent/DK3351620T3/da active
- 2014-10-10 EP EP18161278.9A patent/EP3351620B1/en not_active Revoked
- 2014-10-10 DK DK20193898.2T patent/DK3812453T3/da active
- 2014-10-10 US US15/028,521 patent/US20160244725A1/en not_active Abandoned
- 2014-10-10 EA EA201991976A patent/EA201991976A1/ru unknown
- 2014-10-10 CA CA2926049A patent/CA2926049C/en active Active
- 2014-10-10 HU HUE14851841A patent/HUE039551T2/hu unknown
- 2014-10-10 PL PL14851841T patent/PL3055409T3/pl unknown
- 2014-10-10 MX MX2020011334A patent/MX384960B/es unknown
- 2014-10-10 CN CN201480055499.4A patent/CN105637085A/zh active Pending
- 2014-10-10 KR KR1020237008467A patent/KR102610425B1/ko active Active
- 2014-10-10 EP EP26166760.4A patent/EP4772614A2/en active Pending
- 2014-10-10 SG SG11201601681QA patent/SG11201601681QA/en unknown
- 2014-10-10 HU HUE18161278A patent/HUE051049T2/hu unknown
- 2014-10-10 SG SG10201800772TA patent/SG10201800772TA/en unknown
- 2014-10-10 EA EA201690600A patent/EA033783B1/ru active IP Right Revival
- 2014-10-10 AU AU2014331776A patent/AU2014331776B2/en active Active
- 2014-10-10 KR KR1020227003381A patent/KR102510238B1/ko active Active
- 2014-10-10 ES ES14851841.8T patent/ES2678945T3/es active Active
- 2014-10-10 DK DK14851841.8T patent/DK3055409T3/en active
- 2014-10-10 CN CN202210497778.2A patent/CN114717196A/zh active Pending
- 2014-10-10 EP EP20193898.2A patent/EP3812453B1/en active Active
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2016
- 2016-03-04 ZA ZA2016/01550A patent/ZA201601550B/en unknown
- 2016-03-08 IL IL244511A patent/IL244511A0/en unknown
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2018
- 2018-11-06 IL IL262833A patent/IL262833A/en unknown
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2020
- 2020-02-17 JP JP2020024484A patent/JP6967620B2/ja active Active
- 2020-08-04 US US16/984,531 patent/US20210087535A1/en active Pending
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2021
- 2021-01-14 AU AU2021200193A patent/AU2021200193B2/en active Active
- 2021-10-25 JP JP2021173755A patent/JP7377243B2/ja active Active
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