FI2760882T3 - Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa - Google Patents

Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa Download PDF

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Publication number
FI2760882T3
FI2760882T3 FIEP12836545.9T FI12836545T FI2760882T3 FI 2760882 T3 FI2760882 T3 FI 2760882T3 FI 12836545 T FI12836545 T FI 12836545T FI 2760882 T3 FI2760882 T3 FI 2760882T3
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FI
Finland
Prior art keywords
plant
influenza
protein
seq
vlp
Prior art date
Application number
FIEP12836545.9T
Other languages
English (en)
Finnish (fi)
Inventor
Marc-Andre D'aoust
Manon Couture
Louis-Philippe Vezina
Original Assignee
Medicago Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Medicago Inc filed Critical Medicago Inc
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Publication of FI2760882T3 publication Critical patent/FI2760882T3/fi

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16223—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16251—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
FIEP12836545.9T 2011-09-30 2012-09-28 Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa FI2760882T3 (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161541780P 2011-09-30 2011-09-30
PCT/CA2012/050681 WO2013044390A1 (en) 2011-09-30 2012-09-28 Increasing virus-like particle yield in plants

Publications (1)

Publication Number Publication Date
FI2760882T3 true FI2760882T3 (fi) 2023-07-17

Family

ID=47994080

Family Applications (1)

Application Number Title Priority Date Filing Date
FIEP12836545.9T FI2760882T3 (fi) 2011-09-30 2012-09-28 Viruksen kaltaisen partikkelin saantojen lisääminen kasveissa

Country Status (27)

Country Link
US (1) US11155581B2 (enExample)
EP (2) EP2760882B1 (enExample)
JP (1) JP6248040B2 (enExample)
KR (1) KR101974017B1 (enExample)
CN (2) CN116218900A (enExample)
AU (1) AU2012315421C1 (enExample)
BR (1) BR112014007474A2 (enExample)
CA (1) CA2850407C (enExample)
DK (1) DK2760882T5 (enExample)
ES (1) ES2951259T3 (enExample)
FI (1) FI2760882T3 (enExample)
HR (1) HRP20230695T1 (enExample)
HU (1) HUE062759T2 (enExample)
IL (1) IL231587B (enExample)
IN (1) IN2014CN03077A (enExample)
MX (2) MX358883B (enExample)
MY (1) MY184072A (enExample)
NZ (1) NZ622731A (enExample)
PH (1) PH12014500640A1 (enExample)
PL (1) PL2760882T3 (enExample)
PT (1) PT2760882T (enExample)
RU (1) RU2682752C2 (enExample)
SG (2) SG11201400712VA (enExample)
SI (1) SI2760882T1 (enExample)
TW (1) TWI700368B (enExample)
WO (1) WO2013044390A1 (enExample)
ZA (1) ZA201403059B (enExample)

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RU2682752C2 (ru) 2011-09-30 2019-03-21 Медикаго Инк. Повышение выхода вирусоподобных частиц в растениях
US12467058B2 (en) 2013-03-28 2025-11-11 Aramis Biotechnologies Inc. Influenza virus-like particle production in plants
KR102199018B1 (ko) 2013-03-28 2021-01-07 메디카고 인코포레이티드 식물에서 인플루엔자 바이러스-유사 입자 생산
WO2015103704A1 (en) * 2014-01-10 2015-07-16 Medicago Inc. Cpmv enhancer elements
US10563213B2 (en) 2014-03-27 2020-02-18 Medicago Inc. Modified CPMV enhancer elements
MX2020009495A (es) * 2018-03-14 2020-12-07 Medicago Inc Potenciador de la expresion en plantas.
JP2021528970A (ja) 2018-06-27 2021-10-28 メディカゴ インコーポレイテッド インフルエンザウイルスヘマグルチニン変異体
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WO2021236908A2 (en) * 2020-05-20 2021-11-25 Biomarin Pharmaceutical Inc. Use of regulatory proteins for the production of adeno-associated virus

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Also Published As

Publication number Publication date
MX358883B (es) 2018-08-31
HRP20230695T1 (hr) 2023-12-22
TW201329235A (zh) 2013-07-16
EP2760882A1 (en) 2014-08-06
CA2850407C (en) 2021-11-23
DK2760882T3 (da) 2023-07-03
RU2682752C2 (ru) 2019-03-21
TWI700368B (zh) 2020-08-01
SG10201708052XA (en) 2017-11-29
CA2850407A1 (en) 2013-04-04
AU2012315421A1 (en) 2014-04-10
ZA201403059B (en) 2019-07-31
NZ622731A (en) 2016-04-29
JP2014530006A (ja) 2014-11-17
ES2951259T3 (es) 2023-10-19
PT2760882T (pt) 2023-08-07
IL231587B (en) 2020-06-30
JP6248040B2 (ja) 2017-12-13
SI2760882T1 (sl) 2023-10-30
CN103930435A (zh) 2014-07-16
MY184072A (en) 2021-03-17
MX2014003776A (es) 2014-08-21
RU2014116371A (ru) 2015-11-10
SG11201400712VA (en) 2014-04-28
EP2760882B1 (en) 2023-05-24
PH12014500640A1 (en) 2014-05-05
EP3626733A1 (en) 2020-03-25
EP3626733B1 (en) 2024-01-24
HK1200179A1 (en) 2015-07-31
DK2760882T5 (da) 2024-06-24
BR112014007474A2 (pt) 2017-04-04
US20150104480A1 (en) 2015-04-16
IN2014CN03077A (enExample) 2015-07-03
PL2760882T3 (pl) 2023-09-11
IL231587A0 (en) 2014-05-28
AU2012315421C1 (en) 2019-12-05
EP2760882A4 (en) 2015-06-10
KR101974017B1 (ko) 2019-04-30
US11155581B2 (en) 2021-10-26
HUE062759T2 (hu) 2023-12-28
AU2012315421B2 (en) 2017-10-19
WO2013044390A1 (en) 2013-04-04
KR20140068260A (ko) 2014-06-05
CN116218900A (zh) 2023-06-06
MX2018006627A (es) 2020-11-12

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