FI20105572A0 - Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt - Google Patents

Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt

Info

Publication number
FI20105572A0
FI20105572A0 FI20105572A FI20105572A FI20105572A0 FI 20105572 A0 FI20105572 A0 FI 20105572A0 FI 20105572 A FI20105572 A FI 20105572A FI 20105572 A FI20105572 A FI 20105572A FI 20105572 A0 FI20105572 A0 FI 20105572A0
Authority
FI
Finland
Prior art keywords
lactamase
methods
modified beta
uses related
beta
Prior art date
Application number
FI20105572A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Inventor
Pertti Koski
Ulla Airaksinen
Katja Vaelimaeki
Original Assignee
Prevab R Lcc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prevab R Lcc filed Critical Prevab R Lcc
Priority to FI20105572A priority Critical patent/FI20105572A0/fi
Publication of FI20105572A0 publication Critical patent/FI20105572A0/fi
Priority to PCT/FI2011/050450 priority patent/WO2011148041A1/fr
Priority to BR112012030029-6A priority patent/BR112012030029B1/pt
Priority to US13/699,434 priority patent/US9034602B2/en
Priority to ES11786185.6T priority patent/ES2588279T3/es
Priority to PL11786185T priority patent/PL2576776T3/pl
Priority to EP11786185.6A priority patent/EP2576776B1/fr
Priority to HUE11786185A priority patent/HUE030689T2/en
Priority to KR1020127033615A priority patent/KR101708703B1/ko
Priority to JP2013511709A priority patent/JP5827681B2/ja
Priority to DK11786185.6T priority patent/DK2576776T3/en
Priority to CA2800671A priority patent/CA2800671C/fr
Priority to AU2011257092A priority patent/AU2011257092C1/en
Priority to RU2012155420/10A priority patent/RU2570551C2/ru
Priority to CN201180035810.5A priority patent/CN103038341B/zh
Priority to ZA2012/08948A priority patent/ZA201208948B/en
Priority to HK13111298.1A priority patent/HK1183905A1/zh
Priority to US14/047,882 priority patent/US8894994B2/en
Priority to US14/517,539 priority patent/US9301995B2/en
Priority to US14/676,559 priority patent/US9301996B2/en
Priority to US15/054,292 priority patent/US9587234B2/en
Priority to US15/138,767 priority patent/US9765320B2/en
Priority to US15/417,501 priority patent/US10041056B2/en
Priority to US15/661,416 priority patent/US10253306B2/en
Priority to US16/279,547 priority patent/US11214787B2/en
Priority to US17/533,739 priority patent/US20220090044A1/en
Priority to US18/315,122 priority patent/US20230332128A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/02006—Beta-lactamase (3.5.2.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Hematology (AREA)
FI20105572A 2010-05-24 2010-05-24 Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt FI20105572A0 (fi)

Priority Applications (27)

Application Number Priority Date Filing Date Title
FI20105572A FI20105572A0 (fi) 2010-05-24 2010-05-24 Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
KR1020127033615A KR101708703B1 (ko) 2010-05-24 2011-05-17 변형된 베타-락타마아제 및 이와 관련된 방법 및 용도
AU2011257092A AU2011257092C1 (en) 2010-05-24 2011-05-17 Modified beta-lactamases and methods and uses related thereto
CN201180035810.5A CN103038341B (zh) 2010-05-24 2011-05-17 经修饰的β-内酰胺酶及其相关方法和应用
US13/699,434 US9034602B2 (en) 2010-05-24 2011-05-17 Modified beta-lactamases and methods and uses related thereto
ES11786185.6T ES2588279T3 (es) 2010-05-24 2011-05-17 Beta-lactamasas modificadas y métodos y usos relacionados con las mismas
PL11786185T PL2576776T3 (pl) 2010-05-24 2011-05-17 Modyfikowane beta-laktamazy oraz powiązane z nimi sposoby i zastosowania
EP11786185.6A EP2576776B1 (fr) 2010-05-24 2011-05-17 Bêta-lactamases modifiées et procédés et utilisations associés
HUE11786185A HUE030689T2 (en) 2010-05-24 2011-05-17 Modified beta-lactamases and related methods and applications
BR112012030029-6A BR112012030029B1 (pt) 2010-05-24 2011-05-17 Beta-lactamases modificadas, métodos, polinucleotídeo e composições relacionadas
JP2013511709A JP5827681B2 (ja) 2010-05-24 2011-05-17 改変型β−ラクタマーゼ並びにそれに関する方法及び使用
DK11786185.6T DK2576776T3 (en) 2010-05-24 2011-05-17 MODIFIED betalactamases AND PRACTICES AND USES RELATED ARTICLES
CA2800671A CA2800671C (fr) 2010-05-24 2011-05-17 Beta-lactamases modifiees et procedes et utilisations associes
PCT/FI2011/050450 WO2011148041A1 (fr) 2010-05-24 2011-05-17 Bêta-lactamases modifiées et procédés et utilisations associés
RU2012155420/10A RU2570551C2 (ru) 2010-05-24 2011-05-17 Бета-лактамаза, способ ее модификации, получения и применение
ZA2012/08948A ZA201208948B (en) 2010-05-24 2012-11-27 Modified beta-lactamases and methods and uses related thereto
HK13111298.1A HK1183905A1 (zh) 2010-05-24 2013-10-04 經修飾的β-內酰胺酶及其相關方法和應用
US14/047,882 US8894994B2 (en) 2010-05-24 2013-10-07 Modified beta-lactamases and methods and uses related thereto
US14/517,539 US9301995B2 (en) 2010-05-24 2014-10-17 Modified beta-lactamases and methods and uses related thereto
US14/676,559 US9301996B2 (en) 2010-05-24 2015-04-01 Modified beta-lactamases and methods and uses related thereto
US15/054,292 US9587234B2 (en) 2010-05-24 2016-02-26 Modified beta-lactamases and methods and uses related thereto
US15/138,767 US9765320B2 (en) 2010-05-24 2016-04-26 Modified beta-lactamases and methods and uses related thereto
US15/417,501 US10041056B2 (en) 2010-05-24 2017-01-27 Modified beta-lactamases and methods and uses related thereto
US15/661,416 US10253306B2 (en) 2010-05-24 2017-07-27 Modified beta-lactamases and methods and uses related thereto
US16/279,547 US11214787B2 (en) 2010-05-24 2019-02-19 Modified beta-lactamases and methods and uses related thereto
US17/533,739 US20220090044A1 (en) 2010-05-24 2021-11-23 Modified beta-lactamases and methods and uses related thereto
US18/315,122 US20230332128A1 (en) 2010-05-24 2023-05-10 Modified beta-lactamases and methods and uses related thereto

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI20105572A FI20105572A0 (fi) 2010-05-24 2010-05-24 Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt

Publications (1)

Publication Number Publication Date
FI20105572A0 true FI20105572A0 (fi) 2010-05-24

Family

ID=42234353

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20105572A FI20105572A0 (fi) 2010-05-24 2010-05-24 Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt

Country Status (17)

Country Link
US (11) US9034602B2 (fr)
EP (1) EP2576776B1 (fr)
JP (1) JP5827681B2 (fr)
KR (1) KR101708703B1 (fr)
CN (1) CN103038341B (fr)
AU (1) AU2011257092C1 (fr)
BR (1) BR112012030029B1 (fr)
CA (1) CA2800671C (fr)
DK (1) DK2576776T3 (fr)
ES (1) ES2588279T3 (fr)
FI (1) FI20105572A0 (fr)
HK (1) HK1183905A1 (fr)
HU (1) HUE030689T2 (fr)
PL (1) PL2576776T3 (fr)
RU (1) RU2570551C2 (fr)
WO (1) WO2011148041A1 (fr)
ZA (1) ZA201208948B (fr)

Families Citing this family (19)

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US8992422B2 (en) 2006-03-23 2015-03-31 Ethicon Endo-Surgery, Inc. Robotically-controlled endoscopic accessory channel
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
JP6685925B2 (ja) * 2014-04-17 2020-04-22 シンセティック バイオロジクス，インコーポレイテッド 治療用として改善された特性を有するβ−ラクタマーゼ
WO2016033327A1 (fr) 2014-08-28 2016-03-03 Synthetic Biologics, Inc. Production de bêta-lactamase à partir d'e-coli
AU2015330937B2 (en) * 2014-10-08 2021-07-15 Theriva Biologics, Inc. Beta-lactamase formulations and uses thereof
FR3027307B1 (fr) * 2014-10-16 2016-11-04 Azurrx Sas Molecule proteique hybride apte a inhiber au moins un antibiotique et composition pharmaceutique la comportant
US9744221B2 (en) 2014-12-23 2017-08-29 Synthetic Biologics, Inc. Method and compositions for inhibiting or preventing adverse effects of oral antibiotics
EP3261662B1 (fr) 2015-02-23 2021-07-21 Synthetic Biologics Inc. Carbapénémases à utiliser avec des antibiotiques pour la protection du microbiome intestinal
AU2016229976B2 (en) 2015-03-06 2021-11-11 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
ES2922009T3 (es) * 2016-02-23 2022-09-06 Da Volterra Variantes de beta-lactamasa
US11185555B2 (en) 2016-04-11 2021-11-30 Noah James Harrison Method to kill pathogenic microbes in a patient
CN109562147B (zh) * 2016-06-28 2023-09-01 特里瓦生物制剂有限公司 保护微生物组免受口服抗生素
CN116270991A (zh) * 2016-11-01 2023-06-23 合成生物制品有限公司 用于减弱抗生素抗性的方法和组合物
CN110157699B (zh) * 2018-02-12 2021-07-23 中国科学院微生物研究所 β-内酰胺酶及其编码基因以及它们的应用
AU2019317986A1 (en) 2018-08-05 2021-02-11 Da Volterra Method for improving anticancer agent efficacy
CA3106433A1 (fr) 2018-08-05 2020-02-13 Da Volterra Compositions pour le traitement d'une maladie du greffon contre l'hote
CN110777178A (zh) * 2019-12-02 2020-02-11 河北慧林生物科技有限公司 固定化羧基酯水解酶在氯唑西林、双氯西林、氟氯西林及苯唑西林侧链合成中的应用
CN114075560A (zh) * 2020-08-18 2022-02-22 杭州俊丰生物工程有限公司 一种β-内酰胺酶的稳定组合物
EP4148136A1 (fr) 2021-09-08 2023-03-15 Da Volterra Cellule de levure modifiée pour l'administration d'enzymes d'inactivation d'antibiotique

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GB1463513A (en) 1974-08-13 1977-02-02 Beecham Group Ltd Enzymes
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FR2613624B1 (fr) 1987-04-10 1990-11-23 Roussy Inst Gustave Composition pharmaceutique, administrable par voie orale, destinee a reduire les effets des b-lactamines
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US20160230160A1 (en) 2016-08-11
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CN103038341B (zh) 2016-04-20
CA2800671C (fr) 2018-09-18
US20150209418A1 (en) 2015-07-30
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CA2800671A1 (fr) 2011-12-01
US20190169590A1 (en) 2019-06-06
DK2576776T3 (en) 2016-10-03
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AU2011257092B2 (en) 2013-12-19
KR101708703B1 (ko) 2017-02-21
US20140127785A1 (en) 2014-05-08
US9587234B2 (en) 2017-03-07
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US20170327812A1 (en) 2017-11-16
US10041056B2 (en) 2018-08-07
US9301995B2 (en) 2016-04-05
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US9765320B2 (en) 2017-09-19
US10253306B2 (en) 2019-04-09
BR112012030029B1 (pt) 2021-08-17
EP2576776B1 (fr) 2016-07-13
US20220090044A1 (en) 2022-03-24
US20160168557A1 (en) 2016-06-16
US9301996B2 (en) 2016-04-05
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US9034602B2 (en) 2015-05-19
AU2011257092C1 (en) 2014-06-19
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US8894994B2 (en) 2014-11-25
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US11214787B2 (en) 2022-01-04
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US20170145402A1 (en) 2017-05-25
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