FI121075B - Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö - Google Patents
Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö Download PDFInfo
- Publication number
- FI121075B FI121075B FI950628A FI950628A FI121075B FI 121075 B FI121075 B FI 121075B FI 950628 A FI950628 A FI 950628A FI 950628 A FI950628 A FI 950628A FI 121075 B FI121075 B FI 121075B
- Authority
- FI
- Finland
- Prior art keywords
- fungal cell
- dna
- leu
- ser
- gene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4226971A DE4226971C2 (de) | 1992-08-14 | 1992-08-14 | Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte |
DE4226971 | 1992-08-14 | ||
EP9302179 | 1993-08-16 | ||
PCT/EP1993/002179 WO1994004687A1 (en) | 1992-08-14 | 1993-08-16 | Modified fungal cells and method for producing recombinant products |
Publications (3)
Publication Number | Publication Date |
---|---|
FI950628A0 FI950628A0 (fi) | 1995-02-13 |
FI950628A FI950628A (fi) | 1995-02-13 |
FI121075B true FI121075B (fi) | 2010-06-30 |
Family
ID=6465579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI950628A FI121075B (fi) | 1992-08-14 | 1995-02-13 | Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö |
Country Status (13)
Country | Link |
---|---|
US (1) | US5714377A (ja) |
EP (1) | EP0658203B1 (ja) |
JP (1) | JP3630424B2 (ja) |
AT (1) | ATE245701T1 (ja) |
AU (1) | AU679935B2 (ja) |
CA (1) | CA2140894C (ja) |
DE (3) | DE4226971C2 (ja) |
ES (1) | ES2203619T3 (ja) |
FI (1) | FI121075B (ja) |
NO (1) | NO320349B1 (ja) |
NZ (1) | NZ255350A (ja) |
WO (1) | WO1994004687A1 (ja) |
ZA (1) | ZA935915B (ja) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5728553A (en) | 1992-09-23 | 1998-03-17 | Delta Biotechnology Limited | High purity albumin and method of producing |
JPH08173170A (ja) * | 1994-05-25 | 1996-07-09 | Kirin Brewery Co Ltd | キャンディダ・ユティリス酵母の形質転換系、およびそれによる異種遺伝子の発現 |
CA2221271A1 (en) * | 1995-05-18 | 1996-11-21 | Genencor International, Inc. | Expression of glycosyltransferase in aspergillus |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
AU2007200859A1 (en) * | 1999-01-30 | 2007-03-22 | Novozymes Delta Limited | Process |
GB9902000D0 (en) * | 1999-01-30 | 1999-03-17 | Delta Biotechnology Ltd | Process |
US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1276756A4 (en) * | 2000-04-12 | 2004-06-09 | Human Genome Sciences Inc | ALBUMIN FUSION PROTEINS |
JP2005515749A (ja) * | 2000-12-05 | 2005-06-02 | ザ ペン ステイト リサーチ ファウンデイション | 酵母中での異種たんぱく質の高効率生産のための方法および組成物 |
US20050244931A1 (en) * | 2001-04-12 | 2005-11-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20050054051A1 (en) * | 2001-04-12 | 2005-03-10 | Human Genome Sciences, Inc. | Albumin fusion proteins |
US20060084794A1 (en) * | 2001-04-12 | 2006-04-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
CA2383556A1 (en) * | 2001-05-16 | 2002-11-16 | Pharmacia & Upjohn Company | High-efficiency assay for protein mannosyl transferases |
US7176278B2 (en) | 2001-08-30 | 2007-02-13 | Biorexis Technology, Inc. | Modified transferrin fusion proteins |
AU2002332041A1 (en) * | 2001-10-05 | 2003-04-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
ES2545090T3 (es) * | 2001-12-21 | 2015-09-08 | Human Genome Sciences, Inc. | Proteínas de fusión de albúmina y GCSF |
WO2003059934A2 (en) * | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
KR20040095217A (ko) | 2002-02-07 | 2004-11-12 | 델타 바이오테크놀로지 리미티드 | 알부민-융합 항-혈관신생 펩타이드 |
BRPI0315943B1 (pt) * | 2002-12-20 | 2019-07-09 | Unilever N.V. | Método para a produção de proteína anticongelante |
GB0329681D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Gene expression technique |
GB0329722D0 (en) | 2003-12-23 | 2004-01-28 | Delta Biotechnology Ltd | Modified plasmid and use thereof |
EP1831375B1 (en) | 2004-12-23 | 2014-07-16 | Novozymes Biopharma DK A/S | Gene expression technique |
US8206949B2 (en) | 2005-11-15 | 2012-06-26 | Glycofi, Inc. | Production of glycoproteins with reduced O-glycosylation |
AU2012203729B2 (en) * | 2005-11-22 | 2014-01-30 | Glycofi, Inc | Production of glycoproteins with reduced O-glycosylation |
EP1816201A1 (en) * | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
KR20090031359A (ko) * | 2006-05-16 | 2009-03-25 | 교와 핫꼬 기린 가부시키가이샤 | 단백질의 고분비 생산 방법 |
WO2008012629A2 (en) | 2006-07-24 | 2008-01-31 | Biorexis Pharmaceutical Corporation | Exendin fusion proteins |
GB0711424D0 (en) * | 2007-06-13 | 2007-07-25 | Novozymes Delta Ltd | Recombinant transferrin mutants |
CN101835801B (zh) | 2007-08-08 | 2014-09-10 | 诺维信生物制药丹麦公司 | 转铁蛋白变体和偶联物 |
US8637435B2 (en) * | 2007-11-16 | 2014-01-28 | Merck Sharp & Dohme Corp. | Eukaryotic cell display systems |
AU2009215739A1 (en) | 2008-02-20 | 2009-08-27 | Glycofi, Inc. | Vectors and yeast strains for protein production |
JP5731827B2 (ja) | 2008-03-03 | 2015-06-10 | グライコフィ, インコーポレイテッド | 下等真核生物中での組換えタンパク質の表面ディスプレイ |
US8507224B2 (en) | 2008-08-12 | 2013-08-13 | Glycofi, Inc. | Vectors and yeast strains for protein production: Ca2+ ATPase overexpression |
US9120871B2 (en) | 2009-01-23 | 2015-09-01 | Novo Nordisk A/S | Process for preparing FGF21 with low degree of O-glycosylation |
JP2012516878A (ja) | 2009-02-06 | 2012-07-26 | ノボザイムス バイオファーマ デーコー アクティーゼルスカブ | 精製プロセス |
JP5936112B2 (ja) | 2009-02-11 | 2016-06-15 | アルブミディクス アクティーゼルスカブ | アルブミン変異体及び複合体 |
JP2012518419A (ja) | 2009-02-25 | 2012-08-16 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖操作酵母ピチア・パストリスにおけるガラクトース同化経路の代謝操作 |
JP2013509181A (ja) | 2009-10-30 | 2013-03-14 | メルク・シャープ・エンド・ドーム・コーポレイション | ジペプチジルアミノペプチダーゼ活性を欠くピチア・パストリスにおける治療用タンパク質の製造方法 |
CA2776241A1 (en) | 2009-10-30 | 2011-05-05 | Novozymes Biopharma Dk A/S | Albumin variants |
WO2011099028A1 (en) * | 2010-02-10 | 2011-08-18 | Biocon Limited | Method of reducing glycosylation of proteins, processes and proteins thereof |
KR101930961B1 (ko) | 2010-02-24 | 2018-12-19 | 머크 샤프 앤드 돔 코포레이션 | 피키아 파스토리스에서 생산된 치료 당단백질 상의 n-글리코실화 부위 점유를 증가시키는 방법 |
WO2011124718A1 (en) | 2010-04-09 | 2011-10-13 | Novozymes A/S | Albumin derivatives and variants |
RU2604811C2 (ru) | 2010-05-27 | 2016-12-10 | Мерк Шарп Энд Домэ Корп. | Способ получения антител с улучшенными свойствами |
JP5885191B2 (ja) | 2011-01-04 | 2016-03-15 | 国立研究開発法人産業技術総合研究所 | 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法 |
AU2012220890A1 (en) | 2011-02-25 | 2013-08-29 | Merck Sharp & Dohme Corp. | Yeast strain for the production of proteins with modified O-glycosylation |
US9328170B2 (en) | 2011-05-25 | 2016-05-03 | Merck Sharp & Dohme Corp. | Method for preparing Fc containing polypeptides having improved properties |
EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
EP3330283A3 (en) | 2012-03-16 | 2018-07-11 | Albumedix A/S | Albumin variants |
EP2917233A1 (en) | 2012-11-08 | 2015-09-16 | Novozymes Biopharma DK A/S | Albumin variants |
EP3004156A1 (en) | 2013-06-07 | 2016-04-13 | Novo Nordisk A/S | Method for making mature insulin polypeptides |
KR102111078B1 (ko) | 2013-07-04 | 2020-05-18 | 노파르티스 아게 | O-만노실트랜스퍼라제 결핍 사상균 세포 및 이의 이용 방법 |
SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
WO2017029407A1 (en) | 2015-08-20 | 2017-02-23 | Albumedix A/S | Albumin variants and conjugates |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0001929B1 (en) * | 1977-11-08 | 1989-04-19 | Genentech, Inc. | Plasmid for transforming bacterial host to render it capable of polypeptide expression |
IT1203758B (it) * | 1986-03-27 | 1989-02-23 | Univ Roma | Vettori di clonazione e di espressione di geni eterologhi in lieviti e lieviti trasformati con tali vettori |
US4929553A (en) * | 1987-05-29 | 1990-05-29 | Canadian Patents & Development Ltd. | Protease for specific processing of secreted proteins |
FR2649991B2 (fr) * | 1988-08-05 | 1994-03-04 | Rhone Poulenc Sante | Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces |
FR2655660B1 (fr) * | 1989-12-11 | 1992-03-20 | Rhone Poulenc Sante | Nouveaux polypeptides, sequences d'adn permettant leur expression, procede de preparation et leur utilisation. |
-
1992
- 1992-08-14 DE DE4226971A patent/DE4226971C2/de not_active Expired - Lifetime
- 1992-08-14 DE DE4244915A patent/DE4244915C2/de not_active Expired - Lifetime
-
1993
- 1993-08-13 ZA ZA935915A patent/ZA935915B/xx unknown
- 1993-08-16 CA CA002140894A patent/CA2140894C/en not_active Expired - Lifetime
- 1993-08-16 ES ES93919067T patent/ES2203619T3/es not_active Expired - Lifetime
- 1993-08-16 EP EP93919067A patent/EP0658203B1/en not_active Expired - Lifetime
- 1993-08-16 US US08/381,931 patent/US5714377A/en not_active Expired - Lifetime
- 1993-08-16 DE DE69333112T patent/DE69333112T2/de not_active Expired - Lifetime
- 1993-08-16 AT AT93919067T patent/ATE245701T1/de active
- 1993-08-16 JP JP50589294A patent/JP3630424B2/ja not_active Expired - Lifetime
- 1993-08-16 AU AU49482/93A patent/AU679935B2/en not_active Expired
- 1993-08-16 WO PCT/EP1993/002179 patent/WO1994004687A1/en active IP Right Grant
- 1993-08-16 NZ NZ255350A patent/NZ255350A/en not_active IP Right Cessation
-
1995
- 1995-02-13 NO NO19950534A patent/NO320349B1/no not_active IP Right Cessation
- 1995-02-13 FI FI950628A patent/FI121075B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO950534L (no) | 1995-04-05 |
EP0658203B1 (en) | 2003-07-23 |
DE4244915C2 (de) | 1998-12-03 |
NZ255350A (en) | 1996-11-26 |
NO950534D0 (no) | 1995-02-13 |
JPH08500975A (ja) | 1996-02-06 |
JP3630424B2 (ja) | 2005-03-16 |
DE4226971C2 (de) | 1997-01-16 |
DE4226971A1 (de) | 1994-02-17 |
ZA935915B (en) | 1995-04-13 |
FI950628A0 (fi) | 1995-02-13 |
DE69333112D1 (de) | 2003-08-28 |
FI950628A (fi) | 1995-02-13 |
DE69333112T2 (de) | 2004-06-09 |
ES2203619T3 (es) | 2004-04-16 |
CA2140894A1 (en) | 1994-03-03 |
US5714377A (en) | 1998-02-03 |
EP0658203A1 (en) | 1995-06-21 |
NO320349B1 (no) | 2005-11-28 |
AU679935B2 (en) | 1997-07-17 |
WO1994004687A1 (en) | 1994-03-03 |
CA2140894C (en) | 2010-03-02 |
ATE245701T1 (de) | 2003-08-15 |
AU4948293A (en) | 1994-03-15 |
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