FI121075B - Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö - Google Patents

Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö Download PDF

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Publication number
FI121075B
FI121075B FI950628A FI950628A FI121075B FI 121075 B FI121075 B FI 121075B FI 950628 A FI950628 A FI 950628A FI 950628 A FI950628 A FI 950628A FI 121075 B FI121075 B FI 121075B
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Finland
Prior art keywords
fungal cell
dna
leu
ser
gene
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FI950628A
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English (en)
Finnish (fi)
Swedish (sv)
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FI950628A0 (fi
FI950628A (fi
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Reinhard Fleer
Alain Fournier
Widmar Tanner
Sabine Strahl-Bolsinger
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Novozymes Biopharma Dk As
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI950628A 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö FI121075B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4226971 1992-08-14
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
EP9302179 1993-08-16
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products

Publications (3)

Publication Number Publication Date
FI950628A0 FI950628A0 (fi) 1995-02-13
FI950628A FI950628A (fi) 1995-02-13
FI121075B true FI121075B (fi) 2010-06-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI950628A FI121075B (fi) 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö

Country Status (13)

Country Link
US (1) US5714377A (es)
EP (1) EP0658203B1 (es)
JP (1) JP3630424B2 (es)
AT (1) ATE245701T1 (es)
AU (1) AU679935B2 (es)
CA (1) CA2140894C (es)
DE (3) DE4244915C2 (es)
ES (1) ES2203619T3 (es)
FI (1) FI121075B (es)
NO (1) NO320349B1 (es)
NZ (1) NZ255350A (es)
WO (1) WO1994004687A1 (es)
ZA (1) ZA935915B (es)

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US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
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WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
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NZ534492A (en) 2002-02-07 2009-10-30 Novozymes Delta Ltd Albumin-fused kunitz domain peptides
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GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
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DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
JP5284789B2 (ja) * 2005-11-15 2013-09-11 グライコフィ, インコーポレイテッド O−グリコシル化を減少している糖タンパク質の生成
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
WO2007132949A1 (ja) 2006-05-16 2007-11-22 National Institute Of Advanced Industrial Science And Technology タンパク質の高分泌生産方法
KR101193722B1 (ko) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
US20110124576A1 (en) 2007-08-08 2011-05-26 Novozymes A/S Transferrin Variants and Conjugates
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
CN101945998B (zh) 2008-02-20 2013-09-18 格利科菲公司 用于蛋白生产的载体和酵母菌株
JP5731827B2 (ja) * 2008-03-03 2015-06-10 グライコフィ, インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
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CA2916594C (en) 2013-07-04 2020-03-10 Novartis Ag O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
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Also Published As

Publication number Publication date
AU679935B2 (en) 1997-07-17
WO1994004687A1 (en) 1994-03-03
AU4948293A (en) 1994-03-15
FI950628A0 (fi) 1995-02-13
ATE245701T1 (de) 2003-08-15
DE69333112D1 (de) 2003-08-28
FI950628A (fi) 1995-02-13
JPH08500975A (ja) 1996-02-06
JP3630424B2 (ja) 2005-03-16
NO950534L (no) 1995-04-05
DE69333112T2 (de) 2004-06-09
US5714377A (en) 1998-02-03
ES2203619T3 (es) 2004-04-16
NZ255350A (en) 1996-11-26
NO950534D0 (no) 1995-02-13
EP0658203B1 (en) 2003-07-23
EP0658203A1 (en) 1995-06-21
DE4244915C2 (de) 1998-12-03
ZA935915B (en) 1995-04-13
DE4226971A1 (de) 1994-02-17
CA2140894A1 (en) 1994-03-03
NO320349B1 (no) 2005-11-28
CA2140894C (en) 2010-03-02
DE4226971C2 (de) 1997-01-16

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