FI121075B - Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö - Google Patents

Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö Download PDF

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Publication number
FI121075B
FI121075B FI950628A FI950628A FI121075B FI 121075 B FI121075 B FI 121075B FI 950628 A FI950628 A FI 950628A FI 950628 A FI950628 A FI 950628A FI 121075 B FI121075 B FI 121075B
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FI
Finland
Prior art keywords
fungal cell
dna
leu
ser
gene
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FI950628A
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English (en)
Finnish (fi)
Swedish (sv)
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FI950628A0 (fi
FI950628A (fi
Inventor
Reinhard Fleer
Alain Fournier
Widmar Tanner
Sabine Strahl-Bolsinger
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Novozymes Biopharma Dk As
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Publication of FI950628A0 publication Critical patent/FI950628A0/fi
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI950628A 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö FI121075B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4226971 1992-08-14
DE4226971A DE4226971C2 (de) 1992-08-14 1992-08-14 Modifizierte Pilzzellen und Verfahren zur Herstellung rekombinanter Produkte
EP9302179 1993-08-16
PCT/EP1993/002179 WO1994004687A1 (en) 1992-08-14 1993-08-16 Modified fungal cells and method for producing recombinant products

Publications (3)

Publication Number Publication Date
FI950628A0 FI950628A0 (fi) 1995-02-13
FI950628A FI950628A (fi) 1995-02-13
FI121075B true FI121075B (fi) 2010-06-30

Family

ID=6465579

Family Applications (1)

Application Number Title Priority Date Filing Date
FI950628A FI121075B (fi) 1992-08-14 1995-02-13 Geneettisesti muokattu sienisolu, menetelmä rekombinanttituotteiden tuottamiseksi sekä DNA-molekyyli ja DNA-fragmentti ja näiden käyttö

Country Status (13)

Country Link
US (1) US5714377A (es)
EP (1) EP0658203B1 (es)
JP (1) JP3630424B2 (es)
AT (1) ATE245701T1 (es)
AU (1) AU679935B2 (es)
CA (1) CA2140894C (es)
DE (3) DE4244915C2 (es)
ES (1) ES2203619T3 (es)
FI (1) FI121075B (es)
NO (1) NO320349B1 (es)
NZ (1) NZ255350A (es)
WO (1) WO1994004687A1 (es)
ZA (1) ZA935915B (es)

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US7507413B2 (en) 2001-04-12 2009-03-24 Human Genome Sciences, Inc. Albumin fusion proteins
US20060084794A1 (en) * 2001-04-12 2006-04-20 Human Genome Sciences, Inc. Albumin fusion proteins
US20050244931A1 (en) * 2001-04-12 2005-11-03 Human Genome Sciences, Inc. Albumin fusion proteins
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US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
WO2003030821A2 (en) * 2001-10-05 2003-04-17 Human Genome Sciences, Inc. Albumin fusion proteins
AU2002364587A1 (en) * 2001-12-21 2003-07-30 Human Genome Sciences, Inc. Albumin fusion proteins
EP2261250B1 (en) * 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
NZ534492A (en) 2002-02-07 2009-10-30 Novozymes Delta Ltd Albumin-fused kunitz domain peptides
BR0315943A (pt) * 2002-12-20 2005-09-13 Unilever Nv Método para a produção de uma proteìna anticongelante e composição
GB0329722D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
DK2330200T3 (en) 2004-12-23 2017-07-24 Albumedix As GENE EXPRESSION TECHNIQUE
JP5284789B2 (ja) * 2005-11-15 2013-09-11 グライコフィ， インコーポレイテッド Ｏ−グリコシル化を減少している糖タンパク質の生成
AU2012203729B2 (en) * 2005-11-22 2014-01-30 Glycofi, Inc Production of glycoproteins with reduced O-glycosylation
EP1816201A1 (en) * 2006-02-06 2007-08-08 CSL Behring GmbH Modified coagulation factor VIIa with extended half-life
WO2007132949A1 (ja) 2006-05-16 2007-11-22 National Institute Of Advanced Industrial Science And Technology タンパク質の高分泌生産方法
KR101193722B1 (ko) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 엑센딘 융합 단백질
GB0711424D0 (en) * 2007-06-13 2007-07-25 Novozymes Delta Ltd Recombinant transferrin mutants
US20110124576A1 (en) 2007-08-08 2011-05-26 Novozymes A/S Transferrin Variants and Conjugates
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
CN101945998B (zh) 2008-02-20 2013-09-18 格利科菲公司 用于蛋白生产的载体和酵母菌株
JP5731827B2 (ja) * 2008-03-03 2015-06-10 グライコフィ， インコーポレイテッド 下等真核生物中での組換えタンパク質の表面ディスプレイ
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US9120871B2 (en) 2009-01-23 2015-09-01 Novo Nordisk A/S Process for preparing FGF21 with low degree of O-glycosylation
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KR101930961B1 (ko) 2010-02-24 2018-12-19 머크 샤프 앤드 돔 코포레이션 피키아 파스토리스에서 생산된 치료 당단백질 상의 ｎ-글리코실화 부위 점유를 증가시키는 방법
JP5969458B2 (ja) 2010-04-09 2016-08-17 アルブミディクス アクティーゼルスカブ アルブミン誘導体及び変異体
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JP5885191B2 (ja) 2011-01-04 2016-03-15 国立研究開発法人産業技術総合研究所 糖鎖改変酵母及びそれを用いた糖タンパク質の製造方法
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JP2016521701A (ja) 2013-06-07 2016-07-25 ノヴォ ノルディスク アー／エス 成熟インスリンポリペプチドを作製するための方法
CA2916594C (en) 2013-07-04 2020-03-10 Novartis Ag O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
EP3172333B1 (en) 2014-07-21 2020-05-13 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
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Also Published As

Publication number Publication date
AU679935B2 (en) 1997-07-17
WO1994004687A1 (en) 1994-03-03
AU4948293A (en) 1994-03-15
FI950628A0 (fi) 1995-02-13
ATE245701T1 (de) 2003-08-15
DE69333112D1 (de) 2003-08-28
FI950628A (fi) 1995-02-13
JPH08500975A (ja) 1996-02-06
JP3630424B2 (ja) 2005-03-16
NO950534L (no) 1995-04-05
DE69333112T2 (de) 2004-06-09
US5714377A (en) 1998-02-03
ES2203619T3 (es) 2004-04-16
NZ255350A (en) 1996-11-26
NO950534D0 (no) 1995-02-13
EP0658203B1 (en) 2003-07-23
EP0658203A1 (en) 1995-06-21
DE4244915C2 (de) 1998-12-03
ZA935915B (en) 1995-04-13
DE4226971A1 (de) 1994-02-17
CA2140894A1 (en) 1994-03-03
NO320349B1 (no) 2005-11-28
CA2140894C (en) 2010-03-02
DE4226971C2 (de) 1997-01-16

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