FI120693B - Menetelmä tiettyjen atsasykloheksapeptidien valmistamiseksi - Google Patents

Menetelmä tiettyjen atsasykloheksapeptidien valmistamiseksi Download PDF

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Publication number
FI120693B
FI120693B FI973281A FI973281A FI120693B FI 120693 B FI120693 B FI 120693B FI 973281 A FI973281 A FI 973281A FI 973281 A FI973281 A FI 973281A FI 120693 B FI120693 B FI 120693B
Authority
FI
Finland
Prior art keywords
compound
process according
formula
seq
ethylenediamine
Prior art date
Application number
FI973281A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI973281A0 (fi
FI973281A (fi
Inventor
David L Hughes
Kevin M Belyk
Dean R Bender
Regina M Black
William Leonard
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI973281A0 publication Critical patent/FI973281A0/fi
Publication of FI973281A publication Critical patent/FI973281A/fi
Application granted granted Critical
Publication of FI120693B publication Critical patent/FI120693B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B17/06133—Packages or dispensers for needles or sutures of parallelepipedal shape, e.g. made of rectangular or slightly oval panels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
    • A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
    • A61B17/06114—Packages or dispensers for needles or sutures
    • A61B2017/06142—Packages or dispensers for needles or sutures having needle- or suture- retaining members, e.g. holding tabs or needle parks
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Dentistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI973281A 1995-02-10 1997-08-08 Menetelmä tiettyjen atsasykloheksapeptidien valmistamiseksi FI120693B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/386,618 US5552521A (en) 1995-02-10 1995-02-10 Process for preparing certain aza cyclohexapeptides
US38661895 1995-02-10
PCT/US1996/001523 WO1996024613A1 (en) 1995-02-10 1996-02-06 A process for preparing certain aza cyclohexapeptides
US9601523 1996-02-06

Publications (3)

Publication Number Publication Date
FI973281A0 FI973281A0 (fi) 1997-08-08
FI973281A FI973281A (fi) 1997-08-08
FI120693B true FI120693B (fi) 2010-01-29

Family

ID=23526350

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973281A FI120693B (fi) 1995-02-10 1997-08-08 Menetelmä tiettyjen atsasykloheksapeptidien valmistamiseksi

Country Status (21)

Country Link
US (1) US5552521A (de)
EP (1) EP0808330B1 (de)
CN (1) CN1127515C (de)
AR (2) AR001081A1 (de)
AT (1) ATE309266T1 (de)
AU (1) AU692071B2 (de)
BR (1) BR9607721A (de)
CA (1) CA2211314C (de)
CZ (2) CZ286683B6 (de)
DE (1) DE69635405T2 (de)
EA (1) EA000564B1 (de)
ES (1) ES2249778T3 (de)
FI (1) FI120693B (de)
HK (1) HK1004676A1 (de)
HR (1) HRP960054B1 (de)
HU (1) HU229780B1 (de)
NZ (1) NZ302967A (de)
SK (1) SK283115B6 (de)
TW (1) TW515805B (de)
WO (1) WO1996024613A1 (de)
YU (1) YU49459B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co Inc Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
ATE223226T1 (de) * 1994-09-16 2002-09-15 Merck & Co Inc Azazyklohexapeptid-verbindungen
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU1517900A (en) * 1998-10-28 2000-05-15 Eli Lilly And Company Photochemical process for making 1-deoxy-2-keto derivatives
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
EP1785432A1 (de) * 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
SI2049142T2 (sl) 2006-07-26 2016-04-29 Sandoz Ag Formulacije kaspofungina
CA2692053A1 (en) * 2007-06-26 2008-12-31 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (de) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur herstellung von hochreinen azacyclohexapeptiden
EP2183271A1 (de) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Von der caspofungin-unreinheit a freies caspofungin
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
EP2463293A4 (de) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptid bzw. sein pharmazeutisch akzeptables salz, herstellungsverfahren und verwendung
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
CN103180336B (zh) 2010-09-28 2016-06-15 中化帝斯曼制药有限公司荷兰公司 用于分离环六肽的方法
JP6000254B2 (ja) * 2010-09-29 2016-09-28 上海天偉生物制薬有限公司 環状リポペプチド化合物又はその塩の精製方法
CN102367267B (zh) * 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) * 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CN102219833A (zh) * 2011-04-18 2011-10-19 深圳市健元医药科技有限公司 一种更加安全的棘白菌类抗真菌药的制备方法
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
TWI597293B (zh) 2011-04-28 2017-09-01 江蘇盛迪醫藥有限公司 用於合成卡帕芬淨的中間體及其製備方法
CN103483426A (zh) * 2012-06-14 2014-01-01 博瑞生物医药技术(苏州)有限公司 一种氮杂环己肽的制备方法
PT2922530T (pt) 2012-11-20 2016-12-22 Fresenius Kabi Usa Llc Formulações de acetato de caspofungina
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
IE910892A1 (en) * 1990-03-19 1991-09-25 Merck & Co Inc Lipopeptide compounds
US5939384A (en) * 1991-10-01 1999-08-17 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co Inc Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
ATE223226T1 (de) * 1994-09-16 2002-09-15 Merck & Co Inc Azazyklohexapeptid-verbindungen

Also Published As

Publication number Publication date
NZ302967A (en) 1998-11-25
DE69635405D1 (de) 2005-12-15
EP0808330B1 (de) 2005-11-09
EA000564B1 (ru) 1999-12-29
US5552521A (en) 1996-09-03
HK1004676A1 (en) 1998-12-04
HUP9901085A3 (en) 2000-11-28
FI973281A0 (fi) 1997-08-08
FI973281A (fi) 1997-08-08
HU229780B1 (en) 2014-07-28
CA2211314C (en) 2007-04-17
MX9706101A (es) 1997-10-31
HRP960054B1 (en) 2008-07-31
TW515805B (en) 2003-01-01
SK107997A3 (en) 1998-02-04
BR9607721A (pt) 1998-07-14
AU692071B2 (en) 1998-05-28
CZ252597A3 (cs) 1998-01-14
CN1173875A (zh) 1998-02-18
AR001081A1 (es) 1997-09-24
HRP960054A2 (en) 1997-10-31
YU49459B (sh) 2006-03-03
AR005462A1 (es) 1999-06-23
AU4914796A (en) 1996-08-27
CZ286767B6 (cs) 2000-06-14
YU8496A (sh) 1999-06-15
CZ286683B6 (en) 2000-06-14
WO1996024613A1 (en) 1996-08-15
CA2211314A1 (en) 1996-08-15
ES2249778T3 (es) 2006-04-01
CN1127515C (zh) 2003-11-12
DE69635405T2 (de) 2006-07-27
EP0808330A1 (de) 1997-11-26
ATE309266T1 (de) 2005-11-15
EA199700170A1 (ru) 1997-12-30
SK283115B6 (sk) 2003-02-04
HUP9901085A2 (hu) 1999-09-28

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