FI119913B - Ekokontrastmedel - Google Patents
Ekokontrastmedel Download PDFInfo
- Publication number
- FI119913B FI119913B FI933137A FI933137A FI119913B FI 119913 B FI119913 B FI 119913B FI 933137 A FI933137 A FI 933137A FI 933137 A FI933137 A FI 933137A FI 119913 B FI119913 B FI 119913B
- Authority
- FI
- Finland
- Prior art keywords
- negatively charged
- composition according
- polyoxyethylene polyoxypropylene
- polyoxypropylene polymers
- polyoxyethylene
- Prior art date
Links
- 239000002961 echo contrast media Substances 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 229920000642 polymer Polymers 0.000 claims abstract description 18
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 14
- -1 polyoxyethylene Polymers 0.000 claims abstract description 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims description 20
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000000087 stabilizing effect Effects 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 4
- 238000004090 dissolution Methods 0.000 claims description 4
- FVJZSBGHRPJMMA-IOLBBIBUSA-N PG(18:0/18:0) Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-IOLBBIBUSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 2
- 229940067605 phosphatidylethanolamines Drugs 0.000 claims description 2
- 229940067626 phosphatidylinositols Drugs 0.000 claims description 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 2
- 150000008106 phosphatidylserines Chemical class 0.000 claims description 2
- 229920005862 polyol Polymers 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
- 230000006641 stabilisation Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 description 9
- 238000002604 ultrasonography Methods 0.000 description 6
- BIABMEZBCHDPBV-MPQUPPDSSA-N 1,2-palmitoyl-sn-glycero-3-phospho-(1'-sn-glycerol) Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-MPQUPPDSSA-N 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 229920001993 poloxamer 188 Polymers 0.000 description 5
- 239000004094 surface-active agent Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 description 4
- 239000002872 contrast media Substances 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 229920001983 poloxamer Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 239000012153 distilled water Substances 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
- 210000003712 lysosome Anatomy 0.000 description 3
- 230000001868 lysosomic effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- FVJZSBGHRPJMMA-UHFFFAOYSA-N distearoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCCCC FVJZSBGHRPJMMA-UHFFFAOYSA-N 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 229960000502 poloxamer Drugs 0.000 description 2
- 229940044519 poloxamer 188 Drugs 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010002885 Polygeline Proteins 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 210000005240 left ventricle Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 210000005241 right ventricle Anatomy 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Graft Or Block Polymers (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Fish Paste Products (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Radiation-Therapy Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Claims (10)
1. Vattenhaltigt preparat för mottagning och stabi-lisering av mikrogasbubblor för användning som ekokontrast- 5 medel, vilket innehäller polyoxietylenpolyoxipropylenpoly- merer och negativt laddade foefolipider, uteslutet vatten-haltig lösning som innehäller antikroppar och dessutom po-lyoxietylenpolyoksipropylenpolymerer och fosfolipider.
2. Preparat enligt patentkrav 1, kanne- 10 tecknat därav, att man använder polyoxietylenpoly- oxipropylenpolymerer med en medelmolekylvikt frän 8 350 -14 000.
3. Preparat enligt patentkrav 1, kanne-tecknat därav, att det innehäller polyoxietylenpoly- 15 oxipropylenpolymerer i en mängd frän 0,1 - 10 % (vikt/volym) .
4. Preparat enligt patentkrav 3, kanne- tecknat därav, att det innehäller polyoxietylenpoly-oxipropylenpolymerer i en mängd frän 1 - 5 % (vikt/volym) .
5. Preparat enligt patentkrav 1, kanne- tecknat därav, att det som negativt laddade fosfolipider innehäller fosfatidylglyceroler, fosfatidylinosito-ler, fosfatidyletanolaminer och/eller fosfatidylseriner.
6. Preparat enligt patentkrav 5, k ä n n e- 25 tecknat därav, att det som negativt laddad fosfolipid innehäller distearoylfosfatidylglycerol-
7. Preparat enligt patentkrav 1, kanne- tecknat därav, att det innehäller negativt laddad fosfolipid i en mängd frän 0,01 - 5 % (vikt/volym). 3 0
8. Preparat enligt patentkrav 1, k anneta c k n a t därav, att det innehäller 3 % (vikt/volym) j polyoxietylenpolyoxipropylenpolymerer med en medelmolekyl- j vikt av 8 4 00 och 1 % (vikt/volym) distearoylfosfatidylgly- | cerol.
9. Preparat enligt patentkrav l, kanne-t e c k n a t därav, att den eller de negativt laddade fos-folipiden (fosfolipiderna) är närvarande i lysoform.
10. Förfarande för f rams täi lning av ett vattenhal-5 tigt preparat för mottagning och stabilisering av mikrobubb- lor för användning som ekokontrastmedel, k ä n n et e c k-n a t därav, att man i vatten loser polyoxietylenpolyoxipro-pylenpolymerer tillsammans med en negativt laddad fosfoli-pid och sedvanliga hjälpmedel för uppnäende av isotonin.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4100470A DE4100470A1 (de) | 1991-01-09 | 1991-01-09 | Echokontrastmittel |
| DE4100470 | 1991-01-09 | ||
| EP9200012 | 1992-01-04 | ||
| PCT/EP1992/000012 WO1992011873A1 (de) | 1991-01-09 | 1992-01-04 | Echokontrastmittel |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI933137A FI933137A (fi) | 1993-07-08 |
| FI933137A0 FI933137A0 (fi) | 1993-07-08 |
| FI119913B true FI119913B (sv) | 2009-05-15 |
Family
ID=6422745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI933137A FI119913B (sv) | 1991-01-09 | 1993-07-08 | Ekokontrastmedel |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5599523A (sv) |
| EP (2) | EP0566601B2 (sv) |
| JP (1) | JP3290655B2 (sv) |
| KR (1) | KR100203221B1 (sv) |
| AT (1) | ATE126708T1 (sv) |
| AU (1) | AU652803B2 (sv) |
| BG (1) | BG61667B2 (sv) |
| CA (1) | CA2098915C (sv) |
| CZ (1) | CZ280939B6 (sv) |
| DE (3) | DE4100470A1 (sv) |
| DK (1) | DK0566601T4 (sv) |
| ES (1) | ES2079176T5 (sv) |
| FI (1) | FI119913B (sv) |
| GR (1) | GR3017925T3 (sv) |
| HK (1) | HK1006147A1 (sv) |
| HU (1) | HU220763B1 (sv) |
| IE (1) | IE70131B1 (sv) |
| IL (1) | IL100607A (sv) |
| NZ (1) | NZ241246A (sv) |
| PL (1) | PL167253B1 (sv) |
| RU (1) | RU2091079C1 (sv) |
| SK (1) | SK278776B6 (sv) |
| UA (1) | UA27121C2 (sv) |
| WO (1) | WO1992011873A1 (sv) |
| ZA (1) | ZA92118B (sv) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US5578292A (en) | 1991-11-20 | 1996-11-26 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US20040208826A1 (en) * | 1990-04-02 | 2004-10-21 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| IN172208B (sv) | 1990-04-02 | 1993-05-01 | Sint Sa | |
| USRE39146E1 (en) | 1990-04-02 | 2006-06-27 | Bracco International B.V. | Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof |
| US6989141B2 (en) * | 1990-05-18 | 2006-01-24 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US5445813A (en) * | 1992-11-02 | 1995-08-29 | Bracco International B.V. | Stable microbubble suspensions as enhancement agents for ultrasound echography |
| US6613306B1 (en) | 1990-04-02 | 2003-09-02 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US7083778B2 (en) * | 1991-05-03 | 2006-08-01 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| US20010024638A1 (en) * | 1992-11-02 | 2001-09-27 | Michel Schneider | Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| US20030194376A1 (en) * | 1990-05-18 | 2003-10-16 | Bracco International B.V. | Ultrasound contrast agents and methods of making and using them |
| GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| GB9107628D0 (en) * | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| MX9205298A (es) * | 1991-09-17 | 1993-05-01 | Steven Carl Quay | Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido |
| US6723303B1 (en) | 1991-09-17 | 2004-04-20 | Amersham Health, As | Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane |
| ES2145011T5 (es) * | 1991-09-17 | 2008-02-01 | Ge Healthcare As | Medios de contraste gaseoso para ecografias. |
| US5409688A (en) * | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| US6875420B1 (en) | 1991-09-17 | 2005-04-05 | Amersham Health As | Method of ultrasound imaging |
| GB9200388D0 (en) * | 1992-01-09 | 1992-02-26 | Nycomed As | Improvements in or relating to contrast agents |
| IL104084A (en) * | 1992-01-24 | 1996-09-12 | Bracco Int Bv | Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| GB9221329D0 (en) * | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| EP0680341B1 (en) * | 1993-01-25 | 2001-05-09 | Sonus Pharmaceuticals, Inc. | Phase shift colloids as ultrasound contrast agents |
| IL108416A (en) | 1993-01-25 | 1998-10-30 | Sonus Pharma Inc | Colloids with phase difference as contrast ultrasound agents |
| US5558855A (en) * | 1993-01-25 | 1996-09-24 | Sonus Pharmaceuticals | Phase shift colloids as ultrasound contrast agents |
| US5716597A (en) * | 1993-06-04 | 1998-02-10 | Molecular Biosystems, Inc. | Emulsions as contrast agents and method of use |
| US5798091A (en) | 1993-07-30 | 1998-08-25 | Alliance Pharmaceutical Corp. | Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement |
| EP1550464A1 (en) | 1993-07-30 | 2005-07-06 | IMCOR Pharmaceutical Co. | Stabilized microbubble composition for ultrasound |
| DE4328642A1 (de) * | 1993-08-26 | 1995-03-02 | Byk Gulden Lomberg Chem Fab | Ultraschallkontrastmittel |
| GB9318288D0 (en) * | 1993-09-03 | 1993-10-20 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| CA2154867C (en) * | 1993-12-15 | 2007-05-29 | Feng Yan | Gas mixtures useful as ultrasound contrast media |
| GB9417941D0 (en) * | 1994-09-06 | 1994-10-26 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5540909A (en) * | 1994-09-28 | 1996-07-30 | Alliance Pharmaceutical Corp. | Harmonic ultrasound imaging with microbubbles |
| GB9423419D0 (en) * | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| WO2004073750A1 (en) | 1995-06-07 | 2004-09-02 | Harald Dugstad | Improvements in or relating to contrast agents |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| HU229090B1 (en) * | 1996-02-19 | 2013-07-29 | Ge Healthcare As | Improvements in or relating to contrast agents |
| IL126073A (en) * | 1996-03-05 | 2002-02-10 | Acusphere Inc | Microencapsulated fluorinated gases for use as imaging agents |
| DE19626530A1 (de) * | 1996-07-02 | 1998-01-15 | Byk Gulden Lomberg Chem Fab | MR-Kontrastmittelzubereitungen |
| MXPA99001053A (es) * | 1996-08-02 | 2002-03-11 | Nycomed Imaging As | Mejoramientos en o que se relacionan con agentes de contraste. |
| US6017310A (en) * | 1996-09-07 | 2000-01-25 | Andaris Limited | Use of hollow microcapsules |
| US6068600A (en) * | 1996-12-06 | 2000-05-30 | Quadrant Healthcare (Uk) Limited | Use of hollow microcapsules |
| GB9701237D0 (en) * | 1997-01-22 | 1997-03-12 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US6054118A (en) * | 1997-01-22 | 2000-04-25 | Nycomed Imaging As | Contrast agents comprising two types of gas-containing microparticles |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| DE19805012A1 (de) * | 1998-02-07 | 1999-08-12 | Thomas Gieselmann | Kontrastmittel zur Verwendung als Diagnostikum bei bildgebenden Verfahren sowie seine Herstellung |
| GB9912356D0 (en) | 1999-05-26 | 1999-07-28 | Btg Int Ltd | Generation of microfoam |
| US8512680B2 (en) | 2001-08-08 | 2013-08-20 | Btg International Ltd. | Injectables in foam, new pharmaceutical applications |
| US8048439B2 (en) | 2003-11-17 | 2011-11-01 | Btg International Ltd. | Therapeutic foam |
| ES2330341T5 (es) | 2003-11-17 | 2017-06-21 | Btg International Limited | Espuma terapéutica que comprende una solución esclerosante y una baja cantidad de nitrógeno gaseoso |
| US8012457B2 (en) | 2004-06-04 | 2011-09-06 | Acusphere, Inc. | Ultrasound contrast agent dosage formulation |
| GB0509824D0 (en) | 2005-05-13 | 2005-06-22 | Btg Int Ltd | Therapeutic foam |
| WO2007070827A2 (en) * | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3141641A1 (de) * | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4900540A (en) * | 1983-06-20 | 1990-02-13 | Trustees Of The University Of Massachusetts | Lipisomes containing gas for ultrasound detection |
| DE3863908D1 (de) * | 1987-11-27 | 1991-08-29 | Akzo Nv | Stabilisierung von antikoerpern. |
| IN172208B (sv) * | 1990-04-02 | 1993-05-01 | Sint Sa |
-
1991
- 1991-01-09 DE DE4100470A patent/DE4100470A1/de not_active Ceased
-
1992
- 1992-01-04 JP JP50166892A patent/JP3290655B2/ja not_active Expired - Lifetime
- 1992-01-04 AU AU11547/92A patent/AU652803B2/en not_active Expired
- 1992-01-04 PL PL92299987A patent/PL167253B1/pl unknown
- 1992-01-04 ES ES92901804T patent/ES2079176T5/es not_active Expired - Lifetime
- 1992-01-04 DE DEEP9200012T patent/DE4290068D2/de not_active Expired - Lifetime
- 1992-01-04 RU RU9293052889A patent/RU2091079C1/ru active
- 1992-01-04 SK SK729-93A patent/SK278776B6/sk unknown
- 1992-01-04 UA UA94040995A patent/UA27121C2/uk unknown
- 1992-01-04 WO PCT/EP1992/000012 patent/WO1992011873A1/de active IP Right Grant
- 1992-01-04 HU HU9301703A patent/HU220763B1/hu unknown
- 1992-01-04 EP EP92901804A patent/EP0566601B2/de not_active Expired - Lifetime
- 1992-01-04 EP EP92100093A patent/EP0494615A1/de active Pending
- 1992-01-04 KR KR1019930702025A patent/KR100203221B1/ko not_active IP Right Cessation
- 1992-01-04 DE DE59203392T patent/DE59203392D1/de not_active Expired - Lifetime
- 1992-01-04 DK DK92901804T patent/DK0566601T4/da active
- 1992-01-04 CZ CS931780A patent/CZ280939B6/cs not_active IP Right Cessation
- 1992-01-04 CA CA002098915A patent/CA2098915C/en not_active Expired - Lifetime
- 1992-01-04 AT AT92901804T patent/ATE126708T1/de not_active IP Right Cessation
- 1992-01-07 IL IL10060792A patent/IL100607A/en not_active IP Right Cessation
- 1992-01-07 IE IE920038A patent/IE70131B1/en not_active IP Right Cessation
- 1992-01-08 ZA ZA92118A patent/ZA92118B/xx unknown
- 1992-01-08 NZ NZ241246A patent/NZ241246A/en not_active IP Right Cessation
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1993
- 1993-07-08 FI FI933137A patent/FI119913B/sv active IP Right Grant
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1994
- 1994-02-28 BG BG98599A patent/BG61667B2/bg unknown
- 1994-11-22 US US08/347,206 patent/US5599523A/en not_active Expired - Lifetime
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1995
- 1995-10-31 GR GR950403031T patent/GR3017925T3/el unknown
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1998
- 1998-06-08 HK HK98105041A patent/HK1006147A1/xx not_active IP Right Cessation
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