FI119377B - Menetelmä tekijän IX valmistamiseksi biologisista lähteistä - Google Patents

Menetelmä tekijän IX valmistamiseksi biologisista lähteistä Download PDF

Info

Publication number
FI119377B
FI119377B FI973469A FI973469A FI119377B FI 119377 B FI119377 B FI 119377B FI 973469 A FI973469 A FI 973469A FI 973469 A FI973469 A FI 973469A FI 119377 B FI119377 B FI 119377B
Authority
FI
Finland
Prior art keywords
factor
chromatography
inactivation
hic
plasma
Prior art date
Application number
FI973469A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI973469A (fi
FI973469A0 (fi
Inventor
Djuro Josic
Lutz Hoffer
Frank Morfeld
Original Assignee
Octapharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Octapharma Ag filed Critical Octapharma Ag
Publication of FI973469A publication Critical patent/FI973469A/fi
Publication of FI973469A0 publication Critical patent/FI973469A0/fi
Application granted granted Critical
Publication of FI119377B publication Critical patent/FI119377B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI973469A 1995-02-25 1997-08-22 Menetelmä tekijän IX valmistamiseksi biologisista lähteistä FI119377B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19506633 1995-02-25
DE19506633A DE19506633A1 (de) 1995-02-25 1995-02-25 Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
EP9600636 1996-02-14
PCT/EP1996/000636 WO1996027003A1 (fr) 1995-02-25 1996-02-14 Procede de preparation du facteur ix a partir de sources biologiques

Publications (3)

Publication Number Publication Date
FI973469A FI973469A (fi) 1997-08-22
FI973469A0 FI973469A0 (fi) 1997-08-22
FI119377B true FI119377B (fi) 2008-10-31

Family

ID=7755037

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973469A FI119377B (fi) 1995-02-25 1997-08-22 Menetelmä tekijän IX valmistamiseksi biologisista lähteistä

Country Status (20)

Country Link
US (1) US5919909A (fr)
EP (1) EP0811058B1 (fr)
JP (1) JPH11500910A (fr)
KR (1) KR100436857B1 (fr)
CN (1) CN1105779C (fr)
AT (1) ATE194167T1 (fr)
AU (1) AU697217B2 (fr)
CA (1) CA2213577C (fr)
DE (2) DE19506633A1 (fr)
DK (1) DK0811058T3 (fr)
EA (1) EA000222B1 (fr)
ES (1) ES2147365T3 (fr)
FI (1) FI119377B (fr)
GR (1) GR3034035T3 (fr)
IL (1) IL117157A (fr)
MY (1) MY119366A (fr)
PT (1) PT811058E (fr)
UA (1) UA46005C2 (fr)
WO (1) WO1996027003A1 (fr)
ZA (1) ZA961450B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen
AT405608B (de) * 1997-04-08 1999-10-25 Immuno Ag Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material
WO2005033140A1 (fr) * 2003-09-30 2005-04-14 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Preparation de facteur ix de coagulation sanguine hautement purifiee et procede de purification associe
KR100567448B1 (ko) * 2003-11-05 2006-04-04 주식회사 인투젠 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법
JP5037331B2 (ja) * 2004-03-19 2012-09-26 バクスター・インターナショナル・インコーポレイテッド 出血性障害の処置のための第ｉｘａ因子
US10928366B2 (en) * 2007-01-26 2021-02-23 Sigma-Aldrich Co. Llc Compositions and methods for combining protein precipitation and solid phase extraction
US10434492B2 (en) * 2007-01-26 2019-10-08 Sigma-Aldrich Co. Llc Compositions and methods for solid phase extraction of lipids
US20130079498A1 (en) * 2010-03-30 2013-03-28 Octapharma Ag Process for purifying vitamin k dependent proteins such as coagulation factor ix
CN104560925B (zh) * 2014-12-30 2017-11-03 山东泰邦生物制品有限公司 一种从人凝血因子ⅸ层析废液中激活制备人凝血酶的方法
CN107540743A (zh) * 2017-10-11 2018-01-05 南岳生物制药有限公司 一种双层析法制备人纤维蛋白原的方法
CN111378029B (zh) * 2018-12-29 2023-05-05 四川远大蜀阳药业有限责任公司 一种人凝血因子ix的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124506B1 (fr) * 1983-05-02 1988-08-17 IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte Procédé pour inactiver des pathogènes
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
DE3877529T2 (de) * 1987-10-23 1996-11-07 Centre Regional De Transfusion Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung.
AT402261B (de) * 1991-01-25 1997-03-25 Immuno Ag Komplex enthaltend den gerinnungsfaktor ix
DE69231401T2 (de) 1991-03-01 2001-02-08 Rhone-Poulenc Rorer International (Holdings) Inc., Greenville Herstellung von faktor-ix
WO1994017834A1 (fr) 1993-02-09 1994-08-18 Octapharma Ag Procede pour l'inactivation de virus ne comportant pas d'enveloppes lipidiques
DE19506633A1 (de) * 1995-02-25 1996-08-29 Octapharma Ag Verfahren zur Herstellung von Faktor IX aus biologischen Quellen

Also Published As

Publication number Publication date
IL117157A (en) 1999-12-22
KR19980702453A (ko) 1998-07-15
EP0811058A1 (fr) 1997-12-10
MY119366A (en) 2005-05-31
DE69609054T2 (de) 2001-03-08
IL117157A0 (en) 1996-06-18
EP0811058B1 (fr) 2000-06-28
CA2213577A1 (fr) 1996-09-06
AU4876196A (en) 1996-09-18
CN1181782A (zh) 1998-05-13
GR3034035T3 (en) 2000-11-30
ES2147365T3 (es) 2000-09-01
DE69609054D1 (de) 2000-08-03
CN1105779C (zh) 2003-04-16
DK0811058T3 (da) 2000-10-16
JPH11500910A (ja) 1999-01-26
FI973469A (fi) 1997-08-22
US5919909A (en) 1999-07-06
ATE194167T1 (de) 2000-07-15
UA46005C2 (uk) 2002-05-15
ZA961450B (en) 1996-08-27
EA199700196A1 (ru) 1998-02-26
CA2213577C (fr) 2005-01-04
FI973469A0 (fi) 1997-08-22
AU697217B2 (en) 1998-10-01
WO1996027003A1 (fr) 1996-09-06
KR100436857B1 (ko) 2004-09-21
DE19506633A1 (de) 1996-08-29
PT811058E (pt) 2000-10-31
EA000222B1 (ru) 1998-12-24

Similar Documents

Publication Publication Date Title
JP3094167B2 (ja) 免疫血清グロブリンの精製方法
Burnouf et al. Affinity chromatography in the industrial purification of plasma proteins for therapeutic use
FI96210B (fi) Plasmaproteiinien kromatograafinen erottaminen
JP3018412B2 (ja) 血漿蛋白の分画方法
JP5704918B2 (ja) 第ｖｉｉｉ因子およびフォンビルブラント因子の精製方法
CA2024667C (fr) Procede de preparation d'un concentre de complexe de facteur viii de coagulation sanguine et de facteur de willebrnad a partir de plasma total
JP4250770B2 (ja) カチオン交換クロマトグラフィーによるフォンビルブラント因子の精製
JPH04504720A (ja) タンパク質精製のための方法
EP0295645A2 (fr) Méthode de purification du facteur VIII:C, facteur von Willegrand, et leurs complexes
FI119377B (fi) Menetelmä tekijän IX valmistamiseksi biologisista lähteistä
CA2621025A1 (fr) Preparation d'immunoglobuline intraveineuse a tres haut rendement
AU744919B2 (en) Method for purifying factor VIII/VWF complex by cation-exchange chromatography
JPH04243899A (ja) 第ｖｉｉｉ因子の精製およびこの方法で得られた第ｖｉｉｉ因子
JP4250769B2 (ja) 高度に精製されたｖＷＦまたは因子ＶＩＩＩ／ｖＷＦ複合体を得る方法
EP1928915A2 (fr) Preparation d'immunoglobuline intraveineuse a tres haut rendement
US7041798B1 (en) Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use
EP2640413B1 (fr) Procédé de réduction et/ou d'extraction de fxi et de fxia de solutions contenant lesdits facteurs de coagulation
HU219828B (hu) Eljárás K-vitamin-függő proteinek izolálására és tisztítására
CA2279494A1 (fr) Procede de purification ou de fractionnement chromatographique du facteur willebrand contenu dans un materiau de depart
de Lille llllll" 111 ill Ilill ll| l| lllll lllll|||| l lilil lllll| l|||" II" III lllll| ll|
MX2008009204A (en) Purification and use of a factor for supporting wound healing
JPH04108799A (ja) 血液凝固第８因子結合性ペプチド及びその使用
LV10194B (en) Blood coagulation factor xi concentrate having high specific activity, suitable for therapeutic use, and process for preparing same

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 119377

Country of ref document: FI

MM Patent lapsed