FI119377B - Menetelmä tekijän IX valmistamiseksi biologisista lähteistä - Google Patents
Menetelmä tekijän IX valmistamiseksi biologisista lähteistä Download PDFInfo
- Publication number
- FI119377B FI119377B FI973469A FI973469A FI119377B FI 119377 B FI119377 B FI 119377B FI 973469 A FI973469 A FI 973469A FI 973469 A FI973469 A FI 973469A FI 119377 B FI119377 B FI 119377B
- Authority
- FI
- Finland
- Prior art keywords
- factor
- chromatography
- inactivation
- hic
- plasma
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19506633 | 1995-02-25 | ||
DE19506633A DE19506633A1 (de) | 1995-02-25 | 1995-02-25 | Verfahren zur Herstellung von Faktor IX aus biologischen Quellen |
EP9600636 | 1996-02-14 | ||
PCT/EP1996/000636 WO1996027003A1 (fr) | 1995-02-25 | 1996-02-14 | Procede de preparation du facteur ix a partir de sources biologiques |
Publications (3)
Publication Number | Publication Date |
---|---|
FI973469A FI973469A (fi) | 1997-08-22 |
FI973469A0 FI973469A0 (fi) | 1997-08-22 |
FI119377B true FI119377B (fi) | 2008-10-31 |
Family
ID=7755037
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI973469A FI119377B (fi) | 1995-02-25 | 1997-08-22 | Menetelmä tekijän IX valmistamiseksi biologisista lähteistä |
Country Status (20)
Country | Link |
---|---|
US (1) | US5919909A (fr) |
EP (1) | EP0811058B1 (fr) |
JP (1) | JPH11500910A (fr) |
KR (1) | KR100436857B1 (fr) |
CN (1) | CN1105779C (fr) |
AT (1) | ATE194167T1 (fr) |
AU (1) | AU697217B2 (fr) |
CA (1) | CA2213577C (fr) |
DE (2) | DE19506633A1 (fr) |
DK (1) | DK0811058T3 (fr) |
EA (1) | EA000222B1 (fr) |
ES (1) | ES2147365T3 (fr) |
FI (1) | FI119377B (fr) |
GR (1) | GR3034035T3 (fr) |
IL (1) | IL117157A (fr) |
MY (1) | MY119366A (fr) |
PT (1) | PT811058E (fr) |
UA (1) | UA46005C2 (fr) |
WO (1) | WO1996027003A1 (fr) |
ZA (1) | ZA961450B (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19506633A1 (de) * | 1995-02-25 | 1996-08-29 | Octapharma Ag | Verfahren zur Herstellung von Faktor IX aus biologischen Quellen |
AT405608B (de) * | 1997-04-08 | 1999-10-25 | Immuno Ag | Verfahren zur inaktivierung von pathogenen, insbesondere von viren, in einem biologischen material |
WO2005033140A1 (fr) * | 2003-09-30 | 2005-04-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Preparation de facteur ix de coagulation sanguine hautement purifiee et procede de purification associe |
KR100567448B1 (ko) * | 2003-11-05 | 2006-04-04 | 주식회사 인투젠 | 형질전환 동물의 유즙 전처리방법 및 이를 통한 인체단백질의 정제방법 |
JP5037331B2 (ja) * | 2004-03-19 | 2012-09-26 | バクスター・インターナショナル・インコーポレイテッド | 出血性障害の処置のための第ixa因子 |
US10928366B2 (en) * | 2007-01-26 | 2021-02-23 | Sigma-Aldrich Co. Llc | Compositions and methods for combining protein precipitation and solid phase extraction |
US10434492B2 (en) * | 2007-01-26 | 2019-10-08 | Sigma-Aldrich Co. Llc | Compositions and methods for solid phase extraction of lipids |
US20130079498A1 (en) * | 2010-03-30 | 2013-03-28 | Octapharma Ag | Process for purifying vitamin k dependent proteins such as coagulation factor ix |
CN104560925B (zh) * | 2014-12-30 | 2017-11-03 | 山东泰邦生物制品有限公司 | 一种从人凝血因子ⅸ层析废液中激活制备人凝血酶的方法 |
CN107540743A (zh) * | 2017-10-11 | 2018-01-05 | 南岳生物制药有限公司 | 一种双层析法制备人纤维蛋白原的方法 |
CN111378029B (zh) * | 2018-12-29 | 2023-05-05 | 四川远大蜀阳药业有限责任公司 | 一种人凝血因子ix的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0124506B1 (fr) * | 1983-05-02 | 1988-08-17 | IMMUNO Aktiengesellschaft für chemisch-medizinische Produkte | Procédé pour inactiver des pathogènes |
US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
DE3877529T2 (de) * | 1987-10-23 | 1996-11-07 | Centre Regional De Transfusion | Herstellung von hoch-gereingtem menschlichen Faktor IX sowie anderem Plasmaproteinkonzentrat und dessen therapeutische Verwendung. |
AT402261B (de) * | 1991-01-25 | 1997-03-25 | Immuno Ag | Komplex enthaltend den gerinnungsfaktor ix |
DE69231401T2 (de) | 1991-03-01 | 2001-02-08 | Rhone-Poulenc Rorer International (Holdings) Inc., Greenville | Herstellung von faktor-ix |
WO1994017834A1 (fr) | 1993-02-09 | 1994-08-18 | Octapharma Ag | Procede pour l'inactivation de virus ne comportant pas d'enveloppes lipidiques |
DE19506633A1 (de) * | 1995-02-25 | 1996-08-29 | Octapharma Ag | Verfahren zur Herstellung von Faktor IX aus biologischen Quellen |
-
1995
- 1995-02-25 DE DE19506633A patent/DE19506633A1/de not_active Ceased
-
1996
- 1996-02-14 EA EA199700196A patent/EA000222B1/ru not_active IP Right Cessation
- 1996-02-14 JP JP8525986A patent/JPH11500910A/ja active Pending
- 1996-02-14 UA UA97084352A patent/UA46005C2/uk unknown
- 1996-02-14 EP EP96904778A patent/EP0811058B1/fr not_active Expired - Lifetime
- 1996-02-14 ES ES96904778T patent/ES2147365T3/es not_active Expired - Lifetime
- 1996-02-14 AU AU48761/96A patent/AU697217B2/en not_active Ceased
- 1996-02-14 PT PT96904778T patent/PT811058E/pt unknown
- 1996-02-14 CN CN96193308A patent/CN1105779C/zh not_active Expired - Fee Related
- 1996-02-14 DE DE69609054T patent/DE69609054T2/de not_active Expired - Lifetime
- 1996-02-14 WO PCT/EP1996/000636 patent/WO1996027003A1/fr active IP Right Grant
- 1996-02-14 US US08/894,654 patent/US5919909A/en not_active Expired - Lifetime
- 1996-02-14 CA CA002213577A patent/CA2213577C/fr not_active Expired - Fee Related
- 1996-02-14 KR KR1019970705853A patent/KR100436857B1/ko not_active IP Right Cessation
- 1996-02-14 AT AT96904778T patent/ATE194167T1/de active
- 1996-02-14 DK DK96904778T patent/DK0811058T3/da active
- 1996-02-15 MY MYPI96000576A patent/MY119366A/en unknown
- 1996-02-16 IL IL11715796A patent/IL117157A/xx not_active IP Right Cessation
- 1996-02-23 ZA ZA961450A patent/ZA961450B/xx unknown
-
1997
- 1997-08-22 FI FI973469A patent/FI119377B/fi not_active IP Right Cessation
-
2000
- 2000-07-27 GR GR20000401725T patent/GR3034035T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IL117157A (en) | 1999-12-22 |
KR19980702453A (ko) | 1998-07-15 |
EP0811058A1 (fr) | 1997-12-10 |
MY119366A (en) | 2005-05-31 |
DE69609054T2 (de) | 2001-03-08 |
IL117157A0 (en) | 1996-06-18 |
EP0811058B1 (fr) | 2000-06-28 |
CA2213577A1 (fr) | 1996-09-06 |
AU4876196A (en) | 1996-09-18 |
CN1181782A (zh) | 1998-05-13 |
GR3034035T3 (en) | 2000-11-30 |
ES2147365T3 (es) | 2000-09-01 |
DE69609054D1 (de) | 2000-08-03 |
CN1105779C (zh) | 2003-04-16 |
DK0811058T3 (da) | 2000-10-16 |
JPH11500910A (ja) | 1999-01-26 |
FI973469A (fi) | 1997-08-22 |
US5919909A (en) | 1999-07-06 |
ATE194167T1 (de) | 2000-07-15 |
UA46005C2 (uk) | 2002-05-15 |
ZA961450B (en) | 1996-08-27 |
EA199700196A1 (ru) | 1998-02-26 |
CA2213577C (fr) | 2005-01-04 |
FI973469A0 (fi) | 1997-08-22 |
AU697217B2 (en) | 1998-10-01 |
WO1996027003A1 (fr) | 1996-09-06 |
KR100436857B1 (ko) | 2004-09-21 |
DE19506633A1 (de) | 1996-08-29 |
PT811058E (pt) | 2000-10-31 |
EA000222B1 (ru) | 1998-12-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP3094167B2 (ja) | 免疫血清グロブリンの精製方法 | |
Burnouf et al. | Affinity chromatography in the industrial purification of plasma proteins for therapeutic use | |
FI96210B (fi) | Plasmaproteiinien kromatograafinen erottaminen | |
JP3018412B2 (ja) | 血漿蛋白の分画方法 | |
JP5704918B2 (ja) | 第viii因子およびフォンビルブラント因子の精製方法 | |
CA2024667C (fr) | Procede de preparation d'un concentre de complexe de facteur viii de coagulation sanguine et de facteur de willebrnad a partir de plasma total | |
JP4250770B2 (ja) | カチオン交換クロマトグラフィーによるフォンビルブラント因子の精製 | |
JPH04504720A (ja) | タンパク質精製のための方法 | |
EP0295645A2 (fr) | Méthode de purification du facteur VIII:C, facteur von Willegrand, et leurs complexes | |
FI119377B (fi) | Menetelmä tekijän IX valmistamiseksi biologisista lähteistä | |
CA2621025A1 (fr) | Preparation d'immunoglobuline intraveineuse a tres haut rendement | |
AU744919B2 (en) | Method for purifying factor VIII/VWF complex by cation-exchange chromatography | |
JPH04243899A (ja) | 第viii因子の精製およびこの方法で得られた第viii因子 | |
JP4250769B2 (ja) | 高度に精製されたvWFまたは因子VIII/vWF複合体を得る方法 | |
EP1928915A2 (fr) | Preparation d'immunoglobuline intraveineuse a tres haut rendement | |
US7041798B1 (en) | Method for the chromatographic fractionation of plasma or serum, preparations, so obtained, and their use | |
EP2640413B1 (fr) | Procédé de réduction et/ou d'extraction de fxi et de fxia de solutions contenant lesdits facteurs de coagulation | |
HU219828B (hu) | Eljárás K-vitamin-függő proteinek izolálására és tisztítására | |
CA2279494A1 (fr) | Procede de purification ou de fractionnement chromatographique du facteur willebrand contenu dans un materiau de depart | |
de Lille | llllll" 111 ill Ilill ll| l| lllll lllll|||| l lilil lllll| l|||" II" III lllll| ll| | |
MX2008009204A (en) | Purification and use of a factor for supporting wound healing | |
JPH04108799A (ja) | 血液凝固第8因子結合性ペプチド及びその使用 | |
LV10194B (en) | Blood coagulation factor xi concentrate having high specific activity, suitable for therapeutic use, and process for preparing same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Ref document number: 119377 Country of ref document: FI |
|
MM | Patent lapsed |