FI118885B - Skopolaminplåster - Google Patents

Skopolaminplåster Download PDF

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Publication number
FI118885B
FI118885B FI971097A FI971097A FI118885B FI 118885 B FI118885 B FI 118885B FI 971097 A FI971097 A FI 971097A FI 971097 A FI971097 A FI 971097A FI 118885 B FI118885 B FI 118885B
Authority
FI
Finland
Prior art keywords
transdermal therapeutic
active substance
therapeutic system
scopolamine
base
Prior art date
Application number
FI971097A
Other languages
English (en)
Finnish (fi)
Other versions
FI971097A (sv
FI971097A0 (sv
Inventor
Walter Mueller
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4438989A external-priority patent/DE4438989C2/de
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of FI971097A publication Critical patent/FI971097A/sv
Publication of FI971097A0 publication Critical patent/FI971097A0/sv
Application granted granted Critical
Publication of FI118885B publication Critical patent/FI118885B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)

Claims (7)

1. Transdermalt terapeutiskt system i form av ett pläster med en skiktvis konstruktion, vilket system bestär 5 av ett bakgrundsskikt, ett kontaktiimmande förräd av verk-samt ämne, eventuellt en membran, som reglerar strommen av verksamt ämne, om sä önskas ett extra hudlimskikt och en löstagbar skyddsfolie och som innehäller som verksamt ämne en skopolaminbas, kännetecknat av att skikten som 10 innehäller det verksamma ämnet i nämnda pläster innehäller som baspolymer kopolymerer av akrylsyra- eller metakrylsy-raderivat, väri förekommer polära grupper och som i sig själva eller tillsammans med polära hjälpmedel förmär upp-lösa 10 - 30 vikt-% av en skopolaminbas, och en skopol-15 aminbas i en hait som motsvarar en 50 - 100 %:s andel av dess mättnadslöslighet, företrädesvis en 60 - 100 %:s andel av dess mättnadslöslighet, i den kompletta vehikelfor-men.
2. Transdermalt terapeutiskt system enligt patent-20 krav 1, kännetecknat av att det är ett matrixsystem.
3. Transdermalt terapeutiskt system enligt patent- * i *·* krav 1, kännetecknat av att det är ett membransys- • · · V * tem.
4. Transdermalt terapeutiskt system enligt ett el- *:*·· 25 ler flera av patentkraven 1 - 3, kännetecknat av att ϊ*.<4 membranen innehäller en kopolymer av eten och vinylacetat. t
5. Transdermalt terapeutiskt system enligt patent- i * · krav 4, kännetecknat av att membranen innehäller . . minst 4 % vinylacetat. • · *
6. Transdermalt terapeutiskt system enligt patent- • · *···' krav 1 - 5, kännetecknat av att skikten som innehäl- ler det verksamma ämnet i plästret innehäller kolväten, • · * ·"’· företrädesvis dioktylcyklohexan, för att minska skopol- • · ,* . aminbasens mättnadslöslighet. • · · * M • · « · 17 1 1 8885
7. Transdermalt terapeutiskt system enligt ett el-ler flera av patentkraven 1 - 6, kännetecknat av att skikten som innehäller det verksamma ämnet i plästret in-nehdller fettsyror eller fettalkoholer, företrädesvis ol-5 jesyra och oleylalkohol, för att höja mättnadslösligheten. ·· * • M ··· • · · • · « * • · • · ··· • · ·· • 1· «·· • · · • · · * • · • 1 · • · · ♦ · • · • « • · • · • ·♦ • · • 1 • · ·»· • · · • · · • ·· • ·
FI971097A 1994-09-16 1997-03-14 Skopolaminplåster FI118885B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4433004 1994-09-16
DE4433004 1994-09-16
DE4438989 1994-10-31
DE4438989A DE4438989C2 (de) 1994-09-16 1994-10-31 Scopolaminpflaster
PCT/EP1995/003555 WO1996008251A1 (de) 1994-09-16 1995-09-09 Scopolaminpflaster
EP9503555 1995-09-09

Publications (3)

Publication Number Publication Date
FI971097A FI971097A (sv) 1997-03-14
FI971097A0 FI971097A0 (sv) 1997-03-14
FI118885B true FI118885B (sv) 2008-04-30

Family

ID=25940173

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971097A FI118885B (sv) 1994-09-16 1997-03-14 Skopolaminplåster

Country Status (20)

Country Link
US (1) US5714162A (sv)
EP (1) EP0781134B9 (sv)
JP (1) JP4466977B2 (sv)
CN (1) CN1087938C (sv)
AT (1) ATE262333T1 (sv)
AU (1) AU695698B2 (sv)
CA (1) CA2200189C (sv)
CZ (1) CZ289313B6 (sv)
DE (1) DE59510883D1 (sv)
ES (1) ES2219665T3 (sv)
FI (1) FI118885B (sv)
HU (1) HUT77383A (sv)
IL (1) IL115189A (sv)
MX (1) MX9701968A (sv)
MY (1) MY112477A (sv)
NO (1) NO312496B1 (sv)
NZ (1) NZ292921A (sv)
PL (1) PL182158B1 (sv)
SK (1) SK282640B6 (sv)
WO (1) WO1996008251A1 (sv)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19738643C2 (de) * 1997-09-04 2001-10-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung
US6087341A (en) * 1998-02-12 2000-07-11 The Board Of Trustees Of The Leland Standford Junior University Introduction of nucleic acid into skin cells by topical application
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US20050208117A1 (en) * 2001-03-16 2005-09-22 Venkatraman Subramanian S Transdermal administration of fentanyl and analogs thereof
US20030026829A1 (en) * 2001-03-16 2003-02-06 Venkatraman Subramanian S. Transdermal administration of fentanyl and analogs thereof
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
NZ541956A (en) * 2003-04-14 2008-09-26 Lohmann Therapie Syst Lts Therapeutic patch with polysiloxane matrix comprising capsaicin
CA2522184A1 (en) * 2003-04-17 2004-11-04 The Trustees Of Columbia University In The City Of New York Desmoglein 4 is a novel gene involved in hair growth
AU2005238034A1 (en) 2004-04-23 2005-11-10 The Trustees Of Columbia University In The City Of New York Inhibition of hairless protein mRNA
FR2884143B1 (fr) * 2005-04-08 2007-06-22 Millet Innovation Sa Timbre dermique rechargeable
US20070010550A1 (en) * 2005-07-08 2007-01-11 The Board Of Regents Of The University Of Texas Scopolamine to Reduce or Eliminate Hot Flashes, Night Sweats, and Insomnia
CN101431988A (zh) * 2006-02-27 2009-05-13 诺芬药品公司 包含东莨菪碱的透皮治疗系统
DE102006028987A1 (de) * 2006-06-24 2007-12-27 Lts Lohmann Therapie-Systeme Ag Ultraschallverstärktes transdermales therapeutisches System
MY154027A (en) * 2007-10-15 2015-04-30 Alza Corp Once-a-day replacement transdermal administration of fentanyl
CN102764342B (zh) * 2012-07-17 2013-12-04 陈鼎汉 治疗褥疮、糖尿病伤口、烫伤的药膏
CN113677343B (zh) * 2019-03-19 2023-11-24 耐贝医药株式会社 生物体对药物的吸收性优异且化学稳定性也优异的医药组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8104929A (nl) * 1980-11-12 1982-06-01 Alza Corp Anticholinergische preparaten, alsmede de bereiding en de toepassing ervan.
US5310559A (en) * 1982-09-01 1994-05-10 Hercon Laboratories Corporation Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5474783A (en) * 1988-03-04 1995-12-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
EP0356382B1 (de) * 1988-08-02 1994-02-16 Ciba-Geigy Ag Mehrschichtiges Pflaster
DE3908431A1 (de) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
US5176917A (en) * 1989-03-15 1993-01-05 Lts Lohmann Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances
JPH04261119A (ja) * 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤

Also Published As

Publication number Publication date
PL319259A1 (en) 1997-08-04
CA2200189C (en) 2008-06-17
ATE262333T1 (de) 2004-04-15
HUT77383A (hu) 1998-04-28
JP4466977B2 (ja) 2010-05-26
FI971097A (sv) 1997-03-14
PL182158B1 (pl) 2001-11-30
CA2200189A1 (en) 1996-03-21
MY112477A (en) 2001-06-30
CN1087938C (zh) 2002-07-24
MX9701968A (es) 1998-02-28
EP0781134B9 (de) 2004-09-29
NO312496B1 (no) 2002-05-21
DE59510883D1 (de) 2004-04-29
EP0781134B1 (de) 2004-03-24
SK282640B6 (sk) 2002-10-08
FI971097A0 (sv) 1997-03-14
WO1996008251A1 (de) 1996-03-21
IL115189A0 (en) 1995-12-31
US5714162A (en) 1998-02-03
AU695698B2 (en) 1998-08-20
NO971203L (no) 1997-03-14
NZ292921A (en) 1998-09-24
AU3523195A (en) 1996-03-29
SK33897A3 (en) 1997-09-10
IL115189A (en) 1999-12-22
NO971203D0 (no) 1997-03-14
CN1158084A (zh) 1997-08-27
EP0781134A1 (de) 1997-07-02
CZ289313B6 (cs) 2001-12-12
JPH10505825A (ja) 1998-06-09
CZ75797A3 (en) 1997-07-16
ES2219665T3 (es) 2004-12-01

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