FI118885B - Skopolaminplåster - Google Patents
Skopolaminplåster Download PDFInfo
- Publication number
- FI118885B FI118885B FI971097A FI971097A FI118885B FI 118885 B FI118885 B FI 118885B FI 971097 A FI971097 A FI 971097A FI 971097 A FI971097 A FI 971097A FI 118885 B FI118885 B FI 118885B
- Authority
- FI
- Finland
- Prior art keywords
- transdermal therapeutic
- active substance
- therapeutic system
- scopolamine
- base
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Polyurethanes Or Polyureas (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Claims (7)
1. Transdermalt terapeutiskt system i form av ett pläster med en skiktvis konstruktion, vilket system bestär 5 av ett bakgrundsskikt, ett kontaktiimmande förräd av verk-samt ämne, eventuellt en membran, som reglerar strommen av verksamt ämne, om sä önskas ett extra hudlimskikt och en löstagbar skyddsfolie och som innehäller som verksamt ämne en skopolaminbas, kännetecknat av att skikten som 10 innehäller det verksamma ämnet i nämnda pläster innehäller som baspolymer kopolymerer av akrylsyra- eller metakrylsy-raderivat, väri förekommer polära grupper och som i sig själva eller tillsammans med polära hjälpmedel förmär upp-lösa 10 - 30 vikt-% av en skopolaminbas, och en skopol-15 aminbas i en hait som motsvarar en 50 - 100 %:s andel av dess mättnadslöslighet, företrädesvis en 60 - 100 %:s andel av dess mättnadslöslighet, i den kompletta vehikelfor-men.
2. Transdermalt terapeutiskt system enligt patent-20 krav 1, kännetecknat av att det är ett matrixsystem.
3. Transdermalt terapeutiskt system enligt patent- * i *·* krav 1, kännetecknat av att det är ett membransys- • · · V * tem.
4. Transdermalt terapeutiskt system enligt ett el- *:*·· 25 ler flera av patentkraven 1 - 3, kännetecknat av att ϊ*.<4 membranen innehäller en kopolymer av eten och vinylacetat. t
5. Transdermalt terapeutiskt system enligt patent- i * · krav 4, kännetecknat av att membranen innehäller . . minst 4 % vinylacetat. • · *
6. Transdermalt terapeutiskt system enligt patent- • · *···' krav 1 - 5, kännetecknat av att skikten som innehäl- ler det verksamma ämnet i plästret innehäller kolväten, • · * ·"’· företrädesvis dioktylcyklohexan, för att minska skopol- • · ,* . aminbasens mättnadslöslighet. • · · * M • · « · 17 1 1 8885
7. Transdermalt terapeutiskt system enligt ett el-ler flera av patentkraven 1 - 6, kännetecknat av att skikten som innehäller det verksamma ämnet i plästret in-nehdller fettsyror eller fettalkoholer, företrädesvis ol-5 jesyra och oleylalkohol, för att höja mättnadslösligheten. ·· * • M ··· • · · • · « * • · • · ··· • · ·· • 1· «·· • · · • · · * • · • 1 · • · · ♦ · • · • « • · • · • ·♦ • · • 1 • · ·»· • · · • · · • ·· • ·
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4433004 | 1994-09-16 | ||
DE4433004 | 1994-09-16 | ||
DE4438989 | 1994-10-31 | ||
DE4438989A DE4438989C2 (de) | 1994-09-16 | 1994-10-31 | Scopolaminpflaster |
PCT/EP1995/003555 WO1996008251A1 (de) | 1994-09-16 | 1995-09-09 | Scopolaminpflaster |
EP9503555 | 1995-09-09 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI971097A FI971097A (sv) | 1997-03-14 |
FI971097A0 FI971097A0 (sv) | 1997-03-14 |
FI118885B true FI118885B (sv) | 2008-04-30 |
Family
ID=25940173
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI971097A FI118885B (sv) | 1994-09-16 | 1997-03-14 | Skopolaminplåster |
Country Status (20)
Country | Link |
---|---|
US (1) | US5714162A (sv) |
EP (1) | EP0781134B9 (sv) |
JP (1) | JP4466977B2 (sv) |
CN (1) | CN1087938C (sv) |
AT (1) | ATE262333T1 (sv) |
AU (1) | AU695698B2 (sv) |
CA (1) | CA2200189C (sv) |
CZ (1) | CZ289313B6 (sv) |
DE (1) | DE59510883D1 (sv) |
ES (1) | ES2219665T3 (sv) |
FI (1) | FI118885B (sv) |
HU (1) | HUT77383A (sv) |
IL (1) | IL115189A (sv) |
MX (1) | MX9701968A (sv) |
MY (1) | MY112477A (sv) |
NO (1) | NO312496B1 (sv) |
NZ (1) | NZ292921A (sv) |
PL (1) | PL182158B1 (sv) |
SK (1) | SK282640B6 (sv) |
WO (1) | WO1996008251A1 (sv) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19738643C2 (de) * | 1997-09-04 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
US6087341A (en) * | 1998-02-12 | 2000-07-11 | The Board Of Trustees Of The Leland Standford Junior University | Introduction of nucleic acid into skin cells by topical application |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
US20050208117A1 (en) * | 2001-03-16 | 2005-09-22 | Venkatraman Subramanian S | Transdermal administration of fentanyl and analogs thereof |
US20030026829A1 (en) * | 2001-03-16 | 2003-02-06 | Venkatraman Subramanian S. | Transdermal administration of fentanyl and analogs thereof |
DE10141650C1 (de) | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
NZ541956A (en) * | 2003-04-14 | 2008-09-26 | Lohmann Therapie Syst Lts | Therapeutic patch with polysiloxane matrix comprising capsaicin |
CA2522184A1 (en) * | 2003-04-17 | 2004-11-04 | The Trustees Of Columbia University In The City Of New York | Desmoglein 4 is a novel gene involved in hair growth |
AU2005238034A1 (en) | 2004-04-23 | 2005-11-10 | The Trustees Of Columbia University In The City Of New York | Inhibition of hairless protein mRNA |
FR2884143B1 (fr) * | 2005-04-08 | 2007-06-22 | Millet Innovation Sa | Timbre dermique rechargeable |
US20070010550A1 (en) * | 2005-07-08 | 2007-01-11 | The Board Of Regents Of The University Of Texas | Scopolamine to Reduce or Eliminate Hot Flashes, Night Sweats, and Insomnia |
CN101431988A (zh) * | 2006-02-27 | 2009-05-13 | 诺芬药品公司 | 包含东莨菪碱的透皮治疗系统 |
DE102006028987A1 (de) * | 2006-06-24 | 2007-12-27 | Lts Lohmann Therapie-Systeme Ag | Ultraschallverstärktes transdermales therapeutisches System |
MY154027A (en) * | 2007-10-15 | 2015-04-30 | Alza Corp | Once-a-day replacement transdermal administration of fentanyl |
CN102764342B (zh) * | 2012-07-17 | 2013-12-04 | 陈鼎汉 | 治疗褥疮、糖尿病伤口、烫伤的药膏 |
CN113677343B (zh) * | 2019-03-19 | 2023-11-24 | 耐贝医药株式会社 | 生物体对药物的吸收性优异且化学稳定性也优异的医药组合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL8104929A (nl) * | 1980-11-12 | 1982-06-01 | Alza Corp | Anticholinergische preparaten, alsmede de bereiding en de toepassing ervan. |
US5310559A (en) * | 1982-09-01 | 1994-05-10 | Hercon Laboratories Corporation | Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer |
US4832953A (en) * | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
US5474783A (en) * | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
EP0356382B1 (de) * | 1988-08-02 | 1994-02-16 | Ciba-Geigy Ag | Mehrschichtiges Pflaster |
DE3908431A1 (de) * | 1989-03-15 | 1990-09-27 | Lohmann Therapie Syst Lts | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
US5176917A (en) * | 1989-03-15 | 1993-01-05 | Lts Lohmann | Transdermal system exhibiting graduated drug release and its use for the local or systemic administration of active substances |
JPH04261119A (ja) * | 1991-02-13 | 1992-09-17 | Lintec Corp | 経皮吸収型貼付剤 |
-
1995
- 1995-01-05 US US08/369,019 patent/US5714162A/en not_active Expired - Lifetime
- 1995-09-06 IL IL11518995A patent/IL115189A/xx not_active IP Right Cessation
- 1995-09-06 MY MYPI95002638A patent/MY112477A/en unknown
- 1995-09-09 JP JP50989096A patent/JP4466977B2/ja not_active Expired - Lifetime
- 1995-09-09 EP EP95932020A patent/EP0781134B9/de not_active Expired - Lifetime
- 1995-09-09 SK SK338-97A patent/SK282640B6/sk unknown
- 1995-09-09 AT AT95932020T patent/ATE262333T1/de not_active IP Right Cessation
- 1995-09-09 CA CA002200189A patent/CA2200189C/en not_active Expired - Fee Related
- 1995-09-09 HU HU9701966A patent/HUT77383A/hu not_active Application Discontinuation
- 1995-09-09 WO PCT/EP1995/003555 patent/WO1996008251A1/de active IP Right Grant
- 1995-09-09 AU AU35231/95A patent/AU695698B2/en not_active Ceased
- 1995-09-09 ES ES95932020T patent/ES2219665T3/es not_active Expired - Lifetime
- 1995-09-09 MX MX9701968A patent/MX9701968A/es not_active IP Right Cessation
- 1995-09-09 DE DE59510883T patent/DE59510883D1/de not_active Expired - Lifetime
- 1995-09-09 CZ CZ1997757A patent/CZ289313B6/cs not_active IP Right Cessation
- 1995-09-09 PL PL95319259A patent/PL182158B1/pl not_active IP Right Cessation
- 1995-09-09 NZ NZ292921A patent/NZ292921A/en not_active IP Right Cessation
- 1995-09-09 CN CN95195097A patent/CN1087938C/zh not_active Expired - Fee Related
-
1997
- 1997-03-14 FI FI971097A patent/FI118885B/sv not_active IP Right Cessation
- 1997-03-14 NO NO19971203A patent/NO312496B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
PL319259A1 (en) | 1997-08-04 |
CA2200189C (en) | 2008-06-17 |
ATE262333T1 (de) | 2004-04-15 |
HUT77383A (hu) | 1998-04-28 |
JP4466977B2 (ja) | 2010-05-26 |
FI971097A (sv) | 1997-03-14 |
PL182158B1 (pl) | 2001-11-30 |
CA2200189A1 (en) | 1996-03-21 |
MY112477A (en) | 2001-06-30 |
CN1087938C (zh) | 2002-07-24 |
MX9701968A (es) | 1998-02-28 |
EP0781134B9 (de) | 2004-09-29 |
NO312496B1 (no) | 2002-05-21 |
DE59510883D1 (de) | 2004-04-29 |
EP0781134B1 (de) | 2004-03-24 |
SK282640B6 (sk) | 2002-10-08 |
FI971097A0 (sv) | 1997-03-14 |
WO1996008251A1 (de) | 1996-03-21 |
IL115189A0 (en) | 1995-12-31 |
US5714162A (en) | 1998-02-03 |
AU695698B2 (en) | 1998-08-20 |
NO971203L (no) | 1997-03-14 |
NZ292921A (en) | 1998-09-24 |
AU3523195A (en) | 1996-03-29 |
SK33897A3 (en) | 1997-09-10 |
IL115189A (en) | 1999-12-22 |
NO971203D0 (no) | 1997-03-14 |
CN1158084A (zh) | 1997-08-27 |
EP0781134A1 (de) | 1997-07-02 |
CZ289313B6 (cs) | 2001-12-12 |
JPH10505825A (ja) | 1998-06-09 |
CZ75797A3 (en) | 1997-07-16 |
ES2219665T3 (es) | 2004-12-01 |
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