FI118766B - Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset - Google Patents

Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset Download PDF

Info

Publication number
FI118766B
FI118766B FI955085A FI955085A FI118766B FI 118766 B FI118766 B FI 118766B FI 955085 A FI955085 A FI 955085A FI 955085 A FI955085 A FI 955085A FI 118766 B FI118766 B FI 118766B
Authority
FI
Finland
Prior art keywords
compound
hydroxy
benzopyran
formula
methoxy
Prior art date
Application number
FI955085A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955085A (fi
FI955085A0 (fi
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Tony Verbeuren
Marie-Odile Vallez
Emmanuel Canet
Yves Rolland
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of FI955085A0 publication Critical patent/FI955085A0/fi
Publication of FI955085A publication Critical patent/FI955085A/fi
Application granted granted Critical
Publication of FI118766B publication Critical patent/FI118766B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
FI955085A 1994-10-26 1995-10-25 Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset FI118766B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9412783 1994-10-26
FR9412783A FR2726273B1 (fr) 1994-10-26 1994-10-26 Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
FI955085A0 FI955085A0 (fi) 1995-10-25
FI955085A FI955085A (fi) 1996-04-27
FI118766B true FI118766B (fi) 2008-03-14

Family

ID=9468215

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955085A FI118766B (fi) 1994-10-26 1995-10-25 Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset

Country Status (17)

Country Link
US (1) US5629339A (ja)
EP (1) EP0709383B1 (ja)
JP (1) JP3076231B2 (ja)
CN (1) CN1058494C (ja)
AT (1) ATE187720T1 (ja)
AU (1) AU693599B2 (ja)
CA (1) CA2161297C (ja)
CY (1) CY2173B1 (ja)
DE (1) DE69513935T2 (ja)
DK (1) DK0709383T3 (ja)
ES (1) ES2145234T3 (ja)
FI (1) FI118766B (ja)
FR (1) FR2726273B1 (ja)
GR (1) GR3032168T3 (ja)
NO (1) NO311132B1 (ja)
NZ (1) NZ280330A (ja)
ZA (1) ZA959076B (ja)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
FR2778663B1 (fr) * 1998-05-15 2001-05-18 Coletica Nouveaux esters de flavonoides,leur utilisation en cosmetique, dermopharmacie, en pharmacie et en agro-alimentaire
JP2001122791A (ja) * 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
US20040151794A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Method of improvement of blood circulation
US20040151769A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Film coated tablet containing an extract of red vine leaves
EP1550450A1 (en) * 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Composition comprising an aqueous extract of red vine leaves and a blood circulating-improving agent for the treatment of chronic venous insufficiencies
RU2367464C2 (ru) * 2004-02-19 2009-09-20 Берингер Ингельхайм Интернациональ Гмбх Состав для лечения хронических венозных недостаточностей, содержащий водный экстракт листьев красного винограда и противовоспалительное средство
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP2019507796A (ja) * 2016-03-11 2019-03-22 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド イカリイン及びイカリチン誘導体
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928150A (en) * 1961-02-08 1963-06-06 Upjohn Co Topical pharmaceutical compositions comprising steroids and flavonoids
CH644374A5 (en) * 1981-05-18 1984-07-31 Espanola Prod Quimicos Water-soluble hydroxyflavone ethers and medicaments containing them
FR2623808B1 (fr) 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
EP0709383B1 (fr) 1999-12-15
NO954173L (no) 1996-04-29
US5629339A (en) 1997-05-13
GR3032168T3 (en) 2000-04-27
CN1058494C (zh) 2000-11-15
FR2726273A1 (fr) 1996-05-03
FI955085A (fi) 1996-04-27
DE69513935D1 (de) 2000-01-20
NZ280330A (en) 1996-12-20
NO311132B1 (no) 2001-10-15
JPH08225563A (ja) 1996-09-03
ATE187720T1 (de) 2000-01-15
CA2161297C (fr) 2001-10-09
FR2726273B1 (fr) 1996-12-06
CN1129701A (zh) 1996-08-28
DK0709383T3 (da) 2000-04-25
ES2145234T3 (es) 2000-07-01
DE69513935T2 (de) 2000-07-20
AU693599B2 (en) 1998-07-02
CY2173B1 (en) 2002-08-23
NO954173D0 (no) 1995-10-19
FI955085A0 (fi) 1995-10-25
ZA959076B (en) 1996-05-22
EP0709383A1 (fr) 1996-05-01
JP3076231B2 (ja) 2000-08-14
CA2161297A1 (fr) 1996-04-27
AU3440495A (en) 1996-05-09

Similar Documents

Publication Publication Date Title
RU2520098C2 (ru) Способы получения производных хиназолинона
FI80018C (fi) Foerfarande foer framstaellning av optiskt aktiva karbazolderivat, nya r- och s- karbazolderivat.
FI118766B (fi) Uudet diosmetiiniyhdisteet, menetelmä niiden valmistamiseksi sekä niitä sisältävät farmaseuttiset koostumukset
ES2363196T3 (es) Derivados de diosmetina, su procedimiento de preparación y composiciones farmacéuticas que los contienen.
WO2021068952A1 (zh) 靶向醛酮还原酶1c3的苯并二氢吡喃类化合物
WO1998011111A1 (fr) Composes de thienotriazolodiazepine et leurs utilisations a des fins medicinales
MXPA06004076A (es) Proceso para la preparacion de compuestos de aminocrotonilo.
PT91330A (pt) Processo para a preparacao de novos derivados de guanina
WO2017000379A1 (zh) 酞菁硅配合物、其制备方法及其在医药上的应用
ES2597652T3 (es) Síntesis optimizada de ácidos biliares puros, cristalinos, no polimórficos, con tamaño de partícula definido
CN118076586A (zh) Kif18a抑制剂
PT2882753T (pt) Processo para a preparação de pemetrexed e sal de lisina do mesmo
WO2022116968A1 (zh) 一种新型n-杂环bet溴结构域抑制剂、其制备方法及医药用途
JPS6160074B2 (ja)
JPH054985A (ja) 新規な化合物
AU2018209577B2 (en) Linked cyclic compound as caspase inhibitor
CA2179314A1 (en) Esters and amides of 9(z)-retinoic acid
HU223349B1 (hu) Diozmetinsavak és észterek és a vegyületeket tartalmazó gyógyszerkészítmények
JP2001515900A (ja) 抗ウイルス薬
KR100196973B1 (ko) 콜레스테롤 강하용 약제학적 조성물
CA2022732A1 (fr) Derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20040089106A (ko) 벤즈아제핀 화합물의 고체 염 및 약제학적 화합물의제조에서 이의 용도
US4775673A (en) Substituted acylpiperazinoquinazolines and pharmaceutical compositions containing same
CN110372614B (zh) 一种四氢喹喔啉类化合物及制备方法与应用
JP2003512424A (ja) ６−メトキシ−２−ナフチル酢酸プロドラッグ

Legal Events

Date Code Title Description
MM Patent lapsed