DE69513935T2 - Diosmetin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen - Google Patents

Diosmetin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen

Info

Publication number
DE69513935T2
DE69513935T2 DE69513935T DE69513935T DE69513935T2 DE 69513935 T2 DE69513935 T2 DE 69513935T2 DE 69513935 T DE69513935 T DE 69513935T DE 69513935 T DE69513935 T DE 69513935T DE 69513935 T2 DE69513935 T2 DE 69513935T2
Authority
DE
Germany
Prior art keywords
allyl
propyl
processes
preparation
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69513935T
Other languages
English (en)
Other versions
DE69513935D1 (de
Inventor
Michel Wierzbicki
Marie-Francoise Boussard
Tony Verbeuren
Marie-Odile Vallez
Emmanuel Canet
Yves Rolland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
ADIR SARL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADIR SARL filed Critical ADIR SARL
Application granted granted Critical
Publication of DE69513935D1 publication Critical patent/DE69513935D1/de
Publication of DE69513935T2 publication Critical patent/DE69513935T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69513935T 1994-10-26 1995-10-25 Diosmetin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen Expired - Lifetime DE69513935T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9412783A FR2726273B1 (fr) 1994-10-26 1994-10-26 Nouveaux derives de la diosmetine, leur procede de preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
DE69513935D1 DE69513935D1 (de) 2000-01-20
DE69513935T2 true DE69513935T2 (de) 2000-07-20

Family

ID=9468215

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69513935T Expired - Lifetime DE69513935T2 (de) 1994-10-26 1995-10-25 Diosmetin Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammenstellungen

Country Status (17)

Country Link
US (1) US5629339A (de)
EP (1) EP0709383B1 (de)
JP (1) JP3076231B2 (de)
CN (1) CN1058494C (de)
AT (1) ATE187720T1 (de)
AU (1) AU693599B2 (de)
CA (1) CA2161297C (de)
CY (1) CY2173B1 (de)
DE (1) DE69513935T2 (de)
DK (1) DK0709383T3 (de)
ES (1) ES2145234T3 (de)
FI (1) FI118766B (de)
FR (1) FR2726273B1 (de)
GR (1) GR3032168T3 (de)
NO (1) NO311132B1 (de)
NZ (1) NZ280330A (de)
ZA (1) ZA959076B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2748025B1 (fr) * 1996-04-25 1998-10-30 Adir Nouveaux acides et esters de la diosmetine, et les compositions pharmaceutiques les contenant
FR2778663B1 (fr) 1998-05-15 2001-05-18 Coletica Nouveaux esters de flavonoides,leur utilisation en cosmetique, dermopharmacie, en pharmacie et en agro-alimentaire
JP2001122791A (ja) * 1999-10-20 2001-05-08 Boehringer Ingelheim Internatl Gmbh 下肢の慢性静脈不全の軽減および予防のための赤色ブドウ樹葉の水性抽出物よりなる食事補強剤
EP1127572A3 (de) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Verwendung von Flavonen zur Behandlung von Cyclooxygenase-2 ermittelten Krankheiten
US20040151769A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Film coated tablet containing an extract of red vine leaves
US20040151794A1 (en) * 2002-12-31 2004-08-05 Boehringer Ingelheim International Gmbh Method of improvement of blood circulation
EP1550450A1 (de) * 2003-12-29 2005-07-06 Boehringer Ingelheim International GmbH Behandlung von chronischer venöser Insuffizienz mit einem Extrakt aus Blättern von roten Weinreben und einem Blutumlauf verbesserndes Mittel
RU2367464C2 (ru) * 2004-02-19 2009-09-20 Берингер Ингельхайм Интернациональ Гмбх Состав для лечения хронических венозных недостаточностей, содержащий водный экстракт листьев красного винограда и противовоспалительное средство
FR2882654B1 (fr) * 2005-03-01 2007-04-27 Servier Lab Utilisation de derives de la diosmetine pour le traitement et la prevention des pathologies thrombotiques
FR2929276B1 (fr) * 2008-04-01 2010-04-23 Servier Lab Nouveaux derives de diosmetine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MX2018010993A (es) * 2016-03-11 2019-01-17 H Lee Moffitt Cancer Ct & Res Derivados de icariina e icaritina.
CN109280067B (zh) * 2017-07-21 2022-07-05 南京正大天晴制药有限公司 香叶木苷衍生物、其制备方法以及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB928150A (en) * 1961-02-08 1963-06-06 Upjohn Co Topical pharmaceutical compositions comprising steroids and flavonoids
CH644374A5 (en) * 1981-05-18 1984-07-31 Espanola Prod Quimicos Water-soluble hydroxyflavone ethers and medicaments containing them
FR2623808B1 (fr) 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2701261B1 (fr) * 1993-02-05 1995-03-31 Adir Nouveaux composés glucuronides de la diosmétine, leur procédé de préparation et les compositions pharmaceutiques les renfermant.

Also Published As

Publication number Publication date
JP3076231B2 (ja) 2000-08-14
JPH08225563A (ja) 1996-09-03
CY2173B1 (en) 2002-08-23
CA2161297A1 (fr) 1996-04-27
FR2726273A1 (fr) 1996-05-03
NO954173D0 (no) 1995-10-19
FI955085A0 (fi) 1995-10-25
FI955085A (fi) 1996-04-27
NO954173L (no) 1996-04-29
CN1129701A (zh) 1996-08-28
EP0709383B1 (de) 1999-12-15
NO311132B1 (no) 2001-10-15
FI118766B (fi) 2008-03-14
DE69513935D1 (de) 2000-01-20
ZA959076B (en) 1996-05-22
GR3032168T3 (en) 2000-04-27
EP0709383A1 (de) 1996-05-01
NZ280330A (en) 1996-12-20
ATE187720T1 (de) 2000-01-15
AU693599B2 (en) 1998-07-02
CN1058494C (zh) 2000-11-15
CA2161297C (fr) 2001-10-09
FR2726273B1 (fr) 1996-12-06
AU3440495A (en) 1996-05-09
US5629339A (en) 1997-05-13
ES2145234T3 (es) 2000-07-01
DK0709383T3 (da) 2000-04-25

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: LES LABORATOIRES SERVIER, NEUILLY SUR SEINE, FR