FI117438B - Förfarande för framställning av optiskt anrikat bupivakain - Google Patents

Förfarande för framställning av optiskt anrikat bupivakain Download PDF

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Publication number
FI117438B
FI117438B FI971711A FI971711A FI117438B FI 117438 B FI117438 B FI 117438B FI 971711 A FI971711 A FI 971711A FI 971711 A FI971711 A FI 971711A FI 117438 B FI117438 B FI 117438B
Authority
FI
Finland
Prior art keywords
bupivacaine
water
optically enriched
tartaric acid
levobupivacaine
Prior art date
Application number
FI971711A
Other languages
English (en)
Finnish (fi)
Other versions
FI971711A (sv
FI971711A0 (sv
Inventor
Marianne Langston
Benjamin Mark Skead
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9421476A external-priority patent/GB9421476D0/en
Priority claimed from GBGB9504926.8A external-priority patent/GB9504926D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Publication of FI971711A publication Critical patent/FI971711A/sv
Publication of FI971711A0 publication Critical patent/FI971711A0/sv
Application granted granted Critical
Publication of FI117438B publication Critical patent/FI117438B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (8)

1. Förfarande för framställning av optiskt anrikat t bupivakain, vid vilket förfarande bupivakainet bringas att 5 reagera med ett vinsyra-resolveringsmedel i ett med vatten j blandbart organiskt lösningsmedium, kanne tecknat av att mediet innehäller 1 - 20 % vatten.
2. Förfarande enligt patentkrav 1, känneteck-nat av att mängden resolveringsmedel är under 0,5 ekviva- 10 lenter per en molekvivalent bupivakain.
3. Förfarande enligt patentkrav 2, kanne tee k-nat av att mängden resolveringsmedel är 0,2 - 0,5 molek-vivalenter per en molekvivalent bupivakain.
4. Förfarande enligt nägot av de föregäende pa-15 tentkraven, kännetecknat av att resolveringsmedlet är (S, S)-vinsyra.
5. Förfarande enligt nägot av de föregäende pa-tentkraven, kännetecknat av att lösningsmedlet omfat- tar en C; ,,-alkanol. . , ' : 20
6. Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att mediet innehäller 1 - 5. vatten. d tttm·
7. Förfarande enligt nägot av de föregäende pa- • · . tentkraven, kännetecknat av att det ytterligare om- ;i ,, * 25 fattar konversion av det optiskt anrikade bupivakainet ; " tili ett hydrokloridsalt.
* * 8. Förfarande enligt nägot av de föregäende pa- ·* :’·* tentkraven, kännetecknat av att man framställer levo- • · · ί.ί ί bupivakain. • · · • · · ΐ • · ♦ • · • · • · · • · · » · • · ' • ♦ · • · ... • » ...··* • · · • ·· • · ’ V • ♦ *·* ··*·· • * .
FI971711A 1994-10-25 1997-04-22 Förfarande för framställning av optiskt anrikat bupivakain FI117438B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB9421476A GB9421476D0 (en) 1994-10-25 1994-10-25 Process and salt
GB9421476 1994-10-25
GBGB9504926.8A GB9504926D0 (en) 1995-03-10 1995-03-10 Crystallisation
GB9504926 1995-03-10
PCT/GB1995/002513 WO1996012699A1 (en) 1994-10-25 1995-10-23 Crystallisation of levobupivacaine and analogues thereof
GB9502513 1995-10-23

Publications (3)

Publication Number Publication Date
FI971711A FI971711A (sv) 1997-04-22
FI971711A0 FI971711A0 (sv) 1997-04-22
FI117438B true FI117438B (sv) 2006-10-13

Family

ID=26305863

Family Applications (1)

Application Number Title Priority Date Filing Date
FI971711A FI117438B (sv) 1994-10-25 1997-04-22 Förfarande för framställning av optiskt anrikat bupivakain

Country Status (16)

Country Link
US (1) US5994548A (sv)
EP (1) EP0788480B1 (sv)
JP (1) JP3911545B2 (sv)
AT (1) ATE245629T1 (sv)
AU (1) AU698637B2 (sv)
CA (1) CA2200355C (sv)
DE (1) DE69531356T2 (sv)
DK (1) DK0788480T3 (sv)
ES (1) ES2202375T3 (sv)
FI (1) FI117438B (sv)
HU (1) HU227420B1 (sv)
MX (1) MX9703024A (sv)
NO (1) NO309266B1 (sv)
PL (1) PL183210B1 (sv)
PT (1) PT788480E (sv)
WO (1) WO1996012699A1 (sv)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0002246A (pt) 2000-04-06 2003-04-15 Cristalia Prod Quimicos Farm Processo de obtenção dos enantiÈmeros da bupivacaìna racêmica, processo de obtenção de composições farmacêuticas a base de levobupivacaìna: composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis e utilização das composições farmacêuticas a base de levobupivacaìna formuladas nas formas básicas ou sais farmaceuticamente aceitáveis
BRPI0104491B8 (pt) * 2001-10-10 2021-05-25 Cristalia Produtos Quim Farmaceuticos Ltda n-(2,6-dimetilfenil)-1-propil-2-piperidinocarboxamida; processo de obtenção dos enantiômeros; mistura não racêmica dos anantiômeros e seu processo de obtenção e composição farmacêutica.
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK1575569T3 (da) 2002-12-13 2011-01-10 Durect Corp Oralt indgivelsessystem omfattende flydende bærematerialer med høj viskositet
US6790267B1 (en) * 2003-04-24 2004-09-14 Xerox Corporation Colorant compositions
US7094812B2 (en) * 2003-04-24 2006-08-22 Xerox Corporations Colorant compositions
EA014852B1 (ru) 2004-09-17 2011-02-28 Дьюрект Корпорейшн Система контролируемой доставки
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20090187024A1 (en) * 2006-04-25 2009-07-23 Dishman Pharmaceuticals And Chemicals Ltd. Ropivacaine hydrochloride anhydrate and the preparation thereof
PT2117521E (pt) 2006-11-03 2012-09-10 Durect Corp Sistemas de administração transdérmica que compreendem bupivacaína
AU2008347158B8 (en) 2007-12-06 2013-08-22 Durect Corporation Oral pharmaceutical dosage forms
ATE555093T1 (de) * 2008-01-15 2012-05-15 Pharmathen Sa Verfahren zur herstellung einer (s)-1-alkyl-2i,6i-pipecoloxylididverbindung
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
CN103073484B (zh) * 2013-01-28 2014-10-22 山东诚创医药技术开发有限公司 一种甲哌卡因及其光学对映体的制备方法
CN105120659A (zh) 2013-03-15 2015-12-02 度瑞公司 用于降低溶解可变性的具有流变改性剂的组合物
US11000487B2 (en) * 2016-12-26 2021-05-11 Cellix Bio Private Limited Compositions and methods for the treatment of chronic pain
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE341404B (sv) * 1967-05-18 1971-12-27 Sterling Drug Inc
US4695576A (en) * 1984-07-09 1987-09-22 Astra Lake Medel Aktiebolag L-N-n-propylpipecolic acid-2,6-xylidide

Also Published As

Publication number Publication date
HUT77631A (hu) 1998-06-29
NO309266B1 (no) 2001-01-08
ATE245629T1 (de) 2003-08-15
AU3704895A (en) 1996-05-15
US5994548A (en) 1999-11-30
CA2200355A1 (en) 1996-05-02
HU227420B1 (en) 2011-05-30
EP0788480B1 (en) 2003-07-23
CA2200355C (en) 2007-03-06
ES2202375T3 (es) 2004-04-01
AU698637B2 (en) 1998-11-05
PL319829A1 (en) 1997-09-01
MX9703024A (es) 1997-10-31
FI971711A (sv) 1997-04-22
PT788480E (pt) 2003-12-31
WO1996012699A1 (en) 1996-05-02
DK0788480T3 (da) 2003-09-29
FI971711A0 (sv) 1997-04-22
NO971903D0 (no) 1997-04-24
EP0788480A1 (en) 1997-08-13
JPH10507464A (ja) 1998-07-21
DE69531356D1 (de) 2003-08-28
JP3911545B2 (ja) 2007-05-09
DE69531356T2 (de) 2004-05-27
NO971903L (no) 1997-04-24
PL183210B1 (pl) 2002-06-28

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