FI115050B - Menetelmä terapeuttisesti käyttökelpoisten gastriini- ja CCK-reseptoriligandien valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten gastriini- ja CCK-reseptoriligandien valmistamiseksi Download PDFInfo
- Publication number
- FI115050B FI115050B FI960572A FI960572A FI115050B FI 115050 B FI115050 B FI 115050B FI 960572 A FI960572 A FI 960572A FI 960572 A FI960572 A FI 960572A FI 115050 B FI115050 B FI 115050B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- dicarboxyphenylaminocarbonyl
- ethylaminocarbonyl
- adamantane
- benzimidazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9316608 | 1993-08-10 | ||
GB939316608A GB9316608D0 (en) | 1993-08-10 | 1993-08-10 | Gastrin and cck receptor ligands |
GB9410688A GB9410688D0 (en) | 1993-08-10 | 1994-05-27 | Gastrin and CCK receptor ligands |
GB9410688 | 1994-05-27 | ||
GB9401741 | 1994-08-09 | ||
PCT/GB1994/001741 WO1995004720A2 (en) | 1993-08-10 | 1994-08-09 | Gastrin and cck receptor ligands |
Publications (3)
Publication Number | Publication Date |
---|---|
FI960572A FI960572A (fi) | 1996-02-07 |
FI960572A0 FI960572A0 (fi) | 1996-02-07 |
FI115050B true FI115050B (fi) | 2005-02-28 |
Family
ID=26303354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI960572A FI115050B (fi) | 1993-08-10 | 1996-02-07 | Menetelmä terapeuttisesti käyttökelpoisten gastriini- ja CCK-reseptoriligandien valmistamiseksi |
Country Status (18)
Country | Link |
---|---|
US (1) | US5919829A (hu) |
EP (1) | EP0720601B1 (hu) |
JP (1) | JP3980052B2 (hu) |
AT (1) | ATE197146T1 (hu) |
AU (1) | AU682051B2 (hu) |
CA (1) | CA2167154A1 (hu) |
DE (1) | DE69426205T2 (hu) |
DK (1) | DK0720601T3 (hu) |
ES (1) | ES2152989T3 (hu) |
FI (1) | FI115050B (hu) |
GR (1) | GR3035100T3 (hu) |
HU (1) | HU222178B1 (hu) |
NO (1) | NO306945B1 (hu) |
NZ (1) | NZ269827A (hu) |
PL (1) | PL181782B1 (hu) |
PT (1) | PT720601E (hu) |
SG (1) | SG52229A1 (hu) |
WO (1) | WO1995004720A2 (hu) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5912260A (en) * | 1994-05-27 | 1999-06-15 | James Black Foundation Limited | Gastrin and CCK antagonists |
WO1998002419A1 (fr) * | 1996-07-12 | 1998-01-22 | Chugai Seiyaku Kabushiki Kaisha | Inhibiteurs de proliferation de cellules cancereuses |
US6747027B1 (en) | 1996-07-22 | 2004-06-08 | Pharmacia Corporation | Thiol sulfonamide metalloprotease inhibitors |
IL128079A0 (en) * | 1996-07-22 | 1999-11-30 | Monsanto Co | Thiol sulfone metalloprotease inhibitors |
SE9704544D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
SE9704545D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
AU9297998A (en) * | 1998-05-15 | 1999-12-06 | Guilford Pharmaceuticals Inc. | Carboxamide compounds, compositions, and methods for inhibiting parp activity |
PL347591A1 (en) | 1998-11-09 | 2002-04-08 | Gastrin and cholecystokinin receptor ligands | |
US6800646B1 (en) | 1999-02-08 | 2004-10-05 | Pharmacia Corporation | Sulfamato hydroxamic acid metalloprotease inhibitor |
BR0009651A (pt) | 1999-04-09 | 2002-01-08 | Astrazeneca Ab | Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto, e, método para tratar artrite reumatóide e uma doença obstrutiva das vias aéreas |
WO2000063171A1 (fr) | 1999-04-20 | 2000-10-26 | Meiji Seika Kaisha, Ltd. | Composes tricycliques |
US7045287B2 (en) * | 1999-07-20 | 2006-05-16 | Agilent Technologies, Inc. | Method for contacting fluid components with moieties on a surface |
SE9904505D0 (sv) | 1999-12-09 | 1999-12-09 | Astra Pharma Prod | Novel compounds |
TWI258462B (en) | 1999-12-17 | 2006-07-21 | Astrazeneca Ab | Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same |
GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
SE0103836D0 (sv) | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
SE0200920D0 (sv) * | 2002-03-25 | 2002-03-25 | Astrazeneca Ab | Novel compounds |
JP2005537228A (ja) | 2002-04-25 | 2005-12-08 | ファルマシア・コーポレーション | ピペリジニル−及びピペラジニル−スルホニルメチルヒドロキサム酸並びにプロテアーゼ阻害剤としてのその使用 |
UA79804C2 (en) * | 2002-07-03 | 2007-07-25 | Janssen Pharmaceutica Nv | Cck-1 receptor modulators |
SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
DE602004015614D1 (de) * | 2003-08-08 | 2008-09-18 | Janssen Pharmaceutica Nv | 2- (chinoxalin-5-ylsulfonylamino) -benzamidverbindungen als cck2-modulatoren |
WO2006040329A1 (en) * | 2004-10-12 | 2006-04-20 | Novo Nordisk A/S | 1 ibeta- hydroxysteroid dehydrogenase type 1 active spiro compounds |
WO2006095922A1 (ja) * | 2005-03-10 | 2006-09-14 | Kyoto Pharmaceutical Industries, Ltd. | テトラヒドロイソキノリン化合物およびその医薬用途 |
WO2007051811A2 (en) * | 2005-11-01 | 2007-05-10 | Transtech Pharma | Pharmaceutical use of substituted amides |
EA200801243A1 (ru) * | 2005-11-01 | 2008-10-30 | Транстек Фарма | Фармацевтическое применение замещенных амидов |
JP2009530346A (ja) * | 2006-03-21 | 2009-08-27 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | メタボリックシンドロームの治療用のアダマンタン誘導体 |
KR20090014347A (ko) | 2006-04-07 | 2009-02-10 | 하이 포인트 파마슈티칼스, 엘엘씨 | 11β-히드록시스테로이드 탈수소효소 타입 1 활성 화합물 |
CA2655282A1 (en) * | 2006-06-16 | 2007-12-21 | High Point Pharmaceuticals, Llc | Pharmaceutical use of substituted piperidine carboxamides |
EP1878721A1 (en) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamides as 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors |
EP2044073A1 (en) * | 2006-07-13 | 2009-04-08 | High Point Pharmaceuticals, LLC | 11beta-hydroxysteroid dehydrogenase type 1 active compounds |
WO2008101886A1 (en) * | 2007-02-23 | 2008-08-28 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
ZA200904916B (en) | 2007-02-23 | 2010-09-29 | High Point Pharmaceuticals Llc | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
JP2010519242A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規化合物 |
EP2146952A1 (en) * | 2007-02-23 | 2010-01-27 | High Point Pharmaceuticals, LLC | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
KR20100015414A (ko) * | 2007-03-09 | 2010-02-12 | 하이 포인트 파마슈티칼스, 엘엘씨 | 히드록시스테로이드 탈수소효소 억제제로서 인돌- 및 벤즈이미다졸 아미드 |
JP2010522227A (ja) | 2007-03-22 | 2010-07-01 | アストラゼネカ・アクチエボラーグ | 炎症性疾患の処置のためのキノリン誘導体 |
JP2010522766A (ja) * | 2007-03-28 | 2010-07-08 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 11ベータ−hsd1活性化合物 |
WO2008127924A1 (en) * | 2007-04-11 | 2008-10-23 | High Point Pharmaceuticals, Llc. | Novel compounds |
EP2150109B1 (en) * | 2007-04-24 | 2012-09-19 | High Point Pharmaceuticals, LLC | Pharmaceutical use of substituted amides |
US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
CN102223797A (zh) * | 2008-11-21 | 2011-10-19 | 高点制药有限责任公司 | 金刚烷基苯甲酰胺化合物 |
CN114369040B (zh) * | 2022-03-21 | 2022-07-05 | 广州同隽医药科技有限公司 | 2-(3-(对羟苯基)-丙酰胺基)-苯甲酸葡糖胺盐及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4343804A (en) * | 1979-03-26 | 1982-08-10 | A. H. Robins Company, Inc. | 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory anti-ulcer compounds |
US4757151A (en) * | 1985-11-14 | 1988-07-12 | Warner-Lambert Company | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
CA1326108C (en) * | 1988-04-12 | 1994-01-11 | Sun Hyuk Kim | Cck antagonists |
KR920701162A (ko) * | 1990-03-28 | 1992-08-11 | 오츠카 아끼히코 | 퀴놀린 유도체, 당해 유도체를 함유하는 항궤양제 및 당해 유도체의 제조방법 |
US5217957A (en) * | 1991-08-20 | 1993-06-08 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
GB9206757D0 (en) * | 1992-03-27 | 1992-05-13 | Ferring Bv | Novel peptide receptor ligands |
US5795907A (en) * | 1994-05-27 | 1998-08-18 | James Black Foundation Limited | Gastin and CCK receptor ligands |
-
1994
- 1994-08-09 AT AT94922318T patent/ATE197146T1/de not_active IP Right Cessation
- 1994-08-09 PT PT94922318T patent/PT720601E/pt unknown
- 1994-08-09 WO PCT/GB1994/001741 patent/WO1995004720A2/en active IP Right Grant
- 1994-08-09 JP JP50630695A patent/JP3980052B2/ja not_active Expired - Lifetime
- 1994-08-09 CA CA002167154A patent/CA2167154A1/en not_active Abandoned
- 1994-08-09 PL PL94312960A patent/PL181782B1/pl not_active IP Right Cessation
- 1994-08-09 EP EP94922318A patent/EP0720601B1/en not_active Expired - Lifetime
- 1994-08-09 DK DK94922318T patent/DK0720601T3/da active
- 1994-08-09 HU HU9600070A patent/HU222178B1/hu active IP Right Grant
- 1994-08-09 DE DE69426205T patent/DE69426205T2/de not_active Expired - Fee Related
- 1994-08-09 AU AU73478/94A patent/AU682051B2/en not_active Ceased
- 1994-08-09 NZ NZ269827A patent/NZ269827A/en not_active IP Right Cessation
- 1994-08-09 SG SG1996000865A patent/SG52229A1/en unknown
- 1994-08-09 ES ES94922318T patent/ES2152989T3/es not_active Expired - Lifetime
-
1996
- 1996-02-06 NO NO960488A patent/NO306945B1/no unknown
- 1996-02-07 FI FI960572A patent/FI115050B/fi active IP Right Grant
-
1998
- 1998-04-23 US US09/064,849 patent/US5919829A/en not_active Expired - Fee Related
-
2000
- 2000-12-18 GR GR20000402788T patent/GR3035100T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NZ269827A (en) | 1996-10-28 |
PL181782B1 (pl) | 2001-09-28 |
HU9600070D0 (en) | 1996-03-28 |
NO306945B1 (no) | 2000-01-17 |
PL312960A1 (en) | 1996-05-27 |
GR3035100T3 (en) | 2001-03-30 |
HU222178B1 (hu) | 2003-04-28 |
CA2167154A1 (en) | 1995-02-16 |
US5919829A (en) | 1999-07-06 |
WO1995004720A3 (en) | 1995-08-03 |
AU682051B2 (en) | 1997-09-18 |
WO1995004720A2 (en) | 1995-02-16 |
DE69426205T2 (de) | 2001-03-08 |
FI960572A (fi) | 1996-02-07 |
ES2152989T3 (es) | 2001-02-16 |
JP3980052B2 (ja) | 2007-09-19 |
EP0720601B1 (en) | 2000-10-25 |
DK0720601T3 (da) | 2000-11-20 |
HUT75301A (en) | 1997-05-28 |
EP0720601A1 (en) | 1996-07-10 |
JPH09502430A (ja) | 1997-03-11 |
SG52229A1 (en) | 1998-09-28 |
FI960572A0 (fi) | 1996-02-07 |
AU7347894A (en) | 1995-02-28 |
NO960488L (no) | 1996-03-15 |
NO960488D0 (no) | 1996-02-06 |
DE69426205D1 (de) | 2000-11-30 |
ATE197146T1 (de) | 2000-11-15 |
PT720601E (pt) | 2001-02-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI115050B (fi) | Menetelmä terapeuttisesti käyttökelpoisten gastriini- ja CCK-reseptoriligandien valmistamiseksi | |
US5795907A (en) | Gastin and CCK receptor ligands | |
US5939437A (en) | CCK and gastrin receptor ligands | |
AU679085B2 (en) | Benzodiazepine analogs | |
KR100364948B1 (ko) | 콜레시스토키닌길항활성또는작용활성을갖는1,5-벤조디아제핀유도체 | |
AU640113B2 (en) | Benzodiazepine analogs | |
US5912260A (en) | Gastrin and CCK antagonists | |
US4663321A (en) | Triazolobenzodiazepines and pharmaceutical use | |
CA2032427A1 (en) | Benzodiazepines analogs | |
US5166151A (en) | 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof | |
JPH05255279A (ja) | コレシストキニン拮抗薬 | |
US5302591A (en) | Benzodiazepine derivatives | |
AU3509793A (en) | Bicyclo(2.2.2.)octane derivatives as cholestocystokinin inhibitors | |
US4847248A (en) | 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists | |
US5514683A (en) | Bicyclo 2,2,2!octane derivatives | |
HRP980258A2 (en) | New triazole derivatives, process for the preparation thereof and pharmaceutical preparations containing them | |
EP0719251B1 (en) | Bicyclo (2.2.2) octane derivatives cholecystokinin and/or gastrin antagonists | |
US5319096A (en) | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use | |
PT98842B (pt) | Processo para a preparacao de derivados de fenilalanina e de fenetilamina n-substituidos com cicloalquilo e policicloalquilo, alfa-substituidos com arilo e heteroarilo e de composicoes farmaceuticas que os contem | |
CA2065703A1 (en) | Cholecystokinin antagonists | |
US4735941A (en) | 1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents | |
US5378838A (en) | Benzodiazepine cholecystokinin antagonists | |
US5223509A (en) | β-carbolines as cholecystokinin and gastrin antagonists | |
KR100299419B1 (ko) | 가스트린및cck수용체리간드 | |
GB2268739A (en) | Bicyclo [2.2.2.] octene derivatives |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Patent granted |
Ref document number: 115050 Country of ref document: FI |