FI114444B - Förfarande för framställning av ett transdermalt preparat innehållande ett verksamt ämne - Google Patents

Förfarande för framställning av ett transdermalt preparat innehållande ett verksamt ämne Download PDF

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Publication number
FI114444B
FI114444B FI954990A FI954990A FI114444B FI 114444 B FI114444 B FI 114444B FI 954990 A FI954990 A FI 954990A FI 954990 A FI954990 A FI 954990A FI 114444 B FI114444 B FI 114444B
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FI
Finland
Prior art keywords
tocopherol
preparation
active ingredient
skin
diclofenac
Prior art date
Application number
FI954990A
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English (en)
Finnish (fi)
Other versions
FI954990A (sv
FI954990A0 (sv
Inventor
Wilfried Fischer
Thomas Struengmann
Original Assignee
Hexal Ag
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Publication date
Application filed by Hexal Ag filed Critical Hexal Ag
Publication of FI954990A0 publication Critical patent/FI954990A0/sv
Publication of FI954990A publication Critical patent/FI954990A/sv
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Publication of FI114444B publication Critical patent/FI114444B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Claims (6)

1. Förfarande för framställning av ett transder-malt preparat innehällande ett verksamt ämne, vilket pre- 5 parat innehäller a) fosfolipid, b) vatten, c) en alifatisk Ci-6-alkohol i en hait av 1-50 % (i förhällande tili preparatets totala massa), varvid 7,2 % 10 och mindre än dessa är uteslutna, d) α-tokoferol eller ett a-tokoferolderivat och e) ett hormon, diklofenak-Na eller heparin-Na som ett verksamt ämne, kanne tecknat av att man till ett preparat in-15 nehällande ett verksamt ämne, vilket preparat omfattar komponenterna a), b) , c) och e), tillsätter a-tokoferol eller ett a-tokoferolderivat som komponent d).
2. Förfarande enligt patentkrav 1, kännetecknat av att man tillsätter α-tokoferol eller ett a- 2. tokoferolderivat i en mängd som är mellan 0,1-10 % och : : särskilt 0,5-7 % i förhällande tili preparatets totala : massa.
, 3 . Förfarande enligt nägot av de föregäende pa- tentkraven, kännetecknat av att man tillsätter a-!*’! 25 tokoferol eller ett a-tokof erolderivat som komponent d) • I v *.Ί.' tili ett preparat innehällande ett verksamt ämne, vilket • · • · * • preparat omfattar alifatiskt C2-4-alkohol som en alifatisk Ci-6-alkohol som komponent c) eventuellt utöver nägon annan * * » ··.: alkohol. 3 0
4. Förfarande enligt nägot av de föregäende pa- * I’. tentkraven, kännetecknat av att man tillsätter a- • > » ' tokoferol eller ett a-tokof erolderivat som komponent d) • i tili ett preparat innehällande ett verksamt ämne, vilket i · ’ “ preparats fosfolipidhalt är inom omrädet 0,5-20 % i för- • » > ·...’ 35 hällande tili preparatets totala massa. 1 1 4444
5. Förfarande enligt nagot av de föregäende pa-tentkraven, kännetecknat av att man tillsätter a-tokoferol eller ett a-tokoferolderivat som komponent d) tili ett preparat innehallande ett verksamt ämne, vilket 5 preparat omfattar liposomer baserade pä fosfolipid.
6. Förfarande enligt nagot av de föregäende pa-tentkraven, kännetecknat av att det transdermala pre-paratet innehallande ett verksamt ämne framställs som salva, gel eller spray. « * · * · • · * I * « ' » • > • > » • · • » · · tl· I t ·
FI954990A 1993-04-23 1995-10-19 Förfarande för framställning av ett transdermalt preparat innehållande ett verksamt ämne FI114444B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4313402 1993-04-23
DE4313402A DE4313402A1 (de) 1993-04-23 1993-04-23 Transdermale Wirkstoffzubereitung
PCT/EP1994/001259 WO1994025069A1 (de) 1993-04-23 1994-04-22 Transdermale wirkstoffzubereitung
EP9401259 1994-04-22

Publications (3)

Publication Number Publication Date
FI954990A0 FI954990A0 (sv) 1995-10-19
FI954990A FI954990A (sv) 1995-11-23
FI114444B true FI114444B (sv) 2004-10-29

Family

ID=6486248

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954990A FI114444B (sv) 1993-04-23 1995-10-19 Förfarande för framställning av ett transdermalt preparat innehållande ett verksamt ämne

Country Status (13)

Country Link
US (1) US5738869A (sv)
EP (1) EP0695193B1 (sv)
JP (1) JP4334613B2 (sv)
AT (1) ATE176593T1 (sv)
AU (1) AU6721094A (sv)
DE (2) DE4313402A1 (sv)
DK (1) DK0695193T3 (sv)
ES (1) ES2130420T3 (sv)
FI (1) FI114444B (sv)
GR (1) GR3029963T3 (sv)
NO (1) NO311919B1 (sv)
WO (1) WO1994025069A1 (sv)
ZA (1) ZA942848B (sv)

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DE19945522A1 (de) * 1999-09-23 2001-04-05 Hexal Ag Pharmazeutisches, wirkstoffhaltiges Gel
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DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10137082A1 (de) * 2001-07-28 2003-02-13 Hexal Ag Matrixkontrolliertes transdermales therapeutisches System zur Anwendung von Pramiprexol und Ropinirol
US20040224010A1 (en) * 2002-11-15 2004-11-11 Optime Therapeutics, Inc. Ophthalmic liposome compositions and uses thereof
US6936273B2 (en) * 2002-12-20 2005-08-30 Idexx Laboratories, Inc. Liposomal analgesic formulation and use
ES2301886T3 (es) * 2002-12-20 2008-07-01 Idexx Laboratories, Inc. Formulacion analgesica liposomal que comprende diclofenac y su uso para tratamiento de caballos.
US9000040B2 (en) 2004-09-28 2015-04-07 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
EP1812022B1 (en) 2004-09-28 2014-01-15 Atrium Medical Corporation Stand-alone film and methods for making the same
US9012506B2 (en) 2004-09-28 2015-04-21 Atrium Medical Corporation Cross-linked fatty acid-based biomaterials
EP1863435B1 (en) * 2005-03-31 2016-11-02 Unilever PLC Enhanced delivery of skin benefit agents
US9278161B2 (en) 2005-09-28 2016-03-08 Atrium Medical Corporation Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) 2009-03-10 2016-08-30 Atrium Medical Corporation Fatty-acid based particles
DK2086504T3 (da) 2006-10-17 2014-04-07 Nuvo Res Inc Diclofenac-gel
JP5371235B2 (ja) * 2006-12-06 2013-12-18 ロート製薬株式会社 皮膚外用剤
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Also Published As

Publication number Publication date
DE59407810D1 (de) 1999-03-25
ZA942848B (en) 1995-10-25
JP4334613B2 (ja) 2009-09-30
AU6721094A (en) 1994-11-21
EP0695193A1 (de) 1996-02-07
DK0695193T3 (da) 1999-09-20
GR3029963T3 (en) 1999-07-30
NO954215L (no) 1995-12-14
FI954990A (sv) 1995-11-23
DE4313402A1 (de) 1994-10-27
US5738869A (en) 1998-04-14
ES2130420T3 (es) 1999-07-01
NO311919B1 (no) 2002-02-18
FI954990A0 (sv) 1995-10-19
ATE176593T1 (de) 1999-02-15
EP0695193B1 (de) 1999-02-10
NO954215D0 (no) 1995-10-20
WO1994025069A1 (de) 1994-11-10
JPH08509715A (ja) 1996-10-15

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