FI114102B - Förfarande för att framställa en plasminogenanalog som spjälks under effekten av trombin - Google Patents

Förfarande för att framställa en plasminogenanalog som spjälks under effekten av trombin Download PDF

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Publication number
FI114102B
FI114102B FI952071A FI952071A FI114102B FI 114102 B FI114102 B FI 114102B FI 952071 A FI952071 A FI 952071A FI 952071 A FI952071 A FI 952071A FI 114102 B FI114102 B FI 114102B
Authority
FI
Finland
Prior art keywords
vektor
plasminogen
cys
som
gly
Prior art date
Application number
FI952071A
Other languages
English (en)
Finnish (fi)
Other versions
FI952071A0 (sv
FI952071A (sv
Inventor
Keith Martyn Dawson
Michael George Hunter
Richard James Gilbert
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Publication of FI952071A0 publication Critical patent/FI952071A0/sv
Publication of FI952071A publication Critical patent/FI952071A/sv
Application granted granted Critical
Publication of FI114102B publication Critical patent/FI114102B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
FI952071A 1992-10-29 1995-04-28 Förfarande för att framställa en plasminogenanalog som spjälks under effekten av trombin FI114102B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929222758A GB9222758D0 (en) 1992-10-29 1992-10-29 Proteins and nucleic acids
GB9222758 1992-10-29
GB9302219 1993-10-28
PCT/GB1993/002219 WO1994010318A1 (en) 1992-10-29 1993-10-28 Thrombin activatable plasminogen derivatives

Publications (3)

Publication Number Publication Date
FI952071A0 FI952071A0 (sv) 1995-04-28
FI952071A FI952071A (sv) 1995-04-28
FI114102B true FI114102B (sv) 2004-08-13

Family

ID=10724266

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952071A FI114102B (sv) 1992-10-29 1995-04-28 Förfarande för att framställa en plasminogenanalog som spjälks under effekten av trombin

Country Status (15)

Country Link
EP (1) EP0666920B1 (sv)
JP (1) JP3329340B2 (sv)
AT (1) ATE171213T1 (sv)
AU (1) AU674180B2 (sv)
CA (1) CA2145749C (sv)
DE (1) DE69321134T2 (sv)
DK (1) DK0666920T3 (sv)
ES (1) ES2123669T3 (sv)
FI (1) FI114102B (sv)
GB (1) GB9222758D0 (sv)
HK (1) HK1008047A1 (sv)
NO (1) NO317661B1 (sv)
NZ (1) NZ257175A (sv)
WO (1) WO1994010318A1 (sv)
ZA (1) ZA938120B (sv)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
BR9711015A (pt) * 1996-08-02 1999-08-17 Boehringer Mannheim Gmbh Ativador de plasminog-nio capaz de ser ativado por trombina
DK1343903T3 (da) 2000-12-21 2008-03-10 Thrombogenics Nv En gærekspressionsvektor og en fremgangsmåde til fremstilling af et rekombinant protein ved ekspression i en gærcelle
WO2003066842A2 (de) * 2002-02-06 2003-08-14 Trommsdorff Gmbh & Co. Kg Arzneimittel Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen
FR2841904B1 (fr) * 2002-07-03 2004-08-20 Inst Nat Sante Rech Med Analogues de facteurs x clivables par la thrombine
PL213309B1 (pl) 2006-02-09 2013-02-28 Polska Akademia Nauk Inst Biochemii I Biofizyki Sposób hydrolizy wiazania peptydowego

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
DK0666920T3 (da) 1999-06-14
ES2123669T3 (es) 1999-01-16
NO951648D0 (no) 1995-04-28
ZA938120B (en) 1994-08-01
HK1008047A1 (en) 1999-04-30
NZ257175A (en) 1996-07-26
DE69321134T2 (de) 1999-02-25
ATE171213T1 (de) 1998-10-15
FI952071A0 (sv) 1995-04-28
EP0666920B1 (en) 1998-09-16
JPH08504575A (ja) 1996-05-21
GB9222758D0 (en) 1992-12-09
JP3329340B2 (ja) 2002-09-30
NO317661B1 (no) 2004-11-29
NO951648L (no) 1995-04-28
FI952071A (sv) 1995-04-28
AU5343294A (en) 1994-05-24
CA2145749C (en) 2005-06-21
CA2145749A1 (en) 1994-05-11
AU674180B2 (en) 1996-12-12
WO1994010318A1 (en) 1994-05-11
EP0666920A1 (en) 1995-08-16
DE69321134D1 (de) 1998-10-22

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