FI113543B - Menetelmä uuden terapeuttisesti käyttökelpoisen 16alfa,17-(22R,S)-sykloheksyylimetyleenidioksi-11beta,21-dihydroksipregna-1,4-dieeni-3,20-dionin ja sen epimeerien valmistamiseksi - Google Patents
Menetelmä uuden terapeuttisesti käyttökelpoisen 16alfa,17-(22R,S)-sykloheksyylimetyleenidioksi-11beta,21-dihydroksipregna-1,4-dieeni-3,20-dionin ja sen epimeerien valmistamiseksiInfo
- Publication number
- FI113543B FI113543B FI954579A FI954579A FI113543B FI 113543 B FI113543 B FI 113543B FI 954579 A FI954579 A FI 954579A FI 954579 A FI954579 A FI 954579A FI 113543 B FI113543 B FI 113543B
- Authority
- FI
- Finland
- Prior art keywords
- cyclohexylmethylenedioxy
- dihydroxypregna
- 16alpha
- 11beta
- epimers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH102393 | 1993-04-02 | ||
PCT/EP1994/001015 WO1994022899A1 (de) | 1993-04-02 | 1994-03-31 | Neue prednisolonderivate |
Publications (3)
Publication Number | Publication Date |
---|---|
FI954579A0 FI954579A0 (fi) | 1995-09-27 |
FI954579A FI954579A (fi) | 1995-09-27 |
FI113543B true FI113543B (fi) | 2004-05-14 |
Family
ID=4200650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI954579A FI113543B (fi) | 1993-04-02 | 1995-09-27 | Menetelmä uuden terapeuttisesti käyttökelpoisen 16alfa,17-(22R,S)-sykloheksyylimetyleenidioksi-11beta,21-dihydroksipregna-1,4-dieeni-3,20-dionin ja sen epimeerien valmistamiseksi |
Country Status (21)
Country | Link |
---|---|
US (1) | US5733901A (sk) |
EP (1) | EP0701565B1 (sk) |
JP (1) | JP3333210B2 (sk) |
KR (1) | KR100330941B1 (sk) |
CN (1) | CN1062869C (sk) |
AT (1) | ATE172739T1 (sk) |
AU (1) | AU683463B2 (sk) |
BG (1) | BG62491B1 (sk) |
CZ (1) | CZ287877B6 (sk) |
DE (1) | DE59407183D1 (sk) |
DK (1) | DK0701565T3 (sk) |
ES (1) | ES2124884T3 (sk) |
FI (1) | FI113543B (sk) |
HU (1) | HU220868B1 (sk) |
NO (1) | NO305990B1 (sk) |
NZ (1) | NZ265054A (sk) |
PL (1) | PL179489B1 (sk) |
RU (1) | RU2132854C1 (sk) |
SK (1) | SK281226B6 (sk) |
UA (1) | UA45311C2 (sk) |
WO (1) | WO1994022899A1 (sk) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19635498A1 (de) * | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
JP4456811B2 (ja) * | 2000-11-10 | 2010-04-28 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ケタール交換反応による、16,17−[(シクロヘキシルメチレン)ビス(オキシ)]−11,12−ジヒドロキシ−プレグナ−1,4−ジエン−3,20−ジオンまたはその21−イソブチレートの製造方法 |
DE10055820C1 (de) * | 2000-11-10 | 2002-07-25 | Byk Gulden Lomberg Chem Fab | Verfahren zur Herstellung eines Glucocorticoids |
PL373433A1 (en) | 2002-08-30 | 2005-08-22 | Altana Pharma Ag | The use of the combination of ciclesonide and antihistamines for the treatment of allergic rhinitis |
AU2003293833B2 (en) * | 2002-12-12 | 2009-10-01 | Covis Pharma B.V. | Combination medicament |
MY143936A (en) * | 2003-03-27 | 2011-07-29 | Nycomed Gmbh | Process for preparing crystalline ciclesonide with defined particle size |
WO2004110460A1 (en) | 2003-06-13 | 2004-12-23 | Altana Pharma Ag | Formoterol and ciclesonide combination |
WO2005025577A1 (en) * | 2003-09-15 | 2005-03-24 | Altana Pharma Ag | Use of ciclesonide for the treatment of inflammatory bowel diseases |
ES2452691T5 (es) | 2003-09-16 | 2022-09-14 | Covis Pharma Gmbh | Uso de ciclesonida para el tratamiento de enfermedades respiratorias |
PE20050941A1 (es) | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
AU2005235384B2 (en) * | 2004-04-20 | 2010-09-09 | Covis Pharma B.V. | Use of ciclesonide for the treatment of respiratory diseases in a smoking patient |
JP2008512428A (ja) * | 2004-09-10 | 2008-04-24 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | シクレソニドとSykインヒビターとの組合せ物並びにその使用方法 |
CN100345864C (zh) * | 2004-10-29 | 2007-10-31 | 天津药业研究院有限公司 | 一种治疗呼吸道疾病的甾体药物的制备方法及其中间体 |
US20100209508A1 (en) * | 2005-06-14 | 2010-08-19 | Corus Pharma, Inc. | Substituted Phenylphosphates as Mutual Prodrugs of Steroids and ß-Agonists for the Treatment of Title Pulmonary Inflammation and Bronchoconstriction |
WO2007054974A2 (en) * | 2005-09-28 | 2007-05-18 | Arch Pharmalab Limited | A green chemistry process for the preparation of pregnadiene esters |
WO2008015696A2 (en) * | 2006-05-23 | 2008-02-07 | Cadila Healthcare Limited | Process for preparing ciclesonide |
WO2008035066A2 (en) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Processes for the preparation of ciclesonide and its crystal form |
MX2010009303A (es) * | 2008-03-13 | 2010-12-02 | Farmabios Spa | Proceso para la preparacion de derivados de pregnano. |
ITMI20080645A1 (it) * | 2008-04-11 | 2009-10-12 | Ind Chimica Srl | Procedimento per la preparazione di budesonide |
EP2407476B1 (en) * | 2009-03-09 | 2014-05-07 | Mikasa Seiyaku Co,. Ltd. | Steroid compound |
WO2011135585A2 (en) | 2010-04-28 | 2011-11-03 | Cadila Healthcare Limited | Aqueous pharmaceutical solution of ciclesonide |
US9109005B2 (en) | 2012-02-23 | 2015-08-18 | Boehringer Ingelheim International Gmbh | Method for manufacturing of ciclesonide |
CN103421075B (zh) * | 2012-05-16 | 2017-07-28 | 上海特化医药科技有限公司 | 孕烷衍生物16,17‑缩醛(酮)的制备方法 |
MY194619A (en) | 2016-06-02 | 2022-12-07 | Abbvie Inc | Glucocorticoid receptor agonist and immunoconjugates thereof |
PT3658192T (pt) | 2017-12-01 | 2021-06-25 | Abbvie Inc | Agonista recetor de glucocorticóide e imunoconjugados do mesmo |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
GB1382614A (en) * | 1972-01-10 | 1975-02-05 | Squibb & Sons Inc | Steroid compositions |
IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
-
1994
- 1994-03-31 AU AU65381/94A patent/AU683463B2/en not_active Expired
- 1994-03-31 CZ CZ19952529A patent/CZ287877B6/cs not_active IP Right Cessation
- 1994-03-31 HU HU9502819A patent/HU220868B1/hu unknown
- 1994-03-31 WO PCT/EP1994/001015 patent/WO1994022899A1/de active IP Right Grant
- 1994-03-31 RU RU95119827A patent/RU2132854C1/ru active
- 1994-03-31 PL PL94311474A patent/PL179489B1/pl unknown
- 1994-03-31 AT AT94913100T patent/ATE172739T1/de active
- 1994-03-31 DK DK94913100T patent/DK0701565T3/da not_active Application Discontinuation
- 1994-03-31 KR KR1019950704088A patent/KR100330941B1/ko not_active IP Right Cessation
- 1994-03-31 NZ NZ265054A patent/NZ265054A/xx not_active IP Right Cessation
- 1994-03-31 SK SK1223-95A patent/SK281226B6/sk not_active IP Right Cessation
- 1994-03-31 JP JP52167794A patent/JP3333210B2/ja not_active Expired - Lifetime
- 1994-03-31 ES ES94913100T patent/ES2124884T3/es not_active Expired - Lifetime
- 1994-03-31 CN CN94191673A patent/CN1062869C/zh not_active Expired - Lifetime
- 1994-03-31 US US08/530,173 patent/US5733901A/en not_active Expired - Lifetime
- 1994-03-31 EP EP94913100A patent/EP0701565B1/de not_active Expired - Lifetime
- 1994-03-31 UA UA95094314A patent/UA45311C2/uk unknown
- 1994-03-31 DE DE59407183T patent/DE59407183D1/de not_active Expired - Lifetime
-
1995
- 1995-09-27 BG BG100032A patent/BG62491B1/bg unknown
- 1995-09-27 FI FI954579A patent/FI113543B/fi not_active IP Right Cessation
- 1995-09-29 NO NO19953861A patent/NO305990B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
SK281226B6 (sk) | 2001-01-18 |
BG100032A (bg) | 1996-05-31 |
JPH08508278A (ja) | 1996-09-03 |
PL179489B1 (pl) | 2000-09-29 |
PL311474A1 (en) | 1996-02-19 |
DK0701565T3 (da) | 1999-07-12 |
CZ252995A3 (en) | 1996-01-17 |
AU683463B2 (en) | 1997-11-13 |
SK122395A3 (en) | 1996-01-10 |
HUT72594A (en) | 1996-05-28 |
AU6538194A (en) | 1994-10-24 |
BG62491B1 (bg) | 1999-12-30 |
UA45311C2 (uk) | 2002-04-15 |
NO953861L (no) | 1995-09-29 |
EP0701565B1 (de) | 1998-10-28 |
US5733901A (en) | 1998-03-31 |
HU9502819D0 (en) | 1995-11-28 |
HU220868B1 (en) | 2002-06-29 |
ATE172739T1 (de) | 1998-11-15 |
WO1994022899A1 (de) | 1994-10-13 |
RU2132854C1 (ru) | 1999-07-10 |
NZ265054A (en) | 1997-08-22 |
NO305990B1 (no) | 1999-08-30 |
DE59407183D1 (de) | 1998-12-03 |
CZ287877B6 (cs) | 2001-03-14 |
KR100330941B1 (ko) | 2002-10-12 |
ES2124884T3 (es) | 1999-02-16 |
FI954579A0 (fi) | 1995-09-27 |
NO953861D0 (no) | 1995-09-29 |
CN1062869C (zh) | 2001-03-07 |
CN1120339A (zh) | 1996-04-10 |
FI954579A (fi) | 1995-09-27 |
EP0701565A1 (de) | 1996-03-20 |
JP3333210B2 (ja) | 2002-10-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI113543B (fi) | Menetelmä uuden terapeuttisesti käyttökelpoisen 16alfa,17-(22R,S)-sykloheksyylimetyleenidioksi-11beta,21-dihydroksipregna-1,4-dieeni-3,20-dionin ja sen epimeerien valmistamiseksi | |
RU95119827A (ru) | Новые производные преднизолона | |
EE03927B1 (et) | Meetod R-epimeeri suhtelise sisalduse suurendamiseks [11B,16a(R/S)]-16,17-[(tsükloheksüülmetüleen)bis(oksü)]-11-hüdroksü-21-(2-metüül-1-oksopropoksü)pregna-1,4-dieen-3,20-diooni R/S-epimeerses segus ja selle segu valmistamismeetod | |
NZ312303A (en) | Novel nor-pregnanes for inducing hypothalamic effects | |
IE44473L (en) | 6,9,21-trihalo pregnanes | |
HU9503578D0 (en) | Androstane steroids as neurochemical initilators of change in human hypothalamic function and related pharmaceutical compositions and methods | |
CA2258177A1 (en) | 19-nor-cholane steroids as neurochemical initiators of change in human hypothalamic function | |
AU2953602A (en) | Process for the production of 16,17-((cyclohexylmethylen)bis(oxy))-11,21-dihydroxy-pregna- 1,4-dien-3,20-dion or its 21-isobutyrat by transketalisation | |
KR970706297A (ko) | 시상하부의 효능을 유도하기 위한 신규 에스트렌류(novel estrenes for inducing hypothalamic effects) | |
GB1508745A (en) | Steroidal(16alpha,17-d)cyclohexenes | |
AU1847892A (en) | New substituted 16-methyl steroid derivatives of pregna-1,4-diene-3,20-dione, their preparation, their use in the preparation of 16-methylene steroids and new intermediates | |
IE37444B1 (en) | Novel steroids of the d-homo pregnane series | |
YU22903A (sh) | 17alfa-fluoroalkil steroidi, postupak njihove proizvodnje i farmaceutski sastavi koji sadrže ova jedinjenja | |
MX9700881A (es) | Pregnanos y colanos como indicadores neuroquimicos del cambio en la funcion hipotalamica. | |
JPS52136157A (en) | Preparation of steroid 17-esters | |
JPS51149258A (en) | A process for preparing steroid derivatives | |
GB1428347A (en) | 6alpha-, 7alpha-dihydro-3h-cyclopropa-6,7-pregna-4,6-diene- 3,15,20-trione and related compound | |
CA2159627A1 (en) | Novel prednisolone derivatives | |
FI946082A0 (fi) | Menetelmä steroidisten perasyyliglykosidien valmistamiseksi | |
MXPA03011751A (es) | Proceso para preparar 21-acetato de 11b,17a, 21-trihidroxi-6a-metilpregna-1, 4-dieno-3, 20- diona. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Transfer of assignment of patent |
Owner name: NYCOMED GMBH Free format text: NYCOMED GMBH |
|
PC | Transfer of assignment of patent |
Owner name: TAKEDA GMBH |
|
MA | Patent expired |