FI113537B - Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi Download PDFInfo
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- FI113537B FI113537B FI955709A FI955709A FI113537B FI 113537 B FI113537 B FI 113537B FI 955709 A FI955709 A FI 955709A FI 955709 A FI955709 A FI 955709A FI 113537 B FI113537 B FI 113537B
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- compound
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- iii
- halogen
- defined above
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
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- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6917893A | 1993-05-28 | 1993-05-28 | |
| US6917893 | 1993-05-28 | ||
| US9662293A | 1993-07-22 | 1993-07-22 | |
| US9662293 | 1993-07-22 | ||
| PCT/US1994/006082 WO1994027982A1 (fr) | 1993-05-28 | 1994-05-27 | Utilisation de derives de l'indolocarbozole pour traiter une affection de la prostate |
| US9406082 | 1994-05-27 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955709A0 FI955709A0 (fi) | 1995-11-27 |
| FI955709A FI955709A (fi) | 1996-01-03 |
| FI113537B true FI113537B (fi) | 2004-05-14 |
Family
ID=26749764
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955709A FI113537B (fi) | 1993-05-28 | 1995-11-27 | Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi |
| FI20031516A FI114864B (fi) | 1993-05-28 | 2003-10-16 | Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20031516A FI114864B (fi) | 1993-05-28 | 2003-10-16 | Menetelmä terapeuttisesti käyttökelpoisten indolokarbatsolijohdannaisten valmistamiseksi |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5516771A (fr) |
| EP (2) | EP0839814A3 (fr) |
| JP (2) | JP3344586B2 (fr) |
| KR (1) | KR100201343B1 (fr) |
| AT (1) | ATE165097T1 (fr) |
| AU (1) | AU679752B2 (fr) |
| CA (1) | CA2163904C (fr) |
| DE (1) | DE69409641T2 (fr) |
| DK (1) | DK0699204T3 (fr) |
| ES (1) | ES2118414T3 (fr) |
| FI (2) | FI113537B (fr) |
| NO (1) | NO306902B1 (fr) |
| NZ (1) | NZ267337A (fr) |
| WO (1) | WO1994027982A1 (fr) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
| DE4243321A1 (de) * | 1992-12-21 | 1994-06-23 | Goedecke Ag | Aminosäurederivate von Heterocyclen als PKC-Inhibitoren |
| EP0695755B1 (fr) * | 1994-08-04 | 1998-10-21 | F. Hoffmann-La Roche AG | Pyrrolocarbazole |
| US5686444A (en) * | 1995-04-05 | 1997-11-11 | Cephalon, Inc. | Selected soluble esters of hydroxyl-containing indolocarbazoles |
| US5650407A (en) * | 1995-04-05 | 1997-07-22 | Cephalon, Inc. | Selected soluble esters of hydroxyl-containing indolocarbazoles |
| US6676935B2 (en) | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
| US6197293B1 (en) | 1997-03-03 | 2001-03-06 | Calydon, Inc. | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof |
| US5808060A (en) * | 1995-12-11 | 1998-09-15 | Cephalon, Inc. | Fused isoindolones |
| CN1233177A (zh) | 1996-05-01 | 1999-10-27 | 伊莱利利公司 | Vegf相关疾病的治疗 |
| US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
| UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
| US6184217B1 (en) | 1996-06-25 | 2001-02-06 | Cephalon, Inc. | Use of K-252a derivative |
| CN1147317C (zh) * | 1997-08-15 | 2004-04-28 | 赛福伦公司 | 含酪氨酸激酶抑制剂和化学阉割剂的组合物及其用于制药的用途 |
| JP4405667B2 (ja) | 1997-12-31 | 2010-01-27 | セフアロン・インコーポレーテツド | Ｋ−２５２ａの３’−エピマー誘導体 |
| US6127401A (en) * | 1998-06-05 | 2000-10-03 | Cephalon, Inc. | Bridged indenopyrrolocarbazoles |
| US6013646A (en) * | 1998-07-02 | 2000-01-11 | Bayer Corporation | Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer |
| US6200968B1 (en) * | 1998-08-06 | 2001-03-13 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| US7795246B2 (en) * | 1998-08-06 | 2010-09-14 | Cephalon, Inc. | Particle-forming compositions containing fused pyrrolocarbazoles |
| CN1329034C (zh) | 1998-09-25 | 2007-08-01 | 赛福伦公司 | 预防/治疗感觉毛细胞和耳蜗神经元损伤的药物 |
| WO2000024415A2 (fr) * | 1998-10-28 | 2000-05-04 | Cornell Research Foundation, Inc. | Methodes de regulation de l'angiogenese et de l'integrite vasculaire a l'aide de ligands des recepteurs trk |
| US6841567B1 (en) | 1999-02-12 | 2005-01-11 | Cephalon, Inc. | Cyclic substituted fused pyrrolocarbazoles and isoindolones |
| WO2001010440A1 (fr) * | 1999-08-09 | 2001-02-15 | Trustees Of Dartmouth College | COMPOSITIONS ET PROCEDES RENFORCANT LA CHIMIOTHERAPIE DANS LES TUMEURS A DEFICIENCE EN p53 |
| US6399780B1 (en) | 1999-08-20 | 2002-06-04 | Cephalon, Inc. | Isomeric fused pyrrolocarbazoles and isoindolones |
| US7129250B2 (en) | 2000-05-19 | 2006-10-31 | Aegera Therapeutics Inc. | Neuroprotective and anti-proliferative compounds |
| US7018999B2 (en) * | 2001-05-16 | 2006-03-28 | Cephalon, Inc. | Methods for the treatment and prevention of pain |
| IL144583A0 (en) | 2001-07-26 | 2002-05-23 | Peptor Ltd | Chimeric protein kinase inhibitors |
| IL156429A0 (en) * | 2003-06-12 | 2004-01-04 | Peptor Ltd | Cell permeable conjugates of peptides for inhibition of protein kinases |
| JP2009511524A (ja) | 2005-10-11 | 2009-03-19 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ケモカイン発現のｅｇｆｒ依存調節ならびに腫瘍とその副作用の治療及び診断に与えるケモカイン発現調節の影響 |
| US20080021013A1 (en) * | 2006-07-21 | 2008-01-24 | Cephalon, Inc. | JAK inhibitors for treatment of myeloproliferative disorders |
| WO2009067221A2 (fr) * | 2007-11-20 | 2009-05-28 | Cephalon, Inc. | Microémulsion contenant un composé indolocarbazole et formes pharmaceutiques la contenant |
| WO2014095088A1 (fr) | 2012-12-21 | 2014-06-26 | Sykehuset Sørlandet Hf | Thérapie ciblée contre l'egfr de troubles neurologiques et de la douleur |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62155284A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62155285A (ja) * | 1985-12-27 | 1987-07-10 | Kyowa Hakko Kogyo Co Ltd | 生理活性物質ｋ−２５２の誘導体 |
| JPS62240689A (ja) * | 1986-04-07 | 1987-10-21 | Meiji Seika Kaisha Ltd | Ｓｆ−２３７０物質誘導体及びその製法 |
| JPH0826036B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| JPH0826037B2 (ja) * | 1987-01-22 | 1996-03-13 | 協和醗酵工業株式会社 | 生理活性物質ｋ−２５２の誘導体 |
| WO1988007045A1 (fr) * | 1987-03-09 | 1988-09-22 | Kyowa Hakko Kogyo Co., Ltd. | Derives de la substance physiologiquement active k-252 |
| JPH07113027B2 (ja) * | 1987-12-24 | 1995-12-06 | 協和醗酵工業株式会社 | Ｋ−２５２誘導体 |
| DE3803620A1 (de) * | 1988-02-06 | 1989-08-17 | Goedecke Ag | Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
| US5073633A (en) * | 1989-03-23 | 1991-12-17 | Bristol-Myers Company | BMY-41950 antitumor antibiotic |
| DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
| WO1993000909A1 (fr) * | 1991-07-03 | 1993-01-21 | Regeneron Pharmaceuticals, Inc. | Procede et systeme de determination de l'activite de la neurotrophine |
| WO1993008809A1 (fr) * | 1991-11-08 | 1993-05-13 | The University Of Southern California | Compositions contenant des composes k-252 et destinees a potentialiser l'activite de la neurotrophine |
| US6271242B1 (en) * | 1992-02-10 | 2001-08-07 | Bristol-Myers Squibb Co. | Method for treating cancer using a tyrosine protein kinase inhibitor |
| US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
-
1994
- 1994-05-27 NZ NZ267337A patent/NZ267337A/en not_active IP Right Cessation
- 1994-05-27 AU AU69607/94A patent/AU679752B2/en not_active Ceased
- 1994-05-27 WO PCT/US1994/006082 patent/WO1994027982A1/fr active IP Right Grant
- 1994-05-27 JP JP50102695A patent/JP3344586B2/ja not_active Expired - Fee Related
- 1994-05-27 CA CA002163904A patent/CA2163904C/fr not_active Expired - Fee Related
- 1994-05-27 AT AT94918168T patent/ATE165097T1/de not_active IP Right Cessation
- 1994-05-27 DK DK94918168T patent/DK0699204T3/da active
- 1994-05-27 DE DE69409641T patent/DE69409641T2/de not_active Expired - Lifetime
- 1994-05-27 EP EP98200023A patent/EP0839814A3/fr not_active Withdrawn
- 1994-05-27 ES ES94918168T patent/ES2118414T3/es not_active Expired - Lifetime
- 1994-05-27 KR KR1019950705338A patent/KR100201343B1/ko not_active IP Right Cessation
- 1994-05-27 EP EP94918168A patent/EP0699204B1/fr not_active Expired - Lifetime
- 1994-05-27 US US08/250,175 patent/US5516771A/en not_active Expired - Lifetime
-
1995
- 1995-06-05 US US08/463,680 patent/US5654427A/en not_active Expired - Lifetime
- 1995-11-27 FI FI955709A patent/FI113537B/fi not_active IP Right Cessation
- 1995-11-27 NO NO954816A patent/NO306902B1/no not_active IP Right Cessation
-
2002
- 2002-05-27 JP JP2002153049A patent/JP3727613B2/ja not_active Expired - Fee Related
-
2003
- 2003-10-16 FI FI20031516A patent/FI114864B/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5654427A (en) | 1997-08-05 |
| JP2002504064A (ja) | 2002-02-05 |
| NO306902B1 (no) | 2000-01-10 |
| JP3727613B2 (ja) | 2005-12-14 |
| AU6960794A (en) | 1994-12-20 |
| CA2163904C (fr) | 2000-01-25 |
| US5516771A (en) | 1996-05-14 |
| DK0699204T3 (da) | 1999-02-22 |
| AU679752B2 (en) | 1997-07-10 |
| NZ267337A (en) | 2005-01-28 |
| EP0699204A4 (fr) | 1996-01-10 |
| ES2118414T3 (es) | 1998-09-16 |
| FI114864B (fi) | 2005-01-14 |
| FI20031516A (fi) | 2003-10-16 |
| EP0839814A2 (fr) | 1998-05-06 |
| KR960702838A (ko) | 1996-05-23 |
| EP0699204A1 (fr) | 1996-03-06 |
| JP3344586B2 (ja) | 2002-11-11 |
| WO1994027982A1 (fr) | 1994-12-08 |
| CA2163904A1 (fr) | 1994-12-08 |
| EP0839814A3 (fr) | 1998-09-16 |
| NO954816D0 (no) | 1995-11-27 |
| ATE165097T1 (de) | 1998-05-15 |
| DE69409641T2 (de) | 1998-11-26 |
| KR100201343B1 (ko) | 1999-06-15 |
| JP2002356487A (ja) | 2002-12-13 |
| FI955709A (fi) | 1996-01-03 |
| EP0699204B1 (fr) | 1998-04-15 |
| NO954816L (no) | 1996-01-26 |
| DE69409641D1 (de) | 1998-05-20 |
| FI955709A0 (fi) | 1995-11-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |