FI113476B - Förfarande för att framställa ett rekombinantretrovirus - Google Patents

Förfarande för att framställa ett rekombinantretrovirus Download PDF

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FI113476B
FI113476B FI904647A FI904647A FI113476B FI 113476 B FI113476 B FI 113476B FI 904647 A FI904647 A FI 904647A FI 904647 A FI904647 A FI 904647A FI 113476 B FI113476 B FI 113476B
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cells
cell
vector
hiv
gene
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FI904647A
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FI904647A0 (fi
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Douglas J Jolly
Harry E Gruber
Paul K Laikind
James G Respress
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Chiron Corp
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Claims (7)

1. Förfarande för att framställa ett rekombinantretrovirus, kännetecknat av att det innefattar inpackning av en 15 vektorstruktur i en kapsid och ett hölje för att astadkomma ett med avseende pä replikation bristfälligt rekombinantretrovirus, varvid vektorstrukturen styr expression av en sjukdomsantigen vilken härstammar frän en patogen eller en cancerkoloni eller dess transformerade form i objektceller, vilka är infekterade 20 med retrovirus, varvid berörda antigen eller dess transformerade form förmär stimulera ett cellförmedlat immunsvar i djur eller människa.
2. Förfarande för att framställa ett rekombinantretrovirus · · · ; enligt patentkrav 1, kännetecknat av att vektorstrukturen styr 25 expressionen av en transformerad form av en sjukdomsantigen som * härstammar frän en patogen i objektceller, vilka är infekterade med retrovirus, dä ifrägavarande modifierade antigen förmär stimulera ett immunsvar i djur eller människa, men har sänkt patogenitet med avseende pä nämnda patogen. 30
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat av att ·*· den uttryckta antigenen frambringar ett immunsvar som gränsar till HLA-klass I och/eller -klass II. t
4. Förfarande enligt vilket som heist av patentkraven 1-3, kännetecknat av att den uttryckta antigenen är ett HIV-protein, 62 1 1347 - som väljs ur en grupp bestäende av gp 160, gp 120 och gp 41 eller transformerade former av dessa.
5. Förfarande enligt patentkrav 1, kännetecknat av att vektorstrukturen styr expressionen av en särskild T-cellreceptor 5 eller immunglobulin, vilken identifierar den önskade antigenen.
6. Förfarande för att framställa Ex-vivo-celler, kännetecknat av att cellerna infekteras med ett rekombinantretrovirus framställt med ett förfarande enligt nägot av patentkraven 1-5.
7. Förfarande för att framställa en eukaryotcell, kännetecknat 10 av att cellen infekteras med ett rekombinantretrovirus framställt med ett förfarande enligt nägot av patentkraven 1-5, varvid cellen innehäller ett retroviralt genom för det rekombinanta retroviruset, varvid genomet innefattar en packningssignal och som kodar sjukdomsantigenen, vilken 15 härstammar frän patogenen eller som är en cancerantigen eller en transformerad form av denna, utan kodningssekvens för ett eller flera retrovirala proteiner, varvid nämnda cell ocksä förmär uttrycka virala proteiner för att producera nämnda rekombinantretrovirus. • · I • » » > I · ► · > * * » * > » ' »
FI904647A 1988-03-21 1990-09-20 Förfarande för att framställa ett rekombinantretrovirus FI113476B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US17051588A 1988-03-21 1988-03-21
US17051588 1988-03-21
US8901139 1989-03-20
PCT/US1989/001139 WO1989009271A1 (en) 1988-03-21 1989-03-20 Recombinant retroviruses

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FI904647A0 FI904647A0 (fi) 1990-09-20
FI113476B true FI113476B (sv) 2004-04-30

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EP (2) EP0334301B1 (sv)
JP (5) JPH03504079A (sv)
CN (1) CN1038306A (sv)
AT (2) ATE174960T1 (sv)
AU (1) AU651311B2 (sv)
CA (1) CA1341585C (sv)
CH (1) CH684094A5 (sv)
DE (2) DE68929122T2 (sv)
DK (1) DK175857B1 (sv)
ES (1) ES2139810T3 (sv)
FI (1) FI113476B (sv)
GB (2) GB2236753B (sv)
GR (1) GR3032940T3 (sv)
IL (1) IL89701A (sv)
NO (1) NO314596B1 (sv)
WO (1) WO1989009271A1 (sv)

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NO314596B1 (no) 2003-04-14
WO1989009271A1 (en) 1989-10-05
DK226890A (da) 1990-11-20
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EP0702084B1 (en) 1999-12-22
DE68928884T2 (de) 1999-05-12
DE68928884D1 (de) 1999-02-04
GB2236753A (en) 1991-04-17
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IL89701A (en) 1995-07-31
CH684094A5 (de) 1994-07-15
JP2007289206A (ja) 2007-11-08
EP0702084A1 (en) 1996-03-20
CN1038306A (zh) 1989-12-27
GB2255777A (en) 1992-11-18
ATE174960T1 (de) 1999-01-15
AU3364089A (en) 1989-10-16
EP0334301B1 (en) 1998-12-23
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DE68929122D1 (de) 2000-01-27
DK226890D0 (da) 1990-09-20
ATE187983T1 (de) 2000-01-15
GB2236753B (en) 1993-02-03
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JPH03504079A (ja) 1991-09-12
NO904103L (no) 1990-11-16
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GB9217086D0 (en) 1992-09-23
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GR3032940T3 (en) 2000-07-31
DE68929122T2 (de) 2000-04-20
JPH11262397A (ja) 1999-09-28
GB2255777B (en) 1993-02-03
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AU651311B2 (en) 1994-07-21

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