FI111716B - Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi Download PDF

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Publication number
FI111716B
FI111716B FI924453A FI924453A FI111716B FI 111716 B FI111716 B FI 111716B FI 924453 A FI924453 A FI 924453A FI 924453 A FI924453 A FI 924453A FI 111716 B FI111716 B FI 111716B
Authority
FI
Finland
Prior art keywords
group
amino
dimethylamino
dioxo
tetrahydroxy
Prior art date
Application number
FI924453A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924453A (fi
FI924453A0 (fi
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Yakov Gluzman
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI924453A0 publication Critical patent/FI924453A0/fi
Publication of FI924453A publication Critical patent/FI924453A/fi
Application granted granted Critical
Publication of FI111716B publication Critical patent/FI111716B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Seasonings (AREA)
  • Tires In General (AREA)
  • Spinning Or Twisting Of Yarns (AREA)
  • Moulding By Coating Moulds (AREA)
  • Luminescent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924453A 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi FI111716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77169791 1991-10-04
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (3)

Publication Number Publication Date
FI924453A0 FI924453A0 (fi) 1992-10-02
FI924453A FI924453A (fi) 1993-04-05
FI111716B true FI111716B (fi) 2003-09-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924453A FI111716B (fi) 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi

Country Status (25)

Country Link
US (3) US5281628A (no)
EP (1) EP0535346B1 (no)
JP (1) JP3183729B2 (no)
KR (1) KR100261528B1 (no)
CN (1) CN1053182C (no)
AT (1) ATE129697T1 (no)
AU (1) AU651734B2 (no)
CA (1) CA2079703C (no)
CZ (1) CZ285015B6 (no)
DE (1) DE69205792T2 (no)
DK (1) DK0535346T3 (no)
ES (1) ES2081005T3 (no)
FI (1) FI111716B (no)
GR (1) GR3017978T3 (no)
HK (1) HK1000319A1 (no)
HU (2) HU211214B (no)
IL (1) IL103319A (no)
MX (1) MX9205573A (no)
NO (1) NO300129B1 (no)
NZ (1) NZ244556A (no)
PH (1) PH30343A (no)
PL (2) PL170933B1 (no)
SK (1) SK281113B6 (no)
TW (1) TW222616B (no)
ZA (1) ZA927608B (no)

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US5981601A (en) * 1992-05-28 1999-11-09 Centre For Molecular Biology And Medicine Method for enhancing cellular bioenergy
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5834450A (en) * 1994-02-17 1998-11-10 Pfizer Inc. 9- (substituted amino) -alpha-6-deoxy-5-oxy tetracycline derivatives, their preparation and their use as antibiotics
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ES2260051T3 (es) * 1999-09-14 2006-11-01 Trustees Of Tufts College Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion.
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6686365B2 (en) * 2000-02-04 2004-02-03 Eli Lilly And Company Pharmaceutical composition
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US20020132798A1 (en) * 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
AU2001271642B2 (en) * 2000-07-07 2006-01-05 Paratek Pharmaceuticals, Inc. 7-substituted tetracycline compounds
ATE544745T1 (de) * 2000-07-07 2012-02-15 Tufts College 9-substituierte minocyclinverbindungen
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
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US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
EP2332548A1 (en) 2001-07-13 2011-06-15 Paratek Pharmaceuticals, Inc. Tetracyclines for the treatment of stroke
WO2003055441A2 (en) 2001-08-02 2003-07-10 Paratek Pharmaceuticals, Inc. Medicaments
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
AU2003235759A1 (en) 2002-01-08 2003-07-24 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
EA201000491A1 (ru) * 2002-03-08 2010-08-30 Паратек Фармасьютикалс, Инк. Аминометилзамещенные тетрациклиновые соединения
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
KR101148415B1 (ko) 2002-07-12 2012-05-21 파라테크 파마슈티컬스, 인크. 3, 10, 및 12ａ 치환된 테트라시클린 화합물
JP2006516252A (ja) * 2002-12-27 2006-06-29 アンジオテック インターナショナル アクツィエン ゲゼルシャフト コラーゲンおよびｍｍｐｉを用いる組成物および方法
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
EP2298323A3 (en) 2003-07-09 2011-05-11 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2332904A3 (en) 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
CA2585248A1 (en) 2004-10-25 2006-05-04 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP1805134B1 (en) 2004-10-25 2012-06-20 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
US8088755B2 (en) * 2005-02-04 2012-01-03 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
US20070093455A1 (en) * 2005-07-21 2007-04-26 Paul Abato 10-substituted tetracyclines and methods of use thereof
RU2008121238A (ru) * 2005-12-22 2010-01-27 Вайет (Us) Способы лечения инфекций желудочно-кишечного тракта с применением тайгециклина
AU2006331688A1 (en) * 2005-12-22 2007-07-05 Wyeth Oral formulations comprising tigecycline
CA2649221A1 (en) * 2006-04-17 2007-10-25 Evgeny Tsiperman Isolation of tetracycline derivatives
US7871993B2 (en) * 2006-04-24 2011-01-18 Teva Pharmaceutical Industries Ltd. Tigecycline crystalline forms and processes for preparation thereof
US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
EP2016043A1 (en) * 2006-05-10 2009-01-21 Teva Pharmaceutical Industries Ltd. Methods for reducing 7/9-nitrotetracycline derivatives
CA2652346A1 (en) 2006-05-15 2007-11-22 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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EP2084126A1 (en) * 2006-11-30 2009-08-05 Teva Pharmaceutical Industries Ltd. Processes for preparation of 9-haloacetamidominocyclines
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US8518912B2 (en) 2007-11-29 2013-08-27 Actelion Pharmaceuticals Ltd. Phosphonic acid derivates and their use as P2Y12 receptor antagonists
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EP2406213A1 (en) * 2009-03-12 2012-01-18 Wyeth LLC Nitration of tetracyclines
SI2327676T1 (sl) * 2009-11-26 2014-07-31 Sandoz Ag Reakcije organskih spojin z nizkimi količinami vodika

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Also Published As

Publication number Publication date
CA2079703A1 (en) 1993-04-05
IL103319A0 (en) 1993-03-15
AU651734B2 (en) 1994-07-28
NO923856D0 (no) 1992-10-02
NO923856L (no) 1993-04-05
HU211214B (en) 1995-11-28
US5281628A (en) 1994-01-25
EP0535346B1 (en) 1995-11-02
EP0535346A1 (en) 1993-04-07
HK1000319A1 (en) 1998-02-27
FI924453A (fi) 1993-04-05
JPH05239006A (ja) 1993-09-17
HU211922A9 (en) 1996-01-29
JP3183729B2 (ja) 2001-07-09
NO300129B1 (no) 1997-04-14
IL103319A (en) 1996-07-23
GR3017978T3 (en) 1996-02-29
AU2618292A (en) 1993-04-08
ATE129697T1 (de) 1995-11-15
ZA927608B (en) 1993-04-13
HUT64298A (en) 1993-12-28
PL170939B1 (pl) 1997-02-28
PL170933B1 (pl) 1997-02-28
MX9205573A (es) 1993-05-01
NZ244556A (en) 1994-06-27
CN1053182C (zh) 2000-06-07
KR930007895A (ko) 1993-05-20
PL296140A1 (en) 1993-11-02
CZ297292A3 (en) 1993-04-14
KR100261528B1 (ko) 2000-07-15
CZ285015B6 (cs) 1999-05-12
DE69205792D1 (de) 1995-12-07
TW222616B (no) 1994-04-21
US5401863A (en) 1995-03-28
FI924453A0 (fi) 1992-10-02
CN1071415A (zh) 1993-04-28
CA2079703C (en) 2004-07-20
HU9203143D0 (en) 1992-12-28
DK0535346T3 (da) 1995-12-04
US5326759A (en) 1994-07-05
DE69205792T2 (de) 1996-06-20
SK281113B6 (sk) 2000-12-11
SK297292A3 (en) 1994-12-07
ES2081005T3 (es) 1996-02-16
PH30343A (en) 1997-04-02

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