FI110186B - Förfarande för framställning av terapeutiskt aktiva 2-{3-[4-(3-klorfenyl)-1-piperazinyl]propyl}-1,2,4-triazol[4,3-a]pyridin-3-(2H) onderivat - Google Patents
Förfarande för framställning av terapeutiskt aktiva 2-{3-[4-(3-klorfenyl)-1-piperazinyl]propyl}-1,2,4-triazol[4,3-a]pyridin-3-(2H) onderivat Download PDFInfo
- Publication number
- FI110186B FI110186B FI943386A FI943386A FI110186B FI 110186 B FI110186 B FI 110186B FI 943386 A FI943386 A FI 943386A FI 943386 A FI943386 A FI 943386A FI 110186 B FI110186 B FI 110186B
- Authority
- FI
- Finland
- Prior art keywords
- formula
- chlorophenyl
- group
- triazole
- compound
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/16—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of hydrocarbon radicals substituted by amino or carboxyl groups, e.g. ethylenediamine-tetra-acetic acid, iminodiacetic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (5)
1. Förfarande för framställning av ett terapeutiskt aktivt 2—{3— [4—(3-klorfenyl)-1-piperazinyl]propyl)-1,2,4- 5 triazol[4,3-a]pyridin-3-(2H)onderivat med formeln (I) I n n I R Cl
10 J (i) R' R" väri endast en av R, R', R'' och R'' ' är Ci-3-alkyl och de andra är H, och för f ramställning av syraadditionssalter 15 därav med fysiologiskt godtagbara, organiska eller oor-ganiska syror, kännetecknat av att en förening med formeln (III) 20 (III) ; J-NH o* : eller ett alkalimetallsalt därav bringas att reagera med en • 25 piperazinförening med formeln (II) • · « R" R'" Cl
30 T : väri R, R', R" och R' ' 1 är ovan definierade grupper och X är en sedvanlig avgaende grupp, som är en klor- eller bro-matom eller en grupp -0-S02Älk eller -0-S02Ar, väri Alk be- 35 tecknar en alkylgrupp och Ar betecknar en arylgrupp, i när-varo av ett lämpligt organiskt utspädningsmedel eller en • · 1 · r 1 110186 blandning av organiska utspädningsmedel vid en temperatur mellan 40 °C och reaktionsblandningens koktemperatur.
2. Förening som fungerar som mellanprodukt i fdrfa-randet enligt patent krav 1, kännetecknat av 5 att den har formeln (II) R" R"' Cl R' väri endast en av R, R', R'' och R'' ' är Ci_3-alkyl och de andra är H och X är en sedvanlig avgäende grupp, vilken är 15 en klor- eller bromatom eller gruppen -SC^Alk eller -SC>2Ar, väri Aik betecknar en alkylgrupp och Ar betecknar en aryl-grupp, och som är användbar som mellanprodukt i ett förfa-rande enligt patentkrav 1. I · » t * · * * • ·
9 I » ,
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI920084 | 1992-01-17 | ||
| ITMI920084A IT1258790B (it) | 1992-01-17 | 1992-01-17 | Alchil derivati del trazodone |
| PCT/EP1993/000080 WO1993014091A1 (en) | 1992-01-17 | 1993-01-14 | Alkyl derivatives of trazodone with cns activity |
| EP9300080 | 1993-01-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI943386A FI943386A (sv) | 1994-07-15 |
| FI943386A0 FI943386A0 (sv) | 1994-07-15 |
| FI110186B true FI110186B (sv) | 2002-12-13 |
Family
ID=11361589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI943386A FI110186B (sv) | 1992-01-17 | 1994-07-15 | Förfarande för framställning av terapeutiskt aktiva 2-{3-[4-(3-klorfenyl)-1-piperazinyl]propyl}-1,2,4-triazol[4,3-a]pyridin-3-(2H) onderivat |
| FI20021652A FI113266B (sv) | 1992-01-17 | 2002-09-16 | Mellanproduktsföreningar som är användbara vid framställning av alkylderivat av trazodon |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI20021652A FI113266B (sv) | 1992-01-17 | 2002-09-16 | Mellanproduktsföreningar som är användbara vid framställning av alkylderivat av trazodon |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0623131B1 (sv) |
| JP (1) | JP2856912B2 (sv) |
| KR (1) | KR100254690B1 (sv) |
| AT (1) | ATE136307T1 (sv) |
| AU (1) | AU671973B2 (sv) |
| BG (1) | BG61841B1 (sv) |
| BR (1) | BR9305752A (sv) |
| CA (1) | CA2128202C (sv) |
| CZ (1) | CZ282910B6 (sv) |
| DE (1) | DE69302087T2 (sv) |
| DK (1) | DK0623131T3 (sv) |
| ES (1) | ES2088270T3 (sv) |
| FI (2) | FI110186B (sv) |
| GE (1) | GEP20001939B (sv) |
| GR (1) | GR3020420T3 (sv) |
| HU (5) | HU217968B (sv) |
| IT (1) | IT1258790B (sv) |
| NO (2) | NO302365B1 (sv) |
| NZ (1) | NZ246598A (sv) |
| PL (1) | PL170913B1 (sv) |
| RO (1) | RO113465B1 (sv) |
| RU (1) | RU2126801C1 (sv) |
| SK (1) | SK280561B6 (sv) |
| WO (1) | WO1993014091A1 (sv) |
| ZA (1) | ZA93292B (sv) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU718075B2 (en) * | 1993-07-01 | 2000-04-06 | Angelini Ricerche S.P.A. Societa Consortile | Intermediates for the preparation of pharmacologically active enantiomers of triazolone compounds |
| IT1268414B1 (it) * | 1993-07-01 | 1997-02-27 | Angelini Francesco Ist Ricerca | Enantiomeri farmacologicamente attivi |
| US7572808B2 (en) | 2005-06-17 | 2009-08-11 | Bristol-Myers Squibb Company | Triazolopyridine cannabinoid receptor 1 antagonists |
| ITMI20051193A1 (it) * | 2005-06-24 | 2006-12-25 | Acraf | Uso farmaceutico di una 1-3-clorofenil-3-alchilpiperazina |
| WO2012072665A1 (en) | 2010-11-30 | 2012-06-07 | Pharmaneuroboost N.V. | Compositions comprising pipamperone and serotonin antagonist reuptake inhibitors |
| RU2706700C1 (ru) | 2019-09-24 | 2019-11-20 | Общество с ограниченной ответственностью "Научно-производственная компания "СКиФФ" | Фармацевтическая композиция для коррекции поведения кошек и собак в стрессовых ситуациях |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US100505A (en) * | 1870-03-08 | Improvement in sash-bolt | ||
| IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
-
1992
- 1992-01-17 IT ITMI920084A patent/IT1258790B/it active IP Right Grant
- 1992-01-17 GE GEAP19922648A patent/GEP20001939B/en unknown
-
1993
- 1993-01-14 KR KR1019940702475A patent/KR100254690B1/ko not_active IP Right Cessation
- 1993-01-14 RO RO94-01203A patent/RO113465B1/ro unknown
- 1993-01-14 DK DK93902204.2T patent/DK0623131T3/da active
- 1993-01-14 WO PCT/EP1993/000080 patent/WO1993014091A1/en active IP Right Grant
- 1993-01-14 SK SK846-94A patent/SK280561B6/sk not_active IP Right Cessation
- 1993-01-14 BR BR9305752A patent/BR9305752A/pt not_active Application Discontinuation
- 1993-01-14 PL PL93304665A patent/PL170913B1/pl not_active IP Right Cessation
- 1993-01-14 CA CA002128202A patent/CA2128202C/en not_active Expired - Fee Related
- 1993-01-14 RU RU94036769A patent/RU2126801C1/ru not_active IP Right Cessation
- 1993-01-14 AT AT93902204T patent/ATE136307T1/de not_active IP Right Cessation
- 1993-01-14 HU HU9502179A patent/HU217968B/hu not_active IP Right Cessation
- 1993-01-14 NZ NZ246598A patent/NZ246598A/xx not_active IP Right Cessation
- 1993-01-14 JP JP5512150A patent/JP2856912B2/ja not_active Expired - Fee Related
- 1993-01-14 EP EP93902204A patent/EP0623131B1/en not_active Expired - Lifetime
- 1993-01-14 AU AU33504/93A patent/AU671973B2/en not_active Ceased
- 1993-01-14 ES ES93902204T patent/ES2088270T3/es not_active Expired - Lifetime
- 1993-01-14 HU HU9402119A patent/HU218678B/hu not_active IP Right Cessation
- 1993-01-14 CZ CZ941732A patent/CZ282910B6/cs not_active IP Right Cessation
- 1993-01-14 DE DE69302087T patent/DE69302087T2/de not_active Expired - Fee Related
- 1993-01-15 ZA ZA93292A patent/ZA93292B/xx unknown
-
1994
- 1994-07-08 BG BG98896A patent/BG61841B1/bg unknown
- 1994-07-15 NO NO942668A patent/NO302365B1/no not_active IP Right Cessation
- 1994-07-15 FI FI943386A patent/FI110186B/sv active
-
1995
- 1995-07-19 HU HU9502180A patent/HU217982B/hu not_active IP Right Cessation
- 1995-07-19 HU HU9502177A patent/HU219493B/hu not_active IP Right Cessation
- 1995-07-19 HU HU9502178A patent/HU217981B/hu not_active IP Right Cessation
-
1996
- 1996-07-02 GR GR960401793T patent/GR3020420T3/el unknown
-
1997
- 1997-09-26 NO NO974462A patent/NO303686B1/no not_active IP Right Cessation
-
2002
- 2002-09-16 FI FI20021652A patent/FI113266B/sv active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GB | Transfer or assigment of application |
Owner name: ANGELINI RICERCHE S.P.A. |