FI109152B - Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö - Google Patents

Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö Download PDF

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Publication number
FI109152B
FI109152B FI933441A FI933441A FI109152B FI 109152 B FI109152 B FI 109152B FI 933441 A FI933441 A FI 933441A FI 933441 A FI933441 A FI 933441A FI 109152 B FI109152 B FI 109152B
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FI
Finland
Prior art keywords
thromboplastin
calcium
rbap
solution
reagent
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Application number
FI933441A
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English (en)
Finnish (fi)
Swedish (sv)
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FI933441A (fi
FI933441A0 (fi
Inventor
James Rhett Butler
Juan Louis Torres
Rajesh Sharma
Original Assignee
Akzo Nv
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI933441A 1992-08-03 1993-08-02 Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö FI109152B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92421192 1992-08-03
US07/924,211 US5358853A (en) 1992-08-03 1992-08-03 Liquid thromboplastin reagent

Publications (3)

Publication Number Publication Date
FI933441A0 FI933441A0 (fi) 1993-08-02
FI933441A FI933441A (fi) 1994-02-04
FI109152B true FI109152B (fi) 2002-05-31

Family

ID=25449889

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933441A FI109152B (fi) 1992-08-03 1993-08-02 Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö

Country Status (13)

Country Link
US (2) US5358853A (da)
EP (1) EP0585987B2 (da)
JP (1) JP3330685B2 (da)
KR (1) KR100265531B1 (da)
AT (1) ATE179759T1 (da)
AU (1) AU665432B2 (da)
CA (1) CA2100617C (da)
DE (2) DE69324745D1 (da)
DK (1) DK0585987T4 (da)
ES (1) ES2132174T5 (da)
FI (1) FI109152B (da)
GR (1) GR3030728T3 (da)
ZA (1) ZA935180B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
DE69832628T2 (de) * 1997-04-23 2006-09-07 Instrumentation Laboratory S.P.A. Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz
DE19720853A1 (de) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes
DE19811016A1 (de) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor
ES2252986T3 (es) 1998-10-07 2006-05-16 Trinity Biotech Manufacturing Ltd. Reactivos de tromboplastina y metodos para preparar y usar tales reactivos.
US6207661B1 (en) 1999-02-22 2001-03-27 Baxter International Inc. Premixed formulation of piperacillin sodium and tazobactam sodium injection
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US7148067B2 (en) * 2004-08-31 2006-12-12 The Board Of Trustees Of The University Of Illinois Thromboplastin reagents
US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
CA2600907C (en) * 2005-03-04 2016-06-28 The Board Of Trustees Of The University Of Illinois Coagulation and fibrinolytic cascades modulator
US20080003220A1 (en) * 2006-04-21 2008-01-03 Amgen, Inc. Buffering agents for biopharmaceutical formulations
JP4999613B2 (ja) * 2007-08-31 2012-08-15 シスメックス株式会社 血液凝固測定用試薬及び血液凝固時間測定方法
US8821861B2 (en) * 2007-10-05 2014-09-02 The Board Of Trustees Of The University Of Illinois Fibrin sealant
WO2009061697A1 (en) 2007-11-09 2009-05-14 The Board Of Trustees Of The University Of Illinois Anticoagulant antagonist and hemophilia procoagulant
DE102007062323A1 (de) 2007-12-21 2009-06-25 Siemens Healthcare Diagnostics Products Gmbh Langzeitstabiles Thromboplastin-Reagenz
KR101882408B1 (ko) 2009-05-20 2018-07-27 세키스이 메디칼 가부시키가이샤 혈액응고시간 연장제
JP5589103B2 (ja) * 2013-01-23 2014-09-10 株式会社Ｌｓｉメディエンス 二価金属イオン含有の体外診断用試薬組成物および二価金属イオン由来金属化合物の沈殿防止方法
JP6250306B2 (ja) * 2013-05-28 2017-12-20 株式会社Ｌｓｉメディエンス リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法
JP2014197019A (ja) * 2014-06-30 2014-10-16 積水メディカル株式会社 血液凝固反応における血液凝固時間延長剤
JP6709286B2 (ja) 2016-02-12 2020-06-10 インストゥルメンテーション ラボラトリー カンパニー ２成分「混合および使用」の液体トロンボプラスチン試薬、その作製方法および使用方法
EP3489692A1 (de) 2017-11-28 2019-05-29 Siemens Healthcare Diagnostics Products GmbH Prothrombinzeit-reagenz enthaltend einen eisenchelator
JP7527205B2 (ja) * 2018-09-25 2024-08-02 積水メディカル株式会社 血液凝固時間測定方法
CN113005176A (zh) * 2019-12-20 2021-06-22 深圳市帝迈生物技术有限公司 稳定剂、凝血酶原时间检测试剂及其制备方法、试剂盒
CN111638374B (zh) * 2020-06-08 2022-10-18 深圳市国赛生物技术有限公司 一种用于测定凝血酶原时间的体外诊断试剂盒

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2516216A (en) * 1947-06-24 1950-07-25 Sharp & Dohme Inc Thromboplastin as testing agent
US2847350A (en) * 1954-05-27 1958-08-12 Ortho Pharma Corp Preparation of highly active thromboplastin
US2842480A (en) * 1954-05-27 1958-07-08 Ortho Pharma Corp Preparation of thromboplastin
US2847347A (en) * 1954-05-27 1958-08-12 Ortho Pharmacentical Corp Preparation of improved thromboplastin
US2921000A (en) * 1956-05-22 1960-01-12 Ortho Pharma Corp Thromboplastin
US3522148A (en) * 1965-08-13 1970-07-28 Dade Reagents Inc Stabilized thromboplastin preparation
DE3113350A1 (de) * 1981-04-02 1982-10-21 Boehringer Mannheim Gmbh, 6800 Mannheim Reagens zur optischen bestimmung des blutgerinnungsverhaltens
DE3150596A1 (de) * 1981-12-21 1983-06-30 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur herstellung von gewebsthromboplastin
US4755461A (en) * 1986-04-17 1988-07-05 Bio/Data Corporation Tableted blood plasma microconcentrated thromboplastin coagulation reagent
US5270451A (en) * 1988-11-23 1993-12-14 Baxter Diagnostics Inc. Extraction method for preparing thromboplastin reagents
ATE99697T1 (de) * 1988-11-23 1994-01-15 Baxter Diagnostics Inc Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien.
US5091304A (en) * 1989-08-21 1992-02-25 International Technidyne Corporation Whole blood activated partial thromboplastin time test and associated apparatus
DE3929329A1 (de) * 1989-09-04 1991-03-07 Behringwerke Ag Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.

Also Published As

Publication number Publication date
DK0585987T3 (da) 1999-11-08
EP0585987A1 (en) 1994-03-09
AU665432B2 (en) 1996-01-04
AU4215893A (en) 1994-02-10
EP0585987B2 (en) 2004-09-08
DE69324745T2 (de) 1999-10-14
KR940005288A (ko) 1994-03-21
DE69324745T4 (de) 2006-01-05
JP3330685B2 (ja) 2002-09-30
CA2100617C (en) 2003-06-24
DE69324745D1 (de) 1999-06-10
EP0585987B1 (en) 1999-05-06
DK0585987T4 (da) 2005-01-17
ZA935180B (en) 1994-05-25
US5508170A (en) 1996-04-16
FI933441A (fi) 1994-02-04
GR3030728T3 (en) 1999-11-30
JPH06201702A (ja) 1994-07-22
FI933441A0 (fi) 1993-08-02
CA2100617A1 (en) 1994-02-04
ES2132174T3 (es) 1999-08-16
US5358853A (en) 1994-10-25
KR100265531B1 (ko) 2000-09-15
ES2132174T5 (es) 2005-04-16
ATE179759T1 (de) 1999-05-15

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