FI109152B - Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö - Google Patents
Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö Download PDFInfo
- Publication number
- FI109152B FI109152B FI933441A FI933441A FI109152B FI 109152 B FI109152 B FI 109152B FI 933441 A FI933441 A FI 933441A FI 933441 A FI933441 A FI 933441A FI 109152 B FI109152 B FI 109152B
- Authority
- FI
- Finland
- Prior art keywords
- thromboplastin
- calcium
- rbap
- solution
- reagent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92421192 | 1992-08-03 | ||
US07/924,211 US5358853A (en) | 1992-08-03 | 1992-08-03 | Liquid thromboplastin reagent |
Publications (3)
Publication Number | Publication Date |
---|---|
FI933441A0 FI933441A0 (fi) | 1993-08-02 |
FI933441A FI933441A (fi) | 1994-02-04 |
FI109152B true FI109152B (fi) | 2002-05-31 |
Family
ID=25449889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI933441A FI109152B (fi) | 1992-08-03 | 1993-08-02 | Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö |
Country Status (13)
Country | Link |
---|---|
US (2) | US5358853A (da) |
EP (1) | EP0585987B2 (da) |
JP (1) | JP3330685B2 (da) |
KR (1) | KR100265531B1 (da) |
AT (1) | ATE179759T1 (da) |
AU (1) | AU665432B2 (da) |
CA (1) | CA2100617C (da) |
DE (2) | DE69324745D1 (da) |
DK (1) | DK0585987T4 (da) |
ES (1) | ES2132174T5 (da) |
FI (1) | FI109152B (da) |
GR (1) | GR3030728T3 (da) |
ZA (1) | ZA935180B (da) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
DE69832628T2 (de) * | 1997-04-23 | 2006-09-07 | Instrumentation Laboratory S.P.A. | Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz |
DE19720853A1 (de) * | 1997-05-17 | 1998-11-19 | Dade Behring Marburg Gmbh | Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes |
DE19811016A1 (de) * | 1998-03-13 | 1999-09-16 | Dade Behring Marburg Gmbh | Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor |
ES2252986T3 (es) | 1998-10-07 | 2006-05-16 | Trinity Biotech Manufacturing Ltd. | Reactivos de tromboplastina y metodos para preparar y usar tales reactivos. |
US6207661B1 (en) | 1999-02-22 | 2001-03-27 | Baxter International Inc. | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
US6733985B1 (en) * | 1999-05-19 | 2004-05-11 | International Technidyne Corporation | Preparation of stable liquid and dried synthetic prothrombin time reagents |
US6248353B1 (en) | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
US6855509B2 (en) * | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
US20080260858A1 (en) * | 2005-02-16 | 2008-10-23 | The Board Of Trustees Of The University Of Illnois | Universal Procoagulant |
CA2600907C (en) * | 2005-03-04 | 2016-06-28 | The Board Of Trustees Of The University Of Illinois | Coagulation and fibrinolytic cascades modulator |
US20080003220A1 (en) * | 2006-04-21 | 2008-01-03 | Amgen, Inc. | Buffering agents for biopharmaceutical formulations |
JP4999613B2 (ja) * | 2007-08-31 | 2012-08-15 | シスメックス株式会社 | 血液凝固測定用試薬及び血液凝固時間測定方法 |
US8821861B2 (en) * | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
WO2009061697A1 (en) | 2007-11-09 | 2009-05-14 | The Board Of Trustees Of The University Of Illinois | Anticoagulant antagonist and hemophilia procoagulant |
DE102007062323A1 (de) | 2007-12-21 | 2009-06-25 | Siemens Healthcare Diagnostics Products Gmbh | Langzeitstabiles Thromboplastin-Reagenz |
KR101882408B1 (ko) | 2009-05-20 | 2018-07-27 | 세키스이 메디칼 가부시키가이샤 | 혈액응고시간 연장제 |
JP5589103B2 (ja) * | 2013-01-23 | 2014-09-10 | 株式会社Lsiメディエンス | 二価金属イオン含有の体外診断用試薬組成物および二価金属イオン由来金属化合物の沈殿防止方法 |
JP6250306B2 (ja) * | 2013-05-28 | 2017-12-20 | 株式会社Lsiメディエンス | リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法 |
JP2014197019A (ja) * | 2014-06-30 | 2014-10-16 | 積水メディカル株式会社 | 血液凝固反応における血液凝固時間延長剤 |
JP6709286B2 (ja) | 2016-02-12 | 2020-06-10 | インストゥルメンテーション ラボラトリー カンパニー | 2成分「混合および使用」の液体トロンボプラスチン試薬、その作製方法および使用方法 |
EP3489692A1 (de) | 2017-11-28 | 2019-05-29 | Siemens Healthcare Diagnostics Products GmbH | Prothrombinzeit-reagenz enthaltend einen eisenchelator |
JP7527205B2 (ja) * | 2018-09-25 | 2024-08-02 | 積水メディカル株式会社 | 血液凝固時間測定方法 |
CN113005176A (zh) * | 2019-12-20 | 2021-06-22 | 深圳市帝迈生物技术有限公司 | 稳定剂、凝血酶原时间检测试剂及其制备方法、试剂盒 |
CN111638374B (zh) * | 2020-06-08 | 2022-10-18 | 深圳市国赛生物技术有限公司 | 一种用于测定凝血酶原时间的体外诊断试剂盒 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2516216A (en) * | 1947-06-24 | 1950-07-25 | Sharp & Dohme Inc | Thromboplastin as testing agent |
US2847350A (en) * | 1954-05-27 | 1958-08-12 | Ortho Pharma Corp | Preparation of highly active thromboplastin |
US2842480A (en) * | 1954-05-27 | 1958-07-08 | Ortho Pharma Corp | Preparation of thromboplastin |
US2847347A (en) * | 1954-05-27 | 1958-08-12 | Ortho Pharmacentical Corp | Preparation of improved thromboplastin |
US2921000A (en) * | 1956-05-22 | 1960-01-12 | Ortho Pharma Corp | Thromboplastin |
US3522148A (en) * | 1965-08-13 | 1970-07-28 | Dade Reagents Inc | Stabilized thromboplastin preparation |
DE3113350A1 (de) * | 1981-04-02 | 1982-10-21 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur optischen bestimmung des blutgerinnungsverhaltens |
DE3150596A1 (de) * | 1981-12-21 | 1983-06-30 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von gewebsthromboplastin |
US4755461A (en) * | 1986-04-17 | 1988-07-05 | Bio/Data Corporation | Tableted blood plasma microconcentrated thromboplastin coagulation reagent |
US5270451A (en) * | 1988-11-23 | 1993-12-14 | Baxter Diagnostics Inc. | Extraction method for preparing thromboplastin reagents |
ATE99697T1 (de) * | 1988-11-23 | 1994-01-15 | Baxter Diagnostics Inc | Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. |
US5091304A (en) * | 1989-08-21 | 1992-02-25 | International Technidyne Corporation | Whole blood activated partial thromboplastin time test and associated apparatus |
DE3929329A1 (de) * | 1989-09-04 | 1991-03-07 | Behringwerke Ag | Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben |
US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
-
1992
- 1992-08-03 US US07/924,211 patent/US5358853A/en not_active Expired - Lifetime
-
1993
- 1993-07-15 CA CA002100617A patent/CA2100617C/en not_active Expired - Fee Related
- 1993-07-16 ZA ZA935180A patent/ZA935180B/xx unknown
- 1993-07-22 DE DE69324745A patent/DE69324745D1/de not_active Expired - Fee Related
- 1993-07-22 DK DK93202175T patent/DK0585987T4/da active
- 1993-07-22 AT AT93202175T patent/ATE179759T1/de not_active IP Right Cessation
- 1993-07-22 DE DE69324745T patent/DE69324745T4/de not_active Expired - Lifetime
- 1993-07-22 EP EP93202175A patent/EP0585987B2/en not_active Expired - Lifetime
- 1993-07-22 ES ES93202175T patent/ES2132174T5/es not_active Expired - Lifetime
- 1993-07-23 AU AU42158/93A patent/AU665432B2/en not_active Ceased
- 1993-08-02 FI FI933441A patent/FI109152B/fi not_active IP Right Cessation
- 1993-08-02 KR KR1019930014928A patent/KR100265531B1/ko not_active IP Right Cessation
- 1993-08-03 JP JP19255593A patent/JP3330685B2/ja not_active Expired - Fee Related
-
1994
- 1994-06-03 US US08/253,523 patent/US5508170A/en not_active Expired - Fee Related
-
1999
- 1999-07-08 GR GR990401807T patent/GR3030728T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0585987T3 (da) | 1999-11-08 |
EP0585987A1 (en) | 1994-03-09 |
AU665432B2 (en) | 1996-01-04 |
AU4215893A (en) | 1994-02-10 |
EP0585987B2 (en) | 2004-09-08 |
DE69324745T2 (de) | 1999-10-14 |
KR940005288A (ko) | 1994-03-21 |
DE69324745T4 (de) | 2006-01-05 |
JP3330685B2 (ja) | 2002-09-30 |
CA2100617C (en) | 2003-06-24 |
DE69324745D1 (de) | 1999-06-10 |
EP0585987B1 (en) | 1999-05-06 |
DK0585987T4 (da) | 2005-01-17 |
ZA935180B (en) | 1994-05-25 |
US5508170A (en) | 1996-04-16 |
FI933441A (fi) | 1994-02-04 |
GR3030728T3 (en) | 1999-11-30 |
JPH06201702A (ja) | 1994-07-22 |
FI933441A0 (fi) | 1993-08-02 |
CA2100617A1 (en) | 1994-02-04 |
ES2132174T3 (es) | 1999-08-16 |
US5358853A (en) | 1994-10-25 |
KR100265531B1 (ko) | 2000-09-15 |
ES2132174T5 (es) | 2005-04-16 |
ATE179759T1 (de) | 1999-05-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI109152B (fi) | Stabiili nestemäinen tromboplastiinireagenssi, menetelmä sen valmistamiseksi sekä reagenssin sisältävä diagnostinen välineistö | |
Epstein et al. | Cation Transport in Escherichia coli: V. Regulation of cation content | |
Levin et al. | Clottable protein in Limulus: its localization and kinetics of its coagulation by endotoxin | |
JP3055933B2 (ja) | 改良された安定な凝固対照 | |
FI57421C (fi) | Foerfarande foer framstaellning av ett preparat ur maenniskoblodplasma med blodets koagulation befraemjande verkan | |
Gabay et al. | Subcellular location and properties of bactericidal factors from human neutrophils. | |
EP3937631A1 (en) | Canine blood platelet preparations | |
McGucken et al. | Studies on the mode of action of glutaraldehyde on Escherichia coli | |
Barton et al. | The preparation and properties of a stable factory V from bovine plasma | |
Phillips | Thrombin Interaction with Human Platelets Potentiation of Thrombin-induced Aggregation and Release by Inactivated Thrombin | |
JP4399615B2 (ja) | トロンビンの安定化手段および組成物 | |
CA2306972A1 (en) | Particles | |
Nechtman et al. | Comparative studies of oxygen equilibria of human adult and cord blood red cell hemolysates and suspensions | |
Lauf et al. | Solubilization and structural integrity of the human red cell membrane | |
JP3652738B2 (ja) | エンドトキシン安定化剤、エンドトキシン組成物およびエンドトキシンの測定法 | |
Pennell et al. | Preparation of stabilized solutions of hemoglobin | |
Wright et al. | Influence of specific growth rate and nutrient-limitation upon the sensitivity of Escherichia coli towards polymyxin B | |
CN107561296A (zh) | 一种测定凝血酶时间(tt)的试剂盒 | |
Fiehn et al. | Alteration of erythrocyte (Na++ K+)-ATPase by replacement of cholesterol by desmosterol in the membrane | |
CN110763527B (zh) | 一种尿液有形成分质控品及其制备方法和应用 | |
McFaul et al. | Observations on the cytolytic activity of lactoperoxidase using a continuous assay | |
Fleming | Chelation Properties of Bacterial Spore Components and Spore Responses Toionic Environments | |
Custer et al. | Lactoferrin and transferrin fragments react with nitrite to form an inhibitor of Bacillus cereus spore outgrowth | |
Chopin et al. | In vitro effects of lipids on fibrinolysis | |
GABAY | SUBCELLULAR LOCATION AND PROPERTIES OF BACTERICIDAL FACTORS FROM HUMAN NEUTROPHILS BY JOELLE E. GABAY,* JEANNE M. HEIPLE, t ZANVIL A. COHN,¢ AND CARL F. NATHAN |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |