DE69324745D1 - Flüssiges Thromboplastin-Reagens - Google Patents
Flüssiges Thromboplastin-ReagensInfo
- Publication number
- DE69324745D1 DE69324745D1 DE69324745A DE69324745A DE69324745D1 DE 69324745 D1 DE69324745 D1 DE 69324745D1 DE 69324745 A DE69324745 A DE 69324745A DE 69324745 A DE69324745 A DE 69324745A DE 69324745 D1 DE69324745 D1 DE 69324745D1
- Authority
- DE
- Germany
- Prior art keywords
- thromboplastin reagent
- liquid thromboplastin
- reagent
- liquid
- months
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/924,211 US5358853A (en) | 1992-08-03 | 1992-08-03 | Liquid thromboplastin reagent |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69324745D1 true DE69324745D1 (de) | 1999-06-10 |
Family
ID=25449889
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69324745T Expired - Lifetime DE69324745T4 (de) | 1992-08-03 | 1993-07-22 | Flüssiges Thromboplastin-Reagens |
DE69324745A Expired - Fee Related DE69324745D1 (de) | 1992-08-03 | 1993-07-22 | Flüssiges Thromboplastin-Reagens |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69324745T Expired - Lifetime DE69324745T4 (de) | 1992-08-03 | 1993-07-22 | Flüssiges Thromboplastin-Reagens |
Country Status (13)
Country | Link |
---|---|
US (2) | US5358853A (de) |
EP (1) | EP0585987B2 (de) |
JP (1) | JP3330685B2 (de) |
KR (1) | KR100265531B1 (de) |
AT (1) | ATE179759T1 (de) |
AU (1) | AU665432B2 (de) |
CA (1) | CA2100617C (de) |
DE (2) | DE69324745T4 (de) |
DK (1) | DK0585987T4 (de) |
ES (1) | ES2132174T5 (de) |
FI (1) | FI109152B (de) |
GR (1) | GR3030728T3 (de) |
ZA (1) | ZA935180B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
EP1015890B1 (de) * | 1997-04-23 | 2005-11-30 | INSTRUMENTATION LABORATORY S.p.A. | Rekombinant-kaninchengewebefaktor basiertes prothrombinzeitreagenz |
DE19720853A1 (de) * | 1997-05-17 | 1998-11-19 | Dade Behring Marburg Gmbh | Erhöhung der FVII Empfindlichkeit eines Thromboplastinreagenzes |
DE19811016A1 (de) * | 1998-03-13 | 1999-09-16 | Dade Behring Marburg Gmbh | Gebrauchsfertiges Prothrombinzeitreagenz auf der Basis von rekombinantem Gewebsfaktor |
CA2342606A1 (en) | 1998-10-07 | 2000-04-13 | Sigma-Aldrich Co. | Thromboplastin reagents and methods for preparing and using such reagents |
US6207661B1 (en) | 1999-02-22 | 2001-03-27 | Baxter International Inc. | Premixed formulation of piperacillin sodium and tazobactam sodium injection |
US6733985B1 (en) * | 1999-05-19 | 2004-05-11 | International Technidyne Corporation | Preparation of stable liquid and dried synthetic prothrombin time reagents |
US6248353B1 (en) | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
US6855509B2 (en) | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
EP1853926A2 (de) * | 2005-02-16 | 2007-11-14 | The Board Of Trustees Of The University Of Illinois | Prokoagulant auf der basis von metall-chelatierenden lipiden |
CN101184775A (zh) * | 2005-03-04 | 2008-05-21 | 伊利诺斯大学理事会 | 凝血及纤溶级联系统的调控剂 |
AU2007240732B2 (en) * | 2006-04-21 | 2013-07-04 | Amgen, Inc. | Buffering agents for biopharmaceutical formulations |
JP4999613B2 (ja) * | 2007-08-31 | 2012-08-15 | シスメックス株式会社 | 血液凝固測定用試薬及び血液凝固時間測定方法 |
WO2009046194A2 (en) * | 2007-10-05 | 2009-04-09 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
US20100297257A1 (en) * | 2007-11-09 | 2010-11-25 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) | Anticoagulant antagonist and hemophillia procoagulant |
DE102007062323A1 (de) | 2007-12-21 | 2009-06-25 | Siemens Healthcare Diagnostics Products Gmbh | Langzeitstabiles Thromboplastin-Reagenz |
WO2010134345A1 (ja) | 2009-05-20 | 2010-11-25 | 積水メディカル株式会社 | 血液凝固時間延長剤 |
JP5589103B2 (ja) * | 2013-01-23 | 2014-09-10 | 株式会社Lsiメディエンス | 二価金属イオン含有の体外診断用試薬組成物および二価金属イオン由来金属化合物の沈殿防止方法 |
JP6250306B2 (ja) * | 2013-05-28 | 2017-12-20 | 株式会社Lsiメディエンス | リポ化トロンボプラスチン含有血液凝固能測定試薬及び測定方法 |
JP2014197019A (ja) * | 2014-06-30 | 2014-10-16 | 積水メディカル株式会社 | 血液凝固反応における血液凝固時間延長剤 |
WO2017139567A1 (en) | 2016-02-12 | 2017-08-17 | Instrumentation Laboratory Company | A two component "mix and use" liquid thromboplastin reagent, methods of making, and methods of use thereof |
EP3489692A1 (de) | 2017-11-28 | 2019-05-29 | Siemens Healthcare Diagnostics Products GmbH | Prothrombinzeit-reagenz enthaltend einen eisenchelator |
US20210405072A1 (en) * | 2018-09-25 | 2021-12-30 | Sekisui Medical Co., Ltd. | Method for measuring blood coagulation time |
CN113005176A (zh) * | 2019-12-20 | 2021-06-22 | 深圳市帝迈生物技术有限公司 | 稳定剂、凝血酶原时间检测试剂及其制备方法、试剂盒 |
CN111638374B (zh) * | 2020-06-08 | 2022-10-18 | 深圳市国赛生物技术有限公司 | 一种用于测定凝血酶原时间的体外诊断试剂盒 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2516216A (en) * | 1947-06-24 | 1950-07-25 | Sharp & Dohme Inc | Thromboplastin as testing agent |
US2847350A (en) * | 1954-05-27 | 1958-08-12 | Ortho Pharma Corp | Preparation of highly active thromboplastin |
US2842480A (en) * | 1954-05-27 | 1958-07-08 | Ortho Pharma Corp | Preparation of thromboplastin |
US2847347A (en) * | 1954-05-27 | 1958-08-12 | Ortho Pharmacentical Corp | Preparation of improved thromboplastin |
US2921000A (en) * | 1956-05-22 | 1960-01-12 | Ortho Pharma Corp | Thromboplastin |
US3522148A (en) * | 1965-08-13 | 1970-07-28 | Dade Reagents Inc | Stabilized thromboplastin preparation |
DE3113350A1 (de) * | 1981-04-02 | 1982-10-21 | Boehringer Mannheim Gmbh, 6800 Mannheim | Reagens zur optischen bestimmung des blutgerinnungsverhaltens |
DE3150596A1 (de) * | 1981-12-21 | 1983-06-30 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von gewebsthromboplastin |
US4755461A (en) * | 1986-04-17 | 1988-07-05 | Bio/Data Corporation | Tableted blood plasma microconcentrated thromboplastin coagulation reagent |
DE68912115T2 (de) * | 1988-11-23 | 1994-08-11 | Baxter Diagnostics Inc | Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien. |
US5270451A (en) * | 1988-11-23 | 1993-12-14 | Baxter Diagnostics Inc. | Extraction method for preparing thromboplastin reagents |
US5091304A (en) * | 1989-08-21 | 1992-02-25 | International Technidyne Corporation | Whole blood activated partial thromboplastin time test and associated apparatus |
DE3929329A1 (de) * | 1989-09-04 | 1991-03-07 | Behringwerke Ag | Stabilisierungsmittel zur verbesserung der wiederfindung von gerinnungsfaktoren in blutproben |
US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
-
1992
- 1992-08-03 US US07/924,211 patent/US5358853A/en not_active Expired - Lifetime
-
1993
- 1993-07-15 CA CA002100617A patent/CA2100617C/en not_active Expired - Fee Related
- 1993-07-16 ZA ZA935180A patent/ZA935180B/xx unknown
- 1993-07-22 ES ES93202175T patent/ES2132174T5/es not_active Expired - Lifetime
- 1993-07-22 DK DK93202175T patent/DK0585987T4/da active
- 1993-07-22 DE DE69324745T patent/DE69324745T4/de not_active Expired - Lifetime
- 1993-07-22 EP EP93202175A patent/EP0585987B2/de not_active Expired - Lifetime
- 1993-07-22 AT AT93202175T patent/ATE179759T1/de not_active IP Right Cessation
- 1993-07-22 DE DE69324745A patent/DE69324745D1/de not_active Expired - Fee Related
- 1993-07-23 AU AU42158/93A patent/AU665432B2/en not_active Ceased
- 1993-08-02 FI FI933441A patent/FI109152B/fi not_active IP Right Cessation
- 1993-08-02 KR KR1019930014928A patent/KR100265531B1/ko not_active IP Right Cessation
- 1993-08-03 JP JP19255593A patent/JP3330685B2/ja not_active Expired - Fee Related
-
1994
- 1994-06-03 US US08/253,523 patent/US5508170A/en not_active Expired - Fee Related
-
1999
- 1999-07-08 GR GR990401807T patent/GR3030728T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69324745T4 (de) | 2006-01-05 |
ZA935180B (en) | 1994-05-25 |
JP3330685B2 (ja) | 2002-09-30 |
DE69324745T2 (de) | 1999-10-14 |
DK0585987T4 (da) | 2005-01-17 |
EP0585987A1 (de) | 1994-03-09 |
KR940005288A (ko) | 1994-03-21 |
US5358853A (en) | 1994-10-25 |
KR100265531B1 (ko) | 2000-09-15 |
AU4215893A (en) | 1994-02-10 |
EP0585987B1 (de) | 1999-05-06 |
GR3030728T3 (en) | 1999-11-30 |
FI933441A0 (fi) | 1993-08-02 |
FI933441A (fi) | 1994-02-04 |
DK0585987T3 (da) | 1999-11-08 |
ATE179759T1 (de) | 1999-05-15 |
US5508170A (en) | 1996-04-16 |
ES2132174T5 (es) | 2005-04-16 |
CA2100617C (en) | 2003-06-24 |
EP0585987B2 (de) | 2004-09-08 |
FI109152B (fi) | 2002-05-31 |
CA2100617A1 (en) | 1994-02-04 |
ES2132174T3 (es) | 1999-08-16 |
JPH06201702A (ja) | 1994-07-22 |
AU665432B2 (en) | 1996-01-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BIOMERIEUX, INC. (N.D.GES.D. STAATES MISSOURI), DU |
|
8339 | Ceased/non-payment of the annual fee |