ATE99697T1 - Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. - Google Patents
Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien.Info
- Publication number
- ATE99697T1 ATE99697T1 AT90900532T AT90900532T ATE99697T1 AT E99697 T1 ATE99697 T1 AT E99697T1 AT 90900532 T AT90900532 T AT 90900532T AT 90900532 T AT90900532 T AT 90900532T AT E99697 T1 ATE99697 T1 AT E99697T1
- Authority
- AT
- Austria
- Prior art keywords
- thromboplastin
- thromboplastin reagents
- extraction
- sensitivity
- manufacture
- Prior art date
Links
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 4
- 108010000499 Thromboplastin Proteins 0.000 title abstract 4
- 102000002262 Thromboplastin Human genes 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 108010094028 Prothrombin Proteins 0.000 abstract 2
- 102100027378 Prothrombin Human genes 0.000 abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 229940039716 prothrombin Drugs 0.000 abstract 2
- 230000035945 sensitivity Effects 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 208000014763 coagulation protein disease Diseases 0.000 abstract 1
- 229940072645 coumadin Drugs 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000006624 extrinsic pathway Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27608388A | 1988-11-23 | 1988-11-23 | |
| EP90900532A EP0396733B1 (de) | 1988-11-23 | 1989-11-03 | Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien |
| PCT/US1989/004867 WO1990005740A1 (en) | 1988-11-23 | 1989-11-03 | Improved extraction methods for preparing thromboplastin reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE99697T1 true ATE99697T1 (de) | 1994-01-15 |
Family
ID=23055093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90900532T ATE99697T1 (de) | 1988-11-23 | 1989-11-03 | Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5426031A (de) |
| EP (1) | EP0396733B1 (de) |
| JP (1) | JP3348228B2 (de) |
| AT (1) | ATE99697T1 (de) |
| CA (1) | CA2002208C (de) |
| DE (1) | DE68912115T2 (de) |
| DK (1) | DK173090A (de) |
| NO (1) | NO178578C (de) |
| WO (1) | WO1990005740A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
| US5254350A (en) * | 1991-07-22 | 1993-10-19 | Helena Laboratories Corporation | Method of preparing a thromboplastin extract |
| US5358853A (en) * | 1992-08-03 | 1994-10-25 | Akzo Av | Liquid thromboplastin reagent |
| DE4407386B4 (de) * | 1994-03-05 | 2009-01-15 | Dade Behring Marburg Gmbh | Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren |
| ATE202633T1 (de) * | 1994-04-28 | 2001-07-15 | Dade Behring Inc | Kalibrator für prothrombin-zeit-assays |
| US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
| US6100072A (en) * | 1997-04-23 | 2000-08-08 | Instrumentation Laboratory S.P.A. | Recombinant rabbit tissue factor based prothrombin time reagent |
| DE69928961T2 (de) | 1998-10-07 | 2006-07-13 | Trinity Biotech Manufacturing Ltd. | Thromboplastin-reagenzien und verfahren zur herstellung und anwendung derselben |
| US6855509B2 (en) * | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
| US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
| CN101151533A (zh) * | 2005-02-16 | 2008-03-26 | 伊利诺斯大学理事会 | 基于金属螯合脂质的促凝血剂 |
| US7682808B2 (en) * | 2005-03-04 | 2010-03-23 | The Board Of Trustees Of The University Of Illinois | Coagulation and fibrinolytic cascades modulator |
| US8821861B2 (en) * | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
| US20100297257A1 (en) * | 2007-11-09 | 2010-11-25 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) | Anticoagulant antagonist and hemophillia procoagulant |
| CN112481355B (zh) * | 2020-11-16 | 2023-05-30 | 武汉市长立生物技术有限责任公司 | 液体型凝血酶原时间测定试剂盒及其制备方法 |
| CN115166268B (zh) * | 2022-08-02 | 2025-07-04 | 南京颐兰贝生物科技有限责任公司 | 一种凝血酶原时间检测试剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3522148A (en) * | 1965-08-13 | 1970-07-28 | Dade Reagents Inc | Stabilized thromboplastin preparation |
| JPS6366556A (ja) * | 1986-09-09 | 1988-03-25 | Fujitsu Ltd | フオトマスクの修正方法 |
| US5017556A (en) * | 1986-11-04 | 1991-05-21 | Genentech, Inc. | Treatment of bleeding disorders using lipid-free tissue factor protein |
-
1989
- 1989-11-03 EP EP90900532A patent/EP0396733B1/de not_active Expired - Lifetime
- 1989-11-03 WO PCT/US1989/004867 patent/WO1990005740A1/en not_active Ceased
- 1989-11-03 DE DE68912115T patent/DE68912115T2/de not_active Expired - Fee Related
- 1989-11-03 JP JP50074490A patent/JP3348228B2/ja not_active Expired - Fee Related
- 1989-11-03 CA CA002002208A patent/CA2002208C/en not_active Expired - Lifetime
- 1989-11-03 AT AT90900532T patent/ATE99697T1/de not_active IP Right Cessation
-
1990
- 1990-07-19 DK DK173090A patent/DK173090A/da not_active IP Right Cessation
- 1990-07-20 NO NO903261A patent/NO178578C/no not_active IP Right Cessation
-
1993
- 1993-05-25 US US08/070,875 patent/US5426031A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03503534A (ja) | 1991-08-08 |
| EP0396733A1 (de) | 1990-11-14 |
| DE68912115T2 (de) | 1994-08-11 |
| NO178578B (no) | 1996-01-15 |
| CA2002208C (en) | 1998-02-24 |
| DK173090D0 (da) | 1990-07-19 |
| NO903261D0 (no) | 1990-07-20 |
| NO903261L (no) | 1990-07-20 |
| JP3348228B2 (ja) | 2002-11-20 |
| WO1990005740A1 (en) | 1990-05-31 |
| DK173090A (da) | 1990-07-19 |
| CA2002208A1 (en) | 1990-05-23 |
| EP0396733B1 (de) | 1994-01-05 |
| US5426031A (en) | 1995-06-20 |
| NO178578C (no) | 1996-04-24 |
| DE68912115D1 (de) | 1994-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |