ATE99697T1 - Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. - Google Patents
Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien.Info
- Publication number
- ATE99697T1 ATE99697T1 AT90900532T AT90900532T ATE99697T1 AT E99697 T1 ATE99697 T1 AT E99697T1 AT 90900532 T AT90900532 T AT 90900532T AT 90900532 T AT90900532 T AT 90900532T AT E99697 T1 ATE99697 T1 AT E99697T1
- Authority
- AT
- Austria
- Prior art keywords
- thromboplastin
- thromboplastin reagents
- extraction
- sensitivity
- manufacture
- Prior art date
Links
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 4
- 108010000499 Thromboplastin Proteins 0.000 title abstract 4
- 102000002262 Thromboplastin Human genes 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 108010094028 Prothrombin Proteins 0.000 abstract 2
- 102100027378 Prothrombin Human genes 0.000 abstract 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 abstract 2
- 238000000605 extraction Methods 0.000 abstract 2
- 229940039716 prothrombin Drugs 0.000 abstract 2
- 230000035945 sensitivity Effects 0.000 abstract 2
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000003196 chaotropic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 208000014763 coagulation protein disease Diseases 0.000 abstract 1
- 229940072645 coumadin Drugs 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000006624 extrinsic pathway Effects 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- VGTPCRGMBIAPIM-UHFFFAOYSA-M sodium thiocyanate Chemical compound [Na+].[S-]C#N VGTPCRGMBIAPIM-UHFFFAOYSA-M 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/7454—Tissue factor (tissue thromboplastin, Factor III)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27608388A | 1988-11-23 | 1988-11-23 | |
| EP90900532A EP0396733B1 (de) | 1988-11-23 | 1989-11-03 | Ausscheidungsverfahren für die herstellung von thromboplastinreagenzien |
| PCT/US1989/004867 WO1990005740A1 (en) | 1988-11-23 | 1989-11-03 | Improved extraction methods for preparing thromboplastin reagents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE99697T1 true ATE99697T1 (de) | 1994-01-15 |
Family
ID=23055093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90900532T ATE99697T1 (de) | 1988-11-23 | 1989-11-03 | Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5426031A (de) |
| EP (1) | EP0396733B1 (de) |
| JP (1) | JP3348228B2 (de) |
| AT (1) | ATE99697T1 (de) |
| CA (1) | CA2002208C (de) |
| DE (1) | DE68912115T2 (de) |
| DK (1) | DK173090D0 (de) |
| NO (1) | NO178578C (de) |
| WO (1) | WO1990005740A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281528A (en) * | 1989-12-18 | 1994-01-25 | Warner-Lambert Company | Process for purified thromboplastin for ultra-pure thrombin preparation |
| US5254350A (en) * | 1991-07-22 | 1993-10-19 | Helena Laboratories Corporation | Method of preparing a thromboplastin extract |
| US5358853A (en) * | 1992-08-03 | 1994-10-25 | Akzo Av | Liquid thromboplastin reagent |
| DE4407386B4 (de) * | 1994-03-05 | 2009-01-15 | Dade Behring Marburg Gmbh | Verfahren zur Reaktivierung von gereinigten Membranproteinen durch Einfrieren |
| DE69521470T2 (de) * | 1994-04-28 | 2002-05-16 | Dade Behring Inc., Deerfield | Kalibrator für prothrombin-zeit-assays |
| US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
| IL132529A0 (en) * | 1997-04-23 | 2001-03-19 | Instrumentation Lab Spa | A method of preparing a liquid or a lyophilized reagent and a reagent produced thereby |
| JP2002526557A (ja) | 1998-10-07 | 2002-08-20 | シグマ−アルドリッチ・カンパニー | トロンボプラスチン試薬ならびにそのような試薬の製造および使用方法 |
| US6855509B2 (en) * | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
| US7148067B2 (en) * | 2004-08-31 | 2006-12-12 | The Board Of Trustees Of The University Of Illinois | Thromboplastin reagents |
| WO2006088741A2 (en) * | 2005-02-16 | 2006-08-24 | The Board Of Trustees Of The University Of Illinois | Procoagulants based on metal-chelating lipids |
| CN101184775A (zh) * | 2005-03-04 | 2008-05-21 | 伊利诺斯大学理事会 | 凝血及纤溶级联系统的调控剂 |
| WO2009046194A2 (en) * | 2007-10-05 | 2009-04-09 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
| US20100297257A1 (en) * | 2007-11-09 | 2010-11-25 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) | Anticoagulant antagonist and hemophillia procoagulant |
| CN112481355B (zh) * | 2020-11-16 | 2023-05-30 | 武汉市长立生物技术有限责任公司 | 液体型凝血酶原时间测定试剂盒及其制备方法 |
| CN115166268B (zh) * | 2022-08-02 | 2025-07-04 | 南京颐兰贝生物科技有限责任公司 | 一种凝血酶原时间检测试剂及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3522148A (en) * | 1965-08-13 | 1970-07-28 | Dade Reagents Inc | Stabilized thromboplastin preparation |
| JPS6366556A (ja) * | 1986-09-09 | 1988-03-25 | Fujitsu Ltd | フオトマスクの修正方法 |
| US5017556A (en) * | 1986-11-04 | 1991-05-21 | Genentech, Inc. | Treatment of bleeding disorders using lipid-free tissue factor protein |
-
1989
- 1989-11-03 EP EP90900532A patent/EP0396733B1/de not_active Expired - Lifetime
- 1989-11-03 WO PCT/US1989/004867 patent/WO1990005740A1/en not_active Ceased
- 1989-11-03 DE DE68912115T patent/DE68912115T2/de not_active Expired - Fee Related
- 1989-11-03 CA CA002002208A patent/CA2002208C/en not_active Expired - Lifetime
- 1989-11-03 AT AT90900532T patent/ATE99697T1/de not_active IP Right Cessation
- 1989-11-03 JP JP50074490A patent/JP3348228B2/ja not_active Expired - Fee Related
-
1990
- 1990-07-19 DK DK173090A patent/DK173090D0/da not_active IP Right Cessation
- 1990-07-20 NO NO903261A patent/NO178578C/no not_active IP Right Cessation
-
1993
- 1993-05-25 US US08/070,875 patent/US5426031A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0396733A1 (de) | 1990-11-14 |
| CA2002208A1 (en) | 1990-05-23 |
| JPH03503534A (ja) | 1991-08-08 |
| DK173090A (da) | 1990-07-19 |
| EP0396733B1 (de) | 1994-01-05 |
| JP3348228B2 (ja) | 2002-11-20 |
| DK173090D0 (da) | 1990-07-19 |
| NO178578B (no) | 1996-01-15 |
| DE68912115T2 (de) | 1994-08-11 |
| US5426031A (en) | 1995-06-20 |
| DE68912115D1 (de) | 1994-02-17 |
| CA2002208C (en) | 1998-02-24 |
| NO178578C (no) | 1996-04-24 |
| NO903261D0 (no) | 1990-07-20 |
| NO903261L (no) | 1990-07-20 |
| WO1990005740A1 (en) | 1990-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE99697T1 (de) | Ausscheidungsverfahren fuer die herstellung von thromboplastinreagenzien. | |
| ATE203567T1 (de) | Verbesserte in vitro verfahren, testkits und reagenzien zum screening von blutgerinnungsfehlern | |
| ATE78098T1 (de) | Testverfahren mit oberflaechengebundenem fibrinogen und loesliches markiertes fibrinogen. | |
| TWI256975B (en) | Compositions containing a urea derivative dye for detecting an analyte and methods for using the same | |
| DE3587724D1 (de) | Antikörper verwendende diagnostische Methoden. | |
| ES2072970T3 (es) | Metodo para determinar el potencial de trombina endogeno del plasma y de la sangre, y tambien un equipo para su uso en dicho metodo. | |
| WO1991002812A1 (en) | METHOD AND ASSAY USING INACTIVATION OF FACTORS Va AND VIIIa BY PROTEIN C | |
| ATE71459T1 (de) | Verfahren zur ueberwachung der blutgerinnung. | |
| JPH11225796A5 (de) | ||
| DE3780485D1 (de) | Verfahren zur photometrischen bestimmung der protein c- und/oder protein s-aktivitaet. | |
| ES2061459T3 (es) | Procedimiento de ensayo de substancias fisiologicamente activas. | |
| DE60110407D1 (de) | Reagenz zur bestimmung von blutplättchen-mikroteilchen | |
| Walenga et al. | Newer avenues in the monitoring of antithrombotic therapy: The role of automation | |
| ATE16944T1 (de) | Reagens zur optischen bestimmung des blutgerinnungsverhaltens. | |
| US5787901A (en) | Method for the measurement of blood coagulation properties with absorbent materials | |
| CA2019872A1 (en) | Method and kit for determining the functional activity of protein s in human plasma | |
| DE60231144D1 (de) | Test für niedrigmolekulares heparin, system und reagenz dafür | |
| ES2090106T3 (es) | Metodo de asociacion quimica directa de dimero d procedente de una muestra biologica y que permite el diagnostico y el seguimiento de estados de trombolisis y de hipercoagulabilidad. | |
| Lippi et al. | Preoperative screening: the rationale of measuring APTT in risk assessment | |
| Merlini et al. | Laboratory measurement of thrombin activity—What every clinician scientist needs to know | |
| ATE191278T1 (de) | Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen | |
| Quien et al. | Plasma tissue factor antigen levels in capillary whole blood and venous blood: effect of tissue factor on prothrombin time | |
| Hawkins et al. | Extraction methods for preparing thromboplastin reagents | |
| Dati et al. | RESULTS OF THE MULTICENTRIC EVALUATION OF A NEW SYSTEM FOR PHOTOMETRIC DETERMINATION OF COAGULATION PARAMETERS | |
| Bartl et al. | APPLICATION OF THE ROUTINE PHOTOMETRIC COAGULATION ASSAYS PT, APTT AND FIBRINOGEN TO A CENTRIFUGAL ANALYZER |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |