ATE191278T1 - Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen - Google Patents
Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungenInfo
- Publication number
- ATE191278T1 ATE191278T1 AT95901136T AT95901136T ATE191278T1 AT E191278 T1 ATE191278 T1 AT E191278T1 AT 95901136 T AT95901136 T AT 95901136T AT 95901136 T AT95901136 T AT 95901136T AT E191278 T1 ATE191278 T1 AT E191278T1
- Authority
- AT
- Austria
- Prior art keywords
- blood clotting
- tetrahydroxyquinone
- indicator
- time test
- partial thromboplastin
- Prior art date
Links
- 230000023555 blood coagulation Effects 0.000 title abstract 4
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 title abstract 2
- 102000002262 Thromboplastin Human genes 0.000 title abstract 2
- 108010000499 Thromboplastin Proteins 0.000 title abstract 2
- 239000012190 activator Substances 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- DGQOCLATAPFASR-UHFFFAOYSA-N tetrahydroxy-1,4-benzoquinone Chemical compound OC1=C(O)C(=O)C(O)=C(O)C1=O DGQOCLATAPFASR-UHFFFAOYSA-N 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14813993A | 1993-11-04 | 1993-11-04 | |
| PCT/US1994/012693 WO1995012818A1 (en) | 1993-11-04 | 1994-11-04 | Tetrahydroxyquinone as an activator component for activated partial thromboplastine time test of blood coagulation and as a detector of blood coagulation disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE191278T1 true ATE191278T1 (de) | 2000-04-15 |
Family
ID=22524463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95901136T ATE191278T1 (de) | 1993-11-04 | 1994-11-04 | Tetrahydroxychinon als eine aktivatorkomponente für den aktivierten partiellen thromboplastinzeit-test der blutgerinnung und als anzeiger von blutgerinnungsstörungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5550028A (de) |
| EP (1) | EP0677171B1 (de) |
| JP (1) | JPH08510057A (de) |
| AT (1) | ATE191278T1 (de) |
| AU (1) | AU674265B2 (de) |
| CA (1) | CA2152954A1 (de) |
| DE (1) | DE69423738T2 (de) |
| WO (1) | WO1995012818A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT405692B (de) * | 1997-03-27 | 1999-10-25 | Immuno Ag | Reagens zur bestimmung der aptt |
| CA2382143C (en) | 1999-09-03 | 2005-10-18 | Roche Diagnostics Corporation | Method, reagent and test cartridge for determining clotting time |
| US6448024B1 (en) | 2000-10-03 | 2002-09-10 | Roche Diagnostics Corporation | Method, reagent, cartridge, and device for determining fibrinogen |
| JP6577778B2 (ja) * | 2015-07-30 | 2019-09-18 | シスメックス株式会社 | 凝固時間の測定方法およびその装置、凝固時間測定用試薬ならびに試薬キット |
| WO2020067171A1 (ja) * | 2018-09-25 | 2020-04-02 | 積水メディカル株式会社 | 血液凝固時間測定方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3486981A (en) * | 1965-03-15 | 1969-12-30 | Roy E Speck | Substances relating to testing of blood-coagulation |
| BE722746A (de) * | 1967-11-09 | 1969-04-01 | ||
| US3839317A (en) * | 1973-06-29 | 1974-10-01 | Interx Research Corp | Digoxin complexes |
| US3880714A (en) * | 1973-07-18 | 1975-04-29 | Warner Lambert Co | Diagnostic reagent |
| JPS60174952A (ja) * | 1984-02-21 | 1985-09-09 | Sekisui Chem Co Ltd | 血液凝固促進剤 |
| DE3407280A1 (de) * | 1984-02-28 | 1985-09-19 | Gödecke AG, 1000 Berlin | Testsatz zur bestimmung der aktivierten partiellen thromboplastinzeit (ptt) mit erhoehter heparinempfindlichkeit |
| CA1313997C (en) * | 1986-04-11 | 1993-03-02 | Hideo Anraku | Accelerator of the activity of hydrolase |
| US5126247A (en) * | 1988-02-26 | 1992-06-30 | Enzymatics, Inc. | Method, system and devices for the assay and detection of biochemical molecules |
| US5055412A (en) * | 1989-03-21 | 1991-10-08 | Proksch Gary J | Factor sensitive reagent for testing of blood coagulation containing ellagic acid and divalent metal ions and method of making the same |
| FI102273B1 (fi) * | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyttö |
| ATE140034T1 (de) * | 1990-04-17 | 1996-07-15 | Analytical Control Syst Inc | Koagulationsassays und reagenzien |
| US5302531A (en) * | 1992-10-22 | 1994-04-12 | Miles Inc. | Composition for the semiquantitative determination of specific gravity of a test sample |
-
1994
- 1994-11-04 AT AT95901136T patent/ATE191278T1/de not_active IP Right Cessation
- 1994-11-04 AU AU10494/95A patent/AU674265B2/en not_active Ceased
- 1994-11-04 EP EP95901136A patent/EP0677171B1/de not_active Expired - Lifetime
- 1994-11-04 CA CA002152954A patent/CA2152954A1/en not_active Abandoned
- 1994-11-04 JP JP7513430A patent/JPH08510057A/ja active Pending
- 1994-11-04 DE DE69423738T patent/DE69423738T2/de not_active Expired - Fee Related
- 1994-11-04 WO PCT/US1994/012693 patent/WO1995012818A1/en not_active Ceased
-
1995
- 1995-06-07 US US08/484,373 patent/US5550028A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2152954A1 (en) | 1995-05-11 |
| AU1049495A (en) | 1995-05-23 |
| US5550028A (en) | 1996-08-27 |
| DE69423738D1 (de) | 2000-05-04 |
| JPH08510057A (ja) | 1996-10-22 |
| EP0677171B1 (de) | 2000-03-29 |
| DE69423738T2 (de) | 2000-11-23 |
| AU674265B2 (en) | 1996-12-12 |
| EP0677171A1 (de) | 1995-10-18 |
| WO1995012818A1 (en) | 1995-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |