FI109125B - Förfarande för framställning av pamoatadditionssalt av risperidon - Google Patents
Förfarande för framställning av pamoatadditionssalt av risperidon Download PDFInfo
- Publication number
- FI109125B FI109125B FI955166A FI955166A FI109125B FI 109125 B FI109125 B FI 109125B FI 955166 A FI955166 A FI 955166A FI 955166 A FI955166 A FI 955166A FI 109125 B FI109125 B FI 109125B
- Authority
- FI
- Finland
- Prior art keywords
- risperidone
- pamoate
- compounds
- addition salt
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (3)
1. Förfarande för framställning av ett terapeutiskt användbart pamoatsyraadditionssalt av risperidon med for-5 mein (I), O II r^r/YcH3 ^γ^ΟΗ
10 IA, (,) O S O 15 kännetecknat av att 3-[2-[4-(6-fluor-l,2-ben-s isoxazol-3-yl)-1-piperidinyl]etyl]-6,7,8,9-tetrahydro-2-metyl-4H-pyrido [1,2-a] pyrimin-4-on behandlas med pamoinsy-ra i ett reaktionsinert lösningsmedel.
2. Förfarande enligt patentkrav 1, k ä n n e -20 tecknat av att den framställda föreningen har for- meln q II ^ C—OH : ,\S ^V^-ch.-nc«2 o v_y \ j \=y F o .·. :30 • * · ,···.
3. Förfarande enligt patentkrav 1, kanne - t e c k n a t av att 3-[2-[4(6-fluor-l,2-bensisoxazol-3- * · \ ί y.l) l-piperidinyl] etyl] -6,7,8,9-tetrahydro-2-metyl-4H-pyri- do [1,2-a]pyrimidin-4-on behandlas med pamoinsyra i ett .,.,:35 reaktionsinert lösningsmedel. * · ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93201216 | 1993-04-28 | ||
| EP93201216 | 1993-04-28 | ||
| EP9401296 | 1994-04-22 | ||
| PCT/EP1994/001296 WO1994025460A1 (en) | 1993-04-28 | 1994-04-22 | Risperidone pamoate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI955166A FI955166A (sv) | 1995-10-27 |
| FI955166A0 FI955166A0 (sv) | 1995-10-27 |
| FI109125B true FI109125B (sv) | 2002-05-31 |
Family
ID=8213799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI955166A FI109125B (sv) | 1993-04-28 | 1995-10-27 | Förfarande för framställning av pamoatadditionssalt av risperidon |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US5612346A (sv) |
| EP (1) | EP0697019B1 (sv) |
| JP (1) | JP3478397B2 (sv) |
| KR (1) | KR100307101B1 (sv) |
| CN (1) | CN1041727C (sv) |
| AT (1) | ATE163418T1 (sv) |
| AU (1) | AU675136B2 (sv) |
| BG (1) | BG62004B1 (sv) |
| CA (1) | CA2160366C (sv) |
| CY (1) | CY2107B1 (sv) |
| CZ (1) | CZ286688B6 (sv) |
| DE (1) | DE69408666T2 (sv) |
| DK (1) | DK0697019T3 (sv) |
| ES (1) | ES2113652T3 (sv) |
| FI (1) | FI109125B (sv) |
| GR (1) | GR3026028T3 (sv) |
| HK (1) | HK1006059A1 (sv) |
| HU (1) | HU218212B (sv) |
| IL (1) | IL109448A (sv) |
| LV (1) | LV12315B (sv) |
| NO (1) | NO305083B1 (sv) |
| NZ (1) | NZ266143A (sv) |
| PH (1) | PH30476A (sv) |
| PL (1) | PL182466B1 (sv) |
| RO (1) | RO115955B1 (sv) |
| RU (1) | RU2131428C1 (sv) |
| SG (1) | SG47046A1 (sv) |
| SI (1) | SI9420031B (sv) |
| SK (1) | SK280589B6 (sv) |
| TW (1) | TW376319B (sv) |
| WO (1) | WO1994025460A1 (sv) |
| ZA (1) | ZA942909B (sv) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2236700T3 (es) * | 1993-11-19 | 2005-07-16 | Janssen Pharmaceutica N.V. | 1,2-benzazoles microencapsulados. |
| US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
| TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
| US6617321B2 (en) * | 1997-09-30 | 2003-09-09 | Eli Lilly And Company | 2-methyl-thieno-benzodiazepine formulation |
| UA73715C2 (en) * | 1997-09-30 | 2005-09-15 | Lilly Co Eli | Pharmaceutically acceptable formulation of olanzapine pamoate and its use for treatment |
| UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
| PT1468689E (pt) * | 1998-09-30 | 2007-07-09 | Lilly Co Eli | Formulação de 2-metil-tieno-benzodiazepina. |
| AU1816900A (en) * | 1998-11-12 | 2000-05-29 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
| FR2802101B1 (fr) | 1999-12-10 | 2003-02-28 | Aventis Pharma Sa | Association de cymemazine et d'un neuroleptique atypique |
| US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
| US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| AU2002218494A1 (en) * | 2000-11-29 | 2002-06-11 | Takeda Chemical Industries Ltd. | Medicinal compositions and process for producing the same |
| US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
| EP1534288A1 (en) * | 2002-08-23 | 2005-06-01 | Ranbaxy Laboratories, Ltd. | Stable aqueous solutions of risperidone and methods for their preparation |
| KR20040034996A (ko) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | 리스페리돈의 개선된 제조방법 |
| WO2004094415A1 (en) * | 2003-04-22 | 2004-11-04 | Synthon B.V. | Risperidone monohydrochloride |
| US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| CN1870980B (zh) * | 2003-10-23 | 2010-06-23 | 大冢制药株式会社 | 控释无菌阿立哌唑注射剂和方法 |
| CA2547639A1 (en) * | 2003-12-02 | 2005-06-16 | B&B Beheer Nv | Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists |
| US7884096B2 (en) * | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
| WO2005072705A1 (en) * | 2004-01-29 | 2005-08-11 | Neuromolecular, Inc. | Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions |
| US7932249B2 (en) * | 2005-01-05 | 2011-04-26 | Eli Lilly And Company | Olanzapine pamoate dihydrate |
| EP1695973A1 (en) * | 2005-02-24 | 2006-08-30 | Neuro3D | Ocaperidone salt and pharmaceutical compositions containing the same |
| AR055099A1 (es) * | 2005-07-28 | 2007-08-08 | Alza Corp | Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol |
| EP1933814A2 (en) * | 2005-09-15 | 2008-06-25 | Elan Pharma International Limited | Nanoparticulate aripiprazole formulations |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| BRPI0811319A2 (pt) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento |
| BRPI0815382A2 (pt) * | 2007-07-31 | 2015-02-10 | Otsuka Pharma Co Ltd | Métodos para a produção de suspensão de aripiprazol e formulação de secagem por congelamento |
| DK2234617T3 (da) * | 2007-12-19 | 2021-05-25 | Janssen Pharmaceutica Nv | Doseringsskema forbundet med langtidsvirkende injicerbare paliperidonestere |
| EP4327872A3 (en) | 2011-03-18 | 2024-07-10 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
| US9040695B2 (en) * | 2011-04-26 | 2015-05-26 | Torrent Pharmaceuticals Limited | Acid addition salts of risperidone and pharmaceutical compositions thereof |
| NZ630428A (en) * | 2012-03-19 | 2017-02-24 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising benzyl alcohol |
| NZ630643A (en) | 2012-03-19 | 2017-08-25 | Alkermes Pharma Ireland Ltd | Pharmaceutical compositions comprising fatty acid esters |
| ES2764383T3 (es) | 2012-03-19 | 2020-06-03 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que comprenden ésteres de glicerol |
| AU2013245011B2 (en) | 2012-04-04 | 2017-11-23 | Intervet International B.V. | Solid oral pharmaceutical compositions for isoxazoline compounds |
| CN102659577B (zh) * | 2012-04-07 | 2014-07-02 | 安徽绩溪县徽煌化工有限公司 | 一种亚甲基双羟基萘酸的制备方法 |
| CA2885196C (en) | 2012-09-19 | 2021-06-22 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions having improved storage stability |
| US9375433B2 (en) | 2012-09-26 | 2016-06-28 | Tangent Reprofiling Limited | Modulators of androgen synthesis |
| NZ706067A (en) | 2012-09-26 | 2016-07-29 | Tangent Reprofiling Ltd | Modulators of androgen synthesis |
| WO2015143145A1 (en) | 2014-03-20 | 2015-09-24 | Alkermes Pharma Ireland Limited | Aripiprazole formulations having increased injection speeds |
| CN106831594B (zh) * | 2017-01-18 | 2018-02-02 | 力赛生物医药科技（厦门）有限公司 | 可乐定双羟萘酸盐及其制备方法 |
| US11273158B2 (en) | 2018-03-05 | 2022-03-15 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
-
1994
- 1994-03-31 TW TW083102808A patent/TW376319B/zh not_active IP Right Cessation
- 1994-04-08 PH PH48074A patent/PH30476A/en unknown
- 1994-04-22 CA CA002160366A patent/CA2160366C/en not_active Expired - Lifetime
- 1994-04-22 PL PL94311282A patent/PL182466B1/pl unknown
- 1994-04-22 JP JP52386294A patent/JP3478397B2/ja not_active Expired - Lifetime
- 1994-04-22 EP EP94915538A patent/EP0697019B1/en not_active Expired - Lifetime
- 1994-04-22 KR KR1019950704171A patent/KR100307101B1/ko not_active IP Right Cessation
- 1994-04-22 CN CN94191934A patent/CN1041727C/zh not_active Expired - Lifetime
- 1994-04-22 US US08/522,422 patent/US5612346A/en not_active Expired - Lifetime
- 1994-04-22 WO PCT/EP1994/001296 patent/WO1994025460A1/en active IP Right Grant
- 1994-04-22 SG SG1996004131A patent/SG47046A1/en unknown
- 1994-04-22 ES ES94915538T patent/ES2113652T3/es not_active Expired - Lifetime
- 1994-04-22 RU RU95119831A patent/RU2131428C1/ru active
- 1994-04-22 CZ CZ19952706A patent/CZ286688B6/cs not_active IP Right Cessation
- 1994-04-22 AT AT94915538T patent/ATE163418T1/de active
- 1994-04-22 SK SK1313-95A patent/SK280589B6/sk not_active IP Right Cessation
- 1994-04-22 SI SI9420031A patent/SI9420031B/sl unknown
- 1994-04-22 DK DK94915538T patent/DK0697019T3/da active
- 1994-04-22 RO RO95-01879A patent/RO115955B1/ro unknown
- 1994-04-22 HU HU9501934A patent/HU218212B/hu unknown
- 1994-04-22 DE DE69408666T patent/DE69408666T2/de not_active Expired - Lifetime
- 1994-04-22 AU AU67216/94A patent/AU675136B2/en not_active Expired
- 1994-04-22 NZ NZ266143A patent/NZ266143A/en not_active IP Right Cessation
- 1994-04-26 ZA ZA942909A patent/ZA942909B/xx unknown
- 1994-04-27 IL IL109448A patent/IL109448A/xx not_active IP Right Cessation
-
1995
- 1995-10-25 BG BG100094A patent/BG62004B1/bg unknown
- 1995-10-26 NO NO954275A patent/NO305083B1/no not_active IP Right Cessation
- 1995-10-27 FI FI955166A patent/FI109125B/sv not_active IP Right Cessation
-
1996
- 1996-12-24 US US08/773,737 patent/US5723467A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 GR GR980400198T patent/GR3026028T3/el unknown
- 1998-06-11 HK HK98105164A patent/HK1006059A1/xx not_active IP Right Cessation
- 1998-06-16 CY CY9800009A patent/CY2107B1/xx unknown
-
1999
- 1999-02-24 LV LVP-99-32A patent/LV12315B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |