ATE163418T1 - Risperidon pamoate - Google Patents

Risperidon pamoate

Info

Publication number
ATE163418T1
ATE163418T1 AT94915538T AT94915538T ATE163418T1 AT E163418 T1 ATE163418 T1 AT E163418T1 AT 94915538 T AT94915538 T AT 94915538T AT 94915538 T AT94915538 T AT 94915538T AT E163418 T1 ATE163418 T1 AT E163418T1
Authority
AT
Austria
Prior art keywords
pct
risperidone
sec
compositions
compound
Prior art date
Application number
AT94915538T
Other languages
English (en)
Inventor
Jean Louis Mesens
Jozef Peeters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE163418T1 publication Critical patent/ATE163418T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94915538T 1993-04-28 1994-04-22 Risperidon pamoate ATE163418T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93201216 1993-04-28

Publications (1)

Publication Number Publication Date
ATE163418T1 true ATE163418T1 (de) 1998-03-15

Family

ID=8213799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94915538T ATE163418T1 (de) 1993-04-28 1994-04-22 Risperidon pamoate

Country Status (31)

Country Link
US (2) US5612346A (de)
EP (1) EP0697019B1 (de)
JP (1) JP3478397B2 (de)
KR (1) KR100307101B1 (de)
CN (1) CN1041727C (de)
AT (1) ATE163418T1 (de)
AU (1) AU675136B2 (de)
BG (1) BG62004B1 (de)
CA (1) CA2160366C (de)
CY (1) CY2107B1 (de)
CZ (1) CZ286688B6 (de)
DE (1) DE69408666T2 (de)
DK (1) DK0697019T3 (de)
ES (1) ES2113652T3 (de)
FI (1) FI109125B (de)
GR (1) GR3026028T3 (de)
HU (1) HU218212B (de)
IL (1) IL109448A (de)
LV (1) LV12315B (de)
NO (1) NO305083B1 (de)
NZ (1) NZ266143A (de)
PH (1) PH30476A (de)
PL (1) PL182466B1 (de)
RO (1) RO115955B1 (de)
RU (1) RU2131428C1 (de)
SG (1) SG47046A1 (de)
SI (1) SI9420031B (de)
SK (1) SK280589B6 (de)
TW (1) TW376319B (de)
WO (1) WO1994025460A1 (de)
ZA (1) ZA942909B (de)

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CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
ID25533A (id) * 1997-09-30 2000-10-12 Lilly Co Eli Formulasi 2-metil-tieno-benzodiazepin
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
EP1119359B1 (de) * 1998-09-30 2004-05-26 Eli Lilly & Company 2-methyl-thieno-benzodiazepin-formulierung
AU1816900A (en) * 1998-11-12 2000-05-29 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
US6770478B2 (en) * 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
WO2002043766A1 (en) * 2000-11-29 2002-06-06 Takeda Chemical Industries, Ltd. Medicinal compositions and process for producing the same
JP4500679B2 (ja) * 2002-07-29 2010-07-14 アルザ・コーポレーシヨン パリペリドンを制御送達する方法および投薬形態物
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
WO2004017975A1 (en) * 2002-08-23 2004-03-04 Ranbaxy Laboratories Limited Stable aqueous solutions of risperidone and methods for their preparation
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
EP1615923A1 (de) * 2003-04-22 2006-01-18 Synthon B.V. Risperidon monohydrochlorid
RU2249456C1 (ru) * 2003-07-15 2005-04-10 Боев Игорь Викторович Способ комбинированного купирования шизоаффективных синдромов психотического и субпсихотического уровня в условиях дневного стационара
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
KR100931784B1 (ko) * 2003-10-23 2009-12-14 오츠카 세이야쿠 가부시키가이샤 방출조절성 멸균 아리피프라졸 주사제, 그 제조방법
US7884096B2 (en) * 2003-12-02 2011-02-08 Pharmaneuroboost N.V. Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
EP2272514A1 (de) * 2003-12-02 2011-01-12 PharmaNeuroBoost N.V. Verwendung von niedrigdosiertem Pipamperon und einem zweiten Wirkstoff zur Behandlung von neurodegenerativen Erkrankungen
WO2005072705A1 (en) * 2004-01-29 2005-08-11 Neuromolecular, Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions
PL1838716T3 (pl) * 2005-01-05 2011-09-30 Lilly Co Eli Dihydrat embonianu olanzapiny
EP1695973A1 (de) * 2005-02-24 2006-08-30 Neuro3D Ocaperidonsalz und dieser enthaltende pharmazeutische Zubereitung
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
EP1933814A2 (de) * 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoteilchenförmige aripiprazol-formulierungen
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
JP2010531807A (ja) 2007-05-25 2010-09-30 トルマー セラピューティクス， インコーポレイテッド リスペリドン化合物の徐放送達製剤
LT2170279T (lt) * 2007-07-31 2018-03-12 Otsuka Pharmaceutical Co., Ltd. Aripiprazolo suspensijos ir liofilizuotos kompozicijos gamybos būdai
KR20100099292A (ko) * 2007-12-19 2010-09-10 얀센 파마슈티카 엔.브이. 장기 작용성 주사가능 팔리페리돈 에스테르와 관련된 투여 요법
MX358344B (es) 2011-03-18 2018-08-15 Alkermes Pharma Ireland Ltd Composiciones farmaceuticas que comprenden un antipsicotico insoluble en agua y esteres de sorbitan.
US9040695B2 (en) * 2011-04-26 2015-05-26 Torrent Pharmaceuticals Limited Acid addition salts of risperidone and pharmaceutical compositions thereof
NZ630428A (en) * 2012-03-19 2017-02-24 Alkermes Pharma Ireland Ltd Pharmaceutical compositions comprising benzyl alcohol
EP2827868B8 (de) 2012-03-19 2019-12-18 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit fettsäureestern
AU2013235523B9 (en) 2012-03-19 2018-01-04 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising glycerol esters
US9770440B2 (en) 2012-04-04 2017-09-26 Intervet Inc. Solid oral pharmaceutical compositions for isoxazoline compounds
CN102659577B (zh) * 2012-04-07 2014-07-02 安徽绩溪县徽煌化工有限公司 一种亚甲基双羟基萘酸的制备方法
WO2014080285A2 (en) 2012-09-19 2014-05-30 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
NZ706067A (en) 2012-09-26 2016-07-29 Tangent Reprofiling Ltd Modulators of androgen synthesis
US9375433B2 (en) 2012-09-26 2016-06-28 Tangent Reprofiling Limited Modulators of androgen synthesis
CN110368360A (zh) 2014-03-20 2019-10-25 奥克梅斯制药爱尔兰有限公司 具有增加的注射速度的阿立哌唑制剂
CN106831594B (zh) * 2017-01-18 2018-02-02 力赛生物医药科技（厦门）有限公司 可乐定双羟萘酸盐及其制备方法
WO2019173230A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
JP2025508811A (ja) * 2022-02-22 2025-04-10 上海雲晟研新生物科技有限公司 カリプラジン薬用塩及びその結晶形、医薬組成物、製造方法並びに使用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
NO954275L (no) 1995-10-26
PL311282A1 (en) 1996-02-05
HUT72970A (en) 1996-06-28
CZ286688B6 (en) 2000-06-14
SK280589B6 (sk) 2000-04-10
DK0697019T3 (da) 1998-09-28
EP0697019A1 (de) 1996-02-21
CN1121719A (zh) 1996-05-01
BG100094A (bg) 1996-05-31
BG62004B1 (bg) 1998-12-30
GR3026028T3 (en) 1998-04-30
NO305083B1 (no) 1999-03-29
IL109448A0 (en) 1994-07-31
LV12315B (en) 2000-03-20
KR100307101B1 (ko) 2001-11-30
NZ266143A (en) 1996-07-26
CA2160366C (en) 2006-06-06
FI955166A0 (fi) 1995-10-27
ZA942909B (en) 1995-10-26
CA2160366A1 (en) 1994-11-10
CY2107B1 (en) 2002-04-26
PH30476A (en) 1997-05-28
JP3478397B2 (ja) 2003-12-15
DE69408666D1 (de) 1998-04-02
NO954275D0 (no) 1995-10-26
SG47046A1 (en) 1998-03-20
TW376319B (en) 1999-12-11
AU675136B2 (en) 1997-01-23
CN1041727C (zh) 1999-01-20
SI9420031B (sl) 2002-08-31
HK1006059A1 (en) 1999-02-05
DE69408666T2 (de) 1998-06-18
IL109448A (en) 1997-03-18
ES2113652T3 (es) 1998-05-01
RU2131428C1 (ru) 1999-06-10
PL182466B1 (pl) 2002-01-31
LV12315A (lv) 1999-07-20
JPH08509482A (ja) 1996-10-08
AU6721694A (en) 1994-11-21
HU218212B (hu) 2000-06-28
WO1994025460A1 (en) 1994-11-10
HU9501934D0 (en) 1995-09-28
SK131395A3 (en) 1996-06-05
US5612346A (en) 1997-03-18
FI109125B (fi) 2002-05-31
FI955166L (fi) 1995-10-27
SI9420031A (en) 1996-08-31
EP0697019B1 (de) 1998-02-25
CZ270695A3 (en) 1996-01-17
US5723467A (en) 1998-03-03
RO115955B1 (ro) 2000-08-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification