ATE163418T1 - Risperidon pamoate - Google Patents

Risperidon pamoate

Info

Publication number
ATE163418T1
ATE163418T1 AT94915538T AT94915538T ATE163418T1 AT E163418 T1 ATE163418 T1 AT E163418T1 AT 94915538 T AT94915538 T AT 94915538T AT 94915538 T AT94915538 T AT 94915538T AT E163418 T1 ATE163418 T1 AT E163418T1
Authority
AT
Austria
Prior art keywords
pct
risperidone
sec
compositions
compound
Prior art date
Application number
AT94915538T
Other languages
English (en)
Inventor
Jean Louis Mesens
Jozef Peeters
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE163418T1 publication Critical patent/ATE163418T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT94915538T 1993-04-28 1994-04-22 Risperidon pamoate ATE163418T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93201216 1993-04-28

Publications (1)

Publication Number Publication Date
ATE163418T1 true ATE163418T1 (de) 1998-03-15

Family

ID=8213799

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94915538T ATE163418T1 (de) 1993-04-28 1994-04-22 Risperidon pamoate

Country Status (31)

Country Link
US (2) US5612346A (de)
EP (1) EP0697019B1 (de)
JP (1) JP3478397B2 (de)
KR (1) KR100307101B1 (de)
CN (1) CN1041727C (de)
AT (1) ATE163418T1 (de)
AU (1) AU675136B2 (de)
BG (1) BG62004B1 (de)
CA (1) CA2160366C (de)
CY (1) CY2107B1 (de)
CZ (1) CZ286688B6 (de)
DE (1) DE69408666T2 (de)
DK (1) DK0697019T3 (de)
ES (1) ES2113652T3 (de)
FI (1) FI109125B (de)
GR (1) GR3026028T3 (de)
HU (1) HU218212B (de)
IL (1) IL109448A (de)
LV (1) LV12315B (de)
NO (1) NO305083B1 (de)
NZ (1) NZ266143A (de)
PH (1) PH30476A (de)
PL (1) PL182466B1 (de)
RO (1) RO115955B1 (de)
RU (1) RU2131428C1 (de)
SG (1) SG47046A1 (de)
SI (1) SI9420031B (de)
SK (1) SK280589B6 (de)
TW (1) TW376319B (de)
WO (1) WO1994025460A1 (de)
ZA (1) ZA942909B (de)

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ATE288270T1 (de) 1993-11-19 2005-02-15 Janssen Pharmaceutica Nv Mikroverkapselte 1,2-benzazole
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
CA2304568C (en) * 1997-09-30 2008-08-12 Eli Lilly And Company Olanzapine pamoate formulations
US6617321B2 (en) * 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
DE69917663T2 (de) * 1998-09-30 2005-05-25 Eli Lilly And Co., Indianapolis 2-methyl-thieno-benzodiazepin-formulierung
WO2000027849A2 (en) * 1998-11-12 2000-05-18 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
US6770478B2 (en) * 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
WO2002043766A1 (en) * 2000-11-29 2002-06-06 Takeda Chemical Industries, Ltd. Medicinal compositions and process for producing the same
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
RU2321391C2 (ru) * 2002-07-29 2008-04-10 Алза Корпорейшн Способы и лекарственные формы для контролируемой доставки палиперидона
EP1534288A1 (de) * 2002-08-23 2005-06-01 Ranbaxy Laboratories, Ltd. Stabilisierte wässrige risperidonhaltige lösungen und verfahren zu deren herstellung
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
EP1615924A1 (de) * 2003-04-22 2006-01-18 Synthon B.V. Wasserlöslich salze von risperidon
RU2249456C1 (ru) * 2003-07-15 2005-04-10 Боев Игорь Викторович Способ комбинированного купирования шизоаффективных синдромов психотического и субпсихотического уровня в условиях дневного стационара
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
BRPI0415531B8 (pt) * 2003-10-23 2021-05-25 Otsuka Pharma Co Ltd formulação de aripiprazol injetável estéril de liberação controlada e método para a sua preparação
WO2005053796A1 (en) * 2003-12-02 2005-06-16 B & B Beheer Nv Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists
US7884096B2 (en) * 2003-12-02 2011-02-08 Pharmaneuroboost N.V. Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
WO2005072705A1 (en) * 2004-01-29 2005-08-11 Neuromolecular, Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions
EP1838716B1 (de) * 2005-01-05 2011-06-01 Eli Lilly And Company Olanzapinpamoat-dihydrat
EP1695973A1 (de) * 2005-02-24 2006-08-30 Neuro3D Ocaperidonsalz und dieser enthaltende pharmazeutische Zubereitung
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
CA2622758A1 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
BRPI0811319A2 (pt) 2007-05-25 2015-02-10 Tolmar Therapeutics Inc Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento
JP4879349B2 (ja) * 2007-07-31 2012-02-22 大塚製薬株式会社 アリピプラゾール懸濁液及び凍結乾燥製剤の製造方法
CN101932327A (zh) * 2007-12-19 2010-12-29 詹森药业有限公司 与长效注射用帕潘立酮酯相关的给药方案
US9034867B2 (en) 2011-03-18 2015-05-19 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising sorbitan esters
US9040695B2 (en) * 2011-04-26 2015-05-26 Torrent Pharmaceuticals Limited Acid addition salts of risperidone and pharmaceutical compositions thereof
JP6219918B2 (ja) 2012-03-19 2017-10-25 アルカームス ファーマ アイルランド リミテッド グリセロールエステルを含む医薬組成物
WO2013142205A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising benzyl alcohol
WO2013142198A1 (en) 2012-03-19 2013-09-26 Alkermes Pharma Ireland Limited Pharmaaceutical compositions comprising fatty acid esters
BR112014024833B1 (pt) 2012-04-04 2022-10-04 Intervet International B.V. Produto farmacêutico veterinário mastigável macio, processo para sua fabricação e seu uso, bem como uso de pamoato de sódio
CN102659577B (zh) * 2012-04-07 2014-07-02 安徽绩溪县徽煌化工有限公司 一种亚甲基双羟基萘酸的制备方法
EP3718536A1 (de) 2012-09-19 2020-10-07 Alkermes Pharma Ireland Limited Pharmazeutische zusammensetzungen mit verbesserter lagerstabilität
US9375433B2 (en) 2012-09-26 2016-06-28 Tangent Reprofiling Limited Modulators of androgen synthesis
HK1211868A1 (en) * 2012-09-26 2016-06-03 Tangent Reprofiling Limited Modulators of androgen synthesis
EP3119399A4 (de) 2014-03-20 2017-09-27 Alkermes Pharma Ireland Limited Aripiprazolformulierungen mit erhöhten injektionsgeschwindigkeiten
CN106831594B (zh) * 2017-01-18 2018-02-02 力赛生物医药科技（厦门）有限公司 可乐定双羟萘酸盐及其制备方法
CA3092335A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy
CN120698949A (zh) * 2022-02-22 2025-09-26 上海云晟研新生物科技有限公司 卡利拉嗪药用盐及其晶型、药物组合物、制备方法和用途

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Publication number Priority date Publication date Assignee Title
US4352811A (en) * 1981-11-12 1982-10-05 Hoechst-Roussel Pharmaceuticals Inc. 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB9008850D0 (en) * 1990-04-19 1990-06-13 Janssen Pharmaceutica Nv Novel 2,9-disubstituted-4h-pyridol(1,2-a)pyrimidin-4-ones

Also Published As

Publication number Publication date
EP0697019B1 (de) 1998-02-25
NO305083B1 (no) 1999-03-29
JP3478397B2 (ja) 2003-12-15
LV12315B (en) 2000-03-20
WO1994025460A1 (en) 1994-11-10
US5612346A (en) 1997-03-18
SG47046A1 (en) 1998-03-20
TW376319B (en) 1999-12-11
IL109448A0 (en) 1994-07-31
NO954275D0 (no) 1995-10-26
JPH08509482A (ja) 1996-10-08
CN1041727C (zh) 1999-01-20
PL182466B1 (pl) 2002-01-31
PL311282A1 (en) 1996-02-05
DE69408666T2 (de) 1998-06-18
PH30476A (en) 1997-05-28
NZ266143A (en) 1996-07-26
ES2113652T3 (es) 1998-05-01
HUT72970A (en) 1996-06-28
IL109448A (en) 1997-03-18
DE69408666D1 (de) 1998-04-02
CA2160366C (en) 2006-06-06
EP0697019A1 (de) 1996-02-21
BG100094A (bg) 1996-05-31
CA2160366A1 (en) 1994-11-10
SK280589B6 (sk) 2000-04-10
HU218212B (hu) 2000-06-28
KR100307101B1 (ko) 2001-11-30
US5723467A (en) 1998-03-03
LV12315A (lv) 1999-07-20
DK0697019T3 (da) 1998-09-28
GR3026028T3 (en) 1998-04-30
CZ286688B6 (en) 2000-06-14
CY2107B1 (en) 2002-04-26
ZA942909B (en) 1995-10-26
HU9501934D0 (en) 1995-09-28
HK1006059A1 (en) 1999-02-05
AU6721694A (en) 1994-11-21
SK131395A3 (en) 1996-06-05
CZ270695A3 (en) 1996-01-17
SI9420031A (en) 1996-08-31
SI9420031B (sl) 2002-08-31
BG62004B1 (bg) 1998-12-30
RU2131428C1 (ru) 1999-06-10
NO954275L (no) 1995-10-26
FI955166A0 (fi) 1995-10-27
FI109125B (fi) 2002-05-31
RO115955B1 (ro) 2000-08-30
AU675136B2 (en) 1997-01-23
FI955166L (fi) 1995-10-27
CN1121719A (zh) 1996-05-01

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Legal Events

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UEP Publication of translation of european patent specification