RO115955B1 - Derivat de risperidonă, procedeu de obţinere şi compoziţie farmaceutică - Google Patents
Derivat de risperidonă, procedeu de obţinere şi compoziţie farmaceuticăInfo
- Publication number
- RO115955B1 RO115955B1 RO95-01879A RO9501879A RO115955B1 RO 115955 B1 RO115955 B1 RO 115955B1 RO 9501879 A RO9501879 A RO 9501879A RO 115955 B1 RO115955 B1 RO 115955B1
- Authority
- RO
- Romania
- Prior art keywords
- derivative
- preparing
- risperidone
- pharmaceutical composition
- chemical formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
- C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
Grupul de invenţii se referă la un derivat de risperidonă, un procedeu de obţinere a acesteia, precum şi la o compoziţie farmaceutică care are în componenţă acest derivat de risperidonă. Derivatul de risperidonă, utilizat ca medicament, prezintă o structură corespunzătoare formulei chimice (I): are proprietăţi neuroleptice şi prezintă un punct de topire de 269,2°C. Procedeul de obţinere a derivatului de risperidonă cu formula chimică (I) constă în aceea că se tratează o soluţie de 3 - [2-[4-(6-fluor-1,2-benzisoxazol-3-il)-1-piperidinil]-6,7,8,9 -tetrahidro -2-metil -4H -pyrido [1,2 -a] pyrimidin -4 onă aflată într-un solvent inert constând din etanol, cu o soluţie de acid pamoic în solvent de N,N-dimetilformamidă, precipitatul rezultat se filtrează, se spală cu etanol şi se usucă în mod în sine cunoscut. Compoziţia farmaceutică, conform invenţiei, cuprinde un compus cu formula chimică (I), într-o cantitate eficientă din punct de vedere terapeutic, asociat cu un purtător acceptabil din punct de vedere farmaceutic şi se administrează într-o formă de dozare injectabilă, sub formă de suspensie apoasă. Compoziţia conform invenţiei include suplimentar alcool benzilic, esteri de sorbitan şi/sau un derivat de celuloză.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP93201216 | 1993-04-28 | ||
PCT/EP1994/001296 WO1994025460A1 (en) | 1993-04-28 | 1994-04-22 | Risperidone pamoate |
Publications (1)
Publication Number | Publication Date |
---|---|
RO115955B1 true RO115955B1 (ro) | 2000-08-30 |
Family
ID=8213799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO95-01879A RO115955B1 (ro) | 1993-04-28 | 1994-04-22 | Derivat de risperidonă, procedeu de obţinere şi compoziţie farmaceutică |
Country Status (32)
Country | Link |
---|---|
US (2) | US5612346A (ro) |
EP (1) | EP0697019B1 (ro) |
JP (1) | JP3478397B2 (ro) |
KR (1) | KR100307101B1 (ro) |
CN (1) | CN1041727C (ro) |
AT (1) | ATE163418T1 (ro) |
AU (1) | AU675136B2 (ro) |
BG (1) | BG62004B1 (ro) |
CA (1) | CA2160366C (ro) |
CY (1) | CY2107B1 (ro) |
CZ (1) | CZ286688B6 (ro) |
DE (1) | DE69408666T2 (ro) |
DK (1) | DK0697019T3 (ro) |
ES (1) | ES2113652T3 (ro) |
FI (1) | FI109125B (ro) |
GR (1) | GR3026028T3 (ro) |
HK (1) | HK1006059A1 (ro) |
HU (1) | HU218212B (ro) |
IL (1) | IL109448A (ro) |
LV (1) | LV12315B (ro) |
NO (1) | NO305083B1 (ro) |
NZ (1) | NZ266143A (ro) |
PH (1) | PH30476A (ro) |
PL (1) | PL182466B1 (ro) |
RO (1) | RO115955B1 (ro) |
RU (1) | RU2131428C1 (ro) |
SG (1) | SG47046A1 (ro) |
SI (1) | SI9420031B (ro) |
SK (1) | SK280589B6 (ro) |
TW (1) | TW376319B (ro) |
WO (1) | WO1994025460A1 (ro) |
ZA (1) | ZA942909B (ro) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE288270T1 (de) * | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
US5453425A (en) * | 1994-07-11 | 1995-09-26 | Janssen Pharmaceutica N.V. | Risperidone oral formulation |
TW487572B (en) * | 1996-05-20 | 2002-05-21 | Janssen Pharmaceutica Nv | Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters |
UA73715C2 (en) * | 1997-09-30 | 2005-09-15 | Lilly Co Eli | Pharmaceutically acceptable formulation of olanzapine pamoate and its use for treatment |
US6617321B2 (en) * | 1997-09-30 | 2003-09-09 | Eli Lilly And Company | 2-methyl-thieno-benzodiazepine formulation |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
EA002580B1 (ru) * | 1998-09-30 | 2002-06-27 | Эли Лилли Энд Компани | Готовая препаративная форма 2-метил-тиено-бензодиазепина |
CA2349700A1 (en) * | 1998-11-12 | 2000-05-18 | Merck & Co., Inc. | Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same |
FR2802101B1 (fr) | 1999-12-10 | 2003-02-28 | Aventis Pharma Sa | Association de cymemazine et d'un neuroleptique atypique |
US6770478B2 (en) * | 2000-02-10 | 2004-08-03 | The Regents Of The University Of California | Erythrocytic cells and method for preserving cells |
US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
WO2002043766A1 (fr) * | 2000-11-29 | 2002-06-06 | Takeda Chemical Industries, Ltd. | Compositions medicinales et leur procede de preparation |
US20050232995A1 (en) | 2002-07-29 | 2005-10-20 | Yam Nyomi V | Methods and dosage forms for controlled delivery of paliperidone and risperidone |
US20060148826A1 (en) * | 2002-08-23 | 2006-07-06 | Ashish Gogia | Stable aqueous solutions of risperidone and methods for their preparation |
KR20040034996A (ko) * | 2002-10-18 | 2004-04-29 | 한미약품 주식회사 | 리스페리돈의 개선된 제조방법 |
EP1615923A1 (en) * | 2003-04-22 | 2006-01-18 | Synthon B.V. | Risperidone monohydrochloride |
US6987111B2 (en) * | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
ES2315721T5 (es) | 2003-10-23 | 2012-08-24 | Otsuka Pharmaceutical Co., Ltd. | Formulación de aripiprazol inyectable estéril de liberación controlada y procedimiento |
PL1708790T3 (pl) * | 2003-12-02 | 2010-10-29 | Pharmaneuroboost N V | Zastosowanie pipamperonu oraz antagonisty receptora D2 lub antagonisty receptora serotoniny/dopaminy do leczenia zaburzeń psychotycznych |
US7884096B2 (en) * | 2003-12-02 | 2011-02-08 | Pharmaneuroboost N.V. | Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists |
WO2005072705A1 (en) * | 2004-01-29 | 2005-08-11 | Neuromolecular, Inc. | Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions |
ATE511512T1 (de) * | 2005-01-05 | 2011-06-15 | Lilly Co Eli | Olanzapinpamoat-dihydrat |
EP1695973A1 (en) * | 2005-02-24 | 2006-08-30 | Neuro3D | Ocaperidone salt and pharmaceutical compositions containing the same |
AR055099A1 (es) * | 2005-07-28 | 2007-08-08 | Alza Corp | Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol |
JP2009508859A (ja) * | 2005-09-15 | 2009-03-05 | エラン ファーマ インターナショナル リミテッド | ナノ粒子アリピプラゾール製剤 |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
BRPI0811319A2 (pt) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento |
PT2170279T (pt) * | 2007-07-31 | 2018-04-06 | Otsuka Pharma Co Ltd | Métodos para produção de suspensão de aripiprazole e formulação liofilizada |
EP3909585A1 (en) * | 2007-12-19 | 2021-11-17 | Janssen Pharmaceutica NV | Dosing regimen associated with long acting injectable paliperidone esters |
US9034867B2 (en) | 2011-03-18 | 2015-05-19 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising sorbitan esters |
EP2702060B1 (en) * | 2011-04-26 | 2015-12-30 | Torrent Pharmaceuticals Limited | Acid addition salts of risperidone and pharmaceutical compositions thereof |
JP6471089B2 (ja) | 2012-03-19 | 2019-02-13 | アルカームス ファーマ アイルランド リミテッド | 脂肪酸エステルを含む医薬組成物 |
JP6219918B2 (ja) | 2012-03-19 | 2017-10-25 | アルカームス ファーマ アイルランド リミテッド | グリセロールエステルを含む医薬組成物 |
CA2867137C (en) | 2012-03-19 | 2020-12-08 | Alkermes Pharma Ireland Limited | Pharmaceutical compositions comprising aripiprazole prodrugs and benzyl alcohol |
AU2013245008B2 (en) | 2012-04-04 | 2017-03-30 | Intervet International B.V. | Soft chewable pharmaceutical products |
CN102659577B (zh) * | 2012-04-07 | 2014-07-02 | 安徽绩溪县徽煌化工有限公司 | 一种亚甲基双羟基萘酸的制备方法 |
ES2792149T3 (es) | 2012-09-19 | 2020-11-10 | Alkermes Pharma Ireland Ltd | Composiciones farmacéuticas que tienen estabilidad de almacenamiento mejorada |
US9375433B2 (en) | 2012-09-26 | 2016-06-28 | Tangent Reprofiling Limited | Modulators of androgen synthesis |
BR112015006727B1 (pt) | 2012-09-26 | 2022-08-16 | Tangent Reprofiling Limited | Uso de uma composição farmacêutica |
MX2016012041A (es) | 2014-03-20 | 2017-01-19 | Alkermes Pharma Ireland Ltd | Formulaciones de aripiprazol que tienen mayores velocidades de inyeccion. |
CN106831594B (zh) * | 2017-01-18 | 2018-02-02 | 力赛生物医药科技(厦门)有限公司 | 可乐定双羟萘酸盐及其制备方法 |
JP7384812B2 (ja) | 2018-03-05 | 2023-11-21 | アルカームス ファーマ アイルランド リミテッド | アリピプラゾール投与戦略 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
-
1994
- 1994-03-31 TW TW083102808A patent/TW376319B/zh not_active IP Right Cessation
- 1994-04-08 PH PH48074A patent/PH30476A/en unknown
- 1994-04-22 CN CN94191934A patent/CN1041727C/zh not_active Expired - Lifetime
- 1994-04-22 ES ES94915538T patent/ES2113652T3/es not_active Expired - Lifetime
- 1994-04-22 RU RU95119831A patent/RU2131428C1/ru active
- 1994-04-22 EP EP94915538A patent/EP0697019B1/en not_active Expired - Lifetime
- 1994-04-22 AU AU67216/94A patent/AU675136B2/en not_active Expired
- 1994-04-22 HU HU9501934A patent/HU218212B/hu unknown
- 1994-04-22 NZ NZ266143A patent/NZ266143A/en not_active IP Right Cessation
- 1994-04-22 SI SI9420031A patent/SI9420031B/sl unknown
- 1994-04-22 JP JP52386294A patent/JP3478397B2/ja not_active Expired - Lifetime
- 1994-04-22 AT AT94915538T patent/ATE163418T1/de active
- 1994-04-22 CZ CZ19952706A patent/CZ286688B6/cs not_active IP Right Cessation
- 1994-04-22 DK DK94915538T patent/DK0697019T3/da active
- 1994-04-22 US US08/522,422 patent/US5612346A/en not_active Expired - Lifetime
- 1994-04-22 DE DE69408666T patent/DE69408666T2/de not_active Expired - Lifetime
- 1994-04-22 SK SK1313-95A patent/SK280589B6/sk not_active IP Right Cessation
- 1994-04-22 SG SG1996004131A patent/SG47046A1/en unknown
- 1994-04-22 CA CA002160366A patent/CA2160366C/en not_active Expired - Lifetime
- 1994-04-22 RO RO95-01879A patent/RO115955B1/ro unknown
- 1994-04-22 KR KR1019950704171A patent/KR100307101B1/ko not_active IP Right Cessation
- 1994-04-22 WO PCT/EP1994/001296 patent/WO1994025460A1/en active IP Right Grant
- 1994-04-22 PL PL94311282A patent/PL182466B1/pl unknown
- 1994-04-26 ZA ZA942909A patent/ZA942909B/xx unknown
- 1994-04-27 IL IL109448A patent/IL109448A/xx not_active IP Right Cessation
-
1995
- 1995-10-25 BG BG100094A patent/BG62004B1/bg unknown
- 1995-10-26 NO NO954275A patent/NO305083B1/no not_active IP Right Cessation
- 1995-10-27 FI FI955166A patent/FI109125B/fi not_active IP Right Cessation
-
1996
- 1996-12-24 US US08/773,737 patent/US5723467A/en not_active Expired - Lifetime
-
1998
- 1998-02-26 GR GR980400198T patent/GR3026028T3/el unknown
- 1998-06-11 HK HK98105164A patent/HK1006059A1/xx not_active IP Right Cessation
- 1998-06-16 CY CY9800009A patent/CY2107B1/xx unknown
-
1999
- 1999-02-24 LV LVP-99-32A patent/LV12315B/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RO115955B1 (ro) | Derivat de risperidonă, procedeu de obţinere şi compoziţie farmaceutică | |
RU95119831A (ru) | Рисперидонпамоат | |
NO162977B (no) | Filt for fremstilling av en vaatpressefilt for en papirmaskin, samt fremgangsmaate ved fremstilling derav. | |
EP0079545A1 (en) | Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same | |
DE19836697A1 (de) | Substituierte 4-Amino-2-aryl-pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate | |
EP0608565A1 (en) | Pyridopyrimidine derivatives, their production and use | |
DE4425145A1 (de) | Verwendung von Thiazol- und Thiadiazolverbindungen | |
US3594380A (en) | Isoquinolin-1(2h)-ones | |
DE19853278A1 (de) | Substituierte 4-Amino-2-aryl-cyclopenta[d]pyrimidine, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate | |
US3655897A (en) | Anti-inflammatory agents | |
NL7909024A (nl) | 1,4-dihydropyridinen en werkwijzen voor het bereiden en toepassen van deze verbindingen. | |
HU911301D0 (en) | Process for producing 2,9-disubstituted 4h-pyrido(1,2a)-pyrimidine derivatives and pharmaceutical preparatives containing these compounds as active substance | |
NZ198308A (en) | Heterocyclic substituted isoquinoline derivatives | |
CN102459278A (zh) | 取代的-1,3,8-三氮杂螺[4.5]癸烷-2,4-二酮 | |
US3930006A (en) | Antiparkinsonism compositions and method | |
EP0337136A3 (en) | Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy | |
IT1256320B (it) | Derivati eterociclici | |
AU652028B2 (en) | Salts of a 4-amino-3-acyl quinoline derivatives | |
DE102005012875B4 (de) | Verwendung von Amino substituierten 8-N-Benzimidazolen | |
CH638216A5 (de) | Oxadiazolopyrimidin-deriate. | |
GB2081708A (en) | Novel derivatives of (1-benzyl-1h-indazol-3-yl) oxyacetic acid and pharmaceutical composition containing it | |
US4617306A (en) | Pharmaceutical preparation comprising co-dergocrine and a calcium antagonist | |
JPH01211524A (ja) | 抗消化性潰瘍剤 | |
JPH085863B2 (ja) | 14−アニソイルアコニンおよびそれを有効成分とする新規な鎮痛・抗炎症剤 | |
US4590197A (en) | 9,10-substituted 2-mesitylimino-3-alkyl-3,4,6,7-tetra-hydro-2H-pyrimido(6,1-a)isoquinolin-4-ones, and their use as medicaments |