FI107993B - Framställning av mikropartiklar - Google Patents
Framställning av mikropartiklar Download PDFInfo
- Publication number
- FI107993B FI107993B FI940456A FI940456A FI107993B FI 107993 B FI107993 B FI 107993B FI 940456 A FI940456 A FI 940456A FI 940456 A FI940456 A FI 940456A FI 107993 B FI107993 B FI 107993B
- Authority
- FI
- Finland
- Prior art keywords
- microcapsules
- peg
- starch
- microspheres
- oil
- Prior art date
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/225—Microparticles, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
- B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Organic Chemistry (AREA)
- Acoustics & Sound (AREA)
- Dispersion Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (13)
1. Förfarande för framställning av fasta mikrosfärer eller gasfyllda mikrokapslar, kännetecknat av att man bil-5 dar utgängsmikrokapslar innehällande en flytande kärna och avlägsnar ätminstone nägot av nämnda vätska för bildande av antingen fasta mikrosfärer eller gasfyllda mikrokapslar, förutsatt att det för de gasfyllda mikrokapslarna använda väggbildande materialet är antingen (a) ett vattenlösligt 10 stärkelsederivat som icke är amfifiliskt material eller hydroxietylcellulosa, eller (b) ett vattenlösligt PEG-modi-fierat material för vilket ätminstone ett av följande kri-terier gäller: (i) det är icke ett amfifiliskt material och/eller (ii) det omfattar konjugater av PEG-stärkelse,
15 PEG-stärkelsederivat eller PEG-albumin; och förutsatt att det väggbildande materialet i varje fall är kapabelt att bli vattenolösligt da mikrosiärerna eller mikrokapslarna bildats. 20
2. Förfarande enligt patentkrav 1, kännetecknat av att mikrokapselväggarna vid bildande av de fasta mikrosfärerna bildas av ett vattenlösligt stärkelsederivat eller ett PEG-modifierat material och görs därefter vattenolösliga. UM j<;' ; 25
3. Förfarande enligt patentkrav 1 eller 2, kännetecknat ·;· av att stärkelsederivatet är amylodextrin. • · · · • · · • · • · • •I
4. Förfarande enligt nägot av patentkraven 1-3, känne- • « · · tecknat av att det PEG-modifierade materialet är ett konju- 30 gat av PEG-albumin eller ett PEG-stärkelse eller ett PEG- . stärkelsederivat.
• « • · · • · ·;·’ 5. Förfarande enligt nägot av de föregäende patentkraven, ··· kännetecknat av att kärnan är en i vatten oblandbar olja. 35 • I
6. Förfarande enligt patentkrav 5, kännetecknat av att ·;· ; oljan är relativt flyktig och avlägsnas frän de oljefyllda '· '· kapslarna genom indunstning. 107993
7. FÖrfarande enligt nägot av de föregäende patentkraven, kännetecknat av att man bildar utgängsmikrokapslarna me-delst ett dubbelemulsionsförfarande. 5
8. FÖrfarande enligt nägot av de föregäende patentkraven, kännetecknat av att man ytterligare separerar de fasta mik-rosfärerna eller gasfyllda mikrokapslarna frän nägot fly-tande medium och frystorkar de fasta mikrosfärerna eller mikrokapslarna. 10
9. Fasta mikrosfärer, kännetecknade av att de kan erhäl-las med ett förfarande enligt nägot av patentkraven 1-8 väri det väggbildande materialet gjorts olösligt genom dena-turering, kelatering eller ympning. 15
10. Gasfyllda mikrokapslar, kännetecknade av att de kan erhällas med ett förfarande enligt nägot av patentkraven 1- 8.
11. Fasta mikrosfärer enligt patentkrav 9 för användning i frisättningssystem.
12. Gasfyllda mikrokapslar enligt patentkrav 10 för an-vändning i diagnostiska procedurer. ..1·1
13. Användning av gasfyllda mikrokapslar enligt patentkrav : 2J 10 vid framställning av en komposition för användning i ett ··· förfarande där man bildar en diagnostisk bild. • · · · • « · • · · • · · • » • « · • · * * « 4 · · 4 · • · 2 • « · • · • · ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919116610A GB9116610D0 (en) | 1991-08-01 | 1991-08-01 | Preparation of microparticles |
| GB9116610 | 1991-08-01 | ||
| PCT/GB1992/001421 WO1993002712A1 (en) | 1991-08-01 | 1992-08-03 | Preparation of microparticles |
| GB9201421 | 1992-08-03 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI940456A0 FI940456A0 (sv) | 1994-01-31 |
| FI940456A FI940456A (sv) | 1994-01-31 |
| FI107993B true FI107993B (sv) | 2001-11-15 |
Family
ID=10699347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI940456A FI107993B (sv) | 1991-08-01 | 1994-01-31 | Framställning av mikropartiklar |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5648095A (sv) |
| EP (1) | EP0596984B1 (sv) |
| JP (1) | JP3604381B2 (sv) |
| AT (1) | ATE186221T1 (sv) |
| AU (1) | AU665206B2 (sv) |
| CA (1) | CA2113901C (sv) |
| DE (1) | DE69230254T2 (sv) |
| DK (1) | DK0596984T3 (sv) |
| ES (1) | ES2140415T3 (sv) |
| FI (1) | FI107993B (sv) |
| GB (2) | GB9116610D0 (sv) |
| GR (1) | GR3032234T3 (sv) |
| NO (1) | NO308448B1 (sv) |
| WO (1) | WO1993002712A1 (sv) |
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-
1991
- 1991-08-01 GB GB919116610A patent/GB9116610D0/en active Pending
-
1992
- 1992-08-03 DK DK92916557T patent/DK0596984T3/da active
- 1992-08-03 WO PCT/GB1992/001421 patent/WO1993002712A1/en active IP Right Grant
- 1992-08-03 EP EP92916557A patent/EP0596984B1/en not_active Expired - Lifetime
- 1992-08-03 ES ES92916557T patent/ES2140415T3/es not_active Expired - Lifetime
- 1992-08-03 GB GB9400981A patent/GB2273657B/en not_active Revoked
- 1992-08-03 JP JP50340393A patent/JP3604381B2/ja not_active Expired - Fee Related
- 1992-08-03 DE DE69230254T patent/DE69230254T2/de not_active Expired - Fee Related
- 1992-08-03 AT AT92916557T patent/ATE186221T1/de not_active IP Right Cessation
- 1992-08-03 CA CA002113901A patent/CA2113901C/en not_active Expired - Fee Related
- 1992-08-03 AU AU23768/92A patent/AU665206B2/en not_active Ceased
- 1992-08-03 US US08/190,022 patent/US5648095A/en not_active Expired - Fee Related
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1994
- 1994-01-31 FI FI940456A patent/FI107993B/sv not_active IP Right Cessation
- 1994-01-31 NO NO940319A patent/NO308448B1/no unknown
-
1999
- 1999-12-22 GR GR990403321T patent/GR3032234T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0596984B1 (en) | 1999-11-03 |
| ES2140415T3 (es) | 2000-03-01 |
| DE69230254T2 (de) | 2000-03-16 |
| GB9116610D0 (en) | 1991-09-18 |
| FI940456A0 (sv) | 1994-01-31 |
| DE69230254D1 (de) | 1999-12-09 |
| GB2273657A (en) | 1994-06-29 |
| ATE186221T1 (de) | 1999-11-15 |
| JPH06511423A (ja) | 1994-12-22 |
| AU2376892A (en) | 1993-03-02 |
| GB2273657B (en) | 1995-03-15 |
| FI940456A (sv) | 1994-01-31 |
| GR3032234T3 (en) | 2000-04-27 |
| DK0596984T3 (da) | 2000-01-03 |
| US5648095A (en) | 1997-07-15 |
| EP0596984A1 (en) | 1994-05-18 |
| JP3604381B2 (ja) | 2004-12-22 |
| CA2113901A1 (en) | 1993-02-18 |
| NO940319D0 (no) | 1994-01-31 |
| WO1993002712A1 (en) | 1993-02-18 |
| NO940319L (no) | 1994-01-31 |
| GB9400981D0 (en) | 1994-04-13 |
| NO308448B1 (no) | 2000-09-18 |
| AU665206B2 (en) | 1995-12-21 |
| CA2113901C (en) | 2003-12-02 |
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