ES2140415T3 - Preparacion de microparticulas. - Google Patents

Preparacion de microparticulas.

Info

Publication number
ES2140415T3
ES2140415T3 ES92916557T ES92916557T ES2140415T3 ES 2140415 T3 ES2140415 T3 ES 2140415T3 ES 92916557 T ES92916557 T ES 92916557T ES 92916557 T ES92916557 T ES 92916557T ES 2140415 T3 ES2140415 T3 ES 2140415T3
Authority
ES
Spain
Prior art keywords
microcapsules
pct
volatile oil
sec
oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92916557T
Other languages
English (en)
Inventor
Lisbeth Illum
Olufunmiloyo Johnson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Danbiosyst UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Danbiosyst UK Ltd filed Critical Danbiosyst UK Ltd
Application granted granted Critical
Publication of ES2140415T3 publication Critical patent/ES2140415T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/12—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution
    • B01J13/125—Making microcapsules or microballoons by phase separation removing solvent from the wall-forming material solution by evaporation of the solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Dispersion Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

MICROESFERAS SOLIDAS O MICROCAPSULAS HUECAS (POR EJEMPLO RELLENAS DE GAS O VAPOR), POR EJEMPLO DE AMILODEXTRINAS SE PREPARAN FORMANDO UNA CUBIERTA A PARTIR DE UN DERIVADO DEL ALMIDON SOLUBLE EN AGUA ALREDEDOR DE UN NUCLEO SOLIDO O LIQUIDO Y APARTANDO SUBSECUENTEMENTE EL NUCLEO. EL NUCLEO PUEDE SER ACEITE VOLATIL TAL COMO EL PERFLUOROEXANO. LAS MICROESFERAS O MICROCAPSULAS PUEDEN HACERSE MEDIANTE UNA EMULSION DOBLE DE ACEITE/AGUA/ACEITE SEGUIDA POR UN ENDURECIMIENTO QUIMICO O DURANTE CALOR PARA VOLVERLAS INSOLUBLES EN AGUA. LAS MICROESFERAS PUEDEN USARSE PARA SISTEMAS DE SUMINISTRO NASAL Y LAS MICROCAPSULAS PARA ECOCARDIOGRAFIA.
ES92916557T 1991-08-01 1992-08-03 Preparacion de microparticulas. Expired - Lifetime ES2140415T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919116610A GB9116610D0 (en) 1991-08-01 1991-08-01 Preparation of microparticles

Publications (1)

Publication Number Publication Date
ES2140415T3 true ES2140415T3 (es) 2000-03-01

Family

ID=10699347

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92916557T Expired - Lifetime ES2140415T3 (es) 1991-08-01 1992-08-03 Preparacion de microparticulas.

Country Status (14)

Country Link
US (1) US5648095A (es)
EP (1) EP0596984B1 (es)
JP (1) JP3604381B2 (es)
AT (1) ATE186221T1 (es)
AU (1) AU665206B2 (es)
CA (1) CA2113901C (es)
DE (1) DE69230254T2 (es)
DK (1) DK0596984T3 (es)
ES (1) ES2140415T3 (es)
FI (1) FI107993B (es)
GB (2) GB9116610D0 (es)
GR (1) GR3032234T3 (es)
NO (1) NO308448B1 (es)
WO (1) WO1993002712A1 (es)

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FI940456A0 (fi) 1994-01-31
DE69230254D1 (de) 1999-12-09
GB2273657A (en) 1994-06-29
ATE186221T1 (de) 1999-11-15
JPH06511423A (ja) 1994-12-22
AU2376892A (en) 1993-03-02
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FI940456A (fi) 1994-01-31
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US5648095A (en) 1997-07-15
EP0596984A1 (en) 1994-05-18
JP3604381B2 (ja) 2004-12-22
CA2113901A1 (en) 1993-02-18
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WO1993002712A1 (en) 1993-02-18
NO940319L (no) 1994-01-31
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FI107993B (fi) 2001-11-15
NO308448B1 (no) 2000-09-18
AU665206B2 (en) 1995-12-21
CA2113901C (en) 2003-12-02

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