FI107731B - Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi - Google Patents

Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi Download PDF

Info

Publication number
FI107731B
FI107731B FI924189A FI924189A FI107731B FI 107731 B FI107731 B FI 107731B FI 924189 A FI924189 A FI 924189A FI 924189 A FI924189 A FI 924189A FI 107731 B FI107731 B FI 107731B
Authority
FI
Finland
Prior art keywords
formula
compound
amine
process according
reaction
Prior art date
Application number
FI924189A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924189A (fi
FI924189A0 (fi
Inventor
Cynthia A Maryanoff
Lorraine Scott
Kirk L Sorgi
Original Assignee
Mcneilab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mcneilab Inc filed Critical Mcneilab Inc
Publication of FI924189A0 publication Critical patent/FI924189A0/fi
Publication of FI924189A publication Critical patent/FI924189A/fi
Application granted granted Critical
Publication of FI107731B publication Critical patent/FI107731B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/34—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/04—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D309/06—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI924189A 1991-09-19 1992-09-18 Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi FI107731B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76272091A 1991-09-19 1991-09-19
US76272091 1991-09-19
US92626992A 1992-08-05 1992-08-05
US92626992 1992-08-05

Publications (3)

Publication Number Publication Date
FI924189A0 FI924189A0 (fi) 1992-09-18
FI924189A FI924189A (fi) 1993-03-20
FI107731B true FI107731B (fi) 2001-09-28

Family

ID=27117178

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924189A FI107731B (fi) 1991-09-19 1992-09-18 Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi

Country Status (23)

Country Link
US (1) US5387700A (zh)
EP (1) EP0533483B1 (zh)
JP (1) JP3174410B2 (zh)
KR (1) KR100229180B1 (zh)
CN (1) CN1035820C (zh)
AT (1) ATE163937T1 (zh)
AU (1) AU651244B2 (zh)
CA (1) CA2078519C (zh)
DE (1) DE69224691T2 (zh)
DK (1) DK0533483T3 (zh)
EG (1) EG20164A (zh)
ES (1) ES2114917T3 (zh)
FI (1) FI107731B (zh)
GR (1) GR3026618T3 (zh)
HU (1) HU212634B (zh)
IL (1) IL103172A (zh)
MX (1) MX9205305A (zh)
MY (1) MY113564A (zh)
NO (1) NO179284C (zh)
NZ (1) NZ244409A (zh)
PH (1) PH31291A (zh)
TW (1) TW217413B (zh)
ZW (1) ZW14792A1 (zh)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3250777B2 (ja) * 1995-02-13 2002-01-28 セントラル硝子株式会社 イミド類、その塩類およびそれらの製造法
UA65607C2 (uk) * 1998-03-04 2004-04-15 Орто-Макнейл Фармацевтикал, Інк. Фармацевтична композиція (варіанти) та спосіб її приготування
AU779823B2 (en) * 1999-02-17 2005-02-10 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating essential tremor
US6420369B1 (en) 1999-05-24 2002-07-16 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful in treating dementia
ATE320805T1 (de) * 2000-07-07 2006-04-15 Ortho Mcneil Pharm Inc Antikonvulsive derivate zur behandlung und vorbeugung der entwicklung von typ ii diabetes und syndrom x
WO2002009694A1 (en) 2000-08-02 2002-02-07 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivatives useful for the treatment of depression
DK1333887T3 (da) 2000-10-30 2006-11-13 Ortho Mcneil Pharm Inc Kombinationsbehandling omfattende antidiabetiske og antikonvulsive midler
US7041650B2 (en) * 2001-07-09 2006-05-09 Ortho-Mcneil Pharmaceutical, Inc. Anticonvulsant derivative salts
UA78211C2 (en) * 2001-07-09 2007-03-15 Ortho Mcneil Pharm Inc Salts of fructopyranose derivatives as anticonvulsant
EP1450826A1 (en) * 2001-11-06 2004-09-01 Ortho-Mcneil Pharmaceutical Corp. Treatment and prevention of paresthesia comprising co-therapy with anticonvulsant derivatives and potassium
US20030224006A1 (en) 2002-03-01 2003-12-04 Zaworotko Michael J. Multiple-component solid phases containing at least one active pharmaceutical ingredient
AU2003213242A1 (en) * 2002-02-26 2003-09-09 Ortho-Mcneil Pharmaceutical Inc. Co-therapy for the treatment of migraine comprising anticonvulsant derivatives and anti-migraine agents
US7060725B2 (en) * 2002-05-13 2006-06-13 Janssen Pharmaceutica N.V. Substituted sulfamate anticonvulsant derivatives
US20040115262A1 (en) * 2002-07-29 2004-06-17 Frank Jao Formulations and dosage forms for controlled delivery of topiramate
US20050175697A1 (en) * 2003-12-29 2005-08-11 David Edgren Novel drug compositions and dosage forms of topiramate
AR039744A1 (es) * 2002-06-26 2005-03-09 Alza Corp Metodos y formas de dosificacion para aumentar la solubilidad de las composiciones de farmacos para la administracion controlada
UA80450C2 (en) * 2002-10-31 2007-09-25 Ortho Mcneil Pharm Inc Continuous process for the preparation of fructopyranose sulfamate derivatives
US7196209B2 (en) * 2002-10-31 2007-03-27 Ortho-Mcneil Pharmaceutical, Inc. Continuous process for the preparation of fructopyranose sulfamate derivatives
UA81657C2 (ru) * 2003-03-04 2008-01-25 Орто-Макнейл Фармасьютикел, Инк. Способ получения противосудорожных производных топирамата
WO2004108732A1 (en) * 2003-05-12 2004-12-16 Sun Pharmaceutical Industries Limited PROCESS FOR THE PREPARATION OF 2,3:4,5-BIS-O(1-METHYLETHYLIDENE)-ß-D-FRUCTOPYRANOSE SULFAMATE
EP1653922A2 (en) * 2003-08-06 2006-05-10 Alza Corporation Uniform delivery of topiramate over prolonged period of time with enhanced dispersion formulation
AU2004268549A1 (en) * 2003-08-22 2005-03-10 Alza Corporation Stepwise delivery of topiramate over prolonged period of time
EP1701697A2 (en) * 2003-09-02 2006-09-20 ALZA Corporation Novel drug compositions and dosage forms of topiramate
EP1684713A1 (en) * 2003-11-14 2006-08-02 ALZA Corporation Controlled release of topirimate in liquid dosage forms
KR20050062976A (ko) * 2003-12-19 2005-06-28 일동제약주식회사 2,3:4,5-비스-오-(1-메틸에틸리덴)-베타-디-프럭토피라노즈설파메이트의 새로운 개량된 제조방법
JP2007517061A (ja) * 2003-12-29 2007-06-28 アルザ・コーポレーシヨン 新規薬剤組成物及び投与形態物
US20050175696A1 (en) * 2003-12-29 2005-08-11 David Edgren Drug granule coatings that impart smear resistance during mechanical compression
US20050203287A1 (en) * 2004-03-11 2005-09-15 Chandrasekhar Batchu Process for the preparation of sulfamate derivatives
AR049646A1 (es) * 2004-06-16 2006-08-23 Janssen Pharmaceutica Nv Derivados de sulfamato y sulfamida utiles para el tratamiento de la epilepsia y trastornos relacionados
MY147767A (en) * 2004-06-16 2013-01-31 Janssen Pharmaceutica Nv Novel sulfamate and sulfamide derivatives useful for the treatment of epilepsy and related disorders
JP4912312B2 (ja) * 2004-08-24 2012-04-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗痙攣薬として有用な新規なベンゾ−縮合ヘテロアリールスルファミド誘導体
AU2005294611B2 (en) * 2004-10-05 2011-10-06 Fallbrook Intellectual Property Company Llc Continuously variable transmission
AU2006249577A1 (en) * 2005-05-20 2006-11-30 Janssen Pharmaceutica N.V. Process for preparation of sulfamide derivatives
CN101257889A (zh) * 2005-05-25 2008-09-03 詹森药业有限公司 托吡酯的儿科制剂
US8716231B2 (en) * 2005-12-19 2014-05-06 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain
US20070155827A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression
US8691867B2 (en) * 2005-12-19 2014-04-08 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction
US8937096B2 (en) * 2005-12-19 2015-01-20 Janssen Pharmaceutica Nv Use of benzo-fused heterocyle sulfamide derivatives for the treatment of mania and bipolar disorder
AR058389A1 (es) * 2005-12-19 2008-01-30 Janssen Pharmaceutica Nv Uso de derivados heterociclicos benzo-fusionados de sulfamida para el tratamiento de la obesidad
US20070155823A1 (en) * 2005-12-19 2007-07-05 Smith-Swintosky Virginia L Use of benzo-fused heterocycle sulfamide derivatives as neuroprotective agents
US8497298B2 (en) * 2005-12-19 2013-07-30 Janssen Pharmaceutica Nv Use of benzo-fused heterocycle sulfamide derivatives for lowering lipids and lowering blood glucose levels
US20070191459A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for Lowering Lipids and Lowering Blood Glucose Levels
US20070191461A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of migraine
US20070191474A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of migraine
US20070191449A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Depression
US20070191453A1 (en) * 2006-02-15 2007-08-16 Smith-Swintosky Virginia L Use of benzo-heteroaryl sulfamide derivatives for the treatment of substance abuse and addiction
WO2007099388A1 (en) * 2006-03-01 2007-09-07 Glade Organics Private Limited An improved process for the manufacture of topiramate
WO2007108009A1 (en) * 2006-03-17 2007-09-27 Alembic Limited A process for purification of topiramate
JP2009537635A (ja) * 2006-05-19 2009-10-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 癲癇の処置のための共同−療法
JP5424571B2 (ja) * 2007-04-12 2014-02-26 協和発酵キリン株式会社 トピラマート含有固形製剤
CN101720397B (zh) * 2007-04-24 2013-01-02 福博科技术公司 电力牵引传动装置
CN101450951B (zh) * 2007-11-30 2012-10-10 重庆凯林制药有限公司 托吡酯的制备方法
US20090247617A1 (en) * 2008-03-26 2009-10-01 Abdel-Magid Ahmed F Process for the preparation of benzo-fused heteroaryl sulfamates
US20090247616A1 (en) * 2008-03-26 2009-10-01 Smith-Swintosky Virginia L Use of benzo-fused heterocyle sulfamide derivatives for the treatment of anxiety
CA2729056A1 (en) 2008-06-23 2010-01-21 Janssen Pharmaceutica Nv Crystalline form of (2s)-(-)-n-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
US8815939B2 (en) * 2008-07-22 2014-08-26 Janssen Pharmaceutica Nv Substituted sulfamide derivatives
JP5643844B2 (ja) * 2010-02-05 2014-12-17 サイノファーム タイワン リミテッド トピラマート（ｔｏｐｉｒａｍａｔｅ）の製造方法
CN102936268A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种托吡酯中间体丙酮叉的制备方法
CN106397502A (zh) * 2016-08-31 2017-02-15 安徽省润生医药股份有限公司 一种托吡酯的合成工艺
CN108341844A (zh) * 2018-04-25 2018-07-31 广州小桔生物科技有限公司 一种高纯度托吡酯的制备方法
CN110655542A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯的晶型
CN110655541A (zh) * 2018-06-29 2020-01-07 鲁南制药集团股份有限公司 一种2,3:4,5-双-O-(1-甲基亚乙基)-β-D-吡喃果糖氯磺酸酯晶型
US20220016074A1 (en) 2018-11-21 2022-01-20 Rosemont Pharmaceuticals Limited Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability
CN114350340B (zh) * 2022-01-13 2023-01-17 陕西科技大学 一种压裂用增渗剂及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4582916A (en) * 1983-09-26 1986-04-15 Mcneilab, Inc. Chlorosulfate and azidosulfate esters of tetrahydro-2H-pyran-2-yl-methanol
US4513006A (en) * 1983-09-26 1985-04-23 Mcneil Lab., Inc. Anticonvulsant sulfamate derivatives

Also Published As

Publication number Publication date
HUT63612A (en) 1993-09-28
MX9205305A (es) 1993-07-01
DE69224691D1 (de) 1998-04-16
IL103172A (en) 1997-01-10
EP0533483A2 (en) 1993-03-24
DK0533483T3 (da) 1998-09-28
HU9202974D0 (en) 1992-11-30
TW217413B (zh) 1993-12-11
FI924189A (fi) 1993-03-20
JP3174410B2 (ja) 2001-06-11
PH31291A (en) 1998-07-06
EG20164A (en) 1997-08-31
CN1035820C (zh) 1997-09-10
MY113564A (en) 2002-04-30
NO923637D0 (no) 1992-09-18
HU212634B (en) 1996-09-30
ZW14792A1 (en) 1994-04-20
IL103172A0 (en) 1993-02-21
KR100229180B1 (ko) 1999-11-01
KR930006029A (ko) 1993-04-20
US5387700A (en) 1995-02-07
JPH05230011A (ja) 1993-09-07
NO923637L (no) 1993-03-22
CA2078519A1 (en) 1993-03-20
EP0533483B1 (en) 1998-03-11
ATE163937T1 (de) 1998-03-15
DE69224691T2 (de) 1998-08-20
GR3026618T3 (en) 1998-07-31
CA2078519C (en) 2003-09-16
NO179284C (no) 1996-09-11
FI924189A0 (fi) 1992-09-18
EP0533483A3 (en) 1994-11-02
NO179284B (no) 1996-06-03
ES2114917T3 (es) 1998-06-16
AU2451892A (en) 1993-03-25
AU651244B2 (en) 1994-07-14
NZ244409A (en) 1995-02-24
CN1075317A (zh) 1993-08-18

Similar Documents

Publication Publication Date Title
FI107731B (fi) Menetelmä 2,3:4,5-bis-O-(1-metyylietylideeni)-beta-D-fruktopyranoosin ja (1-metyylisykloheksyyli)metanolin kloorisulfaatti- ja sulfamaattijohdannaisten valmistamiseksi
EP0001500A1 (en) 1-Carbocyclic aryl-2-mono or -bis(alkoxycarbonyl) guanidino ethanes, and methods for their preparation and the preparation therefrom of 4,5-dihydro-2-alkoxycarbonylamino-5-carbocyclic aryl imidazoles
US4981996A (en) Method for the production of O-substituted hydroxylamines
US20050203287A1 (en) Process for the preparation of sulfamate derivatives
US6281367B1 (en) Process for the synthesis of HIV protease inhibitors
KR100210731B1 (ko) 2-클로로-5-메틸-피리딘의 제조방법
US6320057B1 (en) Intermediates for the preparation of 2-imidazoline-5-ones
KR100674098B1 (ko) Ｎ,ｎ-디알킬아릴아민 촉매의 존재하에서ｎ-알크(엔)옥시(또는 아릴옥시)카보닐이소티오시아네이트 및 그의 유도체를 제조하는 방법
Rigo et al. Studies on pyrrolidinones. Synthesis of N‐acylpyroglutamic acids having bactericide and fungicide properties
US6175019B1 (en) Process for the preparation of 1,3-dimethylimidazolium 4-carboxylate
EP0157661B1 (fr) Diisocyanates 1-10 décane et leurs procédés de fabrication
GB2170806A (en) N-(b-mercapto-iso-butyryl)proline, derivatives and a process for their preparation
US5352794A (en) Process for the preparation of N-(2-chloro-pyridin-5-yl-methyl)ethylenediamine
KR930006198B1 (ko) 신규 α-클로로케톤 유도체 및 그 제조법
EP0902000B1 (en) A method of preparing 1, 1-Dialkoxycycloalkanes
KR100415520B1 (ko) 1-(2-클로로페닐)-5(4h)-테트라졸리논의제조방법
JPH0528708B2 (zh)
US4892956A (en) 5-cyano-4,5-dihydro-3,4-dicarboxypyrazole derivatives
US4234514A (en) Method of preparing ketoxime carbamates
EP2938595B1 (fr) Procede de synthese d'une hydrazine utile dans le traitement du virus du papillome
FR3037952A1 (fr) Procede de synthese d'oximes aromatiques
US4924001A (en) Process for preparing 5-cyano-4, 5-dihydro-3,4-dicarboxypyrazole derivatives
RU2325380C2 (ru) Способ получения 1-(пиримидин-2-ил)пропан-2-онов
US4264528A (en) Method of preparing ketoxime carbamates
HU190527B (en) Process for preparing thiazole derivatives

Legal Events

Date Code Title Description
MA Patent expired