FI107539B - Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu - Google Patents

Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu Download PDF

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Publication number
FI107539B
FI107539B FI925131A FI925131A FI107539B FI 107539 B FI107539 B FI 107539B FI 925131 A FI925131 A FI 925131A FI 925131 A FI925131 A FI 925131A FI 107539 B FI107539 B FI 107539B
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FI
Finland
Prior art keywords
factor viii
kda
dna
dna sequence
factor
Prior art date
Application number
FI925131A
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English (en)
Finnish (fi)
Swedish (sv)
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FI925131L (fi
FI925131A0 (fi
Inventor
Jack Spira
Peter Lind
Annelie B Almstedt
Eva Maria Gray
Catherine Ljung
Helena Inga Sandberg
Mona Sydow-Baeckman
Helena Wiman
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Pharmacia & Upjohn Ab
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Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of FI925131L publication Critical patent/FI925131L/fi
Publication of FI925131A0 publication Critical patent/FI925131A0/fi
Application granted granted Critical
Publication of FI107539B publication Critical patent/FI107539B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Mold Materials And Core Materials (AREA)
  • Molds, Cores, And Manufacturing Methods Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI925131A 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu FI107539B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9100799 1991-03-15
SE9100799A SE468050C (sv) 1991-03-15 1991-03-15 Rekombinant derivat av human faktor VIII
SE9200150 1992-01-20
PCT/SE1992/000150 WO1992016557A1 (en) 1991-03-15 1992-03-11 Recombinant human factor viii derivatives

Publications (3)

Publication Number Publication Date
FI925131L FI925131L (fi) 1992-11-11
FI925131A0 FI925131A0 (fi) 1992-11-11
FI107539B true FI107539B (fi) 2001-08-31

Family

ID=20382191

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925131A FI107539B (fi) 1991-03-15 1992-11-11 Menetelmä yhdistelmä-humaani-hyytymistekijä VIII:n johdannaisen valmistamiseksi ja menetelmässä käytettävä DNA-jakso, vektori ja isäntäsolu

Country Status (17)

Country Link
EP (1) EP0533862B1 (de)
JP (1) JP2655752B2 (de)
AR (1) AR247590A1 (de)
AT (1) ATE186055T1 (de)
AU (1) AU650730B2 (de)
CA (1) CA2081659C (de)
DE (1) DE69230206T2 (de)
DK (1) DK0533862T3 (de)
ES (1) ES2137182T3 (de)
FI (1) FI107539B (de)
GR (1) GR3032468T3 (de)
IE (1) IE920814A1 (de)
NO (1) NO308174B1 (de)
PT (1) PT100245B (de)
SE (1) SE468050C (de)
WO (1) WO1992016557A1 (de)
ZA (1) ZA921882B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595886A (en) 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US6060447A (en) * 1987-05-19 2000-05-09 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
US5744446A (en) * 1992-04-07 1998-04-28 Emory University Hybrid human/animal factor VIII
US5888974A (en) * 1992-04-07 1999-03-30 Emory University Hybrid human/animal factor VIII
US5663060A (en) * 1992-04-07 1997-09-02 Emory University Hybrid human/animal factor VIII
US5364771A (en) * 1992-04-07 1994-11-15 Emory University Hybrid human/porcine factor VIII
ATE174628T1 (de) 1992-07-31 1999-01-15 Medeva Holdings Bv Expression rekombinanter fusionsproteine in attenuierten bakterien
SE9300509D0 (sv) * 1993-02-16 1993-02-16 Kabi Pharmacia Ab Peg treatment
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
GB9401787D0 (en) * 1994-01-31 1994-03-23 Medeva Holdings Bv Vaccine compositions
SE9303601D0 (sv) * 1993-11-01 1993-11-01 Kabi Pharmacia Ab Improved cell cultivation method and medium
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US6200560B1 (en) 1998-10-20 2001-03-13 Avigen, Inc. Adeno-associated virus vectors for expression of factor VIII by target cells
US6221349B1 (en) 1998-10-20 2001-04-24 Avigen, Inc. Adeno-associated vectors for expression of factor VIII by target cells
US6197526B1 (en) * 1999-01-04 2001-03-06 Dyax Corp. Polypeptides for binding human factor VIII and fragments of human factor VIII
US7112438B2 (en) 1999-01-04 2006-09-26 Dyax Corp. Binding molecules for human factor VIII and factor VIII-like proteins
EP1048726B1 (de) * 1999-04-27 2006-07-26 Négrier, Claude Modifizierte Faktor VIII cDNA
EP1038959A1 (de) * 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Faktor VIII ohne B-Domän, der ein oder mehrere Insertionsstücke von verkürztem Intron I des Faktors IX enthält
SE9901379D0 (sv) 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1233064A1 (de) * 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modifizierte Faktor VIII cDNA und deren Verwendung bei der Produktion von Faktor VIII
EP1283263A1 (de) * 2001-08-08 2003-02-12 Aventis Behring GmbH Modifizierte cDNA für die erhöhte Expression von Faktor VIII und seinen Derivaten
EP1284290A1 (de) * 2001-08-08 2003-02-19 Aventis Behring GmbH Erhöhung der Expression von Faktor VIII durch Insertion von spleissbaren Nukleotidsequenzen in Faktor VIII cDNA
EP2345731B1 (de) 2003-09-30 2015-10-21 The Trustees of the University of Pennsylvania Adenoassoziierte Virus-Claden, Sequenzen, diese enthaltende Vektoren und ihre Verwendungen
ES2525067T3 (es) 2005-04-07 2014-12-17 The Trustees Of The University Of Pennsylvania Método de incremento de la función de un vector de AAV
KR20080007226A (ko) * 2005-04-14 2008-01-17 체에스엘 베링 게엠베하 증가된 안정성을 가진 변형된 응고 인자 ⅷ 및 이의 유도체
WO2011126808A2 (en) 2010-03-29 2011-10-13 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
US9315825B2 (en) 2010-03-29 2016-04-19 The Trustees Of The University Of Pennsylvania Pharmacologically induced transgene ablation system
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
TR201908020T4 (tr) 2011-02-17 2019-06-21 Univ Pennsylvania Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler.
WO2015012924A2 (en) 2013-04-29 2015-01-29 The Trustees Of The University Of Pennsylvania Tissue preferential codon modified expression cassettes, vectors containing same, and use thereof
CN105017410B (zh) * 2014-04-18 2018-06-08 北京诺思兰德生物技术股份有限公司 一种b区部分缺失型重组人凝血因子ⅷ
EP3283126B1 (de) 2015-04-16 2019-11-06 Emory University Rekombinante promotoren und vektoren zur proteinexpression in leber und verwendung davon
SG11201902998SA (en) * 2016-10-03 2019-05-30 Daiichi Sankyo Co Ltd PROMOTER OF Hspa5 GENE
WO2022032140A2 (en) 2020-08-07 2022-02-10 Amicus Therapeutics, Inc. Vesicle targeting proteins and uses of same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
JPS62181786A (ja) * 1985-08-12 1987-08-10 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 融合蛋白質の製造法
US4935233A (en) * 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
NO872932L (no) * 1986-07-18 1988-01-19 Gist Brocades Nv Fremgangsmaate for fremstilling av proteiner med faktorviiiaktivitet ved hjelp av mikrobielle vertsceller, eksprimeringsvektorer, vertsceller, antibiotika.
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
DE3720246A1 (de) * 1987-06-19 1988-12-29 Behringwerke Ag Faktor viii:c-aehnliches molekuel mit koagulationsaktivitaet
KR960701899A (ko) * 1989-11-17 1996-03-28 안네 제케르 인자 viii:c활성을 갖는 단백질 복합체 및 그의 제조
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
CA2078721A1 (en) * 1991-09-24 1993-03-25 Hiroshi Yonemura Process for preparing human coagulation factor viii protein complex

Also Published As

Publication number Publication date
JP2655752B2 (ja) 1997-09-24
SE468050B (sv) 1992-10-26
SE9100799L (sv) 1992-09-16
AU1351392A (en) 1992-10-21
NO924395L (no) 1993-01-13
DE69230206T2 (de) 2000-05-18
WO1992016557A1 (en) 1992-10-01
EP0533862A1 (de) 1993-03-31
EP0533862B1 (de) 1999-10-27
NO924395D0 (no) 1992-11-13
FI925131L (fi) 1992-11-11
ES2137182T3 (es) 1999-12-16
SE468050C (sv) 1998-04-27
PT100245B (pt) 1999-08-31
DE69230206D1 (de) 1999-12-02
CA2081659C (en) 2002-06-25
FI925131A0 (fi) 1992-11-11
NO308174B1 (no) 2000-08-07
ATE186055T1 (de) 1999-11-15
DK0533862T3 (da) 2000-01-17
IE920814A1 (en) 1992-09-23
AR247590A1 (es) 1995-01-31
CA2081659A1 (en) 1992-09-16
SE9100799D0 (sv) 1991-03-15
PT100245A (pt) 1993-07-30
AU650730B2 (en) 1994-06-30
GR3032468T3 (en) 2000-05-31
JPH05507420A (ja) 1993-10-28
ZA921882B (en) 1992-11-25

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

MA Patent expired