FI106127B - Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita - Google Patents

Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita Download PDF

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Publication number
FI106127B
FI106127B FI945290A FI945290A FI106127B FI 106127 B FI106127 B FI 106127B FI 945290 A FI945290 A FI 945290A FI 945290 A FI945290 A FI 945290A FI 106127 B FI106127 B FI 106127B
Authority
FI
Finland
Prior art keywords
formula
alkyl
exocyclic
compound
hydrogen
Prior art date
Application number
FI945290A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI945290A0 (fi
FI945290A (fi
Inventor
James Ray Mccarthy
Jeffrey Stephen Sabol
Donald Paul Matthews
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI945290A0 publication Critical patent/FI945290A0/fi
Publication of FI945290A publication Critical patent/FI945290A/fi
Application granted granted Critical
Publication of FI106127B publication Critical patent/FI106127B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
FI945290A 1992-05-12 1994-11-10 Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita FI106127B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US88197892 1992-05-12
US3101293A 1993-03-26 1993-03-26
US3101293 1993-03-26
US9303023 1993-04-01
PCT/US1993/003023 WO1993023414A1 (fr) 1992-05-12 1993-04-01 Procede de preparation d'inhibiteurs de ribonucleotide-reductase

Publications (3)

Publication Number Publication Date
FI945290A0 FI945290A0 (fi) 1994-11-10
FI945290A FI945290A (fi) 1994-11-10
FI106127B true FI106127B (fi) 2000-11-30

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945290A FI106127B (fi) 1992-05-12 1994-11-10 Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita

Country Status (15)

Country Link
EP (1) EP0640092B1 (fr)
JP (1) JP3265548B2 (fr)
KR (1) KR100255258B1 (fr)
AT (1) ATE146183T1 (fr)
AU (1) AU662630B2 (fr)
CA (1) CA2133961C (fr)
DE (1) DE69306570T2 (fr)
DK (1) DK0640092T3 (fr)
ES (1) ES2098032T3 (fr)
FI (1) FI106127B (fr)
GR (1) GR3022400T3 (fr)
HU (1) HU217963B (fr)
NO (1) NO302524B1 (fr)
NZ (1) NZ251886A (fr)
WO (1) WO1993023414A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ279030A (en) * 1994-01-07 1997-05-26 Merrell Pharma Inc 2'-deoxy-2'-(fluoromethylene)cytidine
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
BR0307712A (pt) * 2002-02-14 2005-05-24 Pharmasset Ltd Composto, composição e uso dos mesmos no tratamento de infecções por flaviviridae e proliferação celular anormal
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
EP2794627B1 (fr) 2011-12-22 2018-09-26 Alios Biopharma, Inc. Nucléosides substitués, nucléotides substitués et analogues de ceux-ci
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
CA2002648C (fr) * 1988-11-15 2000-02-29 James R. Mccarthy Derives 2'-halogenomethylidene, 2'-ethenylidene et 2'-ethynyle de cytidine, uridine et guanosine

Also Published As

Publication number Publication date
JP3265548B2 (ja) 2002-03-11
GR3022400T3 (en) 1997-04-30
NO944309D0 (no) 1994-11-11
CA2133961A1 (fr) 1993-11-25
EP0640092A1 (fr) 1995-03-01
FI945290A0 (fi) 1994-11-10
WO1993023414A1 (fr) 1993-11-25
CA2133961C (fr) 1998-03-31
JPH07507774A (ja) 1995-08-31
HU217963B (hu) 2000-05-28
DE69306570T2 (de) 1997-04-10
DK0640092T3 (da) 1996-12-30
NO944309L (no) 1994-11-11
AU662630B2 (en) 1995-09-07
DE69306570D1 (de) 1997-01-23
ATE146183T1 (de) 1996-12-15
FI945290A (fi) 1994-11-10
NZ251886A (en) 1996-02-27
NO302524B1 (no) 1998-03-16
AU4024793A (en) 1993-12-13
EP0640092B1 (fr) 1996-12-11
HUT68903A (en) 1995-08-28
KR100255258B1 (ko) 2000-05-01
ES2098032T3 (es) 1997-04-16
KR950701641A (ko) 1995-04-28
HU9403252D0 (en) 1995-02-28

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Owner name: AVENTIS INC.

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