DK0640092T3 - Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer - Google Patents

Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer

Info

Publication number
DK0640092T3
DK0640092T3 DK93909461.1T DK93909461T DK0640092T3 DK 0640092 T3 DK0640092 T3 DK 0640092T3 DK 93909461 T DK93909461 T DK 93909461T DK 0640092 T3 DK0640092 T3 DK 0640092T3
Authority
DK
Denmark
Prior art keywords
reductase inhibitors
ribonucleotide reductase
preparation
oxy
methylene
Prior art date
Application number
DK93909461.1T
Other languages
Danish (da)
English (en)
Inventor
James R Mccarthy
Donald P Matthews
Jeffrey S Sabol
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0640092T3 publication Critical patent/DK0640092T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK93909461.1T 1992-05-12 1993-04-01 Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer DK0640092T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US3101293A 1993-03-26 1993-03-26

Publications (1)

Publication Number Publication Date
DK0640092T3 true DK0640092T3 (da) 1996-12-30

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93909461.1T DK0640092T3 (da) 1992-05-12 1993-04-01 Fremgangsmåde til fremstilling af ribonucleotid-reduktaseinhibitorer

Country Status (15)

Country Link
EP (1) EP0640092B1 (fr)
JP (1) JP3265548B2 (fr)
KR (1) KR100255258B1 (fr)
AT (1) ATE146183T1 (fr)
AU (1) AU662630B2 (fr)
CA (1) CA2133961C (fr)
DE (1) DE69306570T2 (fr)
DK (1) DK0640092T3 (fr)
ES (1) ES2098032T3 (fr)
FI (1) FI106127B (fr)
GR (1) GR3022400T3 (fr)
HU (1) HU217963B (fr)
NO (1) NO302524B1 (fr)
NZ (1) NZ251886A (fr)
WO (1) WO1993023414A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2179987C (fr) * 1994-01-07 1999-01-19 Richard E. Donaldson Monohydrate de (e)-2'-desoxy-2'-(fluoromethylene)cytidine
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
AU2003217402A1 (en) * 2002-02-14 2003-09-04 Pharmasset Inc Modified fluorinated nucleoside analogues
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
LT2794627T (lt) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives

Also Published As

Publication number Publication date
HUT68903A (en) 1995-08-28
DE69306570T2 (de) 1997-04-10
ATE146183T1 (de) 1996-12-15
KR950701641A (ko) 1995-04-28
CA2133961C (fr) 1998-03-31
JP3265548B2 (ja) 2002-03-11
HU217963B (hu) 2000-05-28
KR100255258B1 (ko) 2000-05-01
NO944309D0 (no) 1994-11-11
FI106127B (fi) 2000-11-30
ES2098032T3 (es) 1997-04-16
NO944309L (no) 1994-11-11
FI945290A0 (fi) 1994-11-10
WO1993023414A1 (fr) 1993-11-25
AU662630B2 (en) 1995-09-07
CA2133961A1 (fr) 1993-11-25
FI945290A (fi) 1994-11-10
DE69306570D1 (de) 1997-01-23
HU9403252D0 (en) 1995-02-28
EP0640092A1 (fr) 1995-03-01
AU4024793A (en) 1993-12-13
EP0640092B1 (fr) 1996-12-11
JPH07507774A (ja) 1995-08-31
NO302524B1 (no) 1998-03-16
GR3022400T3 (en) 1997-04-30
NZ251886A (en) 1996-02-27

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