FI105186B - Menetelmä farmaseuttisesti aktiivisten penemyhdisteiden valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti aktiivisten penemyhdisteiden valmistamiseksi Download PDF

Info

Publication number
FI105186B
FI105186B FI930682A FI930682A FI105186B FI 105186 B FI105186 B FI 105186B FI 930682 A FI930682 A FI 930682A FI 930682 A FI930682 A FI 930682A FI 105186 B FI105186 B FI 105186B
Authority
FI
Finland
Prior art keywords
group
compound
penem
tetrahydrofuryl
preparation
Prior art date
Application number
FI930682A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI930682A0 (fi
FI930682A (fi
Inventor
Hiromitsu Iwata
Takashi Nakatsuka
Rie Tanaka
Masaji Ishiguro
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of FI930682A0 publication Critical patent/FI930682A0/fi
Publication of FI930682A publication Critical patent/FI930682A/fi
Application granted granted Critical
Publication of FI105186B publication Critical patent/FI105186B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/86—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/861—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with only atoms other than nitrogen atoms directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hydrocarbon radical or a substituted hydrocarbon radical, directly attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/893—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with a hetero ring or a condensed hetero ring system, directly attached in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FI930682A 1990-08-20 1993-02-16 Menetelmä farmaseuttisesti aktiivisten penemyhdisteiden valmistamiseksi FI105186B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP21705290 1990-08-20
JP21705290 1990-08-20
PCT/JP1991/001098 WO1992003442A1 (en) 1990-08-20 1991-08-16 Antibacterial penem esters derivatives
JP9101098 1991-08-16

Publications (3)

Publication Number Publication Date
FI930682A0 FI930682A0 (fi) 1993-02-16
FI930682A FI930682A (fi) 1993-02-16
FI105186B true FI105186B (fi) 2000-06-30

Family

ID=16698076

Family Applications (1)

Application Number Title Priority Date Filing Date
FI930682A FI105186B (fi) 1990-08-20 1993-02-16 Menetelmä farmaseuttisesti aktiivisten penemyhdisteiden valmistamiseksi

Country Status (23)

Country Link
US (2) US5830889A (ja)
EP (2) EP0757050B1 (ja)
JP (2) JP3148234B2 (ja)
KR (1) KR0178956B1 (ja)
AT (2) ATE242251T1 (ja)
AU (1) AU652954B2 (ja)
BR (1) BR9106789A (ja)
CA (1) CA2089368C (ja)
CZ (1) CZ282086B6 (ja)
DE (2) DE69131753T2 (ja)
DK (1) DK0544907T3 (ja)
ES (2) ES2137929T3 (ja)
FI (1) FI105186B (ja)
GR (1) GR3032372T3 (ja)
HU (1) HU213403B (ja)
IE (1) IE20000929A1 (ja)
IL (1) IL99243A (ja)
MX (1) MX9203822A (ja)
NO (1) NO302236B1 (ja)
PL (1) PL169584B1 (ja)
RU (1) RU2051919C1 (ja)
SK (1) SK280188B6 (ja)
WO (1) WO1992003442A1 (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365635B1 (en) * 1998-01-13 2002-04-02 Suntory Limited Antibacterial composition for topical administration containing antibiotic
JP2003501488A (ja) * 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
CA2434302A1 (en) * 2001-01-08 2002-08-15 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
WO2003051403A1 (en) 2001-12-13 2003-06-26 Dow Global Technologies Inc. Treatment of osteomyelitis with radiopharmaceuticals
KR100725440B1 (ko) * 2002-10-02 2007-06-07 닛뽕소다 가부시키가이샤 유기 화합물의 제조방법
CN1314691C (zh) * 2005-08-22 2007-05-09 鲁南制药集团股份有限公司 法罗培南钠的制备方法
WO2007039885A1 (en) * 2005-10-05 2007-04-12 Ranbaxy Laboratories Limited A process for the preparation of faropenem
US20080125408A1 (en) * 2006-11-14 2008-05-29 Pfizer Inc Penem prodrug
CN101235044B (zh) * 2008-03-03 2010-11-03 南京华威医药科技开发有限公司 法罗培南酯的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
JPS6019908B2 (ja) * 1980-04-30 1985-05-18 カネボウ株式会社 １，３−ジオキソレン−２−オン誘導体
US4479947A (en) * 1981-07-13 1984-10-30 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
US4654331A (en) * 1981-07-13 1987-03-31 Merck & Co., Inc. Oral absorption enhancement of carboxylic acid pharmaceuticals using (5-alkyl-2-oxo-1,3-dioxolen-4-yl)methyl ester group
JPS58159496A (ja) * 1983-03-02 1983-09-21 Kyoto Yakuhin Kogyo Kk セフエム系化合物
JPH075463B2 (ja) * 1985-03-09 1995-01-25 サントリー株式会社 抗菌剤
EP0275002A1 (en) * 1987-01-09 1988-07-20 Hoechst Aktiengesellschaft Process for the production of 7-oxo-4-thia-1-aza-bicyclo [3.2.0] hept-2-ene derivatives
GB8713515D0 (en) * 1987-06-10 1987-07-15 Erba Farmitalia Methoxymethyl compounds
GB2206578B (en) * 1987-07-07 1991-07-03 Erba Carlo Spa Process for the preparation of penems
JPH026728A (ja) 1988-06-23 1990-01-10 Japan Radio Co Ltd 弾性表面波による液体粘性測定装置
GB2220203B (en) * 1988-07-04 1991-09-11 Erba Carlo Spa Process for penems
DE3839987A1 (de) * 1988-11-26 1990-05-31 Hoechst Ag Penemderivate und verfahren zu ihrer herstellung
EP0399228A1 (de) * 1989-04-29 1990-11-28 Hoechst Aktiengesellschaft Verfahren zur Herstellung von Penemverbindungen

Also Published As

Publication number Publication date
EP0544907A1 (en) 1993-06-09
JP3274854B2 (ja) 2002-04-15
MX9203822A (es) 1992-09-01
KR930701452A (ko) 1993-06-11
IL99243A (en) 1995-07-31
WO1992003442A1 (en) 1992-03-05
DE69133273T2 (de) 2004-05-13
CA2089368A1 (en) 1992-02-21
DE69131753D1 (de) 1999-12-02
AU8333391A (en) 1992-03-17
JP2000302786A (ja) 2000-10-31
SK280188B6 (sk) 1999-09-10
DE69131753T2 (de) 2000-05-04
HU213403B (en) 1997-06-30
EP0757050B1 (en) 2003-06-04
JP3148234B2 (ja) 2001-03-19
IE20000929A1 (en) 2001-05-30
ATE242251T1 (de) 2003-06-15
EP0757050A1 (en) 1997-02-05
ES2137929T3 (es) 2000-01-01
JPH06500769A (ja) 1994-01-27
CA2089368C (en) 2002-08-06
US5885981A (en) 1999-03-23
BR9106789A (pt) 1993-06-29
IL99243A0 (en) 1992-07-15
NO930588L (no) 1993-02-19
CZ20993A3 (en) 1993-10-13
CZ282086B6 (cs) 1997-05-14
US5830889A (en) 1998-11-03
NO930588D0 (no) 1993-02-19
HUT64349A (en) 1993-12-28
SK10793A3 (en) 1993-09-09
KR0178956B1 (ko) 1999-03-20
NO302236B1 (no) 1998-02-09
DE69133273D1 (de) 2003-07-10
FI930682A0 (fi) 1993-02-16
EP0544907B1 (en) 1999-10-27
ES2198455T3 (es) 2004-02-01
ATE186053T1 (de) 1999-11-15
PL169584B1 (pl) 1996-08-30
FI930682A (fi) 1993-02-16
RU2051919C1 (ru) 1996-01-10
GR3032372T3 (en) 2000-04-27
DK0544907T3 (da) 2000-01-24
AU652954B2 (en) 1994-09-15
HU9300461D0 (en) 1993-05-28

Similar Documents

Publication Publication Date Title
KR900007182B1 (ko) 페니실린 유도체의 제조방법
FI105186B (fi) Menetelmä farmaseuttisesti aktiivisten penemyhdisteiden valmistamiseksi
EP0272016B1 (en) 2beta-substituted-methylpenicillanic acid derivatives, and salts and esters thereof
CS228537B2 (en) Method for the production of methandiole bis-ester with derivates of foaming lanic acid
AU744636B2 (en) Tricyclic triazolobenzazepine derivatives, process for producing the same, and antiallergic
US4529592A (en) Penicillin derivatives
KR920005829B1 (ko) 2β-치환된 티오메틸페니실린 유도체 및 그의 염의 제조방법
HU207522B (en) Process for producing esters of antibacterial cepheme-derivatives and pharmaceutical compositions containing them
KR900007183B1 (ko) 페니실린 유도체의 제조방법
US4507239A (en) Penicillin derivatives and process for preparation
KR0178957B1 (ko) 페넴 화합물
US4435413A (en) (5R-6S,8R)-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid
KR0177844B1 (ko) 항균성 페넴화합물
KR830001902B1 (ko) 폐니실란산유도체의 제조방법
KR0183541B1 (ko) 베타-메틸 카르바페넴 카르복시 에스테르 유도체 및 이의 제조방법
US4762827A (en) (5R,6S,8R)-6-(1-hydroxyethyl)-2-(3R-pyrrolidin-2-one-3-yl)thiopenem-3-carboxylic acid
EP0660837A1 (en) Penem derivatives, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: DAIICHI ASUBIO PHARMA CO., LTD.

Free format text: DAIICHI ASUBIO PHARMA CO., LTD.

Owner name: DAIICHI ASUBIO PHARMA CO., LTD.

PC Transfer of assignment of patent

Owner name: ASUBIO PHARMA CO., LTD.

Free format text: ASUBIO PHARMA CO., LTD.